{"id":"https://openalex.org/W2003198613","doi":"https://doi.org/10.1002/mds.21180","title":"Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families","display_name":"Screening for Lrrk2 G2019S and clinical comparison of Tunisian and North American Caucasian Parkinson's disease families","publication_year":2006,"publication_date":"2006-11-17","ids":{"openalex":"https://openalex.org/W2003198613","doi":"https://doi.org/10.1002/mds.21180","mag":"2003198613","pmid":"https://pubmed.ncbi.nlm.nih.gov/17115391"},"language":"en","primary_location":{"id":"doi:10.1002/mds.21180","doi":"https://doi.org/10.1002/mds.21180","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mds.21180","pdf_url":null,"source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047136661","display_name":"Lianna Ishihara","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I241749","display_name":"University of Cambridge","ror":"https://ror.org/013meh722","country_code":"GB","type":"education","lineage":["https://openalex.org/I241749"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lianna Ishihara","raw_affiliation_strings":["Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. lsi20@medschl.com.ac.uk","Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. lsi20@medschl.com.ac.uk","institution_ids":["https://openalex.org/I241749"]},{"raw_affiliation_string":"Department of Public Health & Primary Care, University of Cambridge, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I241749"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066436164","display_name":"Rachel A. Gibson","orcid":"https://orcid.org/0000-0002-1338-1290","observed_orcids":["https://orcid.org/0000-0002-1338-1290"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Rachel A. Gibson","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026956434","display_name":"Liling L. Warren","orcid":"https://orcid.org/0009-0006-0658-2568","observed_orcids":["https://orcid.org/0009-0006-0658-2568"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Liling Warren","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069738625","display_name":"Rim Amouri","orcid":"https://orcid.org/0000-0001-5641-5748","observed_orcids":["https://orcid.org/0000-0001-5641-5748"]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Rim Amouri","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000700731","display_name":"Kelly E. Lyons","orcid":"https://orcid.org/0000-0001-7418-1957","observed_orcids":["https://orcid.org/0000-0001-7418-1957","https://orcid.org/0000-0001-6866-7301"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kelly Lyons","raw_affiliation_strings":["Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033810437","display_name":"Catherine L. Wielinski","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Catherine Wielinski","raw_affiliation_strings":["Struthers Parkinson's Center, Golden Valley, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Struthers Parkinson's Center, Golden Valley, Minnesota, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079629658","display_name":"Christine Hunter","orcid":"https://orcid.org/0000-0002-2583-2052","observed_orcids":["https://orcid.org/0000-0002-2583-2052"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine Hunter","raw_affiliation_strings":["Department of Neurology Baylor College of Medicine Houston Texas USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology Baylor College of Medicine Houston Texas USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015411963","display_name":"Jina Swartz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Jina E. Swartz","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049268048","display_name":"Ramu Elango","orcid":"https://orcid.org/0000-0003-4264-2135","observed_orcids":["https://orcid.org/0000-0003-4264-2135"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ramu Elango","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059248554","display_name":"Patrick Anthony Akkari","orcid":"https://orcid.org/0000-0003-2011-8869","observed_orcids":["https://orcid.org/0000-0003-2011-8869"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Anthony Akkari","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076575343","display_name":"David Leppert","orcid":"https://orcid.org/0000-0001-6172-801X","observed_orcids":["https://orcid.org/0000-0001-6172-801X"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David Leppert","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022052445","display_name":"Linda C. Surh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Linda Surh","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054027762","display_name":"Kevin H. Reeves","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin H. Reeves","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063039527","display_name":"Siwan Thomas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Siwan Thomas","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042164171","display_name":"Leigh J. Ragone","orcid":"https://orcid.org/0000-0001-9847-1879","observed_orcids":["https://orcid.org/0000-0001-9847-1879"]},"institutions":[{"id":"https://openalex.org/I4210114143","display_name":"GlaxoSmithKline (United States)","ror":"https://ror.org/025vn3989","country_code":"US","type":"company","lineage":["https://openalex.org/I188950975","https://openalex.org/I4210114143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leigh