{"id":"https://openalex.org/W2003166322","doi":"https://doi.org/10.1007/bf02255842","title":"Intragenic regions of the murinePgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells","display_name":"Intragenic regions of the murinePgk-1 locus enhance integration of transfected DNAs into genomes of embryonal carcinoma cells","publication_year":1994,"publication_date":"1994-11-01","ids":{"openalex":"https://openalex.org/W2003166322","doi":"https://doi.org/10.1007/bf02255842","mag":"2003166322","pmid":"https://pubmed.ncbi.nlm.nih.gov/7892649"},"language":"en","primary_location":{"id":"doi:10.1007/bf02255842","doi":"https://doi.org/10.1007/bf02255842","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02255842","pdf_url":null,"source":{"id":"https://openalex.org/S198917220","display_name":"Somatic Cell and Molecular Genetics","issn_l":"0098-0366","issn":["0098-0366","0740-7750","1572-9931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic Cell and Molecular Genetics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032401017","display_name":"Michael W. McBurney","orcid":"https://orcid.org/0000-0001-6096-3659","observed_orcids":["https://orcid.org/0000-0001-6096-3659"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Michael W. McBurney","raw_affiliation_strings":["University of Ottawa, Department of Medicine, Ottawa, Ontario, Canada","University of Ottawa - Department of Medicine; Ottawa Ontario Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Ottawa, Department of Medicine, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"University of Ottawa - Department of Medicine; Ottawa Ontario Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062919608","display_name":"Susan Fournier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Susan Fournier","raw_affiliation_strings":["Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","Department of Medicine; University of Ottawa ; Ottawa Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Medicine; University of Ottawa ; Ottawa Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007986348","display_name":"Karen E. Jardine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Karen Jardine","raw_affiliation_strings":["Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","Department of Medicine; University of Ottawa ; Ottawa Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Medicine; University of Ottawa ; Ottawa Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030641089","display_name":"Leslie C. Sutherland","orcid":"https://orcid.org/0000-0002-8619-1834","observed_orcids":["https://orcid.org/0000-0002-8619-1834"]},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Leslie Sutherland","raw_affiliation_strings":["Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","Department of Medicine; University of Ottawa ; Ottawa Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, University of Ottawa, 451 Smyth Road, K1h 8M5, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Medicine; University of Ottawa ; Ottawa Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":null,"apc_paid":null,"fwci":1.2241,"has_fulltext":false,"cited_by_count":30,"citation_normalized_percentile":{"value":0.78697848,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"20","issue":"6","first_page":"515","last_page":"528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.3767000138759613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12929","display_name":"Animal Genetics and Reproduction","score":0.3767000138759613,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.2992999851703644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10613","display_name":"Virus-based gene therapy research","score":0.13609999418258667,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pgk1","display_name":"PGK1","score":0.7599999904632568},{"id":"https://openalex.org/keywords/embryonal-carcinoma-cells","display_name":"embryonal carcinoma cells","score":0.9290000200271606},{"id":"https://openalex.org/keywords/p19-cells","display_name":"P19 cells","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plasmid-copy-number","display_name":"plasmid copy number","score":0.8930000066757202},{"id":"https://openalex.org/keywords/transfection-efficiency","display_name":"transfection efficiency","score":0.6159999966621399},{"id":"https://openalex.org/keywords/transcriptional-activation","display_name":"transcriptional activation","score":0.5180000066757202},{"id":"https://openalex.org/keywords/cotransfection","display_name":"cotransfection","score":0.8040000200271606}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8983138799667358},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.7625117897987366},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.6769667863845825},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.627120852470398},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5356165170669556},{"id":"https://openalex.org/C2780327976","wikidata":"https://www.wikidata.org/wiki/Q1451877","display_name":"Embryonal carcinoma","level":4,"score":0.524614691734314},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46575695276260376},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.44415906071662903},{"id":"https://openalex.org/C148738053","wikidata":"https://www.wikidata.org/wiki/Q210861","display_name":"Cellular differentiation","level":3,"score":0.10190674662590027}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003412","descriptor_name":"Cricetulus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005091","descriptor_name":"Exons","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010735","descriptor_name":"Phosphoglycerate Kinase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018236","descriptor_name":"Carcinoma, Embryonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018236","descriptor_name":"Carcinoma, Embryonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018236","descriptor_name":"Carcinoma, Embryonal","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1007/bf02255842","doi":"https://doi.org/10.1007/bf02255842","is_oa":false,"landing_page_url":"https://doi.org/10.1007/bf02255842","pdf_url":null,"source":{"id":"https://openalex.org/S198917220","display_name":"Somatic Cell and Molecular Genetics","issn_l":"0098-0366","issn":["0098-0366","0740-7750","1572-9931"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic Cell and Molecular Genetics","raw_type":"journal-article"},{"id":"pmid:7892649","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7892649","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Somatic cell and molecular genetics","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5683000087738037}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger","score":0.5199999809265137}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W44781784","https://openalex.org/W73523141","https://openalex.org/W1513717105","https://openalex.org/W1564069694","https://openalex.org/W1589876235","https://openalex.org/W1775605207","https://openalex.org/W1793892684","https://openalex.org/W1840514170","https://openalex.org/W1840795163","https://openalex.org/W1899911036","https://openalex.org/W1943869624","https://openalex.org/W1954929088","https://openalex.org/W1956097919","https://openalex.org/W1968917541","https://openalex.org/W1972528263","https://openalex.org/W1973304749","https://openalex.org/W1973430331","https://openalex.org/W1987351020","https://openalex.org/W1990024877","https://openalex.org/W1990205754","https://openalex.org/W1990731600","https://openalex.org/W1998245693","https://openalex.org/W1999248691","https://openalex.org/W2004211510","https://openalex.org/W2005672514","https://openalex.org/W2010356985","https://openalex.org/W2010790600","https://openalex.org/W2017144933","https://openalex.org/W2023116564","https://openalex.org/W2027411626","https://openalex.org/W2030141157","https://openalex.org/W2043740581","https://openalex.org/W2046746594","https://openalex.org/W2059914212","https://openalex.org/W2061263854","https://openalex.org/W2062438194","https://openalex.org/W2062608060","https://openalex.org/W2064468431","https://openalex.org/W2071757761","https://openalex.org/W2072319696","https://openalex.org/W2073351208","https://openalex.org/W2074244754","https://openalex.org/W2079384901","https://openalex.org/W2086967977","https://openalex.org/W2097610774","https://openalex.org/W2102568876","https://openalex.org/W2108172661","https://openalex.org/W2118299921","https://openalex.org/W2125816354","https://openalex.org/W2138214907","https://openalex.org/W2144634347","https://openalex.org/W2148080727","https://openalex.org/W2153477671","https://openalex.org/W2158610312","https://openalex.org/W2162111156","https://openalex.org/W2163143739","https://openalex.org/W2172620021","https://openalex.org/W2175305763","https://openalex.org/W2275654393","https://openalex.org/W2414382844","https://openalex.org/W4245266055","https://openalex.org/W4254092143"],"related_works":["https://openalex.org/W2372521113","https://openalex.org/W2978251436","https://openalex.org/W1980609410","https://openalex.org/W2361321344","https://openalex.org/W3157865522","https://openalex.org/W2392804297","https://openalex.org/W2391256396","https://openalex.org/W2987420353","https://openalex.org/W1491897707","https://openalex.org/W2954044368"],"abstract_inverted_index":null,"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":5},{"year":2012,"cited_by_count":1}],"updated_date":"2026-10-14T16:39:01.820549","created_date":"2025-10-10T00:00:00"}
