{"id":"https://openalex.org/W2003203546","doi":"https://doi.org/10.1016/s0049-3848(02)00020-8","title":"Differences between neonates and adults in carbohydrate sequences and reaction kinetics of plasmin and \u03b12-antiplasmin","display_name":"Differences between neonates and adults in carbohydrate sequences and reaction kinetics of plasmin and \u03b12-antiplasmin","publication_year":2002,"publication_date":"2002-02-01","ids":{"openalex":"https://openalex.org/W2003203546","doi":"https://doi.org/10.1016/s0049-3848(02)00020-8","mag":"2003203546","pmid":"https://pubmed.ncbi.nlm.nih.gov/11927131"},"language":"en","primary_location":{"id":"doi:10.1016/s0049-3848(02)00020-8","doi":"https://doi.org/10.1016/s0049-3848(02)00020-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0049-3848(02)00020-8","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113765711","display_name":"Martin Ries","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I65163767","display_name":"National Institute for Biological Standards and Control","ror":"https://ror.org/03dnc6n82","country_code":"GB","type":"facility","lineage":["https://openalex.org/I65163767"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Martin Ries","raw_affiliation_strings":["Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK","institution_ids":["https://openalex.org/I65163767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081988685","display_name":"Richard L. Easton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Richard L. Easton","raw_affiliation_strings":["Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017944240","display_name":"Colin Longstaff","orcid":"https://orcid.org/0000-0001-7608-208X","observed_orcids":["https://orcid.org/0000-0001-7608-208X"]},"institutions":[{"id":"https://openalex.org/I65163767","display_name":"National Institute for Biological Standards and Control","ror":"https://ror.org/03dnc6n82","country_code":"GB","type":"facility","lineage":["https://openalex.org/I65163767"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Colin Longstaff","raw_affiliation_strings":["Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK","institution_ids":["https://openalex.org/I65163767"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109937553","display_name":"Martin Zenker","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210088053","display_name":"Universit\u00e4tsklinikum Erlangen","ror":"https://ror.org/0030f2a11","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210088053"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Martin Zenker","raw_affiliation_strings":["Abteilung f\u00fcr Neonatologie, Universit\u00e4tsklinik f\u00fcr Kinder und Jugendliche, Erlangen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abteilung f\u00fcr Neonatologie, Universit\u00e4tsklinik f\u00fcr Kinder und Jugendliche, Erlangen, Germany","institution_ids":["https://openalex.org/I4210088053"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108419311","display_name":"Howard R. Morris","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Howard R. Morris","raw_affiliation_strings":["Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080001443","display_name":"Anne Dell","orcid":"https://orcid.org/0000-0003-1380-2347","observed_orcids":["https://orcid.org/0000-0003-1380-2347"]},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Anne Dell","raw_affiliation_strings":["Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Imperial College of Science, Technology and Medicine,London,UK","institution_ids":["https://openalex.org/I47508984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111592116","display_name":"Patrick J. Gaffney","orcid":"https://orcid.org/0009-0000-6160-9328","observed_orcids":["https://orcid.org/0009-0000-6160-9328"]},"institutions":[{"id":"https://openalex.org/I65163767","display_name":"National Institute for Biological Standards and Control","ror":"https://ror.org/03dnc6n82","country_code":"GB","type":"facility","lineage":["https://openalex.org/I65163767"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Patrick J. Gaffney","raw_affiliation_strings":["Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Haematology, National Institute for Biological Standards and Control, South Mimms, Hertfordshire, UK","institution_ids":["https://openalex.org/I65163767"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4080,"currency":"USD","value_usd":4080},"apc_paid":null,"fwci":0.4865,"has_fulltext":false,"cited_by_count":25,"citation_normalized_percentile":{"value":0.62888516,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"105","issue":"3","first_page":"247","last_page":"256"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9345999956130981,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.01769999973475933,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plasmin","display_name":"plasmin","score":0.9800000190734863},{"id":"https://openalex.org/keywords/alpha2-antiplasmin","display_name":"alpha2-antiplasmin","score":0.9769999980926514},{"id":"https://openalex.org/keywords/plasminogen","display_name":"plasminogen","score":0.9359999895095825},{"id":"https://openalex.org/keywords/slow-binding-inhibition","display_name":"slow-binding