Ragone","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Research Triangle Park, Durham, North Carolina, USA","institution_ids":["https://openalex.org/I4210114143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014705038","display_name":"Nobutaka Hattori","orcid":"https://orcid.org/0000-0002-2034-2556","observed_orcids":["https://orcid.org/0000-0002-2034-2556"]},"institutions":[{"id":"https://openalex.org/I34077901","display_name":"Juntendo University","ror":"https://ror.org/01692sz90","country_code":"JP","type":"education","lineage":["https://openalex.org/I34077901"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Nobutaka Hattori","raw_affiliation_strings":["Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Juntendo University School of Medicine, Tokyo, Japan","institution_ids":["https://openalex.org/I34077901"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009117789","display_name":"Rajesh Pahwa","orcid":"https://orcid.org/0000-0003-3176-6466","observed_orcids":["https://orcid.org/0000-0003-3176-6466"]},"institutions":[{"id":"https://openalex.org/I4210128618","display_name":"University of Kansas Medical Center","ror":"https://ror.org/036c9yv20","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210128618"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajesh Pahwa","raw_affiliation_strings":["Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Kansas Medical Center, Kansas City, Kansas, USA","institution_ids":["https://openalex.org/I4210128618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068655451","display_name":"Joseph J. Jankovic","orcid":"https://orcid.org/0000-0003-4129-3674","observed_orcids":["https://orcid.org/0000-0003-4129-3674","https://orcid.org/0000-0001-5551-3784","https://orcid.org/0000-0002-8773-4677"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joseph Jankovic","raw_affiliation_strings":["Department of Neurology, Baylor College of Medicine, Houston, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Baylor College of Medicine, Houston, Texas, USA","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084937714","display_name":"MARTHA A. NANCE","orcid":"https://orcid.org/0000-0003-4994-8815","observed_orcids":["https://orcid.org/0000-0003-4994-8815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Martha Nance","raw_affiliation_strings":["Struthers Parkinson's Center, Golden Valley, Minnesota, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Struthers Parkinson's Center, Golden Valley, Minnesota, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112003090","display_name":"Alan Freeman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alan Freeman","raw_affiliation_strings":["Department of Neurology, Emory University, Atlanta, Georgia, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Emory University, Atlanta, Georgia, USA","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010104276","display_name":"Neziha Gouider\u2010Khouja","orcid":"https://orcid.org/0000-0003-2919-4788","observed_orcids":["https://orcid.org/0000-0003-2919-4788"]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Neziha Gouider\u2010Khouja","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111622309","display_name":"Mounir Kefi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mounir Kefi","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080005977","display_name":"Mourad Zouari","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Mourad Zouari","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080861807","display_name":"Samia Ben Sassi","orcid":"https://orcid.org/0000-0002-1002-5979","observed_orcids":["https://orcid.org/0000-0002-1002-5979"]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Samia Ben Sassi","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039454970","display_name":"Samia Ben Yahmed","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Samia Ben Yahmed","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031284851","display_name":"G. El Euch","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Ghada El Euch\u2010Fayeche","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102914520","display_name":"Lefkos T. Middleton","orcid":"https://orcid.org/0000-0002-8615-3723","observed_orcids":["https://orcid.org/0000-0002-8615-3723","https://orcid.org/0000-0002-2176-403X"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Lefkos Middleton","raw_affiliation_strings":["Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Research and Development, GlaxoSmithKline Pharmaceuticals, Greenford, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010057774","display_name":"David John Burn","orcid":"https://orcid.org/0000-0001-7658-1209","observed_orcids":["https://orcid.org/0000-0001-7658-1209"]},"institutions":[{"id":"https://openalex.org/I4210124950","display_name":"Newcastle upon Tyne Hospital","ror":"https://ror.org/02w91w637","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210109172","https://openalex.org/I4210124950"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"David J. Burn","raw_affiliation_strings":["Department of Neurology, Newcastle General Hospital, Newcastle-upon-Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Newcastle General Hospital, Newcastle-upon-Tyne, United