{"id":"https://openalex.org/W2003237376","doi":"https://doi.org/10.1212/wnl.51.3.868","title":"Reversible peripheral neuropathy induced by a single administration of high-dose paclitaxel","display_name":"Reversible peripheral neuropathy induced by a single administration of high-dose paclitaxel","publication_year":1998,"publication_date":"1998-09-01","ids":{"openalex":"https://openalex.org/W2003237376","doi":"https://doi.org/10.1212/wnl.51.3.868","mag":"2003237376","pmid":"https://pubmed.ncbi.nlm.nih.gov/9748043"},"language":"en","primary_location":{"id":"doi:10.1212/wnl.51.3.868","doi":"https://doi.org/10.1212/wnl.51.3.868","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.51.3.868","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"C. In\u0303iguez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"C. In\u0303iguez","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064320499","display_name":"Pilar Larrod\u00e9","orcid":"https://orcid.org/0000-0002-5413-1431","observed_orcids":["https://orcid.org/0000-0002-5413-1431"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Larrode\u0301","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019667620","display_name":"Jose Ignacio Mayordomo","orcid":"https://orcid.org/0000-0001-9495-2843","observed_orcids":["https://orcid.org/0000-0001-9495-2843"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J. I. Mayordomo","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072544619","display_name":"P. M. Aramburo Gonz\u00e1lez","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"P. Gonzalez","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010373263","display_name":"S. Adelantado","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S. Adelantado","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023230423","display_name":"Alfonso Yubero","orcid":"https://orcid.org/0000-0003-4995-0325","observed_orcids":["https://orcid.org/0000-0003-4995-0325"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Yubero","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112136269","display_name":"Alejandro Tres","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"A. Tre\u0301s","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5019653947","display_name":"F Morales","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"F. Morales","raw_affiliation_strings":["From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From the Departments of Neurology (Drs. In\u0301iguez, Larrode\u0301, and Morales), Oncology (Drs. Mayordomo, Yubero, and Tre\u0301e), and Neurophysiology (Drs. Gonza\u0301lez and Adelantado), Hospital Clinico Universitario, Zaragoza, Spain","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.5847,"has_fulltext":false,"cited_by_count":32,"citation_normalized_percentile":{"value":0.68367409,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"51","issue":"3","first_page":"868","last_page":"870"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11752","display_name":"Cancer Treatment and Pharmacology","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12937","display_name":"Chemotherapy-related skin toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13467","display_name":"Drug-Induced Ocular Toxicity","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/paclitaxel","display_name":"paclitaxel","score":0.902999997138977},{"id":"https://openalex.org/keywords/peripheral-neuropathy","display_name":"peripheral neuropathy","score":0.9810000061988831},{"id":"https://openalex.org/keywords/chemotherapy-induced-neurotoxicity","display_name":"chemotherapy-induced neurotoxicity","score":0.878000020980835},{"id":"https://openalex.org/keywords/reversible-neuropathy","display_name":"reversible neuropathy","score":0.7670000195503235},{"id":"https://openalex.org/keywords/single-agent-chemotherapy","display_name":"single-agent chemotherapy","score":0.6859999895095825},{"id":"https://openalex.org/keywords/dose-limiting-toxicity","display_name":"dose-limiting toxicity","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2777292972","wikidata":"https://www.wikidata.org/wiki/Q423762","display_name":"Paclitaxel","level":3,"score":0.9136109352111816},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.8657078742980957},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8461742401123047},{"id":"https://openalex.org/C2779491297","wikidata":"https://www.wikidata.org/wiki/Q3338704","display_name":"Neurotoxicity","level":3,"score":0.7493817806243896},{"id":"https://openalex.org/C2779289229","wikidata":"https://www.wikidata.org/wiki/Q17153857","display_name":"Chemotherapy-induced peripheral neuropathy","level":4,"score":0.6868477463722229},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.6856089234352112},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.6782076954841614},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.4971053898334503},{"id":"https://openalex.org/C188198153","wikidata":"https://www.wikidata.org/wiki/Q1613840","display_name":"Limiting","level":2,"score":0.4897499084472656},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4437621533870697},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3703685998916626},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.34514084458351135},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.12291035056114197},{"id":"https://openalex.org/C78519656","wikidata":"https://www.wikidata.org/wiki/Q101333","display_name":"Mechanical engineering","level":1,"score":0.0},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007262","descriptor_name":"Infusions, Intravenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":true},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D017239","descriptor_name":"Paclitaxel","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D018237","descriptor_name":"Germinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1212/wnl.51.3.868","doi":"https://doi.org/10.1212/wnl.51.3.868","is_oa":false,"landing_page_url":"https://doi.org/10.1212/wnl.51.3.868","pdf_url":null,"source":{"id":"https://openalex.org/S79704628","display_name":"Neurology","issn_l":"0028-3878","issn":["0028-3878","1526-632X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"journal-article"},{"id":"pmid:9748043","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/9748043","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neurology","raw_type":"Clinical Trial"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":1.0}],"study_designs":[{"id":"https://openalex.org/study-designs/clinical-trial","display_name":"Clinical Trial"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W2049209075","https://openalex.org/W2055234232","https://openalex.org/W2138588932","https://openalex.org/W2213012239","https://openalex.org/W2261556684","https://openalex.org/W2400815907"],"related_works":["https://openalex.org/W7219021272","https://openalex.org/W2582586059","https://openalex.org/W2127391698","https://openalex.org/W2187772719","https://openalex.org/W2134495718","https://openalex.org/W2015498137","https://openalex.org/W2084042603","https://openalex.org/W2080681962","https://openalex.org/W4282966839","https://openalex.org/W1986759845"],"abstract_inverted_index":{"Peripheral":[0],"neuropathy":[1],"(PN)":[2],"is":[3,27,97],"the":[4,32,90],"main":[5],"side":[6],"effect":[7],"with":[8,53],"cycles":[9],"of":[10,21,34,56,92],"paclitaxel":[11,25,57],"at":[12],"standard":[13],"doses":[14,55],"(175":[15],"mg/m2":[16],"for":[17,31],"21":[18],"days).":[19],"Administration":[20],"a":[22,28,45],"single":[23],"high-dose":[24],"(HDP)":[26],"novel":[29],"approach":[30],"treatment":[33],"cancer.":[35],"We":[36],"have":[37],"prospectively":[38],"measured":[39],"neurotoxicity":[40],"induced":[41,65],"by":[42,58,66],"HDP":[43,67,93],"during":[44],"phase":[46],"I":[47],"trial.":[48],"Nineteen":[49],"patients":[50,80],"were":[51],"treated":[52],"escalating":[54],"24-hour":[59],"infusion.":[60],"In":[61],"our":[62],"study,":[63],"PN":[64,76],"was":[68,77],"moderate,":[69],"reversible,":[70],"and":[71,87],"not":[72],"dose":[73],"limiting.":[74],"Severe":[75],"seen":[78],"in":[79,94],"who":[81],"had":[82],"received":[83],"previous":[84],"neurotoxic":[85],"chemotherapy,":[86],"caution":[88],"on":[89],"administration":[91],"this":[95],"setting":[96],"warranted.":[98]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
