{"id":"https://openalex.org/W2003232486","doi":"https://doi.org/10.1111/cpf.12027","title":"Choline treatment affects the liver reticuloendothelial system and plasma fatty acid composition in diabetic rats","display_name":"Choline treatment affects the liver reticuloendothelial system and plasma fatty acid composition in diabetic rats","publication_year":2013,"publication_date":"2013-01-24","ids":{"openalex":"https://openalex.org/W2003232486","doi":"https://doi.org/10.1111/cpf.12027","mag":"2003232486","pmid":"https://pubmed.ncbi.nlm.nih.gov/23692619"},"language":"en","primary_location":{"id":"doi:10.1111/cpf.12027","doi":"https://doi.org/10.1111/cpf.12027","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cpf.12027","pdf_url":null,"source":{"id":"https://openalex.org/S184889556","display_name":"Clinical Physiology and Functional Imaging","issn_l":"1475-0961","issn":["1475-0961","1475-097X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Physiology and Functional Imaging","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069932424","display_name":"Fatma J. Al\u2010Saeedi","orcid":"https://orcid.org/0000-0003-0932-6261","observed_orcids":["https://orcid.org/0000-0003-0932-6261"]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":true,"raw_author_name":"Fatma J. Al\u2010Saeedi","raw_affiliation_strings":["Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nuclear Medicine, Faculty of Medicine, Kuwait University, Kuwait City, Kuwait","institution_ids":["https://openalex.org/I36721946"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028975012","display_name":"Behling Cheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36721946","display_name":"Kuwait University","ror":"https://ror.org/021e5j056","country_code":"KW","type":"education","lineage":["https://openalex.org/I36721946"]}],"countries":["KW"],"is_corresponding":false,"raw_author_name":"Behling Cheng","raw_affiliation_strings":["Biochemistry Departments; Faculty of Medicine; Kuwait University; Kuwait City; Kuwait"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biochemistry Departments; Faculty of Medicine; Kuwait University; Kuwait City; Kuwait","institution_ids":["https://openalex.org/I36721946"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5069932424"],"corresponding_institution_ids":["https://openalex.org/I36721946"],"apc_list":{"value":4030,"currency":"USD","value_usd":4030},"apc_paid":null,"fwci":0.4836,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.52829392,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"33","issue":"4","first_page":"293","last_page":"301"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.27880001068115234,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.27880001068115234,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.14309999346733093,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11844","display_name":"Lipid metabolism and biosynthesis","score":0.13459999859333038,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/choline","display_name":"choline","score":0.8769999742507935},{"id":"https://openalex.org/keywords/diabetes-mellitus","display_name":"diabetes mellitus","score":0.7689999938011169},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9039999842643738},{"id":"https://openalex.org/keywords/plasma-fatty-acid-composition","display_name":"plasma fatty acid composition","score":0.753000020980835},{"id":"https://openalex.org/keywords/stearoyl-coa-desaturase","display_name":"stearoyl-CoA desaturase","score":0.8700000047683716},{"id":"https://openalex.org/keywords/palmitoleic-acid","display_name":"palmitoleic acid","score":0.8349999785423279},{"id":"https://openalex.org/keywords/oleic-acid","display_name":"oleic acid","score":0.9819999933242798},{"id":"https://openalex.org/keywords/arachidonic-acid","display_name":"arachidonic acid","score":0.9769999980926514},{"id":"https://openalex.org/keywords/linoleic-acid","display_name":"linoleic acid","score":0.9670000076293945},{"id":"https://openalex.org/keywords/hypoproteinemia","display_name":"hypoproteinemia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/hepatobiliary-function","display_name":"hepatobiliary function","score":0.8790000081062317},{"id":"https://openalex.org/keywords/liver-imaging","display_name":"liver imaging","score":0.32600000500679016}],"concepts":[{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.7735357284545898},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.7245867848396301},{"id":"https://openalex.org/C2779641957","wikidata":"https://www.wikidata.org/wiki/Q412366","display_name":"Palmitoleic acid","level":4,"score":0.6773821115493774},{"id":"https://openalex.org/C2781123555","wikidata":"https://www.wikidata.org/wiki/Q193166","display_name":"Choline","level":2,"score":0.5953583717346191},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5644155144691467},{"id":"https://openalex.org/C2781403372","wikidata":"https://www.wikidata.org/wiki/Q207688","display_name":"Oleic acid","level":2,"score":0.5501969456672668},{"id":"https://openalex.org/C2780809830","wikidata":"https://www.wikidata.org/wiki/Q407426","display_name":"Linoleic acid","level":3,"score":0.47047048807144165},{"id":"https://openalex.org/C543025807","wikidata":"https://www.wikidata.org/wiki/Q61476","display_name":"Fatty acid","level":2,"score":0.46122556924819946},{"id":"https://openalex.org/C2778078955","wikidata":"https://www.wikidata.org/wiki/Q407699","display_name":"Arachidonic acid","level":3,"score":0.4454546272754669},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.4114895761013031},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.24670878052711487},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24050360918045044},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000814","descriptor_name":"Aniline Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002794","descriptor_name":"Choline","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D003921","descriptor_name":"Diabetes Mellitus, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005227","descriptor_name":"Fatty