{"id":"https://openalex.org/W2003186747","doi":"https://doi.org/10.1172/jci61143","title":"c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains","display_name":"c-Src and c-Abl kinases control hierarchic phosphorylation and function of the CagA effector protein in Western and East Asian Helicobacter pylori strains","publication_year":2012,"publication_date":"2012-03-01","ids":{"openalex":"https://openalex.org/W2003186747","doi":"https://doi.org/10.1172/jci61143","mag":"2003186747","pmid":"https://pubmed.ncbi.nlm.nih.gov/22378042","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3314471"},"language":"en","primary_location":{"id":"doi:10.1172/jci61143","doi":"https://doi.org/10.1172/jci61143","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci61143","pdf_url":"http://www.jci.org/articles/view/61143/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.jci.org/articles/view/61143/files/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Doreen Mueller","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Doreen Mueller","raw_affiliation_strings":["University of Magdeburg, Department of Medical Microbiology, Magdeburg, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Magdeburg, Department of Medical Microbiology, Magdeburg, Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005740243","display_name":"Nicole Tegtmeyer","orcid":"https://orcid.org/0000-0002-6300-1831","observed_orcids":["https://orcid.org/0000-0002-6300-1831"]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]},{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE","IE"],"is_corresponding":false,"raw_author_name":"Nicole Tegtmeyer","raw_affiliation_strings":["University College Dublin , School of Biomolecular and Biomedical Sciences , Dublin , Ireland","University of Magdeburg , Department of Medical Microbiology , Magdeburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Dublin , School of Biomolecular and Biomedical Sciences , Dublin , Ireland","institution_ids":["https://openalex.org/I100930933"]},{"raw_affiliation_string":"University of Magdeburg , Department of Medical Microbiology , Magdeburg , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014955648","display_name":"Sabine Brandt","orcid":"https://orcid.org/0000-0003-1912-6941","observed_orcids":["https://orcid.org/0000-0003-1912-6941"]},"institutions":[{"id":"https://openalex.org/I95793202","display_name":"Otto-von-Guericke-Universit\u00e4t Magdeburg","ror":"https://ror.org/00ggpsq73","country_code":"DE","type":"education","lineage":["https://openalex.org/I95793202"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Sabine Brandt","raw_affiliation_strings":["University of Magdeburg , Department of Medical Microbiology , Magdeburg , Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Magdeburg , Department of Medical Microbiology , Magdeburg , Germany","institution_ids":["https://openalex.org/I95793202"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025363291","display_name":"Yoshio Yamaoka","orcid":"https://orcid.org/0000-0002-1222-5819","observed_orcids":["https://orcid.org/0000-0002-1222-5819"]},"institutions":[{"id":"https://openalex.org/I1299501804","display_name":"Michael E. DeBakey VA Medical Center","ror":"https://ror.org/052qqbc08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1299501804","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210138636"]},{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]},{"id":"https://openalex.org/I188815454","display_name":"Oita University","ror":"https://ror.org/01nyv7k26","country_code":"JP","type":"education","lineage":["https://openalex.org/I188815454"]}],"countries":["JP","US"],"is_corresponding":false,"raw_author_name":"Yoshio Yamaoka","raw_affiliation_strings":["Department Medicine-Gastroenterology , Houston , Texas , USA. Oita University Faculty of Medicine ,","Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Medicine-Gastroenterology , Houston , Texas , USA. Oita University Faculty of Medicine ,","institution_ids":["https://openalex.org/I188815454"]},{"raw_affiliation_string":"Michael E. DeBakey Veterans Affairs Medical Center and Baylor College of Medicine ,","institution_ids":["https://openalex.org/I1299501804","https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086008783","display_name":"Eimear De