{"id":"https://openalex.org/W2003164415","doi":"https://doi.org/10.1111/and.12229","title":"Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?","display_name":"Is methylenetetrahydrofolate reductase (MTHFR) gene A1298C polymorphism related with varicocele risk?","publication_year":2014,"publication_date":"2014-01-23","ids":{"openalex":"https://openalex.org/W2003164415","doi":"https://doi.org/10.1111/and.12229","mag":"2003164415","pmid":"https://pubmed.ncbi.nlm.nih.gov/24456105"},"language":"en","primary_location":{"id":"doi:10.1111/and.12229","doi":"https://doi.org/10.1111/and.12229","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12229","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12229","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12229","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065707967","display_name":"Vasfiye Betul Ucar","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"V. B. Ucar","raw_affiliation_strings":["Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025981104","display_name":"Babak Nami","orcid":"https://orcid.org/0000-0003-0335-179X","observed_orcids":["https://orcid.org/0000-0003-0335-179X"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"B. Nami","raw_affiliation_strings":["Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101521338","display_name":"Hasan Acar","orcid":"https://orcid.org/0000-0003-1888-2657","observed_orcids":["https://orcid.org/0000-0003-1888-2657","https://orcid.org/0000-0002-1987-3931"]},"institutions":[{"id":"https://openalex.org/I137996928","display_name":"Sel\u00e7uk University","ror":"https://ror.org/045hgzm75","country_code":"TR","type":"education","lineage":["https://openalex.org/I137996928"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"H. Acar","raw_affiliation_strings":["Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Genetics; Sel\u00e7uk University Medical School; Konya Turkey","institution_ids":["https://openalex.org/I137996928"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5025717214","display_name":"Muzaffer Tansel K\u0131l\u0131n\u00e7","orcid":"https://orcid.org/0000-0002-1024-3394","observed_orcids":["https://orcid.org/0000-0002-1024-3394"]},"institutions":[{"id":"https://openalex.org/I4210107659","display_name":"Necmettin Erbakan University","ror":"https://ror.org/013s3zh21","country_code":"TR","type":"education","lineage":["https://openalex.org/I4210107659"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"M. K\u0131l\u0131n\u00e7","raw_affiliation_strings":["Department of Urology; Meram Medical Faculty; Necmettin Erbakan University; Konya Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology; Meram Medical Faculty; Necmettin Erbakan University; Konya Turkey","institution_ids":["https://openalex.org/I4210107659"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5101521338"],"corresponding_institution_ids":["https://openalex.org/I137996928"],"apc_list":{"value":2700,"currency":"USD","value_usd":2700},"apc_paid":null,"fwci":0.8101,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.68495309,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"47","issue":"1","first_page":"42","last_page":"46"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10116","display_name":"Sperm and Testicular Function","score":0.9042999744415283,"subfield":{"id":"https://openalex.org/subfields/2743","display_name":"Reproductive Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10499","display_name":"Folate and B Vitamins Research","score":0.039799999445676804,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13242","display_name":"Male Reproductive Health Studies","score":0.006500000134110451,"subfield":{"id":"https://openalex.org/subfields/2748","display_name":"Urology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/varicocele","display_name":"varicocele","score":0.9480000138282776},{"id":"https://openalex.org/keywords/mthfr","display_name":"MTHFR","score":0.781000018119812},{"id":"https://openalex.org/keywords/mthfr-a1298c-polymorphism","display_name":"MTHFR A1298C polymorphism","score":0.9620000123977661},{"id":"https://openalex.org/keywords/mthfr-c677t-polymorphism","display_name":"MTHFR C677T polymorphism","score":0.9990000128746033},{"id":"https://openalex.org/keywords/male-infertility","display_name":"male infertility","score":0.8450000286102295},{"id":"https://openalex.org/keywords/genetic-risk-factors","display_name":"genetic risk factors","score":0.9409999847412109},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/spermatogenesis","display_name":"spermatogenesis","score":0.8799999952316284},{"id":"https://openalex.org/keywords/genotype-frequency","display_name":"genotype frequency","score":0.6949999928474426}],"concepts":[{"id":"https://openalex.org/C43563269","wikidata":"https://www.wikidata.org/wiki/Q424709","display_name":"Methylenetetrahydrofolate reductase","level":4,"score":0.9091315269470215},{"id":"https://openalex.org/C2778054964","wikidata":"https://www.wikidata.org/wiki/Q549229","display_name":"Varicocele","level":4,"score":0.8982464075088501},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7096856832504272},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.6710882186889648},{"id":"https://openalex.org/C2777688143","wikidata":"https://www.wikidata.org/wiki/Q179399","display_name":"Infertility","level":3,"score":0.6331192255020142},{"id":"https://openalex.org/C2777338322","wikidata":"https://www.wikidata.org/wiki/Q280156","display_name":"Male