{"id":"https://openalex.org/W2003269232","doi":"https://doi.org/10.1182/blood-2003-06-1824","title":"The FIP1L1-PDGFR\u03b1 fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management","display_name":"The FIP1L1-PDGFR\u03b1 fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management","publication_year":2003,"publication_date":"2003-11-25","ids":{"openalex":"https://openalex.org/W2003269232","doi":"https://doi.org/10.1182/blood-2003-06-1824","mag":"2003269232","pmid":"https://pubmed.ncbi.nlm.nih.gov/15070659"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2003-06-1824","doi":"https://doi.org/10.1182/blood-2003-06-1824","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2003-06-1824","pdf_url":"https://ashpublications.org/blood/article-pdf/103/8/2879/1698838/zh800804002879.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://ashpublications.org/blood/article-pdf/103/8/2879/1698838/zh800804002879.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065621786","display_name":"Jason R. Gotlib","orcid":"https://orcid.org/0000-0001-8253-6156","observed_orcids":["https://orcid.org/0000-0001-8253-6156"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Gotlib","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060184481","display_name":"Jan Cools","orcid":"https://orcid.org/0000-0001-6626-5843","observed_orcids":["https://orcid.org/0000-0001-6626-5843"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jan Cools","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":null,"display_name":"James M. Malone","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James M. Malone","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112589761","display_name":"Stanley L. Schrier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanley L. Schrier","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113728001","display_name":"Dwight Gary Gilliland","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Gary Gilliland","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5015491065","display_name":"Steven E. Coutre","orcid":"https://orcid.org/0000-0001-8420-5748","observed_orcids":["https://orcid.org/0000-0001-8420-5748"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210137306","display_name":"Stanford Medicine","ror":"https://ror.org/03mtd9a03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven E. Coutre\u0301","raw_affiliation_strings":["From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","Howard Hughes Medical Institute, Harvard Medical School, Boston, MA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Division of Hematology, Department of Internal Medicine, Stanford University School of Medicine, Stanford, CA; Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA; and Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I1344073410","https://openalex.org/I136199984","https://openalex.org/I4210137306","https://openalex.org/I97018004"]},{"raw_affiliation_string":"Division of Hematology, Department of Medicine, Brigham and Women's Hospital, Boston, MA","institution_ids":["https://openalex.org/I1283280774"]},{"raw_affiliation_string":"Howard Hughes Medical Institute, Harvard Medical School, Boston, MA","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":null,"fwci":13.2188,"has_fulltext":true,"cited_by_count":290,"citation_normalized_percentile":{"value":0.99316024,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"103","issue":"8","first_page":"2879","last_page":"2891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10309","display_name":"Acute Myeloid Leukemia Research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fip1l1-pdgfra-fusion","display_name":"FIP1L1-PDGFRA fusion","score":0.9359999895095825},{"id":"https://openalex.org/keywords/hypereosinophilic-syndrome","display_name":"hypereosinophilic syndrome","score":0.9549999833106995},{"id":"https://openalex.org/keywords/chronic-eosinophilic-leukemia","display_name":"chronic eosinophilic leukemia","score":1.0},{"id":"https://openalex.org/keywords/pdgfra","display_name":"PDGFRA","score":0.7519999742507935},{"id":"https://openalex.org/keywords/tyrosine-kinase","display_name":"tyrosine kinase","score":0.8149999976158142},{"id":"https://openalex.org/keywords/imatinib-response","display_name":"imatinib response","score":0.8379999995231628},{"id":"https://openalex.org/keywords/interstitial-deletion","display_name":"interstitial deletion","score":0.828000009059906},{"id":"https://openalex.org/keywords/disease-classification","display_name":"disease classification","score":0.6359999775886536},{"id":"https://openalex.org/keywords/hypereosinophilia","display_name":"hypereosinophilia","score":0.7649999856948853},{"id":"https://openalex.org/keywords/disease-heterogeneity","display_name":"disease heterogeneity","score":0.5979999899864197},{"id":"https://openalex.org/keywords/molecular-diagnosis","display_name":"molecular diagnosis","score":0.4440000057220459}],"concepts":[{"id":"https://openalex.org/C2777621362","wikidata":"https://www.wikidata.org/wiki/Q2551272","display_name":"Hypereosinophilic