{"id":"https://openalex.org/W2003268292","doi":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","title":"Inhibition of atopic dermatitis\u2010like skin lesions by topical application of a novel ceramide derivative, K6PC\u20109p, in NC/Nga mice","display_name":"Inhibition of atopic dermatitis\u2010like skin lesions by topical application of a novel ceramide derivative, K6PC\u20109p, in NC/Nga mice","publication_year":2008,"publication_date":"2008-08-21","ids":{"openalex":"https://openalex.org/W2003268292","doi":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","mag":"2003268292","pmid":"https://pubmed.ncbi.nlm.nih.gov/18721197"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0625.2008.00737.x","doi":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0625.2008.00737.x","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0625.2008.00737.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046876658","display_name":"Jong Soon Kang","orcid":"https://orcid.org/0000-0001-7698-0162","observed_orcids":["https://orcid.org/0000-0001-7698-0162"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Jong Soon Kang","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Cheongwon, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028469406","display_name":"Won Kee Yoon","orcid":"https://orcid.org/0000-0002-4067-3651","observed_orcids":["https://orcid.org/0000-0002-4067-3651"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Won Kee Yoon","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003271824","display_name":"Jong\u2010Kyung Youm","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jong\u2010Kyung Youm","raw_affiliation_strings":["Neopharm Co. Ltd, Daejoen, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neopharm Co. Ltd, Daejoen, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054936590","display_name":"Se Kyoo Jeong","orcid":"https://orcid.org/0000-0002-9007-3128","observed_orcids":["https://orcid.org/0000-0002-9007-3128"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Se Kyoo Jeong","raw_affiliation_strings":["Neopharm Co. Ltd, Daejoen, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neopharm Co. Ltd, Daejoen, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074764833","display_name":"Byeong Deog Park","orcid":"https://orcid.org/0000-0001-5899-6558","observed_orcids":["https://orcid.org/0000-0001-5899-6558"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Byeong Deog Park","raw_affiliation_strings":["Neopharm Co. Ltd, Daejoen, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neopharm Co. Ltd, Daejoen, Korea","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112550461","display_name":"Mi Hwa Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mi Hwa Han","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100355268","display_name":"Hyunju Lee","orcid":"https://orcid.org/0000-0003-2389-7183","observed_orcids":["https://orcid.org/0000-0003-2389-7183","https://orcid.org/0000-0002-4532-6448"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyunju Lee","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069679336","display_name":"Eun\u2010Yi Moon","orcid":"https://orcid.org/0000-0003-3805-2327","observed_orcids":["https://orcid.org/0000-0003-3805-2327"]},"institutions":[{"id":"https://openalex.org/I28777354","display_name":"Sejong University","ror":"https://ror.org/00aft1q37","country_code":"KR","type":"education","lineage":["https://openalex.org/I28777354"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Eun\u2010Yi Moon","raw_affiliation_strings":["Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioscience and Biotechnology, Sejong University, Seoul, Korea","institution_ids":["https://openalex.org/I28777354"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037204409","display_name":"Sang\u2010Bae Han","orcid":"https://orcid.org/0000-0001-6656-6523","observed_orcids":["https://orcid.org/0000-0001-6656-6523"]},"institutions":[{"id":"https://openalex.org/I163753206","display_name":"Chungbuk National University","ror":"https://ror.org/02wnxgj78","country_code":"KR","type":"education","lineage":["https://openalex.org/I163753206"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Sang\u2010Bae Han","raw_affiliation_strings":["College of Pharmacy, Chungbuk National University, Cheongju, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy, Chungbuk National University, Cheongju, Korea","institution_ids":["https://openalex.org/I163753206"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100714319","display_name":"Chang Woo Lee","orcid":"https://orcid.org/0000-0001-6552-337X","observed_orcids":["https://orcid.org/0000-0001-6552-337X"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Chang Woo Lee","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101718713","display_name":"Kiho Lee","orcid":"https://orcid.org/0000-0001-6151-6543","observed_orcids":["https://orcid.org/0000-0001-6151-6543"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kiho Lee","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035920145","display_name":"Song\u2010Kyu Park","orcid":"https://orcid.org/0000-0002-2858-2300","observed_orcids":["https://orcid.org/0000-0002-2858-2300"]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Song\u2010Kyu