{"id":"https://openalex.org/W2003192209","doi":"https://doi.org/10.1117/12.345404","title":"Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids","display_name":"Surface-enhanced Raman spectroscopy for the in-vitro and ex-vivo detection of excitatory amino acids","publication_year":1999,"publication_date":"1999-04-09","ids":{"openalex":"https://openalex.org/W2003192209","doi":"https://doi.org/10.1117/12.345404","mag":"2003192209"},"language":"en","primary_location":{"id":"doi:10.1117/12.345404","doi":"https://doi.org/10.1117/12.345404","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.345404","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"},"volume":null,"type":"conference-paper","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5008289992","display_name":"D. Patrick O\u2019Neal","orcid":"https://orcid.org/0000-0001-6573-1945","observed_orcids":["https://orcid.org/0000-0001-6573-1945"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. P. O'Neal","raw_affiliation_strings":["Texas A&M Univ. (United States)","Texas A&M University (USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M Univ. (United States)","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University (USA","institution_ids":["https://openalex.org/I91045830"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014674134","display_name":"Massoud Motamedi","orcid":"https://orcid.org/0000-0003-0733-2588","observed_orcids":["https://orcid.org/0000-0003-0733-2588"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Massoud Motamedi","raw_affiliation_strings":["Univ. of Texas Medical Branch at Galveston (United States)","University of Texas Medical Branch at Galveston USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Medical Branch at Galveston (United States)","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068183578","display_name":"Jefferson W. Chen","orcid":"https://orcid.org/0000-0003-0624-6864","observed_orcids":["https://orcid.org/0000-0003-0624-6864"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jefferson Chen","raw_affiliation_strings":["Univ. of Texas Medical Branch at Galveston (United States)","University of Texas Medical Branch at Galveston USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Univ. of Texas Medical Branch at Galveston (United States)","institution_ids":["https://openalex.org/I55302922"]},{"raw_affiliation_string":"University of Texas Medical Branch at Galveston USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5049901219","display_name":"Gerard L. Cot\u00e9","orcid":"https://orcid.org/0000-0002-3164-9625","observed_orcids":["https://orcid.org/0000-0002-3164-9625"]},"institutions":[{"id":"https://openalex.org/I91045830","display_name":"Texas A&M University","ror":"https://ror.org/01f5ytq51","country_code":"US","type":"education","lineage":["https://openalex.org/I91045830"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gerard L. Cote","raw_affiliation_strings":["Texas A&M Univ. (United States)","Texas A&M University (USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Texas A&M Univ. (United States)","institution_ids":["https://openalex.org/I91045830"]},{"raw_affiliation_string":"Texas A&M University (USA","institution_ids":["https://openalex.org/I91045830"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.13352273,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":94},"biblio":{"volume":"3608","issue":null,"first_page":"211","last_page":"216"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11324","display_name":"Spectroscopy Techniques in Biomedical and Chemical Research","score":0.6464999914169312,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10131","display_name":"Gold and Silver Nanoparticles Synthesis and Applications","score":0.3463999927043915,"subfield":{"id":"https://openalex.org/subfields/2504","display_name":"Electronic, Optical and Magnetic Materials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10977","display_name":"Optical Imaging and Spectroscopy Techniques","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surface-enhanced-raman-spectroscopy","display_name":"surface-enhanced Raman spectroscopy","score":0.9950000047683716},{"id":"https://openalex.org/keywords/excitatory-amino-acids","display_name":"excitatory amino acids","score":0.9900000095367432},{"id":"https://openalex.org/keywords/glutamate","display_name":"glutamate","score":0.8840000033378601},{"id":"https://openalex.org/keywords/head-trauma","display_name":"head trauma","score":0.6520000100135803},{"id":"https://openalex.org/keywords/secondary-brain-injury","display_name":"secondary brain injury","score":0.7730000019073486},{"id":"https://openalex.org/keywords/colloidal-silver","display_name":"colloidal silver","score":0.9710000157356262},{"id":"https://openalex.org/keywords/extracellular-fluid","display_name":"extracellular fluid","score":0.7559999823570251},{"id":"https://openalex.org/keywords/in-vitro-detection","display_name":"in vitro detection","score":0.671999990940094},{"id":"https://openalex.org/keywords/real-time-monitoring","display_name":"real-time monitoring","score":0.5199999809265137}],"concepts":[{"id":"https://openalex.org/C26291073","wikidata":"https://www.wikidata.org/wiki/Q310484","display_name":"Ex