{"id":"https://openalex.org/W2003278476","doi":"https://doi.org/10.1177/0091270003262101","title":"Absolute Bioavailability of Imatinib (Glivec\u00ae) Orally versus Intravenous Infusion","display_name":"Absolute Bioavailability of Imatinib (Glivec\u00ae) Orally versus Intravenous Infusion","publication_year":2004,"publication_date":"2004-01-27","ids":{"openalex":"https://openalex.org/W2003278476","doi":"https://doi.org/10.1177/0091270003262101","mag":"2003278476","pmid":"https://pubmed.ncbi.nlm.nih.gov/14747424"},"language":"en","primary_location":{"id":"doi:10.1177/0091270003262101","doi":"https://doi.org/10.1177/0091270003262101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270003262101","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100642759","display_name":"Bin Peng","orcid":"https://orcid.org/0000-0001-5211-1544","observed_orcids":["https://orcid.org/0000-0001-5211-1544"]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bin Peng","raw_affiliation_strings":["Clinical Pharmacology, Novartis Pharmaceuticals Corporation, 180 Park Avenue, Building 105, Room 2W212, Florham Park, NJ 07936-1080, USA","Novartis Pharmaceuticals, Florham Park, New, Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Clinical Pharmacology, Novartis Pharmaceuticals Corporation, 180 Park Avenue, Building 105, Room 2W212, Florham Park, NJ 07936-1080, USA","institution_ids":["https://openalex.org/I4210117619"]},{"raw_affiliation_string":"Novartis Pharmaceuticals, Florham Park, New, Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026261845","display_name":"Catherine Dutreix","orcid":"https://orcid.org/0009-0000-0851-3423","observed_orcids":["https://orcid.org/0009-0000-0851-3423"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Catherine Dutreix","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049231258","display_name":"G\u00fcnther H. Mehring","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Gunther Mehring","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011431249","display_name":"Michael Hayes","orcid":"https://orcid.org/0000-0002-9215-1484","observed_orcids":["https://orcid.org/0000-0002-9215-1484"]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael J. Hayes","raw_affiliation_strings":["Novartis Pharmaceuticals, Florham Park, New, Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, Florham Park, New, Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015933270","display_name":"Monique Ben\u2010Am","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117619","display_name":"Novartis (United States)","ror":"https://ror.org/028fhxy95","country_code":"US","type":"company","lineage":["https://openalex.org/I1283582996","https://openalex.org/I4210117619"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Monique Ben\u2010Am","raw_affiliation_strings":["Novartis Pharmaceuticals, Florham Park, New, Jersey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharmaceuticals, Florham Park, New, Jersey","institution_ids":["https://openalex.org/I4210117619"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044662094","display_name":"Michael Seiberling","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael Seiberling","raw_affiliation_strings":["Swiss Pharma Contract, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Pharma Contract, Allschwil, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087154649","display_name":"Rolf Pokorny","orcid":"https://orcid.org/0000-0002-3681-6007","observed_orcids":["https://orcid.org/0000-0002-3681-6007"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolf Pokorny","raw_affiliation_strings":["Swiss Pharma Contract, Allschwil, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Swiss Pharma Contract, Allschwil, Switzerland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022108188","display_name":"Renaud Capdeville","orcid":"https://orcid.org/0000-0001-7611-0765","observed_orcids":["https://orcid.org/0000-0001-7611-0765"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Renaud Capdeville","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5112508130","display_name":"Peter M. Lloyd","orcid":"https://orcid.org/0009-0007-2337-7459","observed_orcids":["https://orcid.org/0009-0007-2337-7459"]},"institutions":[{"id":"https://openalex.org/I1283582996","display_name":"Novartis (Switzerland)","ror":"https://ror.org/02f9zrr09","country_code":"CH","type":"company","lineage":["https://openalex.org/I1283582996"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Peter Lloyd","raw_affiliation_strings":["Novartis Pharma AG, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Novartis Pharma AG, Basel, Switzerland","institution_ids":["https://openalex.org/I1283582996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5100642759"],"corresponding_institution_ids":["https://openalex.org/I4210117619"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":4.5987,"has_fulltext":false,"cited_by_count":166,"citation_normalized_percentile":{"value":0.95258621,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"44","issue":"2","first_page":"158","last_page":"162"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.27489998936653137,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10256","display_name":"Drug Solubulity and Delivery Systems","score":0.2703000009059906,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12547","display_name":"Pharmaceutical studies and practices","score":0.14890000224113464,"subfield":{"id":"https://openalex.org/subfields/2735","display_name":"Pediatrics, Perinatology