{"id":"https://openalex.org/W2003196086","doi":"https://doi.org/10.1053/j.gastro.2009.07.005","title":"Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome","display_name":"Activation of Human Enteric Neurons by Supernatants of Colonic Biopsy Specimens From Patients With Irritable Bowel Syndrome","publication_year":2009,"publication_date":"2009-07-12","ids":{"openalex":"https://openalex.org/W2003196086","doi":"https://doi.org/10.1053/j.gastro.2009.07.005","mag":"2003196086","pmid":"https://pubmed.ncbi.nlm.nih.gov/19596012"},"language":"en","primary_location":{"id":"doi:10.1053/j.gastro.2009.07.005","doi":"https://doi.org/10.1053/j.gastro.2009.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2009.07.005","pdf_url":"http://www.gastrojournal.org/article/S0016508509011524/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.gastrojournal.org/article/S0016508509011524/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5060044123","display_name":"Sabine B\u00fchner","orcid":"https://orcid.org/0000-0002-9115-0463","observed_orcids":["https://orcid.org/0000-0002-9115-0463"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Buhner","raw_affiliation_strings":["Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100438903","display_name":"Qin Li","orcid":"https://orcid.org/0000-0002-1931-1621","observed_orcids":["https://orcid.org/0000-0002-1931-1621"]},"institutions":[{"id":"https://openalex.org/I154099455","display_name":"Shandong University","ror":"https://ror.org/0207yh398","country_code":"CN","type":"education","lineage":["https://openalex.org/I154099455"]},{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["CN","DE"],"is_corresponding":false,"raw_author_name":"Qin Li","raw_affiliation_strings":["Department of Physiology, Shangdong University, Shangdong, China","Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Shangdong University, Shangdong, China","institution_ids":["https://openalex.org/I154099455"]},{"raw_affiliation_string":"Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000454187","display_name":"Sheila Vignali","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sheila Vignali","raw_affiliation_strings":["Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030632895","display_name":"Giovanni Barbara","orcid":"https://orcid.org/0000-0001-9745-0726","observed_orcids":["https://orcid.org/0000-0001-9745-0726"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Barbara","raw_affiliation_strings":["Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040704698","display_name":"Roberto DE GIORGIO","orcid":"https://orcid.org/0000-0003-0867-5873","observed_orcids":["https://orcid.org/0000-0003-0867-5873"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Roberto De Giorgio","raw_affiliation_strings":["Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068405727","display_name":"Vincenzo Stanghellini","orcid":"https://orcid.org/0000-0003-0559-4875","observed_orcids":["https://orcid.org/0000-0003-0559-4875"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Vincenzo Stanghellini","raw_affiliation_strings":["Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006771456","display_name":"Cesare Cremon","orcid":"https://orcid.org/0000-0002-7777-2936","observed_orcids":["https://orcid.org/0000-0002-7777-2936"]},"institutions":[{"id":"https://openalex.org/I4210097083","display_name":"IRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola","ror":"https://ror.org/00t4vnv68","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210097083"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cesare Cremon","raw_affiliation_strings":["Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Center for Applied Biomedical Research (CRBA), St. Orsola Hospital, Bologna, Italy","institution_ids":["https://openalex.org/I4210097083"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044827987","display_name":"Florian Zeller","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Florian Zeller","raw_affiliation_strings":["Department of Surgery, Klinikum Freising, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Klinikum Freising, Freising, Germany","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091797746","display_name":"Rupert Langer","orcid":"https://orcid.org/0000-0001-9491-3609","observed_orcids":["https://orcid.org/0000-0001-9491-3609"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Rupert Langer","raw_affiliation_strings":["Department of Pathology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Technische Universit\u00e4t M\u00fcnchen, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103067533","display_name":"Hannelore Daniel","orcid":"https://orcid.org/0000-0002-9858-1485","observed_orcids":["https://orcid.org/0000-0002-9858-1485"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Hannelore Daniel","raw_affiliation_strings":["Molecular Nutrition Unit, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Nutrition Unit, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028220766","display_name":"Klaus Michel","orcid":"https://orcid.org/0000-0003-2359-6428","observed_orcids":["https://orcid.org/0000-0003-2359-6428"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Klaus Michel","raw_affiliation_strings":["Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044612561","display_name":"Michael Schemann","orcid":"https://orcid.org/0000-0003-1007-9843","observed_orcids":["https://orcid.org/0000-0003-1007-9843","https://orcid.org/0009-0002-4069-2251"]},"institutions":[{"id":"https://openalex.org/I62916508","display_name":"Technical