syndrome","level":3,"score":0.8137199878692627},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.7963903546333313},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7181532979011536},{"id":"https://openalex.org/C2779084869","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Hypereosinophilia","level":3,"score":0.6407998204231262},{"id":"https://openalex.org/C37307934","wikidata":"https://www.wikidata.org/wiki/Q18030422","display_name":"PDGFRA","level":4,"score":0.6257054805755615},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.6032315492630005},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.6026084423065186},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.6014086008071899},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.5976319313049316},{"id":"https://openalex.org/C2776960273","wikidata":"https://www.wikidata.org/wiki/Q729735","display_name":"Chronic myelogenous leukemia","level":3,"score":0.5842252969741821},{"id":"https://openalex.org/C78221974","wikidata":"https://www.wikidata.org/wiki/Q18030425","display_name":"PDGFRB","level":3,"score":0.5627501010894775},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5224296450614929},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.5193461179733276},{"id":"https://openalex.org/C2778461978","wikidata":"https://www.wikidata.org/wiki/Q29496","display_name":"Leukemia","level":2,"score":0.509454071521759},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.4375920593738556},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3921104073524475},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.38583582639694214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.296474814414978},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2673325538635254},{"id":"https://openalex.org/C2775922572","wikidata":"https://www.wikidata.org/wiki/Q83567","display_name":"GiST","level":3,"score":0.19456622004508972},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.16870161890983582},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1234821081161499},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1047840416431427},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.08941379189491272},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08334064483642578},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.08257037401199341},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.059508681297302246}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003582","descriptor_name":"Cytogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003582","descriptor_name":"Cytogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003582","descriptor_name":"Cytogenetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015514","descriptor_name":"Oncogene Proteins, Fusion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017681","descriptor_name":"Hypereosinophilic Syndrome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020796","descriptor_name":"Receptor, Platelet-Derived Growth Factor alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D039221","descriptor_name":"mRNA Cleavage and Polyadenylation Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1182/blood-2003-06-1824","doi":"https://doi.org/10.1182/blood-2003-06-1824","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2003-06-1824","pdf_url":"https://ashpublications.org/blood/article-pdf/103/8/2879/1698838/zh800804002879.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:15070659","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15070659","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1182/blood-2003-06-1824","doi":"https://doi.org/10.1182/blood-2003-06-1824","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2003-06-1824","pdf_url":"https://ashpublications.org/blood/article-pdf/103/8/2879/1698838/zh800804002879.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1585009851","display_name":null,"funder_award_id":"K23HL04409","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2816037287","display_name":"FTI Biology &Treatment of Myeloproliferative Disorders","funder_award_id":"K23HL004409","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2852253759","display_name":null,"funder_award_id":"#CA66996","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G9000275656","display_name":null,"funder_award_id":"CA66996","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000889887","display_name":"Development of Novel Therapeutic Strategies in Human Leukemias","funder_award_id":"2p01ca066996-26","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320308295","display_name":"Leukemia and Lymphoma Society","ror":"https://ror.org/04m0xav37"},{"id":"https://openalex.org/F4320327336","display_name":"Vlaamse