Poire","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100930933","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47","country_code":"IE","type":"education","lineage":["https://openalex.org/I100930933"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Eimear De Poire","raw_affiliation_strings":["University College Dublin , School of Biomolecular and Biomedical Sciences , Dublin , Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University College Dublin , School of Biomolecular and Biomedical Sciences , Dublin , Ireland","institution_ids":["https://openalex.org/I100930933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003191912","display_name":"Dionyssios N. Sgouras","orcid":"https://orcid.org/0000-0003-0975-2607","observed_orcids":["https://orcid.org/0000-0003-0975-2607"]},"institutions":[{"id":"https://openalex.org/I4210123780","display_name":"Pasteur Hellenic Institute","ror":"https://ror.org/035cy3r13","country_code":"GR","type":"nonprofit","lineage":["https://openalex.org/I4210123780"]}],"countries":["GR"],"is_corresponding":false,"raw_author_name":"Dionyssios Sgouras","raw_affiliation_strings":["Department Environmental and Preventive Medicine , Yufu , Japan. Hellenic Pasteur Institute ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department Environmental and Preventive Medicine , Yufu , Japan. Hellenic Pasteur Institute ,","institution_ids":["https://openalex.org/I4210123780"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073583894","display_name":"Silja We\u00dfler","orcid":"https://orcid.org/0000-0001-7011-6162","observed_orcids":["https://orcid.org/0000-0001-7011-6162"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Silja Wessler","raw_affiliation_strings":["Laboratory of Medical Microbiology , Athens , Greece","Biowissenschaften"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Medical Microbiology , Athens , Greece","institution_ids":[]},{"raw_affiliation_string":"Biowissenschaften","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085665231","display_name":"Javier Torres","orcid":"https://orcid.org/0000-0003-3945-4221","observed_orcids":["https://orcid.org/0000-0003-3945-4221","https://orcid.org/0000-0002-7873-3250"]},"institutions":[{"id":"https://openalex.org/I182212641","display_name":"University of Salzburg","ror":"https://ror.org/05gs8cd61","country_code":"AT","type":"education","lineage":["https://openalex.org/I182212641"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Javier Torres","raw_affiliation_strings":["Division of Microbiology , University Salzburg , Salzburg , Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Microbiology , University Salzburg , Salzburg , Austria","institution_ids":["https://openalex.org/I182212641"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070808152","display_name":"Adam J. Smolka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153297377","display_name":"Medical University of South Carolina","ror":"https://ror.org/012jban78","country_code":"US","type":"education","lineage":["https://openalex.org/I153297377"]},{"id":"https://openalex.org/I164915025","display_name":"Mexican Social Security Institute","ror":"https://ror.org/03xddgg98","country_code":"MX","type":"government","lineage":["https://openalex.org/I164915025"]}],"countries":["MX","US"],"is_corresponding":false,"raw_author_name":"Adam Smolka","raw_affiliation_strings":["Department of Medicine/Gastroenterology , Medical University of South Carolina , Charleston , South Carolina , USA","Unidad de Investigacion en Enfermedades Infecciosas , UMAE Pediatria , IMSS , Mexico"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine/Gastroenterology , Medical University of South Carolina , Charleston , South Carolina , USA","institution_ids":["https://openalex.org/I153297377"]},{"raw_affiliation_string":"Unidad de Investigacion en Enfermedades Infecciosas , UMAE Pediatria , IMSS , Mexico","institution_ids":["https://openalex.org/I164915025"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056524563","display_name":"Steffen Backert","orcid":"https://orcid.org/0000-0002-8948-8254","observed_orcids":["https://orcid.org/0000-0002-8948-8254"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Steffen