{"id":"https://openalex.org/W2003197578","doi":"https://doi.org/10.1248/cpb.48.579","title":"The Controlled Release of a Drug from Biodegradable Chitosan Gel Beads.","display_name":"The Controlled Release of a Drug from Biodegradable Chitosan Gel Beads.","publication_year":2000,"publication_date":"2000-01-01","ids":{"openalex":"https://openalex.org/W2003197578","doi":"https://doi.org/10.1248/cpb.48.579","mag":"2003197578","pmid":"https://pubmed.ncbi.nlm.nih.gov/10783085"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.48.579","doi":"https://doi.org/10.1248/cpb.48.579","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.48.579","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/48/4/48_4_579/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb1958/48/4/48_4_579/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113654840","display_name":"Kyoko Kofuji","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kyoko KOFUJI","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan","Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokuriku University, Kanazawa, Japan","institution_ids":["https://openalex.org/I49155475"]},{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112704487","display_name":"Tomohiro Ito","orcid":"https://orcid.org/0000-0003-3647-0955","observed_orcids":["https://orcid.org/0000-0003-3647-0955"]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tomohiro ITO","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110488619","display_name":"Yoshifumi Murata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoshifumi MURATA","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University","institution_ids":["https://openalex.org/I49155475"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086673855","display_name":"Susumu Kawashima","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49155475","display_name":"Hokuriku University","ror":"https://ror.org/04wcpjy25","country_code":"JP","type":"education","lineage":["https://openalex.org/I49155475"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Susumu KAWASHIMA","raw_affiliation_strings":["Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University, Faculty of Pharmaceutical Sciences, Hokuriku University","institution_ids":["https://openalex.org/I49155475"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I49155475"],"apc_list":null,"apc_paid":null,"fwci":3.4774,"has_fulltext":false,"cited_by_count":38,"citation_normalized_percentile":{"value":0.92544643,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"48","issue":"4","first_page":"579","last_page":"581"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.9307000041007996,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12642","display_name":"Polymer-Based Agricultural Enhancements","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1102","display_name":"Agronomy and Crop Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chitosan-beads","display_name":"chitosan beads","score":0.902999997138977},{"id":"https://openalex.org/keywords/controlled-drug-release","display_name":"controlled drug release","score":0.9190000295639038},{"id":"https://openalex.org/keywords/sustained-release","display_name":"sustained drug release","score":0.6909999847412109},{"id":"https://openalex.org/keywords/prednisolone","display_name":"prednisolone","score":0.9760000109672546},{"id":"https://openalex.org/keywords/enzymatic-degradation","display_name":"enzymatic degradation","score":0.8539999723434448},{"id":"https://openalex.org/keywords/degree-of-deacetylation","display_name":"degree of deacetylation","score":0.9729999899864197},{"id":"https://openalex.org/keywords/chondroitin-sulfate","display_name":"chondroitin sulfate","score":0.9089999794960022},{"id":"https://openalex.org/keywords/biodegradable-drug-delivery-systems","display_name":"biodegradable drug delivery","score":0.7089999914169312},{"id":"https://openalex.org/keywords/ph-dependent-gelation","display_name":"pH-dependent gelation","score":0.5059999823570251}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8873053789138794},{"id":"https://openalex.org/C2779732960","wikidata":"https://www.wikidata.org/wiki/Q408510","display_name":"Chitosan","level":2,"score":0.7864648103713989},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.6505364179611206},{"id":"https://openalex.org/C2779820397","wikidata":"https://www.wikidata.org/wiki/Q1392806","display_name":"Drug delivery","level":2,"score":0.5000455379486084},{"id":"https://openalex.org/C2777756961","wikidata":"https://www.wikidata.org/wiki/Q620730","display_name":"Glycine","level":3,"score":0.48528191447257996},{"id":"https://openalex.org/C77281830","wikidata":"https://www.wikidata.org/wiki/Q718608","display_name":"Dosage