{"id":"https://openalex.org/W2003253108","doi":"https://doi.org/10.1097/00004836-198712000-00005","title":"Treatment of Cryptosporidiosis with Spiramycin in AIDS","display_name":"Treatment of Cryptosporidiosis with Spiramycin in AIDS","publication_year":1987,"publication_date":"1987-12-01","ids":{"openalex":"https://openalex.org/W2003253108","doi":"https://doi.org/10.1097/00004836-198712000-00005","mag":"2003253108","pmid":"https://pubmed.ncbi.nlm.nih.gov/3327883"},"language":"en","primary_location":{"id":"doi:10.1097/00004836-198712000-00005","doi":"https://doi.org/10.1097/00004836-198712000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004836-198712000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044608282","display_name":"Graham M. Woolf","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801259263","display_name":"McMaster University Medical Centre","ror":"https://ror.org/05jyrng31","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801259263","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Graham M. Woolf","raw_affiliation_strings":["McMaster University Medical Center, Department of Medicine, Hamilton Ontario, Canada","the McMaster University Medical Center, Hamilton, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University Medical Center, Department of Medicine, Hamilton Ontario, Canada","institution_ids":["https://openalex.org/I2801259263"]},{"raw_affiliation_string":"the McMaster University Medical Center, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I2801259263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078670467","display_name":"Marie Townsend","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2801259263","display_name":"McMaster University Medical Centre","ror":"https://ror.org/05jyrng31","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801259263","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Marie Townsend","raw_affiliation_strings":["the McMaster University Medical Center, Hamilton, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the McMaster University Medical Center, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I2801259263"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031717153","display_name":"Gordon Henry Guyatt","orcid":"https://orcid.org/0000-0003-2352-5718","observed_orcids":["https://orcid.org/0000-0003-2352-5718"]},"institutions":[{"id":"https://openalex.org/I2801259263","display_name":"McMaster University Medical Centre","ror":"https://ror.org/05jyrng31","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2801259263","https://openalex.org/I76442945"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Gordon Guyatt","raw_affiliation_strings":["the McMaster University Medical Center, Hamilton, Ontario, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"the McMaster University Medical Center, Hamilton, Ontario, Canada","institution_ids":["https://openalex.org/I2801259263"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I2801259263"],"apc_list":null,"apc_paid":null,"fwci":2.0827,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.84972905,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"9","issue":"6","first_page":"632","last_page":"634"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11086","display_name":"Parasitic Infections and Diagnostics","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10976","display_name":"Viral gastroenteritis research and epidemiology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12369","display_name":"Pneumocystis jirovecii pneumonia detection and treatment","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cryptosporidiosis","display_name":"cryptosporidiosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/spiramycin","display_name":"spiramycin","score":0.9559999704360962},{"id":"https://openalex.org/keywords/aids","display_name":"AIDS","score":0.9869999885559082},{"id":"https://openalex.org/keywords/secretory-diarrhea","display_name":"secretory diarrhea","score":0.9190000295639038},{"id":"https://openalex.org/keywords/cryptosporidium","display_name":"Cryptosporidium","score":0.9739999771118164},{"id":"https://openalex.org/keywords/single-patient-trials","display_name":"single-patient trials","score":0.875},{"id":"https://openalex.org/keywords/n-of-1-trials","display_name":"N-of-1 trials","score":0.7429999709129333},{"id":"https://openalex.org/keywords/antibiotic-therapy","display_name":"antibiotic therapy","score":0.4180000126361847},{"id":"https://openalex.org/keywords/gastrointestinal-diseases","display_name":"gastrointestinal diseases","score":0.6140000224113464}],"concepts":[{"id":"https://openalex.org/C2779172262","wikidata":"https://www.wikidata.org/wiki/Q422265","display_name":"Spiramycin","level":4,"score":0.9832794070243835},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9245151877403259},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5814764499664307},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5796741247177124},{"id":"https://openalex.org/C2778877831","wikidata":"https://www.wikidata.org/wiki/Q133078","display_name":"Cryptosporidium","level":3,"score":0.5404142141342163},{"id":"https://openalex.org/C2779802037","wikidata":"https://www.wikidata.org/wiki/Q40878","display_name":"Diarrhea","level":2,"score":0.5198383927345276},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.4722014367580414},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4361107051372528},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.41903072595596313},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3088042736053467},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11388236284255981},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.08898597955703735},{"id":"https://openalex.org/C61716771","wikidata":"https://www.wikidata.org/wiki/Q496","display_name":"Feces","level":2,"score":0.07520762085914612},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C2780206985","wikidata":"https://www.wikidata.org/wiki/Q213511","display_name":"Erythromycin","level":3,"score":0.0},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000163","descriptor_name":"Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002986","descriptor_name":"Clinical Trials as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003457","descriptor_name":"Cryptosporidiosis","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D003457","descriptor_name":"Cryptosporidiosis","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003457","descriptor_name":"Cryptosporidiosis","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D004311","descriptor_name":"Double-Blind Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007933","descriptor_name":"Leucomycins","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011897","descriptor_name":"Random Allocation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1097/00004836-198712000-00005","doi":"https://doi.org/10.1097/00004836-198712000-00005","is_oa":false,"landing_page_url":"https://doi.org/10.1097/00004836-198712000-00005","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},{"id":"pmid:3327883","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3327883","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical gastroenterology","raw_type":"Case Reports"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W78117677","https://openalex.org/W2026165869","https://openalex.org/W2323061991","https://openalex.org/W2102849184","https://openalex.org/W91468588","https://openalex.org/W2094199513","https://openalex.org/W2095752032","https://openalex.org/W2020975582","https://openalex.org/W2466146474","https://openalex.org/W7100033875"],"abstract_inverted_index":{"We":[0],"describe":[1],"a":[2,11,21,29,57],"randomized,":[3],"double-blind,":[4],"placebo-controlled,":[5],"crossover":[6],"trial":[7,51,72],"with":[8,14,73,99],"spiramycin":[9],"in":[10,39,97],"single":[12,46],"patient":[13,47,79,90],"acquired":[15],"immune":[16],"deficiency":[17],"syndrome":[18],"(AIDS)":[19],"and":[20,88,92],"severe":[22],"secretory":[23],"diarrhea":[24],"caused":[25],"by":[26],"cryptosporidium.":[27],"Spiramycin,":[28],"potentially":[30,94],"harmful":[31],"antibiotic,":[32],"had":[33],"no":[34],"clinical":[35,54],"or":[36],"microbiological":[37],"effect":[38],"this":[40],"patient.":[41],"The":[42,68],"application":[43],"of":[44,49,64],"the":[45,62,77],"(N":[48],"1)":[50],"to":[52,60,76],"common":[53],"problems":[55],"is":[56],"simple":[58],"way":[59],"analyze":[61],"value":[63],"different":[65],"therapeutic":[66],"approaches.":[67],"time-consuming,":[69],"expensive,":[70],"multi-patient":[71],"ultimate":[74],"extrapolation":[75],"individual":[78],"can":[80,85],"be":[81],"avoided.":[82],"Single-patient":[83],"trials":[84],"influence":[86],"management":[87],"improve":[89],"care":[91],"have":[93],"wide":[95],"use":[96],"patients":[98],"gastrointestinal":[100],"disease.":[101]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2017,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}