Kingdom","institution_ids":["https://openalex.org/I4210124950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075498105","display_name":"Ray L. Watts","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4390039250","display_name":"UAB Medicine","ror":"https://ror.org/036554539","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039250"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ray L. Watts","raw_affiliation_strings":["Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA","institution_ids":["https://openalex.org/I32389192","https://openalex.org/I4390039250"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109998085","display_name":"Fay\u00e7al Hentati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210098525","display_name":"H\u00f4pital La Rabta","ror":"https://ror.org/00gffbx54","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210098525"]},{"id":"https://openalex.org/I4210158266","display_name":"National Institute of Neurology Mongi-Ben Hamida","ror":"https://ror.org/02mqbx112","country_code":"TN","type":"healthcare","lineage":["https://openalex.org/I4210158266"]}],"countries":["TN"],"is_corresponding":false,"raw_author_name":"Faycal Hentati","raw_affiliation_strings":["Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service de Neurologie, Institut National de Neurologie, La Rabta, Tunis, Tunisia","institution_ids":["https://openalex.org/I4210098525","https://openalex.org/I4210158266"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4480,"currency":"USD","value_usd":4480},"apc_paid":null,"fwci":6.031,"has_fulltext":false,"cited_by_count":93,"citation_normalized_percentile":{"value":0.96192728,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"22","issue":"1","first_page":"55","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13991","display_name":"Nuclear Receptors and Signaling","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lrrk2","display_name":"LRRK2","score":0.8970000147819519},{"id":"https://openalex.org/keywords/g2019s-mutation","display_name":"G2019S mutation","score":0.9259999990463257},{"id":"https://openalex.org/keywords/parkinson-s-disease","display_name":"Parkinson's disease","score":0.9760000109672546},{"id":"https://openalex.org/keywords/familial-parkinson-s-disease","display_name":"familial Parkinson's disease","score":0.9599999785423279},{"id":"https://openalex.org/keywords/mutation-detection","display_name":"mutation detection","score":0.5619999766349792},{"id":"https://openalex.org/keywords/tunisian-family","display_name":"Tunisian family","score":0.7099999785423279},{"id":"https://openalex.org/keywords/homozygous-carriers","display_name":"homozygous carriers","score":0.6779999732971191},{"id":"https://openalex.org/keywords/heterozygous-carriers","display_name":"heterozygous carriers","score":0.9789999723434448},{"id":"https://openalex.org/keywords/age-of-onset","display_name":"age of onset","score":0.8029999732971191},{"id":"https://openalex.org/keywords/penetrance","display_name":"penetrance","score":0.8370000123977661},{"id":"https://openalex.org/keywords/gene-dosage","display_name":"gene dosage","score":0.7179999947547913},{"id":"https://openalex.org/keywords/clinical-phenotype","display_name":"clinical phenotype","score":0.6159999966621399},{"id":"https://openalex.org/keywords/mutation-frequency","display_name":"mutation frequency","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C2780427247","wikidata":"https://www.wikidata.org/wiki/Q409961","display_name":"LRRK2","level":4,"score":0.9847192168235779},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.8643952012062073},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6277410984039307},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.6182770729064941},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5513418316841125},{"id":"https://openalex.org/C2777767895","wikidata":"https://www.wikidata.org/wiki/Q4691924","display_name":"Age of onset","level":3,"score":0.5068817734718323},{"id":"https://openalex.org/C2781179581","wikidata":"https://www.wikidata.org/wiki/Q2857712","display_name":"Family history","level":2,"score":0.4825524687767029},{"id":"https://openalex.org/C2994225774","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Gene mutation","level":4,"score":0.4680730104446411},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4366886615753174},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4282740354537964},{"id":"https://openalex.org/C102306862","wikidata":"https://www.wikidata.org/wiki/Q6943735","display_name":"Mutation frequency","level":4,"score":0.42436307668685913},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4217488169670105},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.41773465275764465},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4074561297893524},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32695168256759644}],"mesh":[{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071158","descriptor_name":"Leucine-Rich Repeat Serine-Threonine Protein Kinase-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003431","descriptor_name":"Cross-Cultural Comparison","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003431","descriptor_name":"Cross-Cultural Comparison","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003431","descriptor_name":"Cross-Cultural