{"id":"https://openalex.org/W2003237175","doi":"https://doi.org/10.1016/j.brainres.2006.07.118","title":"The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: The involvement of cholinergic system","display_name":"The antinociceptive effects of centrally administered CDP-choline on acute pain models in rats: The involvement of cholinergic system","publication_year":2006,"publication_date":"2006-08-31","ids":{"openalex":"https://openalex.org/W2003237175","doi":"https://doi.org/10.1016/j.brainres.2006.07.118","mag":"2003237175","pmid":"https://pubmed.ncbi.nlm.nih.gov/16942753"},"language":"en","primary_location":{"id":"doi:10.1016/j.brainres.2006.07.118","doi":"https://doi.org/10.1016/j.brainres.2006.07.118","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2006.07.118","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003237175"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013186513","display_name":"Emre Hamurtekin","orcid":"https://orcid.org/0000-0001-8305-9283","observed_orcids":["https://orcid.org/0000-0001-8305-9283"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Emre Hamurtekin","raw_affiliation_strings":["Uludag University, Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, G\u00f6r\u00fckle, Bursa, Turkey","Uludag University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, Gorukle, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uludag University, Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, G\u00f6r\u00fckle, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Uludag University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, Gorukle, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5103261436","display_name":"Mine Sibel Gurun","orcid":"https://orcid.org/0000-0001-5050-095X","observed_orcids":["https://orcid.org/0000-0001-5050-095X"]},"institutions":[{"id":"https://openalex.org/I131835042","display_name":"Bursa Uluda\u011f \u00dcni\u0307versi\u0307tesi\u0307","ror":"https://ror.org/03tg3eb07","country_code":"TR","type":"education","lineage":["https://openalex.org/I131835042"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"M. Sibel Gurun","raw_affiliation_strings":["Uludag University, Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, G\u00f6r\u00fckle, Bursa, Turkey","Uludag University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, Gorukle, Bursa, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Uludag University, Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, G\u00f6r\u00fckle, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]},{"raw_affiliation_string":"Uludag University Faculty of Medicine, Department of Pharmacology and Clinical Pharmacology, 16059, Gorukle, Bursa, Turkey","institution_ids":["https://openalex.org/I131835042"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5103261436"],"corresponding_institution_ids":["https://openalex.org/I131835042"],"apc_list":{"value":3360,"currency":"USD","value_usd":3360},"apc_paid":null,"fwci":1.3661,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.78266041,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"1117","issue":"1","first_page":"92","last_page":"100"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cdp-choline","display_name":"CDP-choline","score":0.984000027179718},{"id":"https://openalex.org/keywords/citicoline","display_name":"citicoline","score":0.984000027179718},{"id":"https://openalex.org/keywords/antinociception","display_name":"antinociception","score":0.9649999737739563},{"id":"https://openalex.org/keywords/cholinergic-system","display_name":"cholinergic system","score":0.7609999775886536},{"id":"https://openalex.org/keywords/alpha7-nicotinic-acetylcholine-receptor","display_name":"alpha7 nicotinic acetylcholine receptor","score":0.9380000233650208},{"id":"https://openalex.org/keywords/acute-pain","display_name":"acute pain","score":0.5690000057220459},{"id":"https://openalex.org/keywords/acetic-acid-writhing-test","display_name":"acetic acid-induced writhing","score":0.9860000014305115},{"id":"https://openalex.org/keywords/mecamylamine","display_name":"mecamylamine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/mla","display_name":"MLA","score":0.5830000042915344},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.8080000281333923},{"id":"https://openalex.org/keywords/intracerebroventricular-injection","display_name":"intracerebroventricular administration","score":0.7919999957084656}],"concepts":[{"id":"https://openalex.org/C2776880047","wikidata":"https://www.wikidata.org/wiki/Q3332124","display_name":"Mecamylamine","level":4,"score":0.8894360065460205},{"id":"https://openalex.org/C2780496003","wikidata":"https://www.wikidata.org/wiki/Q28529682","display_name":"Citicoline","level":2,"score":0.7358866930007935},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7015741467475891},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6766968965530396},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6660164594650269},{"id":"https://openalex.org/C22885893","wikidata":"https://www.wikidata.org/wiki/Q4862743","display_name":"Cholinergic","level":2,"score":0.6231764554977417},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.596201479434967},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.559384286403656},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.5439767837524414},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.5396068692207336},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.47416749596595764},{"id":"https://openalex.org/C197711040","wikidata":"https://www.wikidata.org/wiki/Q5910791","display_name":"Hot plate