{"id":"https://openalex.org/W2003191908","doi":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","title":"Ca2+/calmodulin\u2010dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy","display_name":"Ca2+/calmodulin\u2010dependent protein kinase II in the spinal cord contributes to neuropathic pain in a rat model of mononeuropathy","publication_year":2005,"publication_date":"2005-05-01","ids":{"openalex":"https://openalex.org/W2003191908","doi":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","mag":"2003191908","pmid":"https://pubmed.ncbi.nlm.nih.gov/15932604"},"language":"en","primary_location":{"id":"doi:10.1111/j.1460-9568.2005.04091.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033583609","display_name":"Yi Dai","orcid":"https://orcid.org/0000-0003-1349-9886","observed_orcids":["https://orcid.org/0000-0003-1349-9886"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yi Dai","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100401013","display_name":"Hu Wang","orcid":"https://orcid.org/0000-0001-6132-8788","observed_orcids":["https://orcid.org/0000-0001-6132-8788"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hu Wang","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060685182","display_name":"Akiko Ogawa","orcid":"https://orcid.org/0009-0000-9837-2010","observed_orcids":["https://orcid.org/0009-0000-9837-2010"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Akiko Ogawa","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101645176","display_name":"Hiroki Yamanaka","orcid":"https://orcid.org/0000-0002-0604-0551","observed_orcids":["https://orcid.org/0000-0002-0604-0551"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hiroki Yamanaka","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111740212","display_name":"Koichi Obata","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Koichi Obata","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110033191","display_name":"Atsushi Tokunaga","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Atsushi Tokunaga","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044421244","display_name":"Koichi Noguchi","orcid":"https://orcid.org/0000-0001-5398-5833","observed_orcids":["https://orcid.org/0000-0001-5398-5833"]},"institutions":[{"id":"https://openalex.org/I137459256","display_name":"Hyogo Medical University","ror":"https://ror.org/001yc7927","country_code":"JP","type":"education","lineage":["https://openalex.org/I137459256"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Koichi Noguchi","raw_affiliation_strings":["Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neuroscience, Hyogo College of Medicine, 1-1 Mukogawa-cho, Nishinomiya, Hyogo 663-8501, Japan","institution_ids":["https://openalex.org/I137459256"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044421244"],"corresponding_institution_ids":["https://openalex.org/I137459256"],"apc_list":{"value":3560,"currency":"USD","value_usd":3560},"apc_paid":null,"fwci":1.1698,"has_fulltext":false,"cited_by_count":44,"citation_normalized_percentile":{"value":0.75109634,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"21","issue":"9","first_page":"2467","last_page":"2474"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11840","display_name":"Pain Management and Treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camkii","display_name":"CaMKII","score":0.9769999980926514},{"id":"https://openalex.org/keywords/neuropathic-pain","display_name":"neuropathic pain","score":0.8759999871253967},{"id":"https://openalex.org/keywords/chronic-constriction-injury","display_name":"chronic constriction injury","score":0.8569999933242798},{"id":"https://openalex.org/keywords/mononeuropathy","display_name":"mononeuropathy","score":0.9340000152587891},{"id":"https://openalex.org/keywords/spinal-cord","display_name":"spinal cord","score":0.8889999985694885},{"id":"https://openalex.org/keywords/central-sensitization","display_name":"central sensitization","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nmda-receptor","display_name":"NMDA receptor","score":0.6470000147819519},{"id":"https://openalex.org/keywords/mk-801","display_name":"MK-801","score":0.984000027179718},{"id":"https://openalex.org/keywords/kn-93","display_name":"KN-93","score":0.9959999918937683},{"id":"https://openalex.org/keywords/thermal-hyperalgesia","display_name":"thermal hyperalgesia","score":0.9070000052452087},{"id":"https://openalex.org/keywords/mechanical-allodynia","display_name":"mechanical allodynia","score":1.0},{"id":"https://openalex.org/keywords/formalin-test","display_name":"formalin test","score":0.8880000114440918},{"id":"https://openalex.org/keywords/neuroplasticity","display_name":"neuroplasticity","score":0.6919999718666077},{"id":"https://openalex.org/keywords/peripheral-nerve-injury","display_name":"peripheral nerve injury","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.8692145347595215},{"id":"https://openalex.org/C2911082436","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Mononeuropathy","level":4,"score":0.7847855687141418},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.6607491374015808},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.5912840366363525},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.5747258067131042},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5712948441505432},{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.5416143536567688},{"id":"https://openalex.org/C2775991916","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Nerve injury","level":2,"score":0.5225536227226257},{"id":"https://openalex.org/C2776880756","wikidata":"https://www.wikidata.org/wiki/Q2945973","display_name":"Peripheral nerve injury","level":3,"score":0.5066729187965393},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.4344547390937805},{"id":"https://openalex.org/C2780999072","wikidata":"https://www.wikidata.org/wiki/Q937076","display_name":"Spinal nerve","level":3,"score":0.42392492294311523},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.4158863425254822},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.39415109157562256},{"id":"https://openalex.org/C2779901536","wikidata":"https://www.wikidata.org/wiki/Q945238","display_name":"Peripheral