{"id":"https://openalex.org/W2003235416","doi":"https://doi.org/10.1136/thx.48.1.57","title":"Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.","display_name":"Segregation of eosinophil proteins in alveolar macrophage compartments in chronic eosinophilic pneumonia.","publication_year":1993,"publication_date":"1993-01-01","ids":{"openalex":"https://openalex.org/W2003235416","doi":"https://doi.org/10.1136/thx.48.1.57","mag":"2003235416","pmid":"https://pubmed.ncbi.nlm.nih.gov/8434356","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/464245"},"language":"en","primary_location":{"id":"doi:10.1136/thx.48.1.57","doi":"https://doi.org/10.1136/thx.48.1.57","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.48.1.57","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/48/1/57.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://thorax.bmj.com/content/thoraxjnl/48/1/57.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026162865","display_name":"Anne Janin","orcid":"https://orcid.org/0000-0002-9595-6261","observed_orcids":["https://orcid.org/0000-0002-9595-6261"]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A Janin","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004940047","display_name":"G\u00e9rard Torpier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"G Torpier","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109149160","display_name":"P Courtin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Courtin","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063788658","display_name":"Mon\u00edque Capron","orcid":"https://orcid.org/0000-0001-5625-5158","observed_orcids":["https://orcid.org/0000-0001-5625-5158"]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M Capron","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029511025","display_name":"Lionel Prin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"L Prin","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112153662","display_name":"Andr\u00e9\u2010Bernard Tonnel","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"A B Tonnel","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108100485","display_name":"Pierre\u2010Yves Hatron","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"P Y Hatron","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046181171","display_name":"Bernard H. Gosselin","orcid":"https://orcid.org/0000-0002-4853-172X","observed_orcids":["https://orcid.org/0000-0002-4853-172X"]},"institutions":[{"id":"https://openalex.org/I4210098263","display_name":"H\u00f4pital Albert Calmette","ror":"https://ror.org/00w81q081","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I3018718406","https://openalex.org/I4210098263"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"B Gosselin","raw_affiliation_strings":["Department of Pathology C, H\u00f4pital Calmette, Lille, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology C, H\u00f4pital Calmette, Lille, France","institution_ids":["https://openalex.org/I4210098263"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210098263"],"apc_list":null,"apc_paid":null,"fwci":3.5495,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.92273924,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":95},"biblio":{"volume":"48","issue":"1","first_page":"57","last_page":"62"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12600","display_name":"Eosinophilic Disorders and Syndromes","score":0.8866999745368958,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.10670000314712524,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10870","display_name":"Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-eosinophilic-pneumonia","display_name":"chronic eosinophilic pneumonia","score":0.996999979019165},{"id":"https://openalex.org/keywords/eosinophil-activation","display_name":"eosinophil activation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.9139999747276306},{"id":"https://openalex.org/keywords/major-basic-protein","display_name":"major basic protein","score":0.9850000143051147},{"id":"https://openalex.org/keywords/eosinophil-cationic-protein","display_name":"eosinophil cationic protein","score":1.0},{"id":"https://openalex.org/keywords/charcot-leyden-crystal-protein","display_name":"Charcot-Leyden crystal protein","score":0.9800000190734863},{"id":"https://openalex.org/keywords/sjogren-s-syndrome","display_name":"Sj\u00f6gren's syndrome","score":0.8579999804496765},{"id":"https://openalex.org/keywords/graft-versus-host-disease","display_name":"graft-versus-host disease","score":0.7929999828338623},{"id":"https://openalex.org/keywords/macrophage-uptake","display_name":"macrophage uptake","score":0.7540000081062317},{"id":"https://openalex.org/keywords/bronchoalveolar-lavage","display_name":"bronchoalveolar lavage","score":0.8109999895095825}],"concepts":[{"id":"https://openalex.org/C2780942278","wikidata":"https://www.wikidata.org/wiki/Q32540","display_name":"Eosinophilic pneumonia","level":4,"score":0.8992359638214111},{"id":"https://openalex.org/C2777037409","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil","level":3,"score":0.8257765769958496},{"id":"https://openalex.org/C88675164","wikidata":"https://www.wikidata.org/wiki/Q22677314","display_name":"Eosinophil cationic protein","level":4,"score":0.7578157186508179},{"id":"https://openalex.org/C60483475","wikidata":"https://www.wikidata.org/wiki/Q1886099","display_name":"Major basic protein","level":4,"score":0.7253857851028442},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7137801051139832},{"id":"https://openalex.org/C2777961210","wikidata":"https://www.wikidata.org/wiki/Q927148","display_name":"Bronchoalveolar lavage","level":3,"score":0.6234129071235657},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5841081142425537},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.5222281217575073},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.47964388132095337},{"id":"https://openalex.org/C2910475272","wikidata":"https://www.wikidata.org/wiki/Q107238","display_name":"Eosinophil Granule