form","level":2,"score":0.4464263617992401},{"id":"https://openalex.org/C2779553658","wikidata":"https://www.wikidata.org/wiki/Q408014","display_name":"Chondroitin sulfate","level":3,"score":0.42552828788757324},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.3900163173675537},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19065645337104797},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.18552860617637634},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.1299353837966919},{"id":"https://openalex.org/C153074725","wikidata":"https://www.wikidata.org/wiki/Q407553","display_name":"Glycosaminoglycan","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D002686","descriptor_name":"Chitin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003692","descriptor_name":"Delayed-Action Preparations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005782","descriptor_name":"Gels","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012996","descriptor_name":"Solutions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016503","descriptor_name":"Drug Delivery Systems","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D048271","descriptor_name":"Chitosan","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.48.579","doi":"https://doi.org/10.1248/cpb.48.579","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.48.579","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/48/4/48_4_579/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:10783085","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10783085","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.48.579","doi":"https://doi.org/10.1248/cpb.48.579","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.48.579","pdf_url":"https://www.jstage.jst.go.jp/article/cpb1958/48/4/48_4_579/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6240000128746033,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003197578.pdf","grobid_xml":"https://content.openalex.org/works/W2003197578.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2091734064","https://openalex.org/W2017677131","https://openalex.org/W2080336598","https://openalex.org/W2095524390","https://openalex.org/W2055282778","https://openalex.org/W2063694888","https://openalex.org/W2041581549","https://openalex.org/W1971235077","https://openalex.org/W2066662632","https://openalex.org/W2384715594"],"abstract_inverted_index":{"Chitosan":[0],"(CS)":[1],"forms":[2],"a":[3,8,69,129,213],"gel":[4,43,50,75,83,112,124,145,181,196,208,224],"in":[5,21,103,179,193],"solutions":[6],"with":[7,81,85,148,173,183,198,204],"pH":[9,17],"above":[10],"12,":[11],"and":[12,34,136,152,189,219],"the":[13,31,35,48,55,59,73,82,89,98,104,108,117,143,153,160,194,220,230],"gelation":[14],"occurs":[15],"at":[16],"of":[18,39,47,61,65,100,110,119,128,140,222,232,234],"about":[19,170,176,190],"9":[20],"10%":[22,184,199],"amino":[23],"acid":[24],"solutions.":[25],"In":[26],"this":[27,40],"paper,":[28],"we":[29],"investigated":[30,116],"enzymatic":[32],"degradation":[33,221],"drug":[36,120,167,217],"release":[37,64,90,121,139,154,168],"profile":[38],"novel":[41],"CS":[42,49,56,74,111,123,144,180,195,207,223],"beads.":[44,113],"The":[45,63,138,163],"degradability":[46],"beads":[51,76,125,146,182,197,209,225],"was":[52,77,91,150,156,169],"affected":[53,158],"by":[54,97,126,159,229],"properties,":[57],"e.g.":[58],"degree":[60,231],"deacetylation.":[62],"prednisolone":[66],"(PS),":[67],"as":[68,212],"model":[70],"drug,":[71],"from":[72,122,142],"sustained":[78,96,216],"significantly":[79],"compared":[80],"prepared":[84],"NaOH":[86,101],"only.":[87],"However,":[88],"not":[92,157],"able":[93],"to":[94,165],"be":[95,227],"increment":[99],"concentration":[102],"solution":[105],"employed":[106],"for":[107,215],"preparation":[109],"We":[114],"also":[115],"control":[118],"application":[127],"complex":[130],"formed":[131],"between":[132],"chondroitin":[133],"sulfate":[134],"(Cho)":[135],"CS.":[137,235],"PS":[141,174],"treated":[147,203],"Cho":[149],"prolonged,":[151],"pattern":[155],"treatment":[161],"time.":[162],"time":[164],"50%":[166],"5":[171],"min":[172,178,192],"powder,":[175],"200":[177],"glycine":[185],"(Gly)":[186],"(pH":[187,201],"9.0),":[188],"330":[191],"Gly":[200],"9.0)":[202],"Cho.":[205],"Thus":[206],"appear":[210],"promising":[211],"vehicle":[214],"delivery,":[218],"may":[226],"controlled":[228],"deacetylation":[233]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
