{"id":"https://openalex.org/W2003209323","doi":"https://doi.org/10.1182/blood-2007-11-122119","title":"Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation","display_name":"Angiopoietin-like 5 and IGFBP2 stimulate ex vivo expansion of human cord blood hematopoietic stem cells as assayed by NOD/SCID transplantation","publication_year":2008,"publication_date":"2008-01-18","ids":{"openalex":"https://openalex.org/W2003209323","doi":"https://doi.org/10.1182/blood-2007-11-122119","mag":"2003209323","pmid":"https://pubmed.ncbi.nlm.nih.gov/18202223","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2275010"},"language":"en","primary_location":{"id":"doi:10.1182/blood-2007-11-122119","doi":"https://doi.org/10.1182/blood-2007-11-122119","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-11-122119","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3415/1482820/zh800708003415.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://ashpublications.org/blood/article-pdf/111/7/3415/1482820/zh800708003415.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101855673","display_name":"Cheng Cheng Zhang","orcid":"https://orcid.org/0000-0003-4763-3887","observed_orcids":["https://orcid.org/0000-0003-4763-3887","https://orcid.org/0000-0001-9378-7655","https://orcid.org/0000-0001-8932-0585","https://orcid.org/0000-0001-5786-4748"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheng Cheng Zhang","raw_affiliation_strings":["Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and","Whitehead Institute for Biomedical Research, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and","institution_ids":["https://openalex.org/I867280407"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA;","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018569372","display_name":"Megan Kaba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Megan Kaba","raw_affiliation_strings":["Whitehead Institute for Biomedical Research, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA;","institution_ids":["https://openalex.org/I4210157710"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049414579","display_name":"Satoru Iizuka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoru Iizuka","raw_affiliation_strings":["Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112817663","display_name":"HoangDinh Huynh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I867280407","display_name":"The University of Texas Southwestern Medical Center","ror":"https://ror.org/05byvp690","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I867280407"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"HoangDinh Huynh","raw_affiliation_strings":["Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Physiology and Developmental Biology, University of Texas Southwestern Medical Center, Dallas; and","institution_ids":["https://openalex.org/I867280407"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076111394","display_name":"Harvey F. Lodish","orcid":"https://orcid.org/0000-0002-7029-7415","observed_orcids":["https://orcid.org/0000-0002-7029-7415"]},"institutions":[{"id":"https://openalex.org/I4210157710","display_name":"Whitehead Institute for Biomedical Research","ror":"https://ror.org/04vqm6w82","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210157710","https://openalex.org/I63966007"]},{"id":"https://openalex.org/I63966007","display_name":"Massachusetts Institute of Technology","ror":"https://ror.org/042nb2s44","country_code":"US","type":"education","lineage":["https://openalex.org/I63966007"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey F. Lodish","raw_affiliation_strings":["Department of Biology, Massachusetts Institute of Technology, Cambridge","Whitehead Institute for Biomedical Research, Cambridge, MA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Massachusetts Institute of Technology, Cambridge","institution_ids":["https://openalex.org/I63966007"]},{"raw_affiliation_string":"Whitehead Institute for Biomedical Research, Cambridge, MA;","institution_ids":["https://openalex.org/I4210157710"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":5500,"currency":"USD","value_usd":5500},"apc_paid":{"value":5500,"currency":"USD","value_usd":5500},"fwci":15.3112,"has_fulltext":true,"cited_by_count":252,"citation_normalized_percentile":{"value":0.99204128,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"111","issue":"7","first_page":"3415","last_page":"3423"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10345","display_name":"Hematopoietic Stem Cell Transplantation","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12919","display_name":"Blood disorders and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/igf-binding-protein-2","display_name":"IGF binding protein-2","score":0.9729999899864197},{"id":"https://openalex.org/keywords/hematopoietic-stem-cells","display_name":"hematopoietic