{"id":"https://openalex.org/W2003222910","doi":"https://doi.org/10.1167/iovs.06-0522","title":"Minocycline Protects Photoreceptors from Light and Oxidative Stress in Primary Bovine Retinal Cell Culture","display_name":"Minocycline Protects Photoreceptors from Light and Oxidative Stress in Primary Bovine Retinal Cell Culture","publication_year":2006,"publication_date":"2006-12-29","ids":{"openalex":"https://openalex.org/W2003222910","doi":"https://doi.org/10.1167/iovs.06-0522","mag":"2003222910","pmid":"https://pubmed.ncbi.nlm.nih.gov/17197562"},"language":"en","primary_location":{"id":"doi:10.1167/iovs.06-0522","doi":"https://doi.org/10.1167/iovs.06-0522","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.06-0522","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David W. Leung","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David W. Leung","raw_affiliation_strings":["Acucela, Inc., Bothell, Washington 98021, USA. dwleung@acucela.com","From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acucela, Inc., Bothell, Washington 98021, USA. dwleung@acucela.com","institution_ids":["https://openalex.org/I4210113531"]},{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002423853","display_name":"L. Lindlief","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance A. Lindlief","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042107627","display_name":"A\u00efcha Laabich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aicha Laabich","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061527580","display_name":"Ganesh P. Vissvesvaran","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ganesh P. Vissvesvaran","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113623529","display_name":"Mahesh Kamat","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mahesh Kamat","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004630249","display_name":"Kuo Lee Lieu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kuo L. Lieu","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110049644","display_name":"Ahmad B. Fawzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ahmad Fawzi","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038443879","display_name":"Ryo Kubota","orcid":"https://orcid.org/0000-0003-1993-7111","observed_orcids":["https://orcid.org/0000-0003-1993-7111","https://orcid.org/0009-0008-1340-0560"]},"institutions":[{"id":"https://openalex.org/I4210113531","display_name":"Acucela (United States)","ror":"https://ror.org/01hfykw48","country_code":"US","type":"company","lineage":["https://openalex.org/I4210113531"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ryo Kubota","raw_affiliation_strings":["From Acucela, Inc., Bothell, Washington"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Acucela, Inc., Bothell, Washington","institution_ids":["https://openalex.org/I4210113531"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210113531"],"apc_list":{"value":1850,"currency":"USD","value_usd":1850},"apc_paid":null,"fwci":0.5744,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.71156092,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"1","first_page":"412","last_page":"412"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10691","display_name":"Retinal Development and Disorders","score":0.8310999870300293,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13869","display_name":"Ocular and Laser Science Research","score":0.07590000331401825,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.04430000111460686,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/minocycline","display_name":"minocycline","score":1.0},{"id":"https://openalex.org/keywords/photoreceptor-cell-death","display_name":"photoreceptor cell death","score":0.7179999947547913},{"id":"https://openalex.org/keywords/light-induced-retinal-injury","display_name":"light-induced retinal damage","score":0.8360000252723694},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.9980000257492065},{"id":"https://openalex.org/keywords/retinal-protection","display_name":"retinal protection","score":0.5019999742507935},{"id":"https://openalex.org/keywords/tetracycline-analogues","display_name":"tetracycline analogues","score":0.7689999938011169},{"id":"https://openalex.org/keywords/demeclocycline","display_name":"demeclocycline","score":0.9049999713897705},{"id":"https://openalex.org/keywords/methacycline","display_name":"methacycline","score":0.8149999976158142},{"id":"https://openalex.org/keywords/doxycycline","display_name":"doxycycline","score":0.9539999961853027},{"id":"https://openalex.org/keywords/phototoxicity","display_name":"phototoxicity","score":0.9120000004768372}],"concepts":[{"id":"https://openalex.org/C2778275353","wikidata":"https://www.wikidata.org/wiki/Q415336","display_name":"Minocycline","level":3,"score":0.8061099052429199},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.7528893947601318},{"id":"https://openalex.org/C20639190","wikidata":"https://www.wikidata.org/wiki/Q2088972","display_name":"Phototoxicity","level":3,"score":0.6598984599113464},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5667520761489868},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.4962382912635803},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.4780367314815521},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4711284339427948},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.450337678194046},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.400116503238678},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3912542164325714},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.36309096217155457},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.33975616097450256},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.311653733253479},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2957492768764496},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.09315446019172668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.059844017028808594},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D002417","descriptor_name":"Cattle","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005456","descriptor_name":"Fluorescent Dyes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008027","descriptor_name":"Light","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008911","descriptor_name":"Minocycline","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009457","descriptor_name":"Neuroglia","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D009930","descriptor_name":"Organic