Proteins","level":5,"score":0.4525132477283478},{"id":"https://openalex.org/C2777129736","wikidata":"https://www.wikidata.org/wiki/Q505142","display_name":"Eosinophilia","level":2,"score":0.42430272698402405},{"id":"https://openalex.org/C2777914695","wikidata":"https://www.wikidata.org/wiki/Q12192","display_name":"Pneumonia","level":2,"score":0.42221078276634216},{"id":"https://openalex.org/C2779758542","wikidata":"https://www.wikidata.org/wiki/Q2106364","display_name":"Eosinophilic","level":2,"score":0.4214520752429962},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.29777777194976807},{"id":"https://openalex.org/C2776042228","wikidata":"https://www.wikidata.org/wiki/Q35869","display_name":"Asthma","level":2,"score":0.18873044848442078},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.17494234442710876},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.11048650741577148},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.10193026065826416},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001798","descriptor_name":"Blood Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001992","descriptor_name":"Bronchoalveolar Lavage Fluid","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004804","descriptor_name":"Eosinophils","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008245","descriptor_name":"Lysophospholipase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011657","descriptor_name":"Pulmonary Eosinophilia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012260","descriptor_name":"Ribonucleases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016676","descriptor_name":"Macrophages, Alveolar","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047091","descriptor_name":"Eosinophil Granule Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1136/thx.48.1.57","doi":"https://doi.org/10.1136/thx.48.1.57","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.48.1.57","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/48/1/57.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:464245","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/464245","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Text"},{"id":"pmid:8434356","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8434356","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/thx.48.1.57","doi":"https://doi.org/10.1136/thx.48.1.57","is_oa":true,"landing_page_url":"https://doi.org/10.1136/thx.48.1.57","pdf_url":"https://thorax.bmj.com/content/thoraxjnl/48/1/57.full.pdf","source":{"id":"https://openalex.org/S106546978","display_name":"Thorax","issn_l":"0040-6376","issn":["0040-6376","1468-3296"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thorax","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9789000153541565,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003235416.pdf","grobid_xml":"https://content.openalex.org/works/W2003235416.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1445925","https://openalex.org/W151682496","https://openalex.org/W1483618123","https://openalex.org/W1540173584","https://openalex.org/W1549362498","https://openalex.org/W1606940682","https://openalex.org/W1983570627","https://openalex.org/W1984457135","https://openalex.org/W1996195537","https://openalex.org/W1998455553","https://openalex.org/W1999936767","https://openalex.org/W2001001414","https://openalex.org/W2008417456","https://openalex.org/W2032974533","https://openalex.org/W2041378986","https://openalex.org/W2044334537","https://openalex.org/W2048608179","https://openalex.org/W2051594801","https://openalex.org/W2052572787","https://openalex.org/W2072169951","https://openalex.org/W2083195587","https://openalex.org/W2095908910","https://openalex.org/W2106068114","https://openalex.org/W2110311040","https://openalex.org/W2130622453","https://openalex.org/W2287417834","https://openalex.org/W2289001150","https://openalex.org/W2315876050","https://openalex.org/W2415497896","https://openalex.org/W2415836162","https://openalex.org/W2421755145","https://openalex.org/W4299353050","https://openalex.org/W7124763506"],"related_works":["https://openalex.org/W2051339671","https://openalex.org/W2883466956","https://openalex.org/W1983570627","https://openalex.org/W2290409314","https://openalex.org/W2141443944","https://openalex.org/W2065314345","https://openalex.org/W2103156602","https://openalex.org/W7095243070","https://openalex.org/W2080174985","https://openalex.org/W2041378986"],"abstract_inverted_index":{"BACKGROUND:":[0],"The":[1,95,167],"objective":[2],"was":[3,101],"to":[4,22,200],"characterise":[5],"the":[6,109,142],"process":[7],"and":[8,13,21,49,64,76,91,204],"consequences":[9],"of":[10,42,97,160,164,169,171,188,208],"eosinophil":[11,30,83,88,98,125,165,173,190,210],"activation":[12,161],"lysis":[14],"in":[15,27,104,129,133,141,154,175],"patients":[16,28,44,51,111,144],"with":[17,25,29,45,52,56,68,77,112,145,162,183],"chronic":[18,46,113,155],"eosinophilic":[19,47,53,114,146,156],"pneumonia":[20,48,157],"compare":[23],"them":[24],"those":[26],"pulmonary":[31,65,147],"infiltrates":[32,54,148],"from":[33,38,149],"other":[34,150],"causes.":[35,151],"METHODS:":[36],"Cells":[37],"bronchoalveolar":[39,105],"lavage":[40],"fluid":[41],"four":[43,50,110,143],"associated":[55,67],"Sj\u00f6gren's":[57],"syndrome,":[58],"drug":[59],"hypersensitivity":[60],"pneumonia,":[61,115],"postradiotherapy":[62],"fibrosis,":[63],"disease":[66,72],"graft":[69],"versus":[70],"host":[71],"were":[73,127,138],"studied":[74],"ultrastructurally":[75],"immunogold":[78],"labelled":[79],"antibodies":[80],"directed":[81],"against":[82],"proteins:":[84],"major":[85],"basic":[86],"protein,":[87,90],"cationic":[89,99],"Charcot-Leyden":[92],"crystal":[93],"protein.":[94],"concentration":[96],"protein":[100],"also":[102],"measured":[103],"fluid.":[106],"RESULTS:":[107],"In":[108],"ultrastructural":[116],"studies":[117],"demonstrated":[118],"numerous":[119],"lysed":[120],"eosinophils.":[121],"Further,":[122],"three":[123,170],"released":[124,189],"proteins":[126,174,211],"detected":[128],"distinct":[130],"cytoplasmic":[131],"structures":[132],"alveolar":[134],"macrophages.":[135],"These":[136],"features":[137],"not":[139,198],"found":[140],"CONCLUSION:":[152],"Eosinophils":[153],"show":[158],"signs":[159],"release":[163],"proteins.":[166],"appearance":[168],"these":[172,209],"different":[176],"macrophage":[177,181,201,215],"compartments":[178],"suggests":[179],"that":[180],"uptake,":[182],"or":[184,206],"without":[185],"intracellular":[186],"transport":[187],"proteins,":[191],"involves":[192],"separate":[193],"mechanisms.":[194],"This":[195],"interaction":[196],"does":[197],"lead":[199],"lysis,":[202],"however,":[203],"one":[205],"more":[207],"might":[212],"directly":[213],"affect":[214],"function.":[216]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}