stem cells","score":0.9279999732971191},{"id":"https://openalex.org/keywords/umbilical-cord-blood","display_name":"umbilical cord blood","score":0.906000018119812},{"id":"https://openalex.org/keywords/ex-vivo-expansion","display_name":"ex vivo expansion","score":0.871999979019165},{"id":"https://openalex.org/keywords/self-renewal","display_name":"self-renewal","score":0.777999997138977},{"id":"https://openalex.org/keywords/bone-marrow-transplantation","display_name":"bone marrow transplantation","score":0.753000020980835},{"id":"https://openalex.org/keywords/cd133-cells","display_name":"CD133+ cells","score":0.7990000247955322},{"id":"https://openalex.org/keywords/serum-free-culture","display_name":"serum-free culture","score":0.7020000219345093},{"id":"https://openalex.org/keywords/hematopoietic-growth-factors","display_name":"hematopoietic growth factors","score":0.703000009059906}],"concepts":[{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.7237476706504822},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.7077842950820923},{"id":"https://openalex.org/C2780914630","wikidata":"https://www.wikidata.org/wiki/Q914952","display_name":"Cord blood","level":2,"score":0.707309365272522},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.6860193014144897},{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.5837204456329346},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.563787043094635},{"id":"https://openalex.org/C55851684","wikidata":"https://www.wikidata.org/wiki/Q518390","display_name":"Nod","level":3,"score":0.5354651808738708},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.49184203147888184},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.488946795463562},{"id":"https://openalex.org/C2779468541","wikidata":"https://www.wikidata.org/wiki/Q1334408","display_name":"Severe combined immunodeficiency","level":3,"score":0.4158402681350708},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3506237268447876},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3179130554199219},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.24252787232398987},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2221882939338684},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.18136811256408691},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.060022056102752686}],"mesh":[{"descriptor_ui":"D000071916","descriptor_name":"AC133 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075802","descriptor_name":"Angiopoietin-like Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001324","descriptor_name":"Autoantigens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005312","descriptor_name":"Fetal Blood","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006023","descriptor_name":"Glycoproteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D006412","descriptor_name":"Hematopoietic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007453","descriptor_name":"Iodide Peroxidase","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014183","descriptor_name":"Transplantation, Heterologous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015316","descriptor_name":"Genetic Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016220","descriptor_name":"Fibroblast Growth Factor 1","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016513","descriptor_name":"Mice, SCID","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016688","descriptor_name":"Mice, Inbred NOD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016895","descriptor_name":"Culture Media, Serum-Free","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D017077","descriptor_name":"Culture Media, Conditioned","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D018380","descriptor_name":"Hematopoietic Stem Cell Transplantation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018971","descriptor_name":"Insulin-Like Growth Factor Binding Protein 2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D033862","descriptor_name":"Iron-Binding Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D036341","descriptor_name":"Intercellular Signaling Peptides and Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D042682","descriptor_name":"Angiopoietins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1182/blood-2007-11-122119","doi":"https://doi.org/10.1182/blood-2007-11-122119","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-11-122119","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3415/1482820/zh800708003415.