regering","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003269232.pdf","grobid_xml":"https://content.openalex.org/works/W2003269232.grobid-xml"},"referenced_works_count":200,"referenced_works":["https://openalex.org/W11727989","https://openalex.org/W15222133","https://openalex.org/W27937304","https://openalex.org/W58688676","https://openalex.org/W84666014","https://openalex.org/W108038632","https://openalex.org/W110944710","https://openalex.org/W116295454","https://openalex.org/W192836715","https://openalex.org/W293130875","https://openalex.org/W607725005","https://openalex.org/W1538959496","https://openalex.org/W1571014830","https://openalex.org/W1731209109","https://openalex.org/W1765926397","https://openalex.org/W1811953845","https://openalex.org/W1890719904","https://openalex.org/W1906130994","https://openalex.org/W1965472353","https://openalex.org/W1965594055","https://openalex.org/W1967330066","https://openalex.org/W1968147012","https://openalex.org/W1968602572","https://openalex.org/W1971393812","https://openalex.org/W1971477212","https://openalex.org/W1972031015","https://openalex.org/W1972044244","https://openalex.org/W1972144397","https://openalex.org/W1972709346","https://openalex.org/W1973844689","https://openalex.org/W1974402813","https://openalex.org/W1978330466","https://openalex.org/W1982659189","https://openalex.org/W1986529566","https://openalex.org/W1989491765","https://openalex.org/W1991665510","https://openalex.org/W1992089349","https://openalex.org/W1994171871","https://openalex.org/W1994373650","https://openalex.org/W1997249478","https://openalex.org/W1998735239","https://openalex.org/W2002209196","https://openalex.org/W2002286694","https://openalex.org/W2003567031","https://openalex.org/W2004377019","https://openalex.org/W2006597989","https://openalex.org/W2007035402","https://openalex.org/W2008188127","https://openalex.org/W2009378783","https://openalex.org/W2010463305","https://openalex.org/W2010810813","https://openalex.org/W2012747721","https://openalex.org/W2012952884","https://openalex.org/W2016826417","https://openalex.org/W2017095962","https://openalex.org/W2017489622","https://openalex.org/W2018162530","https://openalex.org/W2019070364","https://openalex.org/W2019186253","https://openalex.org/W2019410619","https://openalex.org/W2021323032","https://openalex.org/W2024334468","https://openalex.org/W2025690484","https://openalex.org/W2027481226","https://openalex.org/W2029429990","https://openalex.org/W2032742505","https://openalex.org/W2033806960","https://openalex.org/W2034486606","https://openalex.org/W2035008903","https://openalex.org/W2035667709","https://openalex.org/W2036019382","https://openalex.org/W2036047439","https://openalex.org/W2036180570","https://openalex.org/W2036369565","https://openalex.org/W2038793680","https://openalex.org/W2040662490","https://openalex.org/W2040723328","https://openalex.org/W2044241371","https://openalex.org/W2044327033","https://openalex.org/W2045231568","https://openalex.org/W2045377627","https://openalex.org/W2045800292","https://openalex.org/W2046779758","https://openalex.org/W2047845288","https://openalex.org/W2048138605","https://openalex.org/W2048292375","https://openalex.org/W2049357389","https://openalex.org/W2051329286","https://openalex.org/W2054262065","https://openalex.org/W2056297955","https://openalex.org/W2057383356","https://openalex.org/W2057441293","https://openalex.org/W2058240442","https://openalex.org/W2059455063","https://openalex.org/W2059683705","https://openalex.org/W2064244980","https://openalex.org/W2064559154","https://openalex.org/W2064698668","https://openalex.org/W2065267909","https://openalex.org/W2066913808","https://openalex.org/W2067493324","https://openalex.org/W2067684423","https://openalex.org/W2071656833","https://openalex.org/W2072162450","https://openalex.org/W2073095750","https://openalex.org/W2075428599","https://openalex.org/W2076142428","https://openalex.org/W2076314960","https://openalex.org/W2076569573","https://openalex.org/W2076792202","https://openalex.org/W2079704410","https://openalex.org/W2080686114","https://openalex.org/W2082291978","https://openalex.org/W2082331928","https://openalex.org/W2082679982","https://openalex.org/W2084383996","https://openalex.org/W2087566793","https://openalex.org/W2087931888","https://openalex.org/W2088494713","https://openalex.org/W2089196997","https://openalex.org/W2089289269","https://openalex.org/W2090045594","https://openalex.org/W2090173484","https://openalex.org/W2090249578","https://openalex.org/W2090954373","https://openalex.org/W2091667255","https://openalex.org/W2093254523","https://openalex.org/W2093548393","https://openalex.org/W2095434962","https://openalex.org/W2097460406","https://openalex.org/W2099207012","https://openalex.org/W2100499506","https://openalex.org/W2100505558","https://openalex.org/W2103344353","https://openalex.org/W2104485296","https://openalex.org/W2111914345","https://openalex.org/W2114347486","https://openalex.org/W2117450570","https://openalex.org/W2117563665","https://openalex.org/W2119410012","https://openalex.org/W2120658243","https://openalex.org/W2126524003","https://openalex.org/W2128329993","https://openalex.org/W2130687674","https://openalex.org