{"id":"https://openalex.org/W2003254876","doi":"https://doi.org/10.1620/tjem.58.327","title":"\u201cPeroxidase Response\u201d of Erythron in Anemia","display_name":"\u201cPeroxidase Response\u201d of Erythron in Anemia","publication_year":1953,"publication_date":"1953-01-01","ids":{"openalex":"https://openalex.org/W2003254876","doi":"https://doi.org/10.1620/tjem.58.327","mag":"2003254876","pmid":"https://pubmed.ncbi.nlm.nih.gov/13136174"},"language":"en","primary_location":{"id":"doi:10.1620/tjem.58.327","doi":"https://doi.org/10.1620/tjem.58.327","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.58.327","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/58/3-4/58_3-4_327/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/tjem1920/58/3-4/58_3-4_327/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041483044","display_name":"Ototaka Higashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Ototaka Higashi","raw_affiliation_strings":["Pediatric Department, Faculty of Medicine, Tohoku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pediatric Department, Faculty of Medicine, Tohoku University","institution_ids":["https://openalex.org/I201537933"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5041483044"],"corresponding_institution_ids":["https://openalex.org/I201537933"],"apc_list":null,"apc_paid":null,"fwci":2.1574,"has_fulltext":true,"cited_by_count":2,"citation_normalized_percentile":{"value":0.84564315,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"58","issue":"3-4","first_page":"327","last_page":"343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.3495999872684479,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T13374","display_name":"Hematological disorders and diagnostics","score":0.3495999872684479,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12286","display_name":"Erythrocyte Function and Pathophysiology","score":0.18860000371932983,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.1842000037431717,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythron","display_name":"erythron","score":0.6650000214576721},{"id":"https://openalex.org/keywords/erythroblasts","display_name":"erythroblasts","score":0.9959999918937683},{"id":"https://openalex.org/keywords/anemia","display_name":"anemia","score":0.8140000104904175},{"id":"https://openalex.org/keywords/pernicious-anemia","display_name":"pernicious anemia","score":0.7549999952316284},{"id":"https://openalex.org/keywords/megaloblastic-anemia","display_name":"megaloblastic anemia","score":0.9950000047683716},{"id":"https://openalex.org/keywords/iron-deficiency-anemia","display_name":"iron deficiency anemia","score":0.9380000233650208},{"id":"https://openalex.org/keywords/immune-thrombocytopenic-purpura","display_name":"idiopathic thrombocytopenic purpura","score":0.9480000138282776},{"id":"https://openalex.org/keywords/hemolytic-disease-of-the-newborn","display_name":"hemolytic disease of the newborn","score":0.9850000143051147},{"id":"https://openalex.org/keywords/intestinal-hemorrhage","display_name":"intestinal hemorrhage","score":0.75},{"id":"https://openalex.org/keywords/hematopoiesis","display_name":"hematopoiesis","score":0.6579999923706055},{"id":"https://openalex.org/keywords/reticulocytosis","display_name":"reticulocytosis","score":0.8460000157356262}],"concepts":[{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.7037642002105713},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.6427826881408691},{"id":"https://openalex.org/C2775916456","wikidata":"https://www.wikidata.org/wiki/Q1346016","display_name":"pernicious anemia","level":3,"score":0.5771600008010864},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.5231971740722656},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.46575456857681274},{"id":"https://openalex.org/C2779405478","wikidata":"https://www.wikidata.org/wiki/Q10832211","display_name":"Megaloblastic anemia","level":3,"score":0.4542437791824341},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4532408118247986},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.44706350564956665},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28775861859321594},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2861258387565613},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24803635478019714},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.12803155183792114},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08701768517494202},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D001853","descriptor_name":"Bone Marrow","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009195","descriptor_name":"Peroxidase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010088","descriptor_name":"Oxidoreductases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010544","descriptor_name":"Peroxidases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1620/tjem.58.327","doi":"https://doi.org/10.1620/tjem.58.327","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.58.327","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/58/3-4/58_3-4_327/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:13136174","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/13136174","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku journal of experimental medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1620/tjem.58.327","doi":"https://doi.org/10.1620/tjem.58.327","is_oa":true,"landing_page_url":"https://doi.org/10.1620/tjem.58.327","pdf_url":"https://www.jstage.jst.go.jp/article/tjem1920/58/3-4/58_3-4_327/_pdf","source":{"id":"https://openalex.org/S189069745","display_name":"The Tohoku Journal of Experimental Medicine","issn_l":"0040-8727","issn":["0040-8727","1349-3329"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310313307","host_organization_name":"Tohoku University","host_organization_lineage":["https://openalex.org/P4310313307"],"host_organization_lineage_names":["Tohoku University"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Tohoku Journal of Experimental Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/case-report","display_name":"Case Report"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003254876.pdf","grobid_xml":"https://content.openalex.org/works/W2003254876.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1966411265","https://openalex.org/W2001803514","https://openalex.org/W7146562701","https://openalex.org/W2026977584","https://openalex.org/W1986107913","https://openalex.org/W2004443115","https://openalex.org/W2295545612","https://openalex.org/W2263610912","https://openalex.org/W2026058429","https://openalex.org/W2089281218"],"abstract_inverted_index":{"In":[0,262],"order":[1],"to":[2,44,52,278],"evaluate":[3],"a":[4,30,198,220,269,280,312,320],"hematological":[5,95],"significance":[6],"of":[7,11,17,20,25,29,34,40,49,57,64,76,80,84,92,116,127,135,146,162,172,180,189,193,204,206,222,229,240,243,249,259,266,273,295,301,304,322,325],"the":[8,70,77,89,110,113,124,130,143,185,202,207,215,226,233,241,244,252,257,285,299,323],"peroxidase":[9,85,114,133,271,302],"reaction":[10,86],"erythrocytes":[12,117,149,194,250,274,305],"or/and":[13,118,195,306],"erythroblasts,":[14],"six":[15],"cases":[16],"various":[18],"type":[19],"anemia":[21,28,50,59,205],"i.e.":[22,225],"one":[23,32,38,47,55,61,121,294],"case":[24,33,39,48,56,63,221,265],"iron":[26],"deficiency":[27],"weanling,":[31],"idiopathic":[35],"thrombocytopenic":[36],"purpura,":[37],"erythroblastosis":[41],"fetalis":[42],"due":[43,51],"Rh":[45],"incompatibility,":[46],"intestinal":[53],"hemorrhage,":[54],"pernicious":[58,223],"and":[60,91,123,152,247,317],"infantile":[62,264],"megaloblastic":[65,267],"anemia,":[66,224,268],"were":[67],"observed":[68],"under":[69],"serial":[71],"examination":[72],"by":[73,88],"combined":[74],"use":[75],"new":[78],"technique":[79],"counting":[81],"chamber":[82],"method":[83],"devised":[87],"author":[90,183],"other":[93,141],"routine":[94],"procedures.":[96],"The":[97,132],"results":[98],"may":[99,308],"be":[100,309],"summarized":[101],"as":[102,311,319],"follow;1.":[103],"A":[104],"certain":[105],"regularity":[106],"was":[107,137,197,211],"noticed":[108],"in":[109,140,150,154,219,232,251,275,293],"relationship":[111],"between":[112],"activity":[115,126,134],"erythroblasts":[119,153,196,307],"on":[120,129],"hand":[122],"hemopoietic":[125],"erythron":[128,136,175],"other.":[131],"greatly":[138],"stimulated,":[139],"words":[142],"critical":[144],"increase":[145,171],"strongly":[147,173],"peroxidase-positive":[148,174],"blood":[151,163,181,253,276],"bone":[155,234,313],"marrow":[156,235,314],"developed":[157,236],"at":[158,176],"an":[159,177,263],"early":[160,178],"stage":[161,179],"regeneration.2.":[164],"To":[165],"describe":[166],"this":[167],"remarkable":[168],"phenomenon-the":[169],"striking":[170],"regeneration-the":[182],"suggested":[184],"designation":[186],"\u201cPeroxidase":[187,191,227],"Response\u201d":[188,192,228],"erythron.3.":[190],"favorable":[199],"sign,":[200],"for":[201,328],"course":[203],"presented":[208],"cases.4":[209],"It":[210],"surprising":[212],"how":[213],"rapidly":[214],"phenomenon":[216],"had":[217,290],"occurred":[218],"megalo":[230],"blasts":[231],"within":[237],"five":[238],"hours":[239],"commencement":[242],"specific":[245],"therapy,":[246],"that":[248],"wasobserved":[254],"shortly":[255],"before":[256],"appearance":[258],"reticulocytosis.":[260],"5.":[261],"marked":[270],"response":[272],"seemed":[277],"occur":[279],"few":[281],"days":[282],"earlier":[283],"than":[284],"following":[286],"reticulocyte":[287],"response.6.":[288],"As":[289],"been":[291],"shown":[292],"my":[296],"own":[297],"cases,":[298],"determination":[300],"level":[303],"useful":[310],"function":[315],"test":[316,321],"consequently":[318],"potency":[324],"therapeutic":[326],"agents":[327],"anemic":[329],"cases.":[330]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}