Park","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100836445","display_name":"Kyu\u2010Hwan Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210145313","display_name":"Kyungwoon University","ror":"https://ror.org/050384c29","country_code":"KR","type":"education","lineage":["https://openalex.org/I4210145313"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Kyu\u2010Hwan Yang","raw_affiliation_strings":["Gachon Bionano Research Institute, Kyungwon University, Kyunggi, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gachon Bionano Research Institute, Kyungwon University, Kyunggi, Korea","institution_ids":["https://openalex.org/I4210145313"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111594405","display_name":"Hwan Mook Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I73616290","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07","country_code":"KR","type":"facility","lineage":["https://openalex.org/I2801339556","https://openalex.org/I4210144908","https://openalex.org/I4387152098","https://openalex.org/I73616290"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Hwan Mook Kim","raw_affiliation_strings":["Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioevaluation Center, Korea Research Institute of Bioscience and Biotechnology, Chungbuk, Korea","institution_ids":["https://openalex.org/I73616290"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5111594405"],"corresponding_institution_ids":["https://openalex.org/I73616290"],"apc_list":{"value":4880,"currency":"USD","value_usd":4880},"apc_paid":null,"fwci":5.0007,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.94815914,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"17","issue":"11","first_page":"958","last_page":"964"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10837","display_name":"Dermatology and Skin Diseases","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11033","display_name":"Contact Dermatitis and Allergies","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10704","display_name":"Advancements in Transdermal Drug Delivery","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/atopic-dermatitis","display_name":"atopic dermatitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/topical-therapy","display_name":"topical treatment","score":0.6050000190734863},{"id":"https://openalex.org/keywords/skin-inflammation","display_name":"skin inflammation","score":0.7570000290870667},{"id":"https://openalex.org/keywords/nc-nga-mice","display_name":"NC/Nga mice","score":0.8960000276565552},{"id":"https://openalex.org/keywords/mast-cell-infiltration","display_name":"mast cell infiltration","score":0.7950000166893005},{"id":"https://openalex.org/keywords/il-4","display_name":"IL-4","score":0.9739999771118164},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":1.0},{"id":"https://openalex.org/keywords/macrophage-activation","display_name":"macrophage activation","score":0.9829999804496765},{"id":"https://openalex.org/keywords/leukocyte-infiltration","display_name":"leukocyte infiltration","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2778329239","wikidata":"https://www.wikidata.org/wiki/Q268667","display_name":"Atopic dermatitis","level":2,"score":0.7965130805969238},{"id":"https://openalex.org/C2777851122","wikidata":"https://www.wikidata.org/wiki/Q424213","display_name":"Ceramide","level":3,"score":0.7123486399650574},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6229031682014465},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5097848773002625},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.4427299201488495},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41992855072021484},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4041087329387665},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3216764032840729},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.11710652709007263},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.06531649827957153},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000287","descriptor_name":"Administration, Topical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002518","descriptor_name":"Ceramides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003876","descriptor_name":"Dermatitis, Atopic","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D003877","descriptor_name":"Dermatitis, Contact","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003877","descriptor_name":"Dermatitis, Contact","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003877","descriptor_name":"Dermatitis, Contact","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004431","descriptor_name":"Ear, External","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004431","descriptor_name":"Ear, External","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004431","descriptor_name":"Ear, External","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006854","descriptor_name":"Hydrocortisone","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008262","descriptor_name":"Macrophage Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008815","descriptor_name":"Mice, Inbred Strains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013755","descriptor_name":"Tetradecanoylphorbol