{"id":"https://openalex.org/W2003191145","doi":"https://doi.org/10.1097/mcg.0b013e318265ea7d","title":"Microbiota, Innate Immune System, and Gastrointestinal Muscle","display_name":"Microbiota, Innate Immune System, and Gastrointestinal Muscle","publication_year":2012,"publication_date":"2012-09-06","ids":{"openalex":"https://openalex.org/W2003191145","doi":"https://doi.org/10.1097/mcg.0b013e318265ea7d","mag":"2003191145","pmid":"https://pubmed.ncbi.nlm.nih.gov/22955360"},"language":"en","primary_location":{"id":"doi:10.1097/mcg.0b013e318265ea7d","doi":"https://doi.org/10.1097/mcg.0b013e318265ea7d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcg.0b013e318265ea7d","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073422942","display_name":"Ivan Tattoli","orcid":"https://orcid.org/0000-0001-7925-4609","observed_orcids":["https://orcid.org/0000-0001-7925-4609"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ivan Tattoli","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064693607","display_name":"Chiara Petitta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Chiara Petitta","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069068755","display_name":"Annunziata Scirocco","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Annunziata Scirocco","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056893261","display_name":"Francesca Ammoscato","orcid":"https://orcid.org/0009-0004-0119-297X","observed_orcids":["https://orcid.org/0009-0004-0119-297X"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesca Ammoscato","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068055331","display_name":"Alessia Cicenia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Cicenia","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062629691","display_name":"Carola Severi","orcid":"https://orcid.org/0000-0001-9249-1318","observed_orcids":["https://orcid.org/0000-0001-9249-1318"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carola Severi","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties, University La Sapienza, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":null,"apc_paid":null,"fwci":0.6961,"has_fulltext":false,"cited_by_count":21,"citation_normalized_percentile":{"value":0.67123814,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"46","issue":null,"first_page":"S6","last_page":"S11"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.5702999830245972,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10365","display_name":"Gastrointestinal motility and disorders","score":0.41280001401901245,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10943","display_name":"Escherichia coli research studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.8169999718666077},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.925000011920929},{"id":"https://openalex.org/keywords/colonic-smooth-muscle-cells","display_name":"colonic smooth muscle cells","score":0.8159999847412109},{"id":"https://openalex.org/keywords/gastrointestinal-motility","display_name":"gastrointestinal motility","score":0.9700000286102295},{"id":"https://openalex.org/keywords/shigella-flexneri","display_name":"Shigella flexneri","score":0.9110000133514404},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9269999861717224},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.8040000200271606},{"id":"https://openalex.org/keywords/tlr2-6","display_name":"TLR2/6","score":0.8569999933242798},{"id":"https://openalex.org/keywords/tlr2-1","display_name":"TLR2/1","score":0.8510000109672546},{"id":"https://openalex.org/keywords/pam3csk4","display_name":"Pam3CSK4","score":0.8259999752044678},{"id":"https://openalex.org/keywords/pam2csk4","display_name":"Pam2CSK4","score":0.9599999785423279},{"id":"https://openalex.org/keywords/acetylcholine-induced-contraction","display_name":"acetylcholine-induced contraction","score":0.7749999761581421},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6119999885559082},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8100000023841858}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9032699465751648},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.783057451248169},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5706596374511719},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48644328117370605}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003106","descriptor_name":"Colon","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D005769","descriptor_name":"Gastrointestinal Motility","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007113","descriptor_name":"Immunity, Innate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008070","descriptor_name":"Lipopolysaccharides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009119","descriptor_name":"Muscle Contraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012763","descriptor_name":"Shigella flexneri","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012763","descriptor_name":"Shigella flexneri","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D032389","descriptor_name":"Myocytes, Smooth Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060888","descriptor_name":"Real-Time Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1097/mcg.0b013e318265ea7d","doi":"https://doi.org/10.1097/mcg.0b013e318265ea7d","is_oa":false,"landing_page_url":"https://doi.org/10.1097/mcg.0b013e318265ea7d","pdf_url":null,"source":{"id":"https://openalex.org/S69483707","display_name":"Journal