{"id":"https://openalex.org/W2003274380","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","title":"Abstract P4-16-10: A novel paclitaxel-dendrimer conjugate demonstrates better efficacy in breast cancer models","display_name":"Abstract P4-16-10: A novel paclitaxel-dendrimer conjugate demonstrates better efficacy in breast cancer models","publication_year":2013,"publication_date":"2013-12-15","ids":{"openalex":"https://openalex.org/W2003274380","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","mag":"2003274380"},"language":"en","primary_location":{"id":"doi:10.1158/0008-5472.sabcs13-p4-16-10","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"},"volume":null,"type":"conference-abstract","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012499522","display_name":"Arpan Satsangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Satsangi","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","RANN Research Corporation, San Antonio, TX","University of Texas at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"raw_affiliation_string":"RANN Research Corporation, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017606830","display_name":"SS Roy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"SS Roy","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","RANN Research Corporation, San Antonio, TX","University of Texas at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"raw_affiliation_string":"RANN Research Corporation, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086648107","display_name":"Rajiv K. Satsangi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RK Satsangi","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","RANN Research Corporation, San Antonio, TX","University of Texas at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"raw_affiliation_string":"RANN Research Corporation, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111520385","display_name":"RK Vadlamudi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"RK Vadlamudi","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","RANN Research Corporation, San Antonio, TX","University of Texas at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"raw_affiliation_string":"RANN Research Corporation, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050373045","display_name":"Joo L. Ong","orcid":"https://orcid.org/0000-0003-3330-2390","observed_orcids":["https://orcid.org/0000-0003-3330-2390"]},"institutions":[{"id":"https://openalex.org/I165951966","display_name":"The University of Texas at San Antonio Health Science Center","ror":"https://ror.org/02f6dcw23","country_code":"US","type":"education","lineage":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"id":"https://openalex.org/I45438204","display_name":"The University of Texas at San Antonio","ror":"https://ror.org/01kd65564","country_code":"US","type":"education","lineage":["https://openalex.org/I45438204"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"JL Ong","raw_affiliation_strings":["University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","RANN Research Corporation, San Antonio, TX","University of Texas at San Antonio, San Antonio, TX"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX; University of Texas Health Science Center at San Antonio, San Antonio, TX; RANN Research Corporation, San Antonio, TX","institution_ids":["https://openalex.org/I165951966","https://openalex.org/I45438204"]},{"raw_affiliation_string":"RANN Research Corporation, San Antonio, TX","institution_ids":[]},{"raw_affiliation_string":"University of Texas at San Antonio, San Antonio, TX","institution_ids":["https://openalex.org/I45438204"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"73","issue":"24_Supplement","first_page":"P4","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10725","display_name":"RNA Interference and Gene Delivery","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.9950000047683716},{"id":"https://openalex.org/keywords/dendrimer-conjugates","display_name":"dendrimer conjugates","score":0.7089999914169312},{"id":"https://openalex.org/keywords/pamam-dendrimers","display_name":"PAMAM dendrimers","score":0.9200000166893005},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.8360000252723694},{"id":"https://openalex.org/keywords/active-targeting","display_name":"active