and Child Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imatinib","display_name":"imatinib","score":0.9980000257492065},{"id":"https://openalex.org/keywords/absolute-bioavailability","display_name":"absolute bioavailability","score":0.9710000157356262},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.6380000114440918},{"id":"https://openalex.org/keywords/intravenous-infusion","display_name":"intravenous infusion","score":0.8080000281333923},{"id":"https://openalex.org/keywords/oral-solution","display_name":"oral solution","score":0.6389999985694885},{"id":"https://openalex.org/keywords/capsule-formulation","display_name":"capsule formulation","score":0.7820000052452087},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"pharmacokinetics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/drug-absorption","display_name":"drug absorption","score":0.6930000185966492},{"id":"https://openalex.org/keywords/healthy-volunteers","display_name":"healthy volunteers","score":0.5490000247955322}],"concepts":[{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.7657051086425781},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6863230466842651},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.5554038882255554},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.48413047194480896},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.47116193175315857},{"id":"https://openalex.org/C3017990168","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Orally active","level":3,"score":0.4154323637485504},{"id":"https://openalex.org/C2777056448","wikidata":"https://www.wikidata.org/wiki/Q285166","display_name":"Oral administration","level":2,"score":0.34902340173721313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2768499255180359},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002214","descriptor_name":"Capsules","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006207","descriptor_name":"Half-Life","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008657","descriptor_name":"Metabolic Clearance Rate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010865","descriptor_name":"Pilot Projects","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D018592","descriptor_name":"Cross-Over Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1177/0091270003262101","doi":"https://doi.org/10.1177/0091270003262101","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0091270003262101","pdf_url":null,"source":{"id":"https://openalex.org/S146237847","display_name":"The Journal of Clinical Pharmacology","issn_l":"0021-9754","issn":["0021-9754","0091-2700","0095-9863","1552-4604","2375-0839","2375-0928"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Clinical Pharmacology","raw_type":"journal-article"},{"id":"pmid:14747424","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14747424","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical pharmacology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":16,"referenced_works":["https://openalex.org/W2011474502","https://openalex.org/W2015551422","https://openalex.org/W2016086822","https://openalex.org/W2017399727","https://openalex.org/W2028959752","https://openalex.org/W2030154801","https://openalex.org/W2040396943","https://openalex.org/W2060317640","https://openalex.org/W2114903378","https://openalex.org/W2136776097","https://openalex.org/W2142969636","https://openalex.org/W2151504205","https://openalex.org/W2171722798","https://openalex.org/W2312804644","https://openalex.org/W2324850882","https://openalex.org/W2329648702"],"related_works":["https://openalex.org/W2129433856","https://openalex.org/W2126866083","https://openalex.org/W4389763320","https://openalex.org/W3164604811","https://openalex.org/W2766870013","https://openalex.org/W2092963797","https://openalex.org/W1986773298","https://openalex.org/W1242035707","https://openalex.org/W1499839313","https://openalex.org/W2074498773"],"abstract_inverted_index":{"The":[0,131],"purpose":[1],"of":[2,11,16,50,64,105,135],"this":[3],"study":[4],"was":[5,143,147],"to":[6],"investigate":[7],"the":[8,89,101,120,124,129],"absolute":[9,77],"bioavailability":[10,78,82],"a":[12,39,46,57,60,138,141],"single":[13,40],"oral":[14,23,48,93,121,133],"dose":[15,49,134],"imatinib":[17,51,67,90,106,125],"(Glivec),":[18],"400":[19],"mg":[20,29],"(capsules":[21],"vs.":[22],"solution),":[24],"compared":[25],"with":[26,85],"imatinib,":[27,136],"100":[28],"(intravenous":[30],"[i.v.]":[31],"infusion),":[32],"in":[33,42,52],"healthy":[34],"subjects.":[35],"Twelve":[36],"subjects":[37],"received":[38],"treatment":[41,44],"each":[43,72],"period:":[45],"400-mg":[47,132],"capsule":[53,91,126,139],"form":[54],"or":[55,59,140],"as":[56,108,137],"solution":[58,94,122],"100-mg":[61],"i.v.":[62,86],"infusion":[63],"imatinib.":[65],"Plasma":[66],"concentrations":[68],"were":[69,79,95,117],"measured":[70,109],"following":[71],"treatment;":[73],"pharmacokinetic":[74],"parameters":[75],"and":[76,92,97,103,114,123,146],"determined.":[80],"Absolute":[81],"values":[83],"(compared":[84],"infusion)":[87],"for":[88,119,128],"98.3%":[96],"97.2%,":[98],"respectively.":[99],"Both":[100],"rate":[102],"extent":[104],"absorption,":[107],"by":[110],"C(max),":[111],"partial":[112],"AUC,":[113,116],"total":[115],"similar":[118],"intended":[127],"market.":[130],"solution,":[142],"completely":[144,149],"absorbed":[145],"almost":[148],"bioavailable":[150],"(>":[151],"97%).":[152]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}