{"id":"https://openalex.org/W2003171307","doi":"https://doi.org/10.1016/j.bcp.2012.06.017","title":"The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds","display_name":"The kinetic mechanism of S. pneumoniae DNA ligase and inhibition by adenosine-based antibacterial compounds","publication_year":2012,"publication_date":"2012-06-26","ids":{"openalex":"https://openalex.org/W2003171307","doi":"https://doi.org/10.1016/j.bcp.2012.06.017","mag":"2003171307","pmid":"https://pubmed.ncbi.nlm.nih.gov/22743594"},"language":"en","primary_location":{"id":"doi:10.1016/j.bcp.2012.06.017","doi":"https://doi.org/10.1016/j.bcp.2012.06.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2012.06.017","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110044367","display_name":"Haris Jahi\u0107","orcid":"https://orcid.org/0009-0005-3755-8889","observed_orcids":["https://orcid.org/0009-0005-3755-8889"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haris Jahi\u0107","raw_affiliation_strings":["Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451, USA","Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA 02451, USA","institution_ids":["https://openalex.org/I4210150756"]},{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039046909","display_name":"Ce Feng Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I6902469","display_name":"Brandeis University","ror":"https://ror.org/05abbep66","country_code":"US","type":"education","lineage":["https://openalex.org/I6902469"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ce Feng Liu","raw_affiliation_strings":["Brandeis University, Waltham, MA, USA","Brandeis University, WALTHAM, MA, USA#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brandeis University, Waltham, MA, USA","institution_ids":["https://openalex.org/I6902469"]},{"raw_affiliation_string":"Brandeis University, WALTHAM, MA, USA#TAB#","institution_ids":["https://openalex.org/I6902469"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060810623","display_name":"Jason Thresher","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason Thresher","raw_affiliation_strings":["Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003883061","display_name":"Stephania Livchak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stephania Livchak","raw_affiliation_strings":["Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101675011","display_name":"Hongming Wang","orcid":"https://orcid.org/0000-0003-1689-9738","observed_orcids":["https://orcid.org/0000-0003-1689-9738"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hongming Wang","raw_affiliation_strings":["Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5039007236","display_name":"David E. Ehmann","orcid":"https://orcid.org/0000-0001-7762-862X","observed_orcids":["https://orcid.org/0000-0001-7762-862X"]},"institutions":[{"id":"https://openalex.org/I4210150756","display_name":"AstraZeneca (United States)","ror":"https://ror.org/043cec594","country_code":"US","type":"company","lineage":["https://openalex.org/I105036370","https://openalex.org/I4210150756"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"David E. Ehmann","raw_affiliation_strings":["Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, MA, USA","institution_ids":["https://openalex.org/I4210150756"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5039007236"],"corresponding_institution_ids":["https://openalex.org/I4210150756"],"apc_list":{"value":3590,"currency":"USD","value_usd":3590},"apc_paid":null,"fwci":0.315,"has_fulltext":false,"cited_by_count":7,"citation_normalized_percentile":{"value":0.50819474,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"84","issue":"5","first_page":"654","last_page":"660"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12827","display_name":"Biochemical and Molecular Research","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10432","display_name":"DNA and Nucleic Acid Chemistry","score":0.010599999688565731,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13326","display_name":"Biochemical and Structural Characterization","score":0.009600000455975533,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/streptococcus-pneumoniae","display_name":"Streptococcus pneumoniae","score":0.8809999823570251},{"id":"https://openalex.org/keywords/nad-dependent-dna-ligase","display_name":"NAD+-dependent DNA ligase","score":0.9259999990463257},{"id":"https://openalex.org/keywords/enzyme-kinetics","display_name":"enzyme kinetics","score":0.7929999828338623},{"id":"https://openalex.org/keywords/enzyme-inhibition","display_name":"enzyme inhibition","score":0.7540000081062317},{"id":"https://openalex.org/keywords/substrate-inhibition","display_name":"substrate inhibition","score":0.6620000004768372},{"id":"https://openalex.org/keywords/antibiotic-targets","display_name":"antibiotic targets","score":0.38999998569488525}],"concepts":[{"id":"https://openalex.org/C175114707","wikidata":"https://www.wikidata.org/wiki/Q408483","display_name":"DNA ligase","level":3,"score":0.8248167634010315},{"id":"https://openalex.org/C156911925","wikidata":"https://www.wikidata.org/wiki/Q643384","display_name":"Isothermal titration calorimetry","level":2,"score":0.7267144918441772},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.6915032267570496},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.6443697810173035},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5365780591964722},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.534684419631958},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.5154898762702942},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4315558671951294},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.41846203804016113},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3905380368232727},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3110813796520233},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05685567855834961},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000241","descriptor_name":"Adenosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002151","descriptor_name":"Calorimetry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011088","descriptor_name":"DNA Ligases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013296","descriptor_name":"Streptococcus pneumoniae","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D016297","descriptor_name":"Mutagenesis, Site-Directed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017931","descriptor_name":"DNA Primers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055808","descriptor_name":"Drug Discovery","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.bcp.2012.06.017","doi":"https://doi.org/10.1016/j.bcp.2012.06.017","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.bcp.2012.06.017","pdf_url":null,"source":{"id":"https://openalex.org/S185534594","display_name":"Biochemical Pharmacology","issn_l":"0006-2952","issn":["0006-2952","1873-2968"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical Pharmacology","raw_type":"journal-article"},{"id":"pmid:22743594","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22743594","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Biochemical pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307770","display_name":"AstraZeneca","ror":"https://ror.org/04r9x1a08"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W611976593","https://openalex.org/W1967354453","https://openalex.org/W1974299093","https://openalex.org/W1975764590","https://openalex.org/W1977971905","https://openalex.org/W1979870370","https://openalex.org/W1986192026","https://openalex.org/W1989889086","https://openalex.org/W1997454893","https://openalex.org/W2001000225","https://openalex.org/W2003473175","https://openalex.org/W2004235182","https://openalex.org/W2019527711","https://openalex.org/W2038632434","https://openalex.org/W2052830757","https://openalex.org/W2056151893","https://openalex.org/W2063772352","https://openalex.org/W2108092697","https://openalex.org/W2115121941","https://openalex.org/W2118028651","https://openalex.org/W2146778078","https://openalex.org/W2155564090","https://openalex.org/W2170809234","https://openalex.org/W2336167279"],"related_works":["https://openalex.org/W1979870370","https://openalex.org/W2024954023","https://openalex.org/W2108092697","https://openalex.org/W1971297053","https://openalex.org/W1886571240","https://openalex.org/W2168540905","https://openalex.org/W2013087839","https://openalex.org/W1796038227","https://openalex.org/W2044478710","https://openalex.org/W1981031618"],"abstract_inverted_index":null,"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}