{"id":"https://openalex.org/W2003166231","doi":"https://doi.org/10.1371/journal.pone.0072953","title":"Alpha Cyano-4-Hydroxy-3-Methoxycinnamic Acid Inhibits Proliferation and Induces Apoptosis in Human Breast Cancer Cells","display_name":"Alpha Cyano-4-Hydroxy-3-Methoxycinnamic Acid Inhibits Proliferation and Induces Apoptosis in Human Breast Cancer Cells","publication_year":2013,"publication_date":"2013-09-05","ids":{"openalex":"https://openalex.org/W2003166231","doi":"https://doi.org/10.1371/journal.pone.0072953","mag":"2003166231","pmid":"https://pubmed.ncbi.nlm.nih.gov/24039831","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3764168"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0072953","doi":"https://doi.org/10.1371/journal.pone.0072953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072953&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057820094","display_name":"Lamia Hamdan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4405259121","display_name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques","ror":"https://ror.org/01s3bfe44","country_code":"DZ","type":"other","lineage":["https://openalex.org/I4405259121"]}],"countries":["DZ","FR"],"is_corresponding":false,"raw_author_name":"Lamia Hamdan","raw_affiliation_strings":["Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France ; Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)","UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France ; Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"]},{"raw_affiliation_string":"CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)","institution_ids":["https://openalex.org/I4405259121"]},{"raw_affiliation_string":"UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017013668","display_name":"Zoheir Arrar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I233209018","display_name":"University of Abou Bekr Belka\u00efd","ror":"https://ror.org/00jsjm362","country_code":"DZ","type":"education","lineage":["https://openalex.org/I233209018"]},{"id":"https://openalex.org/I4405259121","display_name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques","ror":"https://ror.org/01s3bfe44","country_code":"DZ","type":"other","lineage":["https://openalex.org/I4405259121"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Zoheir Arrar","raw_affiliation_strings":["Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","institution_ids":["https://openalex.org/I233209018"]},{"raw_affiliation_string":"CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)","institution_ids":["https://openalex.org/I4405259121"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083032034","display_name":"Yacoub Al Muataz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yacoub Al Muataz","raw_affiliation_strings":["Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"]},{"raw_affiliation_string":"UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076466324","display_name":"Lutfi Suleiman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Lutfi Suleiman","raw_affiliation_strings":["Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"]},{"raw_affiliation_string":"UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017113740","display_name":"Claude N\u00e9grier","orcid":"https://orcid.org/0000-0002-2905-055X","observed_orcids":["https://orcid.org/0000-0002-2905-055X","https://orcid.org/0000-0003-3569-0366"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Claude N\u00e9grier","raw_affiliation_strings":["Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"]},{"raw_affiliation_string":"UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)","institution_ids":["https://openalex.org/I100532134"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077744611","display_name":"Joseph Kajima Mulengi","orcid":"https://orcid.org/0000-0002-2662-4271","observed_orcids":["https://orcid.org/0000-0002-2662-4271"]},"institutions":[{"id":"https://openalex.org/I233209018","display_name":"University of Abou Bekr Belka\u00efd","ror":"https://ror.org/00jsjm362","country_code":"DZ","type":"education","lineage":["https://openalex.org/I233209018"]},{"id":"https://openalex.org/I4405259121","display_name":"Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques","ror":"https://ror.org/01s3bfe44","country_code":"DZ","type":"other","lineage":["https://openalex.org/I4405259121"]}],"countries":["DZ"],"is_corresponding":false,"raw_author_name":"Joseph Kajima Mulengi","raw_affiliation_strings":["Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department de Chimie Organique, Substances Naturelles et Analyses, University de Tlemcen, Tlemcen, Algerie","institution_ids":["https://openalex.org/I233209018"]},{"raw_affiliation_string":"CRAPC - Centre de Recherche Scientifique et Technique en Analyses Physico-Chimiques (BP 384, Si\u00e8ge ex-Pasna\r\nZone Industrielle\r\nBou-Ismail CP 42004\r\nTipaza - Algeria)","institution_ids":["https://openalex.org/I4405259121"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029495254","display_name":"Habib Boukerche","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Habib Boukerche","raw_affiliation_strings":["Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit\u00e9 de Recherche Mixte EA4174, Universit\u00e9 Claude Bernard Lyon1, INSERM, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"]},{"raw_affiliation_string":"UCBL - Universit\u00e9 Claude Bernard Lyon 1 (43, boulevard du 11 novembre 1918, 69622 Villeurbanne cedex - France)","institution_ids":["https://openalex.org/I100532134"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5029495254"],"corresponding_institution_ids":["https://openalex.org/I100532134","https://openalex.org/I154526488"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":0.5559,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.59964915,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"8","issue":"9","first_page":"e72953","last_page":"e72953"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.5205000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.5205000042915344,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.16359999775886536,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12582","display_name":"Flavonoids in Medical Research","score":0.08399999886751175,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.6830000281333923},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.921999990940094},{"id":"https://openalex.org/keywords/cell-proliferation-inhibition","display_name":"cell proliferation inhibition","score":0.953000009059906},{"id":"https://openalex.org/keywords/bax-bcl-2-ratio","display_name":"Bax/Bcl-2 ratio","score":0.8500000238418579},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.7599999904632568},{"id":"https://openalex.org/keywords/tumor-growth-inhibition","display_name":"tumor growth inhibition","score":0.8799999952316284},{"id":"https://openalex.org/keywords/selective-cytotoxicity","display_name":"selective cytotoxicity","score":0.7879999876022339},{"id":"https://openalex.org/keywords/mda-mb-231-cells","display_name":"MDA-MB-231 cells","score":0.7590000033378601},{"id":"https://openalex.org/keywords/mcf-7-cells","display_name":"MCF-7 cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/t47d-cells","display_name":"T47D cells","score":0.8619999885559082},{"id":"https://openalex.org/keywords/anticancer-agents","display_name":"anticancer agents","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.7717181444168091},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.6250132918357849},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.599158763885498},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.5659880638122559},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5605928301811218},{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.5510686635971069},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4856818616390228},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.47728171944618225},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4453851282596588},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.43180927634239197},{"id":"https://openalex.org/C109541995","wikidata":"https://www.wikidata.org/wiki/Q1881253","display_name":"MCF-7","level":5,"score":0.415727436542511},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3936624825000763},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.33131134510040283},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.32823753356933594},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32692480087280273},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.16273772716522217},{"id":"https://openalex.org/C2994423619","wikidata":"https://www.wikidata.org/wiki/Q9103","display_name":"Human breast","level":4,"score":0.1243598461151123},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.03913554549217224}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002934","descriptor_name":"Cinnamates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014410","descriptor_name":"Tumor Stem Cell Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D023041","descriptor_name":"Xenograft Model Antitumor Assays","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D047368","descriptor_name":"Tumor Burden","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pone.0072953","doi":"https://doi.org/10.1371/journal.pone.0072953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2763959","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3764168","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:24039831","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24039831","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3764168","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3764168/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:HAL:hal-04771499v1","doi":null,"is_oa":true,"landing_page_url":"https://uca.hal.science/hal-04771499","pdf_url":"https://uca.hal.science/hal-04771499v1/file/Article%20PLOS%20ONE.pdf","source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2013, 8 (9), ⟨10.1371/journal.pone.0072953⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.810.102","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.810.102","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7d/e9/pone.0072953.PMC3764168.