{"id":"https://openalex.org/W2003242964","doi":"https://doi.org/10.1142/s0192415x99000276","title":"Effect of a Urinary Preparation on Liver Injury by Short-term Carbon Tetrachloride Treatment in Rats","display_name":"Effect of a Urinary Preparation on Liver Injury by Short-term Carbon Tetrachloride Treatment in Rats","publication_year":1999,"publication_date":"1999-01-01","ids":{"openalex":"https://openalex.org/W2003242964","doi":"https://doi.org/10.1142/s0192415x99000276","mag":"2003242964","pmid":"https://pubmed.ncbi.nlm.nih.gov/10467457"},"language":"en","primary_location":{"id":"doi:10.1142/s0192415x99000276","doi":"https://doi.org/10.1142/s0192415x99000276","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x99000276","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109216317","display_name":"Tung-Yuan Lai","orcid":"https://orcid.org/0000-0001-9365-8626","observed_orcids":["https://orcid.org/0000-0001-9365-8626"]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Tung-Yuan Lai","raw_affiliation_strings":["Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Graduate Institute of Chinese Pharmaceutical Sciences, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110154194","display_name":"Yueh\u2010Wern Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Yueh-Wern Wu","raw_affiliation_strings":["Department of Pharmacology, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I184693016"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110060809","display_name":"Wen-Chuan Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I184693016","display_name":"China Medical University","ror":"https://ror.org/00v408z34","country_code":"TW","type":"education","lineage":["https://openalex.org/I184693016"]}],"countries":["TW"],"is_corresponding":false,"raw_author_name":"Wen-Chuan Lin","raw_affiliation_strings":["Department of Pharmacology, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, China Medical College, 91 Hsueh Shih Road, Taichung, Taiwan, ROC","institution_ids":["https://openalex.org/I184693016"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I184693016"],"apc_list":null,"apc_paid":null,"fwci":0.2125,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.41448008,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"02","first_page":"241","last_page":"250"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13919","display_name":"Medicinal plant effects and applications","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/human-urine","display_name":"human urine","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.875},{"id":"https://openalex.org/keywords/carbon-tetrachloride","display_name":"carbon tetrachloride","score":0.9269999861717224},{"id":"https://openalex.org/keywords/liver-injury","display_name":"liver injury","score":0.9559999704360962},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9610000252723694},{"id":"https://openalex.org/keywords/catalase","display_name":"catalase","score":0.593999981880188},{"id":"https://openalex.org/keywords/glutathione","display_name":"glutathione","score":0.8579999804496765},{"id":"https://openalex.org/keywords/superoxide-dismutase","display_name":"superoxide dismutase","score":0.8679999709129333},{"id":"https://openalex.org/keywords/glutathione-peroxidase","display_name":"glutathione peroxidase","score":0.8090000152587891},{"id":"https://openalex.org/keywords/reactive-oxygen-species","display_name":"reactive oxygen species","score":0.7360000014305115},{"id":"https://openalex.org/keywords/vitamin-c","display_name":"vitamin C","score":0.6510000228881836},{"id":"https://openalex.org/keywords/hepatic-triglycerides","display_name":"hepatic triglycerides","score":0.6489999890327454},{"id":"https://openalex.org/keywords/hepatic-proteins","display_name":"hepatic proteins","score":0.5040000081062317}],"concepts":[{"id":"https://openalex.org/C2777359374","wikidata":"https://www.wikidata.org/wiki/Q225045","display_name":"Carbon tetrachloride","level":2,"score":0.9271179437637329},{"id":"https://openalex.org/C2780829032","wikidata":"https://www.wikidata.org/wiki/Q898539","display_name":"Lipid peroxidation","level":3,"score":0.7446728348731995},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.6622544527053833},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.6615337133407593},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6136893033981323},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.5636551976203918},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5611805319786072},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.5182014107704163},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4544648230075836},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4089418649673462},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3745132088661194},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.32992029190063477},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3210110664367676},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.31468653678894043},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.18173500895500183},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001205","descriptor_name":"Ascorbic