{"id":"https://openalex.org/W2003258477","doi":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","title":"Intraoperative photodynamic therapy with m-tetrahydroxyphenylchlorin for chest malignancies","display_name":"Intraoperative photodynamic therapy with m-tetrahydroxyphenylchlorin for chest malignancies","publication_year":1996,"publication_date":"1996-01-01","ids":{"openalex":"https://openalex.org/W2003258477","doi":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","mag":"2003258477","pmid":"https://pubmed.ncbi.nlm.nih.gov/8850464"},"language":"en","primary_location":{"id":"doi:10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108677728","display_name":"Hans\u2010Beat Ris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":true,"raw_author_name":"Hans-Beat Ris","raw_affiliation_strings":["Department of Thoracic and Cardiovascular Surgery, University of Bern, Switzerland","Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic and Cardiovascular Surgery, University of Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112766062","display_name":"Hans Joerg Altermatt","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Hans J. Altermatt","raw_affiliation_strings":["Department of Pathology, University of Bern, 3010 Bern, Switzerland","Department of Pathology, University of Bern, 3010 Bern, Switzerland,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, University of Bern, 3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]},{"raw_affiliation_string":"Department of Pathology, University of Bern, 3010 Bern, Switzerland,","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110091118","display_name":"Bernhard H. Nachbur","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Bernhard Nachbur","raw_affiliation_strings":["Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034189995","display_name":"Charles Matthew Stewart","orcid":"https://orcid.org/0000-0002-3265-7467","observed_orcids":["https://orcid.org/0000-0002-3265-7467"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Charles M. Stewart","raw_affiliation_strings":["Scotia Pharmaceuticals, Guildford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Scotia Pharmaceuticals, Guildford, United Kingdom","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022776322","display_name":"Qiang Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Qiang Wang","raw_affiliation_strings":["Medical Research Council Laboratories, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories, Surrey, United Kingdom","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070352874","display_name":"C.K. Lim","orcid":"https://orcid.org/0000-0002-6272-4464","observed_orcids":["https://orcid.org/0000-0002-6272-4464"]},"institutions":[{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Chung K. Lim","raw_affiliation_strings":["Medical Research Council Laboratories, Surrey, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Laboratories, Surrey, United Kingdom","institution_ids":["https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089561848","display_name":"Raymond Bonnett","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I166337079","display_name":"Queen Mary University of London","ror":"https://ror.org/026zzn846","country_code":"GB","type":"education","lineage":["https://openalex.org/I124357947","https://openalex.org/I166337079"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Raymond Bonnett","raw_affiliation_strings":["Department of Chemistry, Queen Mary and Westfield College, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, Queen Mary and Westfield College, London, United Kingdom","institution_ids":["https://openalex.org/I166337079"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058463755","display_name":"Ulrich Althaus","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Ulrich Althaus","raw_affiliation_strings":["Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Thoracic and Cardiovascular Surgery, University of Bern, 3010 Bern, Switzerland","institution_ids":["https://openalex.org/I118564535"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5108677728"],"corresponding_institution_ids":["https://openalex.org/I118564535"],"apc_list":{"value":4620,"currency":"USD","value_usd":4620},"apc_paid":null,"fwci":9.3212,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.98104497,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"18","issue":"1","first_page":"39","last_page":"45"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10957","display_name":"Photodynamic Therapy Research Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10782","display_name":"Nanoplatforms for cancer theranostics","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11026","display_name":"Occupational and environmental lung diseases","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intraoperative-photodynamic-therapy","display_name":"intraoperative photodynamic therapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/malignant-pleural-mesothelioma","display_name":"malignant pleural mesothelioma","score":0.9139999747276306},{"id":"https://openalex.org/keywords/thoracotomy","display_name":"thoracotomy","score":0.8769999742507935},{"id":"https://openalex.org/keywords/surgical-tumor-resection","display_name":"surgical tumor resection","score":0.902999997138977},{"id":"https://openalex.org/keywords/tumor-necrosis","display_name":"tumor necrosis","score":0.9490000009536743},{"id":"https://openalex.org/keywords/skin-photosensitivity","display_name":"skin photosensitivity","score":0.8109999895095825},{"id":"https://openalex.org/keywords/pain-relief","display_name":"analgesia","score":0.6510000228881836}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9053441286087036},{"id":"https://openalex.org/C2781323092","wikidata":"https://www.wikidata.org/wiki/Q1428072","display_name":"Photodynamic therapy","level":2,"score":0.8484147787094116},{"id":"https://openalex.org/C2777407522","wikidata":"https://www.wikidata.org/wiki/Q1077603","display_name":"Mesothelioma","level":2,"score":0.5066493153572083},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.4764566719532013},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3433572053909302},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.18810701370239258},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D001917","descriptor_name":"Brachial