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:5a3c2d282ce84bd38f475a8ef5813d92","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/5a3c2d282ce84bd38f475a8ef5813d92","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e72953 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0072953","doi":"https://doi.org/10.1371/journal.pone.0072953","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072953","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072953&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003166231.pdf","grobid_xml":"https://content.openalex.org/works/W2003166231.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W185074351","https://openalex.org/W1221815709","https://openalex.org/W1608739234","https://openalex.org/W1740580230","https://openalex.org/W1849061857","https://openalex.org/W1955326834","https://openalex.org/W1969653931","https://openalex.org/W1972677660","https://openalex.org/W1984568430","https://openalex.org/W1985495313","https://openalex.org/W1986328213","https://openalex.org/W2017007251","https://openalex.org/W2028897202","https://openalex.org/W2044072446","https://openalex.org/W2047443420","https://openalex.org/W2055816439","https://openalex.org/W2063631892","https://openalex.org/W2064926668","https://openalex.org/W2068146558","https://openalex.org/W2072451938","https://openalex.org/W2072939418","https://openalex.org/W2080830389","https://openalex.org/W2097340167","https://openalex.org/W2105073777","https://openalex.org/W2106888057","https://openalex.org/W2107497146","https://openalex.org/W2118351194","https://openalex.org/W2138735856","https://openalex.org/W2161372685","https://openalex.org/W2166298553","https://openalex.org/W2167138254","https://openalex.org/W2168809860","https://openalex.org/W2181394061","https://openalex.org/W2331669280","https://openalex.org/W3000617624"],"related_works":["https://openalex.org/W2388631786","https://openalex.org/W1997805494","https://openalex.org/W4385483367","https://openalex.org/W2939608929","https://openalex.org/W3047812759","https://openalex.org/W2070587730","https://openalex.org/W3180997183","https://openalex.org/W3040753440","https://openalex.org/W6941745080","https://openalex.org/W1520732228"],"abstract_inverted_index":{"This":[0],"study":[1],"investigated":[2],"the":[3,11,116,130,136,163],"underlying":[4],"mechanism":[5],"of":[6,13,29,45,66,85,87,99,111,118,125,132,140,150,165],"4-hydroxy-3-methoxycinnamic":[7],"acid":[8],"(ACCA),":[9],"on":[10,61,171],"growth":[12,70,96,149],"breast":[14,30,152,192],"cancer":[15,31,72,153],"cells":[16,32,73,142,154],"and":[17,22,35,42,53,115,138],"normal":[18],"immortal":[19],"epithelial":[20],"cells,":[21,173],"compared":[23],"their":[24],"cytotoxic":[25],"effects":[26,60],"responses.":[27],"Treatment":[28],"(MCF-7,":[33],"T47D,":[34],"MDA-231)":[36],"with":[37,58,102,143,160],"ACCA":[38,67,133,144,174],"resulted":[39],"in":[40,49,71,79,93,105,145,155],"dose-":[41],"time-dependent":[43],"decrease":[44],"cell":[46,55,113],"proliferation,":[47],"viability":[48],"colony":[50],"formation":[51],"assay,":[52],"programmed":[54,112],"death":[56],"(apoptosis)":[57],"minimal":[59],"non-tumoral":[62],"cells.":[63],"The":[64],"ability":[65,131],"to":[68,120,134],"suppress":[69],"not":[74],"expressing":[75],"or":[76],"containing":[77],"defects":[78],"p53":[80],"gene":[81],"indicates":[82],"a":[83,177,187],"lack":[84],"involvement":[86],"this":[88],"critical":[89],"tumor":[90,148,172],"suppressor":[91],"element":[92],"mediating":[94],"ACCA-induced":[95],"inhibition.":[97],"Induction":[98],"apoptosis":[100],"correlated":[101],"an":[103,108,122],"increase":[104],"Bax":[106,119],"protein,":[107],"established":[109,123],"inducer":[110],"death,":[114],"ratio":[117],"Bcl-2,":[121],"inhibitor":[124],"apoptosis.":[126],"We":[127],"also":[128],"documented":[129],"inhibit":[135],"migration":[137],"invasion":[139],"MDA-231":[141,151],"vitro.":[146],"Additionally,":[147],"vivo":[156],"was":[157],"dramatically":[158],"affected":[159],"ACCA.":[161],"On":[162],"basis":[164],"its":[166],"selective":[167],"anticancer":[168],"inhibitory":[169],"activity":[170],"may":[175],"represent":[176],"promising":[178],"therapeutic":[179],"drug":[180],"that":[181],"should":[182],"be":[183],"further":[184],"evaluated":[185],"as":[186],"chemotherapeutic":[188],"agent":[189],"for":[190],"human":[191],"cancer.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}