test","level":4,"score":0.4641849398612976},{"id":"https://openalex.org/C2776723954","wikidata":"https://www.wikidata.org/wiki/Q3001265","display_name":"Muscarinic antagonist","level":4,"score":0.44799935817718506},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.306304931640625},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.2718202769756317},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.27057695388793945},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.25219157338142395},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1494346559047699}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000208","descriptor_name":"Acute Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000700","descriptor_name":"Analgesics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002799","descriptor_name":"Cholinergic Fibers","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D002799","descriptor_name":"Cholinergic Fibers","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003566","descriptor_name":"Cytidine Diphosphate Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004347","descriptor_name":"Drug Interactions","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007276","descriptor_name":"Injections, Intraventricular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009435","descriptor_name":"Synaptic Transmission","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009619","descriptor_name":"Nociceptors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":false},{"descriptor_ui":"D010147","descriptor_name":"Pain Measurement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011978","descriptor_name":"Receptors, Nicotinic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014179","descriptor_name":"Neurotransmitter Uptake Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017288","descriptor_name":"Pain Threshold","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018733","descriptor_name":"Nicotinic Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064569","descriptor_name":"alpha7 Nicotinic Acetylcholine Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.brainres.2006.07.118","doi":"https://doi.org/10.1016/j.brainres.2006.07.118","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.brainres.2006.07.118","pdf_url":null,"source":{"id":"https://openalex.org/S96638545","display_name":"Brain Research","issn_l":"0006-8993","issn":["0006-8993","1872-6240"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain Research","raw_type":"journal-article"},{"id":"pmid:16942753","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16942753","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Brain research","raw_type":"Journal Article"},{"id":"pmh:2cf79e11-c7d5-4ab3-a7cd-da56912c5b16","doi":null,"is_oa":false,"landing_page_url":"https://avesis.uludag.edu.tr/publication/details/2cf79e11-c7d5-4ab3-a7cd-da56912c5b16/oai","pdf_url":null,"source":{"id":"https://openalex.org/S7407055210","display_name":"Bursa Uludag University - AVESIS","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9763000011444092,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320318965","display_name":"Bursa Uluda\u011f \u00dcniversitesi","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W1855035655","https://openalex.org/W1886298596","https://openalex.org/W1900806927","https://openalex.org/W1922058701","https://openalex.org/W1963799627","https://openalex.org/W1964619726","https://openalex.org/W1970722468","https://openalex.org/W1972849193","https://openalex.org/W1975912939","https://openalex.org/W1986445622","https://openalex.org/W1988734583","https://openalex.org/W1990251369","https://openalex.org/W1995582364","https://openalex.org/W1996230504","https://openalex.org/W2005909127","https://openalex.org/W2006001085","https://openalex.org/W2014007136","https://openalex.org/W2021720213","https://openalex.org/W2022662128","https://openalex.org/W2029022387","https://openalex.org/W2038168100","https://openalex.org/W2039812684","https://openalex.org/W2042067248","https://openalex.org/W2046048507","https://openalex.org/W2052857020","https://openalex.org/W2055913634","https://openalex.org/W2061403265","https://openalex.org/W2061549429","https://openalex.org/W2061675635","https://openalex.org/W2061707098","https://openalex.org/W2061901670","https://openalex.org/W2071780639","https://openalex.org/W2075300430","https://openalex.org/W2082906930","https://openalex.org/W2087454739","https://openalex.org/W2087596286","https://openalex.org/W2092727345","https://openalex.org/W2092882996","https://openalex.org/W2095341695","https://openalex.org/W2095948686","https://openalex.org/W2101077067","https://openalex.org/W2103824419","https://openalex.org/W2114921184","https://openalex.org/W2117051028","https://openalex.org/W2120352446","https://openalex.org/W2138978398","https://openalex.org/W2149207518","https://openalex.org/W2163138024","https://openalex.org/W2166280481","https://openalex.org/W2240758399","https://openalex.org/W2256167805","https://openalex.org/W2275729009","https://openalex.org/W2288419078","https://openalex.org/W2337485954","https://openalex.org/W2411655827","https://openalex.org/W2466469225","https://openalex.org/W2972999704","https://openalex.org/W4247877352"],"related_works":["https://openalex.org/W2046505184","https://openalex.org/W1972804821","https://openalex.org/W2072878451","https://openalex.org/W7132185367","https://openalex.org/W2371575037","https://openalex.org/W2055913634","https://openalex.org/W7132202137","https://openalex.org/W2000903009","https://openalex.org/W2096781043","https://openalex.org/W2044743438"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}