University of Munich","ror":"https://ror.org/02kkvpp62","country_code":"DE","type":"education","lineage":["https://openalex.org/I62916508"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Michael Schemann","raw_affiliation_strings":["Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Human Biology, Technische Universit\u00e4t M\u00fcnchen, Freising, Germany","institution_ids":["https://openalex.org/I62916508"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5044612561"],"corresponding_institution_ids":["https://openalex.org/I62916508"],"apc_list":{"value":4180,"currency":"USD","value_usd":4180},"apc_paid":null,"fwci":26.0491,"has_fulltext":true,"cited_by_count":360,"citation_normalized_percentile":{"value":0.99743613,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"137","issue":"4","first_page":"1425","last_page":"1434"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11346","display_name":"Mast cells and histamine","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12237","display_name":"Congenital gastrointestinal and neural anomalies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/irritable-bowel-syndrome","display_name":"irritable bowel syndrome","score":1.0},{"id":"https://openalex.org/keywords/enteric-neurons","display_name":"enteric neurons","score":0.8259999752044678},{"id":"https://openalex.org/keywords/submucosal-neurons","display_name":"submucosal neurons","score":0.9580000042915344},{"id":"https://openalex.org/keywords/colonic-mucosa","display_name":"colonic mucosa","score":0.7950000166893005},{"id":"https://openalex.org/keywords/serotonin","display_name":"serotonin","score":0.3889999985694885},{"id":"https://openalex.org/keywords/histamine","display_name":"histamine","score":1.0},{"id":"https://openalex.org/keywords/tryptase","display_name":"tryptase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/mast-cells","display_name":"mast cells","score":0.8640000224113464},{"id":"https://openalex.org/keywords/protease","display_name":"proteolytic enzymes","score":0.722000002861023},{"id":"https://openalex.org/keywords/antihistamines","display_name":"antihistamines","score":0.7720000147819519},{"id":"https://openalex.org/keywords/5-ht3-receptor","display_name":"5-HT3 receptor","score":0.8600000143051147},{"id":"https://openalex.org/keywords/diarrhea-predominant-irritable-bowel-syndrome","display_name":"diarrhea-predominant irritable bowel syndrome","score":0.8679999709129333},{"id":"https://openalex.org/keywords/irritable-bowel-syndrome-with-constipation","display_name":"irritable bowel syndrome with constipation","score":0.9380000233650208}],"concepts":[{"id":"https://openalex.org/C2778271842","wikidata":"https://www.wikidata.org/wiki/Q838966","display_name":"Irritable bowel syndrome","level":2,"score":0.7785401344299316},{"id":"https://openalex.org/C2781406822","wikidata":"https://www.wikidata.org/wiki/Q904140","display_name":"Tryptase","level":3,"score":0.7533228397369385},{"id":"https://openalex.org/C1122143","wikidata":"https://www.wikidata.org/wiki/Q61233","display_name":"Histamine","level":2,"score":0.7442221641540527},{"id":"https://openalex.org/C2779726688","wikidata":"https://www.wikidata.org/wiki/Q191989","display_name":"Mast cell","level":2,"score":0.6045423150062561},{"id":"https://openalex.org/C2777439022","wikidata":"https://www.wikidata.org/wiki/Q586582","display_name":"Enteric nervous system","level":2,"score":0.602515697479248},{"id":"https://openalex.org/C2777310793","wikidata":"https://www.wikidata.org/wiki/Q1725675","display_name":"Lamina propria","level":3,"score":0.5590378046035767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5033275485038757},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.44468653202056885},{"id":"https://openalex.org/C90423213","wikidata":"https://www.wikidata.org/wiki/Q568290","display_name":"Enterochromaffin cell","level":4,"score":0.4291345179080963},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.38933566212654114},{"id":"https://openalex.org/C2775864247","wikidata":"https://www.wikidata.org/wiki/Q167934","display_name":"Serotonin","level":3,"score":0.35663023591041565},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3451305031776428},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3375745117664337},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3333667516708374},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.32322174310684204},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.13532745838165283}],"mesh":[{"descriptor_ui":"D000200","descriptor_name":"Action Potentials","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001706","descriptor_name":"Biopsy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002457","descriptor_name":"Cell Extracts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003248","descriptor_name":"Constipation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003967","descriptor_name":"Diarrhea","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006632","descriptor_name":"Histamine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006633","descriptor_name":"Histamine Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000294","qualifier_name":"innervation","is_major_topic":false},{"descriptor_ui":"D007413","descriptor_name":"Intestinal Mucosa","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008407","descriptor_name":"Mast Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011480","descriptor_name":"Protease Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D012701","descriptor_name":"Serotonin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012702","descriptor_name":"Serotonin Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D017615","descriptor_name":"Enteric Nervous System","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D043183","descriptor_name":"Irritable Bowel Syndrome","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D053802","descriptor_name":"Tryptases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1053/j.gastro.2009.07.005","doi":"https://doi.org/10.1053/j.gastro.2009.