Backert","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":7,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5056524563"],"corresponding_institution_ids":[],"apc_list":{"value":5200,"currency":"USD","value_usd":5200},"apc_paid":null,"fwci":19.8607,"has_fulltext":true,"cited_by_count":240,"citation_normalized_percentile":{"value":0.99603119,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"122","issue":"4","first_page":"1553","last_page":"1566"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/helicobacter-pylori","display_name":"Helicobacter pylori","score":0.9959999918937683},{"id":"https://openalex.org/keywords/caga","display_name":"CagA","score":0.8320000171661377},{"id":"https://openalex.org/keywords/c-src-kinase","display_name":"c-Src kinase","score":0.8309999704360962},{"id":"https://openalex.org/keywords/c-abl-kinase","display_name":"c-Abl kinase","score":0.9980000257492065},{"id":"https://openalex.org/keywords/epiya-motifs","display_name":"EPIYA motifs","score":0.8920000195503235},{"id":"https://openalex.org/keywords/bacterial-effectors","display_name":"bacterial effector proteins","score":0.574999988079071},{"id":"https://openalex.org/keywords/gastric-cancer","display_name":"gastric cancer","score":0.8190000057220459}],"concepts":[{"id":"https://openalex.org/C2778204961","wikidata":"https://www.wikidata.org/wiki/Q83146136","display_name":"CagA","level":4,"score":0.9191361665725708},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7666484117507935},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.6819661259651184},{"id":"https://openalex.org/C125418893","wikidata":"https://www.wikidata.org/wiki/Q587961","display_name":"ABL","level":4,"score":0.563827633857727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5216348767280579},{"id":"https://openalex.org/C2776409635","wikidata":"https://www.wikidata.org/wiki/Q180556","display_name":"Helicobacter pylori","level":2,"score":0.5212351083755493},{"id":"https://openalex.org/C2777553839","wikidata":"https://www.wikidata.org/wiki/Q14330986","display_name":"Tyrosine phosphorylation","level":3,"score":0.5080127716064453},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.483447402715683},{"id":"https://openalex.org/C108636557","wikidata":"https://www.wikidata.org/wiki/Q21109354","display_name":"Proto-oncogene tyrosine-protein kinase Src","level":3,"score":0.4538019299507141},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.38020214438438416},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.29616302251815796},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.28539198637008667},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.14838901162147522},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.09414169192314148},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.056645333766937256}],"mesh":[{"descriptor_ui":"D000081247","descriptor_name":"CSK Tyrosine-Protein Kinase","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000942","descriptor_name":"Antigens, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D005060","descriptor_name":"Europe","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D005202","descriptor_name":"Asia, Eastern","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011499","descriptor_name":"Protein Processing, Post-Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016315","descriptor_name":"Proto-Oncogene Proteins c-abl","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016415","descriptor_name":"Sequence Alignment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D016480","descriptor_name":"Helicobacter pylori","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000208","qualifier_name":"ethnology","is_major_topic":false},{"descriptor_ui":"D016481","descriptor_name":"Helicobacter Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019000","descriptor_name":"Phosphotyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019061","descriptor_name":"src-Family Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020816","descriptor_name":"Amino Acid Motifs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1172/jci61143","doi":"https://doi.org/10.1172/jci61143","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci61143","pdf_url":"http://www.jci.org/articles/view/61143/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3314471","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3314471","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Clin