Acids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007098","descriptor_name":"Imino Acids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008111","descriptor_name":"Liver Function Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011859","descriptor_name":"Radiography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011877","descriptor_name":"Radionuclide Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D012157","descriptor_name":"Mononuclear Phagocyte System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015609","descriptor_name":"Organotechnetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017556","descriptor_name":"Technetium Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017971","descriptor_name":"Tin Compounds","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019275","descriptor_name":"Radiopharmaceuticals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/cpf.12027","doi":"https://doi.org/10.1111/cpf.12027","is_oa":false,"landing_page_url":"https://doi.org/10.1111/cpf.12027","pdf_url":null,"source":{"id":"https://openalex.org/S184889556","display_name":"Clinical Physiology and Functional Imaging","issn_l":"1475-0961","issn":["1475-0961","1475-097X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical Physiology and Functional Imaging","raw_type":"journal-article"},{"id":"pmid:23692619","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23692619","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical physiology and functional imaging","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322668","display_name":"Kuwait University","ror":"https://ror.org/021e5j056"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1516749868","https://openalex.org/W1578374319","https://openalex.org/W1931631004","https://openalex.org/W1964632546","https://openalex.org/W1985706777","https://openalex.org/W1988461951","https://openalex.org/W2005956845","https://openalex.org/W2008092961","https://openalex.org/W2016176612","https://openalex.org/W2034921827","https://openalex.org/W2036699544","https://openalex.org/W2040109162","https://openalex.org/W2044644545","https://openalex.org/W2051256772","https://openalex.org/W2053307994","https://openalex.org/W2054666993","https://openalex.org/W2058953832","https://openalex.org/W2070538749","https://openalex.org/W2074978486","https://openalex.org/W2075009558","https://openalex.org/W2075840596","https://openalex.org/W2097398640","https://openalex.org/W2102808070","https://openalex.org/W2112530229","https://openalex.org/W2131518373","https://openalex.org/W2131762144","https://openalex.org/W2135024461","https://openalex.org/W2135835127","https://openalex.org/W2153432680","https://openalex.org/W2170539205","https://openalex.org/W2398405760","https://openalex.org/W2437142315","https://openalex.org/W3025249850","https://openalex.org/W4206402870","https://openalex.org/W4290353696","https://openalex.org/W6634511426"],"related_works":["https://openalex.org/W3205829721","https://openalex.org/W2739085952","https://openalex.org/W2104016948","https://openalex.org/W4387380296","https://openalex.org/W2017454449","https://openalex.org/W1969545540","https://openalex.org/W2162695177","https://openalex.org/W2077605679","https://openalex.org/W1982738990","https://openalex.org/W2142190501"],"abstract_inverted_index":{"PURPOSE:":[0],"This":[1],"study":[2],"investigated":[3],"effects":[4],"of":[5,38,44,77,90,214,231],"choline":[6,132,150,173,255],"treatment":[7,109,133,151,174,221,237,256],"on":[8,225],"hepatic":[9,239],"reticuloendothelial":[10,240],"and":[11,14,35,64,80,82,94,130,144,157,164,207,242],"biliary":[12,92,142],"functions":[13,54],"plasma":[15,161,204,227,243],"fatty":[16,228,244],"acid":[17,69,163,186,206,216,229,245],"composition":[18,230],"in":[19,123,128,141,148,160,184,190,203,217,251],"diabetic":[20,232,252],"rats.":[21,219,234,253],"METHODS:":[22],"Diabetes":[23,210],"was":[24,30],"induced":[25],"by":[26,49,105],"streptozotocin":[27],"(STZ).":[28],"Choline":[29,108,220,236],"administered":[31],"to":[32],"untreated":[33],"rats":[34,40,116,194,199],"a":[36,50,119,182,188],"portion":[37],"STZ-treated":[39],"for":[41],"two":[42],"sequences":[43],"five":[45],"consecutive":[46],"days,":[47],"separated":[48],"2-day":[51],"interval.":[52],"Hepatic":[53],"were":[55,96,103],"studied":[56],"using":[57],"(99m)":[58],"Tc":[59],"Tin":[60],"(II)":[61],"colloid":[62],"(TIN)":[63],"99":[65],"mTc":[66],"mebrofenin":[67],"[bromo-iminodiacetic":[68],"(BrIDA)]":[70],"imaging.":[71],"The":[72],"TIN-uptake":[73,121],"ratios":[74,85,127,140],"(organ/whole":[75],"body)":[76,89],"heart,":[78],"liver":[79,124],"spleen,":[81],"the":[83,155,178,226],"BrIDA-uptake":[84,139],"(organ":[86],"or":[87],"tissue/whole":[88],"liver,":[91],"tree":[93,143],"abdomen":[95,145],"obtained":[97],"following":[98],"imaging":[99],"studies.":[100,261],"Fatty":[101],"acids":[102],"analysed":[104],"GC/MS.":[106],"RESULTS:":[107],"did":[110,152,175],"not":[111,147,153,176,248],"attenuate":[112,154],"hyperglycaemic":[113],"development.":[114],"Diabetic":[115],"showed":[117],"(i)":[118],"decreased":[120],"ratio":[122],"with":[125,187],"co-increased":[126],"heart":[129],"spleen;":[131],"diminished":[134],"these":[135],"changes,":[136],"(ii)":[137],"elevated":[138],"but":[146,180,247],"liver;":[149],"elevations":[156],"(iii)":[158],"decreases":[159,202],"palmitoleic":[162,205,215],"oleic":[165,208],"acid,":[166],"reflecting":[167],"an":[168],"impaired":[169],"stearoyl-CoA":[170],"desaturase":[171],"function;":[172],"affect":[177],"diminutions,":[179],"caused":[181,211],"decrease":[183],"arachidonic":[185],"co-increase":[189],"linoleic":[191],"acid.":[192,209],"Some":[193],"developed":[195],"hypoproteinemia":[196],"(HPO).":[197],"HPO":[198,218,233],"also":[200],"exhibited":[201],"almost":[212],"absence":[213],"exerted":[222],"no":[223],"effect":[224],"CONCLUSIONS:":[235],"affected":[238],"function":[241],"composition,":[246],"hepatobiliary":[249],"function,":[250],"Whether":[254],"is":[257],"beneficial":[258],"requires":[259],"further":[260]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}