Plexus","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003131","descriptor_name":"Combined Modality Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005240","descriptor_name":"Feasibility Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007238","descriptor_name":"Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007238","descriptor_name":"Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007238","descriptor_name":"Infarction","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007430","descriptor_name":"Intraoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007430","descriptor_name":"Intraoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007430","descriptor_name":"Intraoperative Care","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008652","descriptor_name":"Mesoporphyrins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D008654","descriptor_name":"Mesothelioma","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009336","descriptor_name":"Necrosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010524","descriptor_name":"Peripheral Nervous System Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010524","descriptor_name":"Peripheral Nervous System Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010524","descriptor_name":"Peripheral Nervous System Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010778","descriptor_name":"Photochemotherapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011838","descriptor_name":"Radiation-Sensitizing Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D012867","descriptor_name":"Skin","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013899","descriptor_name":"Thoracic Neoplasms","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D013908","descriptor_name":"Thoracotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013908","descriptor_name":"Thoracotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013908","descriptor_name":"Thoracotomy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D013927","descriptor_name":"Thrombosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","doi":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","is_oa":false,"landing_page_url":"https://doi.org/10.1002/(sici)1096-9101(1996)18:1<39::aid-lsm5>3.0.co;2-s","pdf_url":null,"source":{"id":"https://openalex.org/S155721155","display_name":"Lasers in Surgery and Medicine","issn_l":"0196-8092","issn":["0196-8092","1096-9101"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in Surgery and Medicine","raw_type":"journal-article"},{"id":"pmid:8850464","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8850464","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lasers in surgery and medicine","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.8600000143051147,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":23,"referenced_works":["https://openalex.org/W646110172","https://openalex.org/W1415389227","https://openalex.org/W1511388956","https://openalex.org/W1521676893","https://openalex.org/W1842684227","https://openalex.org/W1974152979","https://openalex.org/W1974989935","https://openalex.org/W2000606023","https://openalex.org/W2013474093","https://openalex.org/W2030382564","https://openalex.org/W2036248563","https://openalex.org/W2058348084","https://openalex.org/W2059748188","https://openalex.org/W2067814332","https://openalex.org/W2086489326","https://openalex.org/W2140210736","https://openalex.org/W2163736054","https://openalex.org/W2402212412","https://openalex.org/W2466062434","https://openalex.org/W2469562731","https://openalex.org/W2506475570","https://openalex.org/W4238346426","https://openalex.org/W4298031624"],"related_works":["https://openalex.org/W2748952813","https://openalex.org/W3031052312","https://openalex.org/W4389568370","https://openalex.org/W3032375762","https://openalex.org/W1995515455","https://openalex.org/W2080531066","https://openalex.org/W3108674512","https://openalex.org/W1506200166","https://openalex.org/W1489783725","https://openalex.org/W2148612803"],"abstract_inverted_index":{"BACKGROUND":[0],"AND":[1,36],"OBJECTIVE:":[2],"Since":[3,38],"there":[4],"is":[5,153,182],"no":[6],"satisfactory":[7],"treatment":[8,176],"modality":[9,177],"for":[10,86,184],"diffuse":[11],"malignant":[12],"mesothelioma":[13,133],"of":[14,94,123,128,140,149,163,180],"the":[15,110,150],"chest,":[16],"we":[17],"assessed":[18],"surgical":[19,53],"tumor":[20,54,58,63,67,103,161,168],"resection":[21,145],"followed":[22],"by":[23,62,132,173],"intraoperative":[24,44,147,186],"photodynamic":[25,45],"therapy":[26,46],"with":[27,47],"mTHPC":[28],"in":[29,99,135],"a":[30,100],"phase":[31],"I":[32],"study.":[33],"STUDY":[34],"DESIGN/MATERIALS":[35],"METHODS:":[37],"1990,":[39],"eight":[40],"patients":[41],"have":[42],"undergone":[43],"m-tetrahydroxyphenylchlorin":[48],"(mTHPC-PDT)":[49],"following":[50],"thoracotomy":[51],"and":[52,70,72,114,146,158,178],"resection.":[55],"RESULTS:":[56],"mTHPC-PDT-mediated":[57],"necrosis":[59,69],"was":[60,107,170],"characterized":[61],"infarction":[64],"due":[65],"to":[66,109,117],"vessel":[68],"thrombosis,":[71],"its":[73],"extent":[74],"depended":[75],"on":[76],"drug-light":[77],"conditions;":[78],"650":[79],"nm":[80],"light":[81],"delivered":[82],"at":[83],"0.1":[84],"W/cm2":[85],"10":[87],"J/cm2":[88],"48":[89],"h":[90],"after":[91,120],"iv":[92,121],"administration":[93,122],"0.3":[95,124],"mg":[96,125],"mTHPC/kg":[97],"resulted":[98,134],"10-mm-deep":[101],"complete":[102],"necrosis.":[104],"Skin":[105],"photosensitivity":[106],"related":[108],"drug":[111],"dose":[112],"applied":[113],"occurred":[115],"up":[116],"17":[118],"days":[119],"mTHPC/kg,":[126],"mTHPC-PDT":[127,148,181],"brachial":[129],"plexus":[130],"infiltrated":[131],"pain":[136],"relief":[137],"without":[138],"deterioration":[139],"nerve":[141],"function.":[142],"CONCLUSION:":[143],"Tumor":[144],"chest":[151],"cavity":[152],"feasible":[154],"under":[155],"clinical":[156],"conditions":[157],"offers":[159],"local":[160],"control":[162],"sites":[164],"involved.":[165],"However,":[166],"distant":[167],"spread":[169],"not":[171],"prevented":[172],"this":[174],"combined":[175],"optimization":[179],"warranted":[183],"further":[185],"application.":[187]},"counts_by_year":[{"year":2017,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}