infertility","level":4,"score":0.623353123664856},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4445376992225647},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.4028683006763458},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3827191889286041},{"id":"https://openalex.org/C29456083","wikidata":"https://www.wikidata.org/wiki/Q1221899","display_name":"Gynecology","level":1,"score":0.36118102073669434},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.361069917678833},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36047983169555664},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.24197745323181152},{"id":"https://openalex.org/C2779234561","wikidata":"https://www.wikidata.org/wiki/Q11995","display_name":"Pregnancy","level":2,"score":0.1229608952999115}],"mesh":[{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005787","descriptor_name":"Gene Frequency","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014646","descriptor_name":"Varicocele","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042965","descriptor_name":"Methylenetetrahydrofolate Reductase (NADPH2)","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/and.12229","doi":"https://doi.org/10.1111/and.12229","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12229","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12229","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},{"id":"pmid:24456105","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24456105","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/and.12229","doi":"https://doi.org/10.1111/and.12229","is_oa":true,"landing_page_url":"https://doi.org/10.1111/and.12229","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/and.12229","source":{"id":"https://openalex.org/S87865284","display_name":"Andrologia","issn_l":"0303-4569","issn":["0303-4569","1439-0272"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Andrologia","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9789000153541565}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313925","display_name":"De La Salle University","ror":"https://ror.org/04xftk194"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003164415.pdf","grobid_xml":"https://content.openalex.org/works/W2003164415.grobid-xml"},"referenced_works_count":23,"referenced_works":["https://openalex.org/W136327257","https://openalex.org/W1487585409","https://openalex.org/W1516346816","https://openalex.org/W1966403813","https://openalex.org/W1974235191","https://openalex.org/W1980425963","https://openalex.org/W1980844385","https://openalex.org/W2012236528","https://openalex.org/W2030469228","https://openalex.org/W2054859060","https://openalex.org/W2067193448","https://openalex.org/W2080751863","https://openalex.org/W2082223066","https://openalex.org/W2092500318","https://openalex.org/W2119065143","https://openalex.org/W2121608455","https://openalex.org/W2127354625","https://openalex.org/W2128319895","https://openalex.org/W2169450014","https://openalex.org/W2187986927","https://openalex.org/W2204734080","https://openalex.org/W2240280269","https://openalex.org/W4214780653"],"related_works":["https://openalex.org/W1982475050","https://openalex.org/W1836119688","https://openalex.org/W2029353554","https://openalex.org/W4394623354","https://openalex.org/W2346896150","https://openalex.org/W2136780000","https://openalex.org/W2017943875","https://openalex.org/W7097514416","https://openalex.org/W3160000522","https://openalex.org/W1985951649"],"abstract_inverted_index":{"Varicocele":[0],"is":[1,20,106],"one":[2],"of":[3,13,70,82,113,161,187],"the":[4,10,38,83,101,111,159,184],"main":[5],"reasons":[6],"for":[7,22,46,110],"male":[8,47],"infertility":[9],"exact":[11],"aetiology":[12],"which":[14,27],"remains":[15],"unclear.":[16],"Methylenetetrahydrofolate":[17],"reductase":[18],"(MTHFR)":[19],"important":[21,181],"DNA":[23],"synthesis":[24],"and":[25,55,65,74,88,99],"methylation,":[26],"has":[28],"a":[29,107],"key":[30],"role":[31,182],"during":[32],"spermatogenesis.":[33],"Numerous":[34],"literature":[35],"suggests":[36],"that":[37,176],"MTHFR":[39,57,84,156],"polymorphism":[40,59],"may":[41],"be":[42],"genetic":[43,177],"risk":[44,160],"factors":[45,178],"infertility.":[48],"In":[49],"this":[50],"study,":[51],"we":[52],"evaluated":[53],"C677T":[54,87],"A1298C":[56,89],"gene":[58,85,157],"frequency":[60,112,134],"in":[61,86,116,135,141,155,183],"patients":[62,73,117],"with":[63,118,121,143,168],"varicocele":[64,72,119,162],"normal":[66,122],"men.":[67],"A":[68],"total":[69],"107":[71],"109":[75],"fertile":[76],"healthy":[77],"individuals":[78],"were":[79],"included.":[80],"Genotyping":[81],"base":[90],"pairs":[91],"carried":[92],"out":[93],"by":[94],"using":[95],"real-time":[96],"PCR":[97],"technique":[98],"afterwards,":[100],"statistical":[102,108],"analysis":[103],"accomplished.":[104],"There":[105],"difference":[109],"1298AA":[114,153],"genotype":[115,154],"compared":[120,167],"controls":[123],"(P":[124,146],"=":[125,128,147],"0.0051,":[126],"OR":[127],"2.2750).":[129],"Instead,":[130],"subsequently,":[131],"1298/A":[132],"allel":[133],"patient":[136],"group":[137,145],"was":[138],"significantly":[139],"higher":[140],"comparison":[142],"control":[144],"0.0174).":[148],"According":[149],"to":[150],"our":[151],"results,":[152],"raises":[158],"approximately":[163],"2.3":[164],"times":[165],"more":[166],"men":[169],"carrying":[170],"other":[171],"genotypes.":[172],"The":[173],"results":[174],"show":[175],"have":[179],"an":[180],"molecular":[185],"basis":[186],"varicocele.":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2024,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