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2009.07.005","pdf_url":"http://www.gastrojournal.org/article/S0016508509011524/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},{"id":"pmid:19596012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19596012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:cris.unibo.it:11585/82056","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11585/82056","pdf_url":null,"source":{"id":"https://openalex.org/S4306402579","display_name":"Archivio istituzionale della ricerca (Alma Mater Studiorum Universit\u00e0 di Bologna)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210117483","host_organization_name":"Istituto di Ematologia di Bologna","host_organization_lineage":["https://openalex.org/I4210117483"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/824560","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/824560","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:sfera.unife.it:11392/2374886","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11392/2374886","pdf_url":null,"source":{"id":"https://openalex.org/S4306400369","display_name":"Institutional Research Information System University of Ferrara (University of Ferrara)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I201324441","host_organization_name":"University of Ferrara","host_organization_lineage":["https://openalex.org/I201324441"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1053/j.gastro.2009.07.005","doi":"https://doi.org/10.1053/j.gastro.2009.07.005","is_oa":true,"landing_page_url":"https://doi.org/10.1053/j.gastro.2009.07.005","pdf_url":"http://www.gastrojournal.org/article/S0016508509011524/pdf","source":{"id":"https://openalex.org/S143352558","display_name":"Gastroenterology","issn_l":"0016-5085","issn":["0016-5085","1528-0012"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Gastroenterology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9391000270843506}],"study_designs":[],"awards":[{"id":"https://openalex.org/G106322621","display_name":null,"funder_award_id":"Sche-267/7-1","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321873","display_name":"Ministero dell\u2019Istruzione, dell\u2019Universit\u00e0 e della Ricerca","ror":"https://ror.org/0166hxq48"},{"id":"https://openalex.org/F4320322848","display_name":"Fondazione del Monte di Bologna e Ravenna","ror":"https://ror.org/04gmrm344"},{"id":"https://openalex.org/F4320323553","display_name":"Universit\u00e0 di Bologna","ror":"https://ror.org/01111rn36"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003196086.pdf","grobid_xml":"https://content.openalex.org/works/W2003196086.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1572397755","https://openalex.org/W1963938486","https://openalex.org/W1969144895","https://openalex.org/W1976068711","https://openalex.org/W1980269992","https://openalex.org/W1983033537","https://openalex.org/W1988842352","https://openalex.org/W1989276224","https://openalex.org/W1992000894","https://openalex.org/W1996099921","https://openalex.org/W2015925270","https://openalex.org/W2017293057","https://openalex.org/W2024601462","https://openalex.org/W2026661267","https://openalex.org/W2027400620","https://openalex.org/W2028890830","https://openalex.org/W2035270569","https://openalex.org/W2048544637","https://openalex.org/W2048871701","https://openalex.org/W2054928012","https://openalex.org/W2058976148","https://openalex.org/W2063550636","https://openalex.org/W2064683282","https://openalex.org/W2104373009","https://openalex.org/W2114437230","https://openalex.org/W2116909437","https://openalex.org/W2125423663","https://openalex.org/W2130505437","https://openalex.org/W2132122176","https://openalex.org/W2134117303","https://openalex.org/W2135006040","https://openalex.org/W2139567104","https://openalex.org/W2140528350","https://openalex.org/W2154034046","https://openalex.org/W2155669185","https://openalex.org/W2158148601","https://openalex.org/W2159231976","https://openalex.org/W2161238054","https://openalex.org/W2166386674","https://openalex.org/W2167343594","https://openalex.org/W2167924325","https://openalex.org/W2329764294","https://openalex.org/W6680329274"],"related_works":["https://openalex.org/W1580742974","https://openalex.org/W2320748684","https://openalex.org/W2315581224","https://openalex.org/W2203492033","https://openalex.org/W1984443811","https://openalex.org/W4400241168","https://openalex.org/W1491075729","https://openalex.org/W2605139774","https://openalex.org/W4212902004","https://openalex.org/W1537609538"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":19},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":23},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":14},{"year":2018,"cited_by_count":22},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":18},{"year":2014,"cited_by_count":31},{"year":2013,"cited_by_count":19},{"year":2012,"cited_by_count":27}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}