Acid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002252","descriptor_name":"Carbon Tetrachloride Poisoning","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002252","descriptor_name":"Carbon Tetrachloride Poisoning","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002252","descriptor_name":"Carbon Tetrachloride Poisoning","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005978","descriptor_name":"Glutathione","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010101","descriptor_name":"Oxygen Consumption","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014556","descriptor_name":"Urine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D015227","descriptor_name":"Lipid Peroxidation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1142/s0192415x99000276","doi":"https://doi.org/10.1142/s0192415x99000276","is_oa":false,"landing_page_url":"https://doi.org/10.1142/s0192415x99000276","pdf_url":null,"source":{"id":"https://openalex.org/S118315377","display_name":"The American Journal of Chinese Medicine","issn_l":"0090-2942","issn":["0090-2942","0192-415X","1793-6853"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-70","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319815","host_organization_name":"World Scientific","host_organization_lineage":["https://openalex.org/P4310319815"],"host_organization_lineage_names":["World Scientific"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American Journal of Chinese Medicine","raw_type":"journal-article"},{"id":"pmid:10467457","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10467457","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The American journal of Chinese medicine","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9940000176429749}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W191793640","https://openalex.org/W1487193306","https://openalex.org/W1603652944","https://openalex.org/W1689859172","https://openalex.org/W1775749144","https://openalex.org/W1838233329","https://openalex.org/W1885679900","https://openalex.org/W1982699466","https://openalex.org/W1983310681","https://openalex.org/W1985087069","https://openalex.org/W1987974863","https://openalex.org/W1993197167","https://openalex.org/W2018789330","https://openalex.org/W2047370961","https://openalex.org/W2063576996","https://openalex.org/W2071546210","https://openalex.org/W2082564221","https://openalex.org/W2088866343","https://openalex.org/W2153060852","https://openalex.org/W2273023265","https://openalex.org/W2321738746","https://openalex.org/W2411848428","https://openalex.org/W2416907819","https://openalex.org/W4229592397"],"related_works":["https://openalex.org/W2071546210","https://openalex.org/W3144431096","https://openalex.org/W1987974863","https://openalex.org/W2474420291","https://openalex.org/W231895930","https://openalex.org/W2467186219","https://openalex.org/W4306950414","https://openalex.org/W2365136105","https://openalex.org/W2078592699","https://openalex.org/W2128406818"],"abstract_inverted_index":{"The":[0,46,67],"hepatoprotective":[1],"effect":[2],"of":[3,6,22,36],"a":[4],"preparation":[5],"human":[7],"urine":[8],"(PHU)":[9],"was":[10,27,78],"assessed":[11],"against":[12],"short-term":[13],"carbon":[14],"tetrachloride":[15],"(CCl4)":[16],"treatment":[17,60,77],"in":[18,69,107,127,141],"rats.":[19],"Significant":[20],"prevention":[21],"liver":[23,48,53,70,92,108,122],"injury":[24,123],"by":[25,33,64,81,125,129,135],"PHU":[26,65,82,101,118],"found":[28],"after":[29,58,75,88,111],"CCl4":[30,59,76,89,112,126],"treatment,":[31,90],"judging":[32],"the":[34,105,142],"changes":[35],"serum":[37],"biochemical":[38],"parameters,":[39],"and":[40,43,51,95,134],"hepatic":[41],"protein":[42],"triglyceride":[44],"contents.":[45],"increased":[47,80],"lipid":[49,132],"peroxidation,":[50],"decreased":[52,87],"vitamin":[54],"C":[55],"concentrations":[56],"observed":[57,74],"were":[61],"significantly":[62],"prevented":[63],"administration.":[66],"increase":[68],"glutathione":[71],"(GSH)":[72],"contents":[73],"further":[79,103],"treatment.":[83,113],"Liver":[84],"catalase":[85,109],"activity":[86,110],"while":[91],"superoxide":[93],"dismutase":[94],"GSH-peroxidase":[96],"activities":[97],"did":[98],"not":[99],"change.":[100],"administration":[102,119],"inhibited":[104],"decrease":[106],"These":[114],"results":[115],"indicate":[116],"that":[117],"can":[120],"prevent":[121],"induced":[124],"rats":[128],"inhibiting":[130],"enhanced":[131],"peroxidation":[133],"improving":[136],"disrupted":[137],"active":[138],"oxygen":[139],"metabolism":[140],"injured":[143],"liver.":[144]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}