inhibition","score":0.5979999899864197},{"id":"https://openalex.org/keywords/reaction-kinetics","display_name":"reaction kinetics","score":0.6949999928474426},{"id":"https://openalex.org/keywords/n-glycosylation","display_name":"N-glycosylation","score":0.7739999890327454},{"id":"https://openalex.org/keywords/o-glycosylation","display_name":"O-glycosylation","score":0.9789999723434448},{"id":"https://openalex.org/keywords/tranexamic-acid","display_name":"tranexamic acid","score":0.8600000143051147},{"id":"https://openalex.org/keywords/fibrinolysis","display_name":"fibrinolysis","score":0.9089999794960022},{"id":"https://openalex.org/keywords/newborns","display_name":"neonates","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C2781071845","wikidata":"https://www.wikidata.org/wiki/Q21173374","display_name":"Plasmin","level":3,"score":0.8343918323516846},{"id":"https://openalex.org/C172680121","wikidata":"https://www.wikidata.org/wiki/Q26513","display_name":"Fetus","level":3,"score":0.6875203847885132},{"id":"https://openalex.org/C64943373","wikidata":"https://www.wikidata.org/wiki/Q2651003","display_name":"Alpha (finance)","level":4,"score":0.5959774255752563},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.5147705078125},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4846963882446289},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47275620698928833},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.44498515129089355},{"id":"https://openalex.org/C2776825266","wikidata":"https://www.wikidata.org/wiki/Q1410794","display_name":"Fibrinolysis","level":2,"score":0.43976378440856934},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3110576868057251},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2873770594596863},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2738790810108185},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.08625444769859314},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.08085983991622925},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06108790636062622},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C2775944032","wikidata":"https://www.wikidata.org/wiki/Q22907659","display_name":"Patient satisfaction","level":2,"score":0.0},{"id":"https://openalex.org/C49453240","wikidata":"https://www.wikidata.org/wiki/Q1592163","display_name":"Construct validity","level":3,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000979","descriptor_name":"alpha-2-Antiplasmin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002240","descriptor_name":"Carbohydrate Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005341","descriptor_name":"Fibrinolysin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007231","descriptor_name":"Infant, Newborn","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013058","descriptor_name":"Mass Spectrometry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0049-3848(02)00020-8","doi":"https://doi.org/10.1016/s0049-3848(02)00020-8","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0049-3848(02)00020-8","pdf_url":null,"source":{"id":"https://openalex.org/S134546602","display_name":"Thrombosis Research","issn_l":"0049-3848","issn":["0049-3848","1879-2472"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis Research","raw_type":"journal-article"},{"id":"pmid:11927131","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11927131","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Thrombosis research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W27915724","https://openalex.org/W173576190","https://openalex.org/W380499458","https://openalex.org/W1488573465","https://openalex.org/W1512610726","https://openalex.org/W1522140074","https://openalex.org/W1629966220","https://openalex.org/W1762632784","https://openalex.org/W1966087742","https://openalex.org/W1972663733","https://openalex.org/W1978579910","https://openalex.org/W1981408213","https://openalex.org/W1983244981","https://openalex.org/W2007402219","https://openalex.org/W2008705973","https://openalex.org/W2012839797","https://openalex.org/W2023594738","https://openalex.org/W2024020978","https://openalex.org/W2031016458","https://openalex.org/W2038581914","https://openalex.org/W2038883402","https://openalex.org/W2040791750","https://openalex.org/W2045017040","https://openalex.org/W2047347411","https://openalex.org/W2049519522","https://openalex.org/W2081929609","https://openalex.org/W2082155638","https://openalex.org/W2088502634","https://openalex.org/W2092467674","https://openalex.org/W2111412025","https://openalex.org/W2184999432","https://openalex.org/W2238866276","https://openalex.org/W2272022737","https://openalex.org/W2397417687","https://openalex.org/W2417487278","https://openalex.org/W2436450483","https://openalex.org/W6671141634"],"related_works":["https://openalex.org/W2040791750","https://openalex.org/W2047347411","https://openalex.org/W2409417930","https://openalex.org/W106067400","https://openalex.org/W4235332705","https://openalex.org/W1972663733","https://openalex.org/W2088502634","https://openalex.org/W2008705973","https://openalex.org/W2082155638","https://openalex.org/W2014249782"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}