targeting","score":0.6819999814033508},{"id":"https://openalex.org/keywords/cathepsin-b","display_name":"cathepsin B","score":0.9340000152587891},{"id":"https://openalex.org/keywords/targeted-drug-delivery","display_name":"targeted drug delivery","score":0.8429999947547913},{"id":"https://openalex.org/keywords/mda-mb-231-xenograft","display_name":"MDA-MB-231 xenograft","score":0.9259999990463257},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.7300000190734863},{"id":"https://openalex.org/keywords/nanoparticle-drug-delivery","display_name":"nanoparticle drug delivery","score":0.5960000157356262},{"id":"https://openalex.org/keywords/tumor-specificity","display_name":"tumor specificity","score":0.32499998807907104}],"concepts":[{"id":"https://openalex.org/C55637122","wikidata":"https://www.wikidata.org/wiki/Q903923","display_name":"Dendrimer","level":2,"score":0.8348499536514282},{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.6789683103561401},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5767307877540588},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.5415816903114319},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5403293967247009},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.5325348377227783},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5224862694740295},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.5166919231414795},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5141739845275879},{"id":"https://openalex.org/C126511603","wikidata":"https://www.wikidata.org/wiki/Q1261145","display_name":"Targeted drug delivery","level":3,"score":0.5021922588348389},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.49317997694015503},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4625052809715271},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3593178391456604},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3274282217025757},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25736570358276367},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23494860529899597},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17216002941131592},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1394304633140564},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1158/0008-5472.sabcs13-p4-16-10","doi":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","is_oa":false,"landing_page_url":"https://doi.org/10.1158/0008-5472.sabcs13-p4-16-10","pdf_url":null,"source":{"id":"https://openalex.org/S168522863","display_name":"Cancer Research","issn_l":"0008-5472","issn":["0008-5472","1538-7445"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Research","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8700000047683716,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070325738","https://openalex.org/W2908143346","https://openalex.org/W2939279536","https://openalex.org/W2005781928","https://openalex.org/W3019569285","https://openalex.org/W2090196023","https://openalex.org/W3017908570","https://openalex.org/W2611181695","https://openalex.org/W2919544596","https://openalex.org/W7164520018"],"abstract_inverted_index":{"Abstract":[0,501],"BACKGROUND:":[1],"Breast":[2],"cancer":[3,11,30,139,223,343,459],"is":[4,16,73],"the":[5,81,165,321,328,358],"2nd":[6],"most":[7],"common":[8],"cause":[9],"of":[10,23,71,77,93,100,107,148,160,171,204,211,254,263,300,311,332,339,360,488],"deaths":[12],"in":[13,43,202,233,278,313,327,335,379,425,477],"women.":[14],"Chemotherapy":[15],"an":[17,151,197],"important":[18],"treatment":[19,439,442],"modality.":[20],"Yet,":[21],"delivery":[22,52,122,137,147,493],"drugs":[24],"such":[25,128],"as":[26,59,232,265,369,480],"paclitaxel":[27,340],"(PTX)":[28],"to":[29,37,53,62,138,176,194,267,306,351,371,384,430,435,457,482],"cells":[31,224,230,344,365,414,460],"remains":[32],"a":[33,38,60,91,142,179,184,205,286,297,324,406,422,444,489],"challenge,":[34],"mainly":[35],"due":[36],"drug's":[39],"low":[40,50],"solubility,":[41],"rapid":[42],"vivo":[44,260,417],"clearance,":[45],"high":[46,101],"systemic":[47],"toxicity,":[48],"and":[49,86,96,103,168,217,225,239],"drug":[51,249],"tumor.":[54],"Nanotechnology":[55],"has":[56,125],"been":[57,126],"proposed":[58],"solution":