Acetate","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015847","descriptor_name":"Interleukin-4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D039741","descriptor_name":"Antigens, Dermatophagoides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1111/j.1600-0625.2008.00737.x","doi":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0625.2008.00737.x","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},{"id":"pmid:18721197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18721197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental dermatology","raw_type":"Journal Article"},{"id":"pmh:oai:http://repository.kribb.re.kr:8080/:201005/8656","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1111/j.1600-0625.2008.00737.x","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/7830.pdf","raw_type":"Article"},{"id":"pmh:oai:https://repository.kribb.re.kr:201005/8656","doi":null,"is_oa":false,"landing_page_url":"http://doi.org/10.1111/j.1600-0625.2008.00737.x","pdf_url":null,"source":{"id":"https://openalex.org/S4406922719","display_name":"KRIBB Repository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"/dspace/upload/original/7830.pdf","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0625.2008.00737.x","doi":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0625.2008.00737.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0625.2008.00737.x","source":{"id":"https://openalex.org/S158010168","display_name":"Experimental Dermatology","issn_l":"0906-6705","issn":["0906-6705","1600-0625"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental Dermatology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322110","display_name":"Korea Research Institute of Bioscience and Biotechnology","ror":"https://ror.org/03ep23f07"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003268292.pdf","grobid_xml":"https://content.openalex.org/works/W2003268292.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W411871732","https://openalex.org/W1967939988","https://openalex.org/W1971804099","https://openalex.org/W1974135937","https://openalex.org/W1981707898","https://openalex.org/W1984891873","https://openalex.org/W1991019957","https://openalex.org/W1998519291","https://openalex.org/W2005149861","https://openalex.org/W2007535805","https://openalex.org/W2010848526","https://openalex.org/W2030071069","https://openalex.org/W2031501484","https://openalex.org/W2032239366","https://openalex.org/W2035544897","https://openalex.org/W2048925802","https://openalex.org/W2049465878","https://openalex.org/W2050601356","https://openalex.org/W2055905930","https://openalex.org/W2062062335","https://openalex.org/W2074547900","https://openalex.org/W2082059820","https://openalex.org/W2094617958","https://openalex.org/W2139312101","https://openalex.org/W2147860005","https://openalex.org/W2155012357","https://openalex.org/W2160858397","https://openalex.org/W2168778910","https://openalex.org/W2171374364","https://openalex.org/W2334762308","https://openalex.org/W2420732138","https://openalex.org/W3022993324","https://openalex.org/W3134986606"],"related_works":["https://openalex.org/W2030071069","https://openalex.org/W1996933334","https://openalex.org/W1992099074","https://openalex.org/W1190175167","https://openalex.org/W2059174274","https://openalex.org/W7053681015","https://openalex.org/W3172080519","https://openalex.org/W2746373712","https://openalex.org/W3134476743","https://openalex.org/W2131751509"],"abstract_inverted_index":{"Atopic":[0],"dermatitis":[1],"(AD)":[2],"is":[3,17],"a":[4,18,157],"chronic":[5],"inflammatory":[6,165],"skin":[7,47,51,78,148,166],"disease":[8],"that":[9,86,121,136,153],"commonly":[10],"begins":[11],"in":[12,31,53,62,65,80,105,115,144],"childhood.":[13],"K6PC-9p":[14,45,56,72,96,98,122,140,154],"(N-(Ethyl":[15],"dihydrogenphosphate)-2-hexyl-3-oxo-decanamide)":[16],"synthetic":[19],"ceramide":[20],"derivative":[21],"of":[22,41,44,71,139,147,164],"PC-9S":[23],"(N-Ethanol-2-mirystyl-3-oxo-staramide),":[24],"which":[25],"was":[26],"known":[27],"to":[28],"be":[29,156],"effective":[30],"atopic":[32],"patients.":[33],"In":[34],"this":[35],"study,":[36],"we":[37],"examined":[38],"the":[39,106,113,162],"effect":[40],"topical":[42,69,137,159],"application":[43,70,138],"on":[46],"inflammation":[48,149],"and":[49,90,102,108,127,150],"AD-like":[50,77],"lesions":[52,79],"mouse":[54],"models.":[55],"dose-dependently":[57],"inhibited":[58,123],"phorbol":[59],"ester-induced":[60],"increase":[61],"ear":[63,88],"thickness":[64],"BALB/c":[66],"mice.":[67,82,117],"Moreover,":[68],"suppressed":[73,94,100],"dust":[74],"mite":[75],"extract-induced":[76],"NC/Nga":[81,116],"Histopathological":[83],"analysis":[84],"revealed":[85],"both":[87],"swelling":[89],"leucocyte":[91],"infiltration":[92,111],"were":[93],"by":[95],"treatment.":[97],"also":[99],"IL-4":[101,125],"TNF-alpha":[103],"expression":[104],"ears":[107,114],"mast":[109],"cell":[110],"into":[112],"Further":[118],"study":[119],"demonstrated":[120],"ConA-induced":[124],"secretion":[126],"LPS-induced":[128],"macrophage":[129],"activation.":[130],"Taken":[131],"together,":[132],"our":[133],"results":[134],"showed":[135],"exerts":[141],"beneficial":[142],"effects":[143],"animal":[145],"model":[146],"AD,":[151],"suggesting":[152],"might":[155],"promising":[158],"agent":[160],"for":[161],"treatment":[163],"diseases.":[167]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}