neuropathy","level":3,"score":0.363788366317749},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.30290699005126953},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2893568277359009},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.1964406967163086},{"id":"https://openalex.org/C2781149210","wikidata":"https://www.wikidata.org/wiki/Q307869","display_name":"Sciatic nerve","level":2,"score":0.1665918529033661},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.11660808324813843},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.0},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009408","descriptor_name":"Nerve Compression Syndromes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009437","descriptor_name":"Neuralgia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016194","descriptor_name":"Receptors, N-Methyl-D-Aspartate","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017871","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020422","descriptor_name":"Mononeuropathies","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020671","descriptor_name":"Posterior Horn Cells","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1460-9568.2005.04091.x","doi":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1460-9568.2005.04091.x","pdf_url":null,"source":{"id":"https://openalex.org/S171130801","display_name":"European Journal of Neuroscience","issn_l":"0953-816X","issn":["0953-816X","1460-9568"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Neuroscience","raw_type":"journal-article"},{"id":"pmid:15932604","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15932604","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The European journal of neuroscience","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W565127267","https://openalex.org/W1532630777","https://openalex.org/W1562207750","https://openalex.org/W1576209550","https://openalex.org/W1914763441","https://openalex.org/W1966751687","https://openalex.org/W1969668074","https://openalex.org/W1979169606","https://openalex.org/W1985019456","https://openalex.org/W1988297823","https://openalex.org/W1989274659","https://openalex.org/W1991245942","https://openalex.org/W1992604915","https://openalex.org/W1998126770","https://openalex.org/W2007944782","https://openalex.org/W2008520902","https://openalex.org/W2012398804","https://openalex.org/W2014007136","https://openalex.org/W2015457797","https://openalex.org/W2017583361","https://openalex.org/W2020518352","https://openalex.org/W2030667526","https://openalex.org/W2032900067","https://openalex.org/W2035550082","https://openalex.org/W2036260428","https://openalex.org/W2041272952","https://openalex.org/W2045632212","https://openalex.org/W2045798386","https://openalex.org/W2050199100","https://openalex.org/W2052322593","https://openalex.org/W2053904152","https://openalex.org/W2058020736","https://openalex.org/W2059680237","https://openalex.org/W2067478772","https://openalex.org/W2067529350","https://openalex.org/W2069351628","https://openalex.org/W2072087613","https://openalex.org/W2083438975","https://openalex.org/W2106389606","https://openalex.org/W2111437850","https://openalex.org/W2125278725","https://openalex.org/W2145277005","https://openalex.org/W2149085099","https://openalex.org/W2160631696","https://openalex.org/W2161455727","https://openalex.org/W2172201406","https://openalex.org/W2180781622","https://openalex.org/W3176799406"],"related_works":["https://openalex.org/W2014243191","https://openalex.org/W2102504608","https://openalex.org/W2069045508","https://openalex.org/W2324430644","https://openalex.org/W2085440151","https://openalex.org/W2009905731","https://openalex.org/W2748296806","https://openalex.org/W1576209550","https://openalex.org/W2886587122","https://openalex.org/W2394056100"],"abstract_inverted_index":{"Ca2+/calmodulin-dependent":[0],"protein":[1],"kinase":[2],"II":[3,151],"(CaMKII)":[4],"is":[5,167,184],"known":[6],"to":[7,82,186,198],"subserve":[8],"activity-dependent":[9],"neuronal":[10],"plasticity":[11],"in":[12,19,27,52,68,149,164,177,193],"the":[13,21,28,46,53,62,69,73,100,112,129,133,146,153,160,202,205],"central":[14,178],"nervous":[15],"system.":[16],"To":[17],"examine":[18],"vivo":[20],"implication":[22],"of":[23,32,44,72,87,102,114,122,125,135,152,162,182,207],"spinal":[24,74,165,194],"CaMKII":[25,64,89,163,183],"activity":[26,161],"generation":[29],"and":[30,76,116,138,173],"development":[31,134,206],"neuropathic":[33,199,211],"pain":[34,212],"after":[35,60,96,169],"peripheral":[36,170],"nerve":[37,171],"injury,":[38],"we":[39],"used":[40],"an":[41,91,123],"animal":[42],"model":[43],"mononeuropathy,":[45],"chronic":[47],"constriction":[48],"injury":[49,172],"(CCI)":[50],"model,":[51],"rat.":[54],"We":[55],"found":[56],"that,":[57],"3":[58],"days":[59],"CCI,":[61,97],"total":[63],"(tCaMKII)":[65],"immunoreactivity":[66,86],"increased":[67],"superficial":[70],"laminae":[71],"cord":[75],"this":[77],"increase":[78,92,113],"continued":[79],"for":[80,204,210],"up":[81],"14":[83],"days.":[84],"The":[85,180],"phosphorylated":[88,117],"showed":[90],"from":[93],"1":[94],"day":[95],"which":[98],"preceded":[99],"up-regulation":[101],"tCaMKII.":[103],"A":[104],"non-selective":[105],"N-methyl-d-aspartate":[106],"receptor":[107],"antagonist,":[108],"MK801,":[109],"significantly":[110,144],"attenuated":[111,132],"tCaMKII":[115],"CaMKII.":[118,215],"Moreover,":[119],"intrathecal":[120],"administration":[121],"inhibitor":[124],"CaMKII,":[126],"KN93,":[127],"before":[128],"CCI":[130],"surgery":[131],"thermal":[136],"hyperalgesia":[137],"mechanical":[139],"allodynia.":[140],"In":[141],"addition,":[142],"KN93":[143],"reduced":[145],"nociceptive":[147],"behavior":[148],"phase":[150],"formalin":[154],"test.":[155],"These":[156],"findings":[157],"demonstrate":[158],"that":[159,191,196,213],"neurons":[166,195],"elevated":[168],"may":[174],"be":[175,187],"involved":[176],"sensitization.":[179],"alteration":[181],"considered":[185],"a":[188],"neuroplastic":[189],"change":[190],"occurs":[192],"contributes":[197],"pain,":[200],"suggesting":[201],"potential":[203],"novel":[208],"therapeutics":[209],"target":[214]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}