Comparison","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004252","descriptor_name":"DNA Mutational Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005192","descriptor_name":"Family Health","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005820","descriptor_name":"Genetic Testing","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009656","descriptor_name":"North America","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D010300","descriptor_name":"Parkinson Disease","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D014416","descriptor_name":"Tunisia","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D044465","descriptor_name":"White People","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/mds.21180","doi":"https://doi.org/10.1002/mds.21180","is_oa":false,"landing_page_url":"https://doi.org/10.1002/mds.21180","pdf_url":null,"source":{"id":"https://openalex.org/S163027424","display_name":"Movement Disorders","issn_l":"0885-3185","issn":["0885-3185","1531-8257"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement Disorders","raw_type":"journal-article"},{"id":"pmid:17115391","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17115391","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Movement disorders : official journal of the Movement Disorder Society","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9940000176429749,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1538524809","https://openalex.org/W1549555528","https://openalex.org/W1593340312","https://openalex.org/W1970687029","https://openalex.org/W1972097907","https://openalex.org/W1996472462","https://openalex.org/W2008886854","https://openalex.org/W2010095758","https://openalex.org/W2020503756","https://openalex.org/W2021097923","https://openalex.org/W2040123229","https://openalex.org/W2046398127","https://openalex.org/W2048496048","https://openalex.org/W2050310121","https://openalex.org/W2056103666","https://openalex.org/W2056145524","https://openalex.org/W2056352890","https://openalex.org/W2063127941","https://openalex.org/W2069221714","https://openalex.org/W2074985552","https://openalex.org/W2080665395","https://openalex.org/W2081139491","https://openalex.org/W2082214922","https://openalex.org/W2088528774","https://openalex.org/W2093875556","https://openalex.org/W2098152756","https://openalex.org/W2100300726","https://openalex.org/W2103306563","https://openalex.org/W2105306382","https://openalex.org/W2105381209","https://openalex.org/W2116200652","https://openalex.org/W2118094114","https://openalex.org/W2135818303","https://openalex.org/W2140688714","https://openalex.org/W2155589626","https://openalex.org/W2160484806"],"related_works":["https://openalex.org/W2159300982","https://openalex.org/W7214484126","https://openalex.org/W2077965380","https://openalex.org/W2041917152","https://openalex.org/W2137875056","https://openalex.org/W2439276620","https://openalex.org/W2058798901","https://openalex.org/W2002287575","https://openalex.org/W2062694658","https://openalex.org/W2146652372"],"abstract_inverted_index":{"Mutations":[0],"in":[1,40,47,103,110,191],"the":[2,30,41,64,80,83,116,154,186],"leucine-rich":[3],"repeat":[4],"kinase-2":[5],"gene":[6,46,177],"(LRRK2)":[7],"are":[8],"responsible":[9],"for":[10,72,153],"some":[11],"forms":[12,69],"of":[13,24,32,44,82,87,101,132,164],"familial":[14,52],"as":[15,17],"well":[16],"sporadic":[18],"Parkinson's":[19],"disease":[20],"(PD).":[21],"The":[22,99],"purpose":[23],"this":[25,45],"study":[26],"was":[27,106,179,189],"to":[28,55,119],"examine":[29],"frequency":[31,81,100],"a":[33],"single":[34],"pathogenic":[35],"mutation":[36],"(6055G":[37],">":[38],"A)":[39],"kinase":[42],"domain":[43],"United":[48],"States":[49],"and":[50,54,62,74,91,96,109,125,171],"Tunisian":[51,104,130],"PD":[53],"compare":[56,120],"clinical":[57,73,162],"characteristics":[58],"between":[59,167],"patients":[60],"with":[61,115,136,150,157,169,182],"without":[63],"mutation.":[65],"Standardized":[66],"case":[67],"report":[68],"were":[70],"used":[71],"demographic":[75],"data":[76],"collection.":[77],"We":[78],"investigated":[79],"most":[84],"common":[85],"substitution":[86],"LRRK2":[88,158,173],"(G2019S,":[89],"6055G>A)":[90],"its":[92],"impact":[93],"on":[94],"epidemiological":[95],"phenotypic":[97,183],"features.":[98],"mutations":[102,159,174],"families":[105,112,151],"42%":[107],"(38/91)":[108],"U.S.":[111],"2.6%":[113],"(1/39),":[114],"unique":[117],"opportunity":[118],"homozygous":[121,172],"(n":[122,127],"=":[123,128],"23)":[124],"heterozygous":[126,170],"109)":[129],"carriers":[131],"G2019S":[133,137],"substitutions.":[134],"Individuals":[135],"substitutions":[138],"had":[139,160],"an":[140],"older":[141],"age":[142,195],"at":[143],"onset":[144],"but":[145],"few":[146],"other":[147],"differences":[148],"compared":[149],"negative":[152],"substitution.":[155],"Patients":[156],"typical":[161],"features":[163],"PD.":[165],"Comparisons":[166],"individuals":[168],"suggested":[175],"that":[176],"dosage":[178],"not":[180],"correlated":[181],"differences;":[184],"however,":[185],"estimated":[187],"penetrance":[188],"greater":[190],"homozygotes":[192],"across":[193],"all":[194],"groups.":[196]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-30T12:39:25.321706","created_date":"2016-06-24T00:00:00"}