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},{"id":"pmid:18202223","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18202223","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2275010","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2275010/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1182/blood-2007-11-122119","doi":"https://doi.org/10.1182/blood-2007-11-122119","is_oa":true,"landing_page_url":"https://doi.org/10.1182/blood-2007-11-122119","pdf_url":"https://ashpublications.org/blood/article-pdf/111/7/3415/1482820/zh800708003415.pdf","source":{"id":"https://openalex.org/S200071133","display_name":"Blood","issn_l":"0006-4971","issn":["0006-4971","1528-0020"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Blood","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1282486039","display_name":"Growth factors and engineered stroma for hematopoietic stem csll (HSC) expansion","funder_award_id":"R01DK067356","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G2503412604","display_name":"Expansion of hematopoietic stem cells by Angiopoietin-like 2","funder_award_id":"K01CA120099","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003209323.pdf","grobid_xml":"https://content.openalex.org/works/W2003209323.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1504115723","https://openalex.org/W1576832162","https://openalex.org/W1607110680","https://openalex.org/W1719320996","https://openalex.org/W1965671668","https://openalex.org/W1972007421","https://openalex.org/W1983049888","https://openalex.org/W1985441355","https://openalex.org/W2001823825","https://openalex.org/W2018906703","https://openalex.org/W2025220707","https://openalex.org/W2025716311","https://openalex.org/W2027500064","https://openalex.org/W2033766516","https://openalex.org/W2035301585","https://openalex.org/W2040827928","https://openalex.org/W2059251144","https://openalex.org/W2061217297","https://openalex.org/W2067420381","https://openalex.org/W2068972073","https://openalex.org/W2069781632","https://openalex.org/W2075940788","https://openalex.org/W2081592444","https://openalex.org/W2082128698","https://openalex.org/W2093015386","https://openalex.org/W2096089376","https://openalex.org/W2116386021","https://openalex.org/W2125326158","https://openalex.org/W2146675666","https://openalex.org/W2170272046","https://openalex.org/W2256952023","https://openalex.org/W2406589751","https://openalex.org/W6636269840"],"related_works":["https://openalex.org/W7098574264","https://openalex.org/W940439484","https://openalex.org/W2560740732","https://openalex.org/W2801611291","https://openalex.org/W1548570528","https://openalex.org/W7099279637","https://openalex.org/W2069047578","https://openalex.org/W2096904352","https://openalex.org/W2148552073","https://openalex.org/W2055670125"],"abstract_inverted_index":{"Hematopoietic":[0],"stem":[1],"cells":[2,15,93],"(HSCs)":[3],"are":[4,12],"the":[5,39,51,84,98,110,130,149],"basis":[6],"of":[7,35,41,53,86,113,129,140,156,181],"bone":[8,76],"marrow":[9,77],"transplantation":[10,46,96,105],"and":[11,60,121,173],"attractive":[13],"target":[14],"for":[16,44],"hematopoietic":[17],"gene":[18],"therapy,":[19],"but":[20],"these":[21],"important":[22],"clinical":[23,193],"applications":[24],"have":[25],"been":[26],"severely":[27],"hampered":[28],"by":[29,50,95,161],"difficulties":[30],"in":[31,79,133],"ex":[32],"vivo":[33],"expansion":[34,128,155,180],"HSCs.":[36,54],"In":[37],"particular,":[38],"use":[40],"cord":[42,135,184],"blood":[43,136,185],"adult":[45],"is":[47],"greatly":[48],"limited":[49],"number":[52,188],"Previously":[55],"we":[56,82],"identified":[57],"angiopoietin-like":[58,142,171],"proteins":[59],"IGF-binding":[61,145],"protein":[62,146],"2":[63,147],"(IGFBP2)":[64],"as":[65,159],"new":[66],"hormones":[67],"that,":[68],"together":[69],"with":[70],"other":[71],"factors,":[72],"can":[73],"expand":[74],"mouse":[75],"HSCs":[78],"culture.":[80],"Here,":[81],"measure":[83],"activity":[85],"multipotent":[87],"human":[88,134,183],"severe":[89],"combined":[90],"immunodeficient":[91],"(SCID)-repopulating":[92],"(SRCs)":[94],"into":[97],"nonobese":[99],"diabetic":[100],"SCID":[101],"(NOD/SCID)":[102],"mice;":[103],"secondary":[104],"was":[106],"performed":[107],"to":[108,148,152,191],"evaluate":[109],"self-renewal":[111],"potential":[112],"SRCs.":[114],"A":[115,164],"serum-free":[116,165],"medium":[117],"containing":[118,167],"SCF,":[119,168],"TPO,":[120,169],"FGF-1":[122],"or":[123,144],"Flt3-L":[124],"cannot":[125],"significantly":[126],"support":[127],"SRCs":[131],"present":[132],"CD133+":[137],"cells.":[138],"Addition":[139],"either":[141],"5":[143],"cultures":[150],"led":[151],"a":[153,187],"sizable":[154],"HSC":[157,196],"numbers,":[158],"assayed":[160],"NOD/SCID":[162],"transplantation.":[163,197],"culture":[166],"FGF-1,":[170],"5,":[172],"IGFBP2":[174],"supports":[175],"an":[176],"approximately":[177],"20-fold":[178],"net":[179],"repopulating":[182],"HSCs,":[186],"potentially":[189],"applicable":[190],"several":[192],"processes":[194],"including":[195]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":21},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":40}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}