vivo","level":3,"score":0.8681633472442627},{"id":"https://openalex.org/C112592302","wikidata":"https://www.wikidata.org/wiki/Q1207387","display_name":"Excitatory postsynaptic potential","level":3,"score":0.7045766115188599},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.6426703333854675},{"id":"https://openalex.org/C40003534","wikidata":"https://www.wikidata.org/wiki/Q862228","display_name":"Raman spectroscopy","level":2,"score":0.6287204623222351},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5696670413017273},{"id":"https://openalex.org/C176777502","wikidata":"https://www.wikidata.org/wiki/Q4774623","display_name":"Anticipation (artificial intelligence)","level":2,"score":0.5264604687690735},{"id":"https://openalex.org/C2777790068","wikidata":"https://www.wikidata.org/wiki/Q2736291","display_name":"Surface-enhanced Raman spectroscopy","level":4,"score":0.48561492562294006},{"id":"https://openalex.org/C113657865","wikidata":"https://www.wikidata.org/wiki/Q5419641","display_name":"Excitatory amino-acid transporter","level":4,"score":0.472308874130249},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.47034576535224915},{"id":"https://openalex.org/C32891209","wikidata":"https://www.wikidata.org/wiki/Q483666","display_name":"Spectroscopy","level":2,"score":0.4644456207752228},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43504413962364197},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4314267635345459},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.42704012989997864},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3725373148918152},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3537119925022125},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.34605515003204346},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.33747535943984985},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3101764917373657},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2602100670337677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.24553310871124268},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.16974496841430664},{"id":"https://openalex.org/C169573571","wikidata":"https://www.wikidata.org/wiki/Q466824","display_name":"Raman scattering","level":3,"score":0.13180848956108093},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.1229860782623291},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.10339906811714172},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09399634599685669},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1117/12.345404","doi":"https://doi.org/10.1117/12.345404","is_oa":false,"landing_page_url":"https://doi.org/10.1117/12.345404","pdf_url":null,"source":{"id":"https://openalex.org/S183492911","display_name":"Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE","issn_l":"0277-786X","issn":["0277-786X","1996-756X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1"],"host_organization":"https://openalex.org/P4310315543","host_organization_name":"SPIE","host_organization_lineage":["https://openalex.org/P4310315543"],"host_organization_lineage_names":["SPIE"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"SPIE Proceedings","raw_type":"proceedings-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.7900000214576721,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2036308708","https://openalex.org/W1983410489","https://openalex.org/W2587494323","https://openalex.org/W4312909439","https://openalex.org/W2077838041","https://openalex.org/W7151793346","https://openalex.org/W4402521642","https://openalex.org/W1982928258","https://openalex.org/W4401995514","https://openalex.org/W2999197386"],"abstract_inverted_index":{"Traditionally":[0],"methods":[1],"for":[2,39,76],"the":[3,56],"detection":[4],"of":[5,36,62],"excitatory":[6,65],"amino":[7,66],"acids,":[8],"which":[9],"have":[10,45],"been":[11],"linked":[12],"to":[13,58],"secondary":[14],"injury":[15],"following":[16,99],"head":[17,40,100],"trauma,":[18],"can":[19],"be":[20],"excessively":[21],"time":[22],"consuming":[23],"clinically.":[24],"A":[25],"near":[26],"real-time":[27],"measurement":[28],"system":[29],"could":[30],"provide":[31],"clinical":[32],"information":[33],"in":[34,63],"anticipation":[35],"pharmaceutical":[37],"intervention":[38],"injured":[41],"patients.":[42],"Our":[43],"studies":[44],"shown":[46],"that":[47],"surface-enhanced":[48],"Raman":[49],"spectroscopy":[50],"(SERS)":[51],"with":[52],"silver":[53],"colloids":[54],"has":[55],"ability":[57],"measure":[59],"physiological":[60],"concentrations":[61],"vitro":[64],"acids":[67],"using":[68],"short":[69],"scan":[70],"times.":[71],"Employing":[72],"a":[73],"damage":[74],"model":[75],"ischemia,":[77],"preliminary":[78],"ex":[79],"vivo":[80],"rat":[81],"extracellular":[82],"grain":[83],"fluid":[84],"analysis":[85],"shows":[86],"an":[87],"intriguing":[88],"correlation":[89],"between":[90],"SERS":[91],"spectral":[92],"features":[93],"and":[94],"expected":[95],"Glutamate":[96],"concentration":[97],"fluctuations":[98],"injuries.":[101]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-08-21T09:56:20.448147","created_date":"2016-06-24T00:00:00"}