Chemicals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011833","descriptor_name":"Radiation Injuries, Experimental","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D012164","descriptor_name":"Retinal Diseases","qualifier_ui":"Q000517","qualifier_name":"prevention & control","is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020122","descriptor_name":"tert-Butylhydroperoxide","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D020419","descriptor_name":"Photoreceptor Cells, Vertebrate","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":true},{"descriptor_ui":"D051245","descriptor_name":"Retinal Bipolar Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051245","descriptor_name":"Retinal Bipolar Cells","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1167/iovs.06-0522","doi":"https://doi.org/10.1167/iovs.06-0522","is_oa":false,"landing_page_url":"https://doi.org/10.1167/iovs.06-0522","pdf_url":null,"source":{"id":"https://openalex.org/S76304953","display_name":"Investigative Ophthalmology & Visual Science","issn_l":"0146-0404","issn":["0146-0404","1552-5783"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310321950","host_organization_name":"Cadmus Press","host_organization_lineage":["https://openalex.org/P4310321950"],"host_organization_lineage_names":["Cadmus Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative Opthalmology &amp; Visual Science","raw_type":"journal-article"},{"id":"pmid:17197562","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17197562","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Investigative ophthalmology & visual science","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7246000170707703,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W190975063","https://openalex.org/W1500709861","https://openalex.org/W1514649841","https://openalex.org/W1519639194","https://openalex.org/W1573078474","https://openalex.org/W1973932342","https://openalex.org/W1975177900","https://openalex.org/W1980636359","https://openalex.org/W1980897236","https://openalex.org/W1986785675","https://openalex.org/W1988564949","https://openalex.org/W1990451725","https://openalex.org/W1991001144","https://openalex.org/W1993374803","https://openalex.org/W1998174286","https://openalex.org/W2004405778","https://openalex.org/W2009469586","https://openalex.org/W2009776458","https://openalex.org/W2021516892","https://openalex.org/W2023723159","https://openalex.org/W2024486785","https://openalex.org/W2024642294","https://openalex.org/W2024741954","https://openalex.org/W2030432776","https://openalex.org/W2030544061","https://openalex.org/W2039607641","https://openalex.org/W2041494047","https://openalex.org/W2047908300","https://openalex.org/W2049817176","https://openalex.org/W2055534476","https://openalex.org/W2060835116","https://openalex.org/W2060952492","https://openalex.org/W2064088958","https://openalex.org/W2086129284","https://openalex.org/W2090778313","https://openalex.org/W2102093612","https://openalex.org/W2118353425","https://openalex.org/W2122311826","https://openalex.org/W2125324546","https://openalex.org/W2131785634","https://openalex.org/W2136359299","https://openalex.org/W2140748691","https://openalex.org/W2143708959","https://openalex.org/W2144839999","https://openalex.org/W2150626397","https://openalex.org/W2163957182","https://openalex.org/W2168505250","https://openalex.org/W2177010324"],"related_works":["https://openalex.org/W2439587339","https://openalex.org/W2404580792","https://openalex.org/W2063180703","https://openalex.org/W2120703680","https://openalex.org/W2991240896","https://openalex.org/W2588061037","https://openalex.org/W1168509203","https://openalex.org/W3155009410","https://openalex.org/W1980897236","https://openalex.org/W2941788805"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"whether":[3,52],"minocycline,":[4],"a":[5,99,216],"compound":[6],"known":[7],"to":[8,50,155,162,180,247],"protect":[9,24],"the":[10,176,192,205,241],"retina":[11],"against":[12,33,122,172,188],"light-induced":[13,189],"damage":[14,127,190],"in":[15,27,45,132,175,191,199,206],"rodent":[16],"models,":[17],"and":[18,35,40,70,118,149,202,245],"its":[19,41],"structurally":[20,142,231],"related":[21,143,232],"analogues":[22,42,144],"would":[23,54],"photoreceptor":[25,108],"cells":[26,72,109],"primary":[28,46,130,211],"bovine":[29,76,129,210],"retinal":[30,47,212,223,249],"cell":[31,48,60,63,81,213],"culture":[32,49,133,214],"light":[34,56,85],"oxidative":[36,58,87,125,173],"stress.":[37],"METHODS:":[38],"Minocycline":[39,117],"were":[43,73,112,120,151],"tested":[44],"see":[51],"they":[53],"inhibit":[55],"or":[57,86,124,227],"stress-induced":[59,126],"death.":[61],"Primary":[62],"cultures":[64],"composed":[65],"of":[66,80,107,128,178,186,243],"photoreceptors,":[67],"bipolar":[68],"cells,":[69],"glial":[71],"prepared":[74],"from":[75,110],"retinas.":[77],"The":[78,183],"extent":[79],"death":[82],"induced":[83],"by":[84,91,230],"stress":[88,111,174],"was":[89,160,166],"assessed":[90],"using":[92,114,209],"Sytox":[93],"Green":[94],"(Invitrogen-Molecular":[95],"Probes,":[96],"Eugene,":[97],"OR)":[98],"nucleic":[100],"acid":[101],"dye":[102],"uptake":[103],"assay.":[104],"Differential":[105],"protection":[106,226],"examined":[113],"immunocytochemistry.":[115],"RESULTS:":[116],"methacycline":[119],"cytoprotective":[121,167],"light-":[123],"photoreceptors":[131],"with":[134,196],"an":[135],"EC(50)":[136],"<":[137],"10":[138],"microM.":[139,157],"In":[140],"contrast,":[141],"such":[145],"as":[146],"demeclocycline,":[147],"meclocycline,":[148],"doxycycline":[150],"phototoxic":[152],"at":[153],">3":[154],">10":[156],"Though":[158],"demeclocycline":[159],"found":[161],"be":[163],"phototoxic,":[164],"it":[165],"(EC(50)":[168],"=":[169],"5":[170],"microM)":[171],"absence":[177],"exposure":[179],"light.":[181],"CONCLUSIONS:":[182],"protective":[184,250],"action":[185],"minocycline":[187,244],"cell-based":[193],"assays":[194],"agrees":[195],"earlier":[197],"reports":[198],"animal":[200],"models":[201],"suggests":[203],"that":[204,235],"vitro":[207],"assay":[208],"is":[215],"suitable":[217],"model":[218],"for":[219,222],"evaluating":[220],"compounds":[221,233],"protection.":[224],"Cellular":[225],"toxicity":[228],"produced":[229],"show":[234],"minor":[236],"structural":[237],"modifications":[238],"can":[239],"alter":[240],"function":[242],"lead":[246],"potent":[248],"compounds.":[251]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}