Invest","raw_type":"Text"},{"id":"pmid:22378042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22378042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of clinical investigation","raw_type":"Comparative Study"},{"id":"pmh:oai:HAL:pasteur-00734657v1","doi":null,"is_oa":false,"landing_page_url":"https://riip.hal.science/pasteur-00734657","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Clinical Investigation, 2012, 122 (4), pp.1553-66. &#x27E8;10.1172/JCI61143&#x27E9;","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1172/jci61143","doi":"https://doi.org/10.1172/jci61143","is_oa":true,"landing_page_url":"https://doi.org/10.1172/jci61143","pdf_url":"http://www.jci.org/articles/view/61143/files/pdf","source":{"id":"https://openalex.org/S114430552","display_name":"Journal of Clinical Investigation","issn_l":"0021-9738","issn":["0021-9738","1558-8238"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320279","host_organization_name":"American Society for Clinical Investigation","host_organization_lineage":["https://openalex.org/P4310320279"],"host_organization_lineage_names":["American Society for Clinical Investigation"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Clinical Investigation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1035922161","display_name":"Mechanisms of H. pylori-Induced Hypochlorhydria","funder_award_id":"R56DK064371","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G1354147244","display_name":"Molecular Epidemiological Studies of Helicobacter pylori in Southeastern Asia: Search for novel virulence factors and clarification of human migration","funder_award_id":"24406015","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2848606123","display_name":"Clarification of mechanisms how H. pylori virulence factor OipA produces cytokines","funder_award_id":"22390085","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2851134092","display_name":null,"funder_award_id":"R11408","funder_id":"https://openalex.org/F4320320858","funder_display_name":"University College Dublin"},{"id":"https://openalex.org/G7387090594","display_name":"REGULATION OF CXC CHEMOKINE EXPRESSION BY H. PYLORI","funder_award_id":"R01DK062813","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8274287476","display_name":"Biological searches for factors interacted with Helicobacter pylori virulence factor OipA","funder_award_id":"24659200","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320858","display_name":"University College Dublin","ror":"https://ror.org/05m7pjf47"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320322967","display_name":"Instituto Mexicano del Seguro Social","ror":"https://ror.org/03xddgg98"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003186747.pdf","grobid_xml":"https://content.openalex.org/works/W2003186747.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1482647135","https://openalex.org/W1483542871","https://openalex.org/W1965323568","https://openalex.org/W1969933155","https://openalex.org/W1976083478","https://openalex.org/W1976740030","https://openalex.org/W1977306646","https://openalex.org/W1978517760","https://openalex.org/W1979188601","https://openalex.org/W1980048554","https://openalex.org/W1983767314","https://openalex.org/W1985005432","https://openalex.org/W1987009735","https://openalex.org/W1990422473","https://openalex.org/W1993429107","https://openalex.org/W1993824855","https://openalex.org/W1997835441","https://openalex.org/W1998408165","https://openalex.org/W1998630067","https://openalex.org/W2003035812","https://openalex.org/W2003890592","https://openalex.org/W2005001379","https://openalex.org/W2012701265","https://openalex.org/W2014119293","https://openalex.org/W2014560396","https://openalex.org/W2016299826","https://openalex.org/W2018707425","https://openalex.org/W2022069644","https://openalex.org/W2024946285","https://openalex.org/W2026907934","https://openalex.org/W2031393440","https://openalex.org/W2032742881","https://openalex.org/W2034140083","https://openalex.org/W2044025776","https://openalex.org/W2045646801","https://openalex.org/W2050490712","https://openalex.org/W2057802360","https://openalex.org/W2058849414","https://openalex.org/W2061920676","https://openalex.org/W2063220206","https://openalex.org/W2065945819","https://openalex.org/W2069958257","https://openalex.org