/W2134045669","https://openalex.org/W2136698483","https://openalex.org/W2138884203","https://openalex.org/W2140626630","https://openalex.org/W2141338109","https://openalex.org/W2142161829","https://openalex.org/W2142962849","https://openalex.org/W2144541148","https://openalex.org/W2151222524","https://openalex.org/W2157693529","https://openalex.org/W2161037099","https://openalex.org/W2162939684","https://openalex.org/W2163052225","https://openalex.org/W2163977389","https://openalex.org/W2165897954","https://openalex.org/W2168217319","https://openalex.org/W2171620774","https://openalex.org/W2172112558","https://openalex.org/W2178260069","https://openalex.org/W2210873565","https://openalex.org/W2238698057","https://openalex.org/W2268842808","https://openalex.org/W2281850830","https://openalex.org/W2295770060","https://openalex.org/W2311403201","https://openalex.org/W2312540243","https://openalex.org/W2312726624","https://openalex.org/W2317274197","https://openalex.org/W2328556759","https://openalex.org/W2330754503","https://openalex.org/W2335061116","https://openalex.org/W2338549889","https://openalex.org/W2341302830","https://openalex.org/W2342251757","https://openalex.org/W2396625417","https://openalex.org/W2402206203","https://openalex.org/W2403933926","https://openalex.org/W2404644835","https://openalex.org/W2405546487","https://openalex.org/W2408425666","https://openalex.org/W2411900611","https://openalex.org/W2412199362","https://openalex.org/W2412979996","https://openalex.org/W2419165975","https://openalex.org/W2440355696","https://openalex.org/W3023846844","https://openalex.org/W3114112552","https://openalex.org/W3119870843","https://openalex.org/W4236968313","https://openalex.org/W4239095946","https://openalex.org/W4250518377","https://openalex.org/W4255955026","https://openalex.org/W4293245940","https://openalex.org/W4299490080","https://openalex.org/W4299782310","https://openalex.org/W6979155757"],"related_works":["https://openalex.org/W2460152703","https://openalex.org/W2239990123","https://openalex.org/W2071328718","https://openalex.org/W2075014705","https://openalex.org/W4300477556","https://openalex.org/W3033051741","https://openalex.org/W2045905423","https://openalex.org/W1995016923","https://openalex.org/W2072982356","https://openalex.org/W2150823273"],"abstract_inverted_index":{"Idiopathic":[0],"hypereosinophilic":[1],"syndrome":[2],"(HES)":[3],"and":[4,30,49,56,139,171,173,184],"chronic":[5,67],"eosinophilic":[6],"leukemia":[7,69],"(CEL)":[8],"comprise":[9],"a":[10,26,88,105],"spectrum":[11],"of":[12,38,85,104,151,167,169,176],"indolent":[13],"to":[14,41,101,128,143],"aggressive":[15],"diseases":[16],"characterized":[17],"by":[18],"unexplained,":[19],"persistent":[20],"hypereosinophilia.":[21],"These":[22,71],"disorders":[23],"have":[24],"eluded":[25],"unique":[27],"molecular":[28],"explanation,":[29],"therapy":[31],"has":[32],"primarily":[33],"been":[34],"oriented":[35],"toward":[36],"palliation":[37],"symptoms":[39],"related":[40],"organ":[42],"involvement.":[43],"Recent":[44],"reports":[45],"indicate":[46],"that":[47,119],"HES":[48,138,170],"CEL":[50,140,172],"are":[51],"imatinib-responsive":[52],"malignancies,":[53],"with":[54],"rapid":[55],"complete":[57],"hematologic":[58],"remissions":[59],"observed":[60],"at":[61],"lower":[62],"doses":[63],"than":[64],"used":[65],"in":[66,92],"myelogenous":[68],"(CML).":[70],"BCR-ABL-negative":[72],"cases":[73],"lack":[74,154],"activating":[75],"mutations":[76],"or":[77],"abnormal":[78],"fusions":[79],"involving":[80],"other":[81],"known":[82],"target":[83],"genes":[84],"imatinib,":[86,144],"implicating":[87],"novel":[89],"tyrosine":[90,109],"kinase":[91,110],"their":[93,181],"pathogenesis.":[94],"A":[95],"bedside-to-benchtop":[96],"translational":[97],"research":[98],"effort":[99],"led":[100],"the":[102,121,155,164,174,177],"identification":[103],"constitutively":[106],"activated":[107],"fusion":[108],"on":[111,180],"chromosome":[112],"4q12,":[113],"derived":[114],"from":[115],"an":[116,129],"interstitial":[117],"deletion,":[118],"fuses":[120],"platelet-derived":[122],"growth":[123],"factor":[124],"receptor-alpha":[125],"gene":[126,132],"(PDGFRA)":[127],"uncharacterized":[130],"human":[131],"FIP1-like-1":[133],"(FIP1L1).":[134],"However,":[135],"not":[136],"all":[137],"patients":[141,153],"respond":[142],"suggesting":[145,158],"disease":[146],"heterogeneity.":[147,160],"Furthermore,":[148],"approximately":[149],"40%":[150],"responding":[152],"FIP1L1-PDGFRA":[156,178],"fusion,":[157],"genetic":[159],"This":[161],"review":[162],"examines":[163],"current":[165],"state":[166],"knowledge":[168],"implications":[175],"discovery":[179],"diagnosis,":[182],"classification,":[183],"management.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":5},{"year":2025,"cited_by_count":7},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":12},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":13}],"updated_date":"2026-10-17T09:40:24.721904","created_date":"2016-06-24T00:00:00"}