[61],"these":[63],"problems.":[64],"In":[65,259,416],"active":[66,133,491],"targeting,":[67],"increased":[68,455],"tumor":[69,237,261,426,478],"specificity":[70],"nanoparticles":[72],"achieved":[74],"through":[75,123,150,452],"attachment":[76],"agents":[78],"that":[79],"target":[80],"molecular":[82],"differences":[83],"between":[84],"normal":[85,228,364,463],"malignant":[87],"cells.":[88,140],"Dendrimers":[89],"are":[90],"category":[92],"synthetic,":[94],"monodisperse":[95],"multivalent":[97],"nanopolymers,":[98],"capable":[99],"drug-loading":[102],"multiple":[104],"covalent":[105],"bonding":[106],"bioactive":[108],"moieties.":[109],"Conjugation":[110],"using":[111],"enzyme":[112],"cleavable":[113,182],"linkers":[114],"allows":[115],"for":[116,135,145,236,320,341,348,354,362,374,412],"specific,":[117],"targeted":[118],"release.":[119],"While":[120],"PTX":[121,149,177,195,255,268,312,333,411,441,449],"dendrimers":[124,174],"established,":[127],"vehicles":[129],"have":[130],"not":[131,462],"used":[132,305],"targeting":[134,492],"specific":[136,146,308],"Thus,":[141],"need":[143],"exists":[144],"active-targeting":[152],"dendrimer-based":[153],"vehicle,":[154],"while":[155,403,440],"maintaining":[156],"high-drug":[157],"loading":[158],"properties":[159],"dendrimers.":[161],"This":[162,302,376,484],"study":[163],"reports":[164,469],"synthesis,":[166],"characterization,":[167],"biological":[169],"assessment":[170],"polyamidoamine":[172],"(PAMAM)":[173],"conjugated":[175,193],"via":[178,196],"peptide":[180,199],"spacer":[181,200],"by":[183,215],"cancer-upregulated":[185],"enzyme,":[186],"Cathepsin":[187],"B":[188],"(CatB).":[189],"METHODS:":[190],"PAMAM":[191,396],"was":[192,213,273,304,345,366],"enzyme-cleavable,":[198],"resulting":[201],"formation":[203],"PTX-laden":[206],"dendrimer":[207],"(PLD).":[208],"Structure":[209],"confirmation":[210],"PLD":[212,264,314,349,361,404,420,453,473],"done":[214],"1H-NMR":[216],"mass":[218],"spectrometry":[219],"(MS).":[220],"MDA-MB-231":[221,276,322,342,413,458],"breast":[222,229],"MCF10A":[226,363,464],"immortalized":[227],"served":[231],"vitro":[234],"models":[235],"efficacy":[238,262],"specificity.":[240],"WST-1":[241],"based":[242],"cytotoxicity":[243,456],"assays":[244,319],"were":[245],"performed":[246,274],"after":[247,438],"72h":[248],"incubation":[250],"at":[251,290,390],"various":[252],"concentrations":[253],"or":[256,270],"PTX-equivalent":[257],"dendrimer.":[258],"compared":[266,370,389,410,429,481],"alone":[269,272,432],"vehicle":[271,431],"on":[275,400,470],"xenografts":[277],"athymic":[279],"nude":[280],"mice.":[281],"RESULTS:":[282],"MS":[283],"data":[284],"showed":[285,443,454],"broad":[287],"peak":[288],"centered":[289],"24":[291],"kDa.":[292],"NMR":[293],"proton":[294],"integration":[295],"revealed":[296,419],"PTX:dendrimer":[298],"ratio":[299,303],"7:1.":[301],"deliver":[307],"molar":[309],"amounts":[310],"form":[315],"during":[316],"assays.":[317],"Cytotoxicity":[318],"demonstrated":[323],"marked":[325],"shift":[326,378],"relative":[329,350,380],"IC50":[330,338,359,381],"values":[331,382],"incorporated":[334],"PLD.":[336],"The":[337],"0.640":[346],"nM":[347,353,368,373,392],"3.29":[352],"PTX.":[355,375,483],"By":[356],"contrast,":[357],"2.45":[367],"2.85":[372],"smaller":[377,445],"correlates":[383],"reported":[385],"CatB":[386,471],"activity.":[387,472],"When":[388],"10":[391],"PTX/PLD,":[393],"negative":[394],"control":[395],"had":[397,405,421],"no":[398],"effect":[399],"cell":[401],"growth,":[402],"statistically-significant":[407],"reduced":[408],"proliferation":[409],"only.":[415],"studies":[418],"strong":[423],"reduction":[424,446,476],"volume":[427],"growth":[428,479],"(p<0.05)":[433],"up":[434],"2":[436],"weeks":[437],"(p>0.05).":[447],"CONCLUSIONS:":[448],"when":[450],"delivered":[451],"but":[461],"cells,":[465],"correlating":[466],"with":[467],"previous":[468],"demonstrates":[474],"enhanced":[475],"suggests":[485],"successful":[486],"development":[487],"cancer-specific":[490],"vehicle.":[494],"Citation":[495],"Information:":[496],"Cancer":[497],"Res":[498],"2013;73(24":[499],"Suppl):":[500],"nr":[502],"P4-16-10.":[503]},"counts_by_year":[{"year":2019,"cited_by_count":1}],"updated_date":"2026-09-25T08:18:29.962427","created_date":"2016-06-24T00:00:00"}