of Clinical Gastroenterology","issn_l":"0192-0790","issn":["0192-0790","1539-2031"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310315671","host_organization_name":"Lippincott Williams & Wilkins","host_organization_lineage":["https://openalex.org/P4310315671","https://openalex.org/P4310318547"],"host_organization_lineage_names":["Lippincott Williams & Wilkins","Wolters Kluwer"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Gastroenterology","raw_type":"journal-article"},{"id":"pmid:22955360","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22955360","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of clinical gastroenterology","raw_type":"Journal Article"},{"id":"pmh:oai:iris.uniroma1.it:11573/498992","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/498992","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W43571233","https://openalex.org/W63367705","https://openalex.org/W1518694802","https://openalex.org/W1564630763","https://openalex.org/W1965814102","https://openalex.org/W1972686367","https://openalex.org/W1974714927","https://openalex.org/W1997883951","https://openalex.org/W2009888627","https://openalex.org/W2023361163","https://openalex.org/W2034509430","https://openalex.org/W2051305329","https://openalex.org/W2066406354","https://openalex.org/W2072221311","https://openalex.org/W2077306969","https://openalex.org/W2096499683","https://openalex.org/W2143316910","https://openalex.org/W2144675149","https://openalex.org/W2147290711","https://openalex.org/W2148422863","https://openalex.org/W2149893688","https://openalex.org/W2151999975","https://openalex.org/W2152753822","https://openalex.org/W2162942194","https://openalex.org/W2167969276","https://openalex.org/W2170278053"],"related_works":["https://openalex.org/W2066406354","https://openalex.org/W2155134319","https://openalex.org/W1989767997","https://openalex.org/W2726481326","https://openalex.org/W2811206540","https://openalex.org/W2527763095","https://openalex.org/W2078344366","https://openalex.org/W2151999975","https://openalex.org/W1979656349","https://openalex.org/W1973696719"],"abstract_inverted_index":{"AIM:":[0],"To":[1],"test":[2],"the":[3,105,119],"activities":[4],"of":[5,29,67,86,122,134,143,159,188,217],"culture-extracted":[6],"or":[7,153,165],"commercially":[8,40],"available":[9],"toll-like":[10],"receptors":[11],"(TLRs)":[12],"ligands":[13,184,219],"to":[14,104],"establish":[15],"their":[16,108,244],"direct":[17,215],"impact":[18],"on":[19,63,220],"target":[20],"gastrointestinal":[21,235],"motor":[22],"cells.":[23],"METHODS:":[24],"Short-term":[25],"and":[26,33,47,49,51,56,77,90,98,140,151,170,211,237],"long-term":[27],"effects":[28,109,116,145],"Shigella":[30],"flexneri":[31],"M90T":[32],"Escherichia":[34],"coli":[35,45,80,127],"K-2":[36],"strains-extracted":[37],"lipopolysaccharides":[38],"(LPS),":[39],"highly":[41],"purified":[42],"LPS":[43,162],"(E.":[44],"O111:B4":[46,169],"EH100),":[48],"Pam2CSK4":[50],"Pam3CSK4,":[52],"which":[53,129,192],"bind":[54],"TLR2/6":[55,154],"TLR1/2":[57],"heterodimers,":[58],"respectively,":[59,172],"have":[60],"been":[61],"assessed":[62],"pure":[64,149],"primary":[65],"cultures":[66],"colonic":[68,222],"human":[69,221],"smooth":[70,174,223],"muscle":[71,175],"cells":[72],"(HSMC).":[73],"RESULTS:":[74],"Pathogenic":[75],"Shigella-LPS":[76,115],"nonpathogenic":[78],"E.":[79,126,167],"K-2-LPS":[81],"induced":[82,173,185],"a":[83,189,214],"time-dependent":[84],"decrease":[85],"resting":[87],"cell":[88],"length":[89],"acetylcholine-induced":[91],"contraction,":[92],"with":[93,114,125,161],"both":[94],"alterations":[95,176],"occurring":[96],"rapidly":[97],"being":[99],"more":[100],"pronounced":[101],"in":[102,138,243],"response":[103],"former.":[106],"However,":[107],"differed,":[110],"prolonging":[111,180],"HSMC":[112,204],"exposure":[113],"maintained":[117],"throughout":[118],"4":[120],"hours":[121],"observation":[123],"compared":[124],"K-2-LPS,":[128],"disappeared":[130],"after":[131],"60":[132],"minutes":[133],"incubation.":[135],"Similar":[136],"differences":[137],"magnitude":[139],"time":[141],"dependency":[142],"myogenic":[144],"were":[146],"observed":[147],"between":[148],"TLR4":[150,160],"TLR2/1":[152],"ligands.":[155],"The":[156,196],"specific":[157],"activation":[158],"from":[163],"pathogen":[164],"nonpathogen":[166],"coli,":[168],"EH100,":[171],"that":[177,203,229,238],"progressively":[178],"increased,":[179],"incubation,":[181],"whereas":[182],"TLR2":[183],"short-term":[186],"alterations,":[187],"lesser":[190],"magnitude,":[191],"decreased":[193],"over":[194],"time.":[195],"real-time":[197],"polymerase":[198],"chain":[199],"reaction":[200],"analysis":[201],"showed":[202],"express":[205],"mRNA":[206],"for":[207],"TLR1,":[208],"2,":[209],"4,":[210],"6,":[212],"substantiating":[213],"effect":[216],"TLR":[218],"muscle.":[224],"CONCLUSIONS:":[225],"This":[226],"study":[227],"highlights":[228],"bacterial":[230],"products":[231],"can":[232],"directly":[233],"affect":[234],"motility":[236],"TLRs":[239],"subtypes":[240],"may":[241],"differ":[242],"cellular":[245],"activity.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}