/W2072556512","https://openalex.org/W2074580771","https://openalex.org/W2075759643","https://openalex.org/W2084150021","https://openalex.org/W2084244500","https://openalex.org/W2087327203","https://openalex.org/W2089999056","https://openalex.org/W2090681869","https://openalex.org/W2101366809","https://openalex.org/W2110132014","https://openalex.org/W2111387110","https://openalex.org/W2116030323","https://openalex.org/W2116757244","https://openalex.org/W2121905156","https://openalex.org/W2125460385","https://openalex.org/W2136625447","https://openalex.org/W2136860804","https://openalex.org/W2137934927","https://openalex.org/W2139130671","https://openalex.org/W2151826056","https://openalex.org/W2151829625","https://openalex.org/W2153833219","https://openalex.org/W2156141845","https://openalex.org/W2157116022","https://openalex.org/W2160687212","https://openalex.org/W2162110497","https://openalex.org/W2162849894","https://openalex.org/W2167573033","https://openalex.org/W2169852844","https://openalex.org/W2171107288","https://openalex.org/W4248856047"],"related_works":["https://openalex.org/W2101366809","https://openalex.org/W6997338104","https://openalex.org/W2116757244","https://openalex.org/W2055832413","https://openalex.org/W2470376539","https://openalex.org/W7061528814","https://openalex.org/W2063724456","https://openalex.org/W2029294641","https://openalex.org/W2515127568","https://openalex.org/W2967716118"],"abstract_inverted_index":{"Many":[0],"bacterial":[1,229],"pathogens":[2],"inject":[3],"into":[4,60],"host":[5,13,27,61],"cells":[6,62],"effector":[7,57,85,230],"proteins":[8,231],"that":[9,117,135],"are":[10],"substrates":[11],"for":[12,48,162,202,218],"tyrosine":[14,72],"kinases":[15],"such":[16],"as":[17,78],"Src":[18],"and":[19,98,106,109,122,130,167,181,223],"Abl":[20],"family":[21],"kinases.":[22],"Phosphorylated":[23],"effectors":[24],"eventually":[25],"subvert":[26],"cell":[28,165],"signaling,":[29],"aiding":[30],"disease":[31],"development.":[32],"In":[33],"the":[34,37,49,54,64,70,155,225],"case":[35],"of":[36,51,74,103,154,172,210,227],"gastric":[38,52],"pathogen":[39],"Helicobacter":[40],"pylori,":[41],"which":[42],"is":[43,63,90],"a":[44,79,196],"major":[45],"risk":[46],"factor":[47],"development":[50],"cancer,":[53],"only":[55,119],"known":[56],"protein":[58],"injected":[59],"oncoprotein":[65],"CagA.":[66],"Here,":[67],"we":[68],"followed":[69,207],"hierarchic":[71,199],"phosphorylation":[73,86,200,209],"H.":[75,104,220],"pylori":[76,105,221],"CagA":[77,89,136,186,203],"model":[80,201],"system":[81],"to":[82],"study":[83,193],"early":[84],"processes.":[87],"Translocated":[88],"phosphorylated":[91,120,126,139,156,173,228],"on":[92,140,149,190],"Glu-Pro-Ile-Tyr-Ala":[93],"(EPIYA)":[94],"motifs":[95,158,175],"EPIYA-A,":[96,107,127],"EPIYA-B,":[97,108,128],"EPIYA-C":[99,121],"in":[100,111,176,232],"Western":[101,177],"strains":[102,178],"EPIYA-D":[110],"East":[112],"Asian":[113],"strains.":[114],"We":[115],"found":[116],"c-Src":[118],"EPIYA-D,":[123],"whereas":[124],"c-Abl":[125],"EPIYA-C,":[129,182],"EPIYA-D.":[131],"Further":[132],"analysis":[133],"revealed":[134],"molecules":[137,187],"were":[138],"1":[141],"or":[142,188,212],"2":[143,185],"EPIYA":[144,157,174],"motifs,":[145],"but":[146],"never":[147],"simultaneously":[148,189],"3":[150],"motifs.":[151],"Furthermore,":[152],"none":[153],"alone":[159],"was":[160,179],"sufficient":[161],"inducing":[163],"AGS":[164],"scattering":[166],"elongation.":[168],"The":[169],"preferred":[170],"combination":[171],"EPIYA-A":[180,211],"either":[183],"across":[184],"1.":[191],"Our":[192],"thus":[194],"identifies":[195],"tightly":[197],"regulated":[198],"starting":[204],"at":[205],"EPIYA-C/D,":[206],"by":[208],"EPIYA-B.":[213],"These":[214],"results":[215],"provide":[216],"insight":[217],"clinical":[219],"typing":[222],"clarify":[224],"role":[226],"pathogenesis.":[233]},"counts_by_year":[{"year":2026,"cited_by_count":12},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":16},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":17},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":17},{"year":2017,"cited_by_count":30},{"year":2016,"cited_by_count":23},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":16},{"year":2013,"cited_by_count":21},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
