{"id":"https://openalex.org/W2003155673","doi":"https://doi.org/10.1086/674312","title":"Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial Hypertension","display_name":"Interaction between Bone Morphogenetic Protein Receptor Type 2 and Estrogenic Compounds in Pulmonary Arterial Hypertension","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2003155673","doi":"https://doi.org/10.1086/674312","mag":"2003155673","pmid":"https://pubmed.ncbi.nlm.nih.gov/24618541","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070799"},"language":"en","primary_location":{"id":"doi:10.1086/674312","doi":"https://doi.org/10.1086/674312","is_oa":true,"landing_page_url":"https://doi.org/10.1086/674312","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/674312","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/674312","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017870559","display_name":"Joshua P. Fessel","orcid":"https://orcid.org/0000-0003-0797-7693","observed_orcids":["https://orcid.org/0000-0003-0797-7693"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua P. Fessel","raw_affiliation_strings":["Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA","1 Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine Vanderbilt University Medical Center Nashville Tennessee USA","institution_ids":["https://openalex.org/I901861585"]},{"raw_affiliation_string":"1 Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee, USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101594771","display_name":"Xinping Chen","orcid":"https://orcid.org/0000-0002-7490-9036","observed_orcids":["https://orcid.org/0000-0002-7490-9036"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xinping Chen","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049719553","display_name":"Andrea L. Frump","orcid":"https://orcid.org/0000-0002-5972-5079","observed_orcids":["https://orcid.org/0000-0002-5972-5079"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Andrea Frump","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058773601","display_name":"Santhi Gladson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Santhi Gladson","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111625927","display_name":"Tom Blackwell","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Blackwell","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111862783","display_name":"Christie Kang","orcid":"https://orcid.org/0009-0000-4049-4752","observed_orcids":["https://orcid.org/0009-0000-4049-4752"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christie Kang","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104049417","display_name":"Jennifer A. Johnson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Johnson","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065762639","display_name":"James E. Loyd","orcid":"https://orcid.org/0000-0002-5042-7390","observed_orcids":["https://orcid.org/0000-0002-5042-7390"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James E. Loyd","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056044508","display_name":"Anna Ryan Hemnes","orcid":"https://orcid.org/0000-0002-2755-5845","observed_orcids":["https://orcid.org/0000-0002-2755-5845"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Hemnes","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030467856","display_name":"Eric D. Austin","orcid":"https://orcid.org/0000-0002-1709-9022","observed_orcids":["https://orcid.org/0000-0002-1709-9022"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Eric Austin","raw_affiliation_strings":["Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042419219","display_name":"James D. West","orcid":"https://orcid.org/0000-0002-6004-0202","observed_orcids":["https://orcid.org/0000-0002-6004-0202"]},"institutions":[{"id":"https://openalex.org/I901861585","display_name":"Vanderbilt University Medical Center","ror":"https://ror.org/05dq2gs74","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210162197","https://openalex.org/I901861585"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"James West","raw_affiliation_strings":["Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee USA","institution_ids":["https://openalex.org/I901861585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5042419219"],"corresponding_institution_ids":["https://openalex.org/I901861585"],"apc_list":{"value":2310,"currency":"USD","value_usd":2310},"apc_paid":null,"fwci":3.9563,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.93826541,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":92,"max":99},"biblio":{"volume":"3","issue":"3","first_page":"564","last_page":"577"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-arterial-hypertension","display_name":"pulmonary arterial hypertension","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bmpr2","display_name":"BMPR2","score":0.7490000128746033},{"id":"https://openalex.org/keywords/estrogen-metabolism","display_name":"estrogen metabolism","score":0.6970000267028809},{"id":"https://openalex.org/keywords/16alpha-hydroxyestrone","display_name":"16\u03b1-hydroxyestrone","score":0.9890000224113464},{"id":"https://openalex.org/keywords/2-methoxyestrone","display_name":"2-methoxyestrone","score":0.9829999804496765},{"id":"https://openalex.org/keywords/estrogen-receptor-alpha","display_name":"estrogen receptor alpha","score":0.6890000104904175},{"id":"https://openalex.org/keywords/disease-penetrance","display_name":"disease penetrance","score":0.8370000123977661},{"id":"https://openalex.org/keywords/estrogen-signaling","display_name":"estrogen signaling","score":0.4659999907016754},{"id":"https://openalex.org/keywords/bmp-signaling","display_name":"BMP signaling","score":0.6389999985694885},{"id":"https://openalex.org/keywords/pulmonary-microvascular-endothelial-cells","display_name":"pulmonary microvascular endothelial cells","score":0.8889999985694885},{"id":"https://openalex.org/keywords/vascular-injury","display_name":"vascular injury","score":0.8130000233650208},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.7419999837875366},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.7609999775886536}],"concepts":[{"id":"https://openalex.org/C73834784","wikidata":"https://www.wikidata.org/wiki/Q17849752","display_name":"BMPR2","level":4,"score":0.9095407724380493},{"id":"https://openalex.org/C200544954","wikidata":"https://www.wikidata.org/wiki/Q516389","display_name":"Penetrance","level":4,"score":0.7553181052207947},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6043047308921814},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5907805562019348},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.581562340259552},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4823712408542633},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4415558874607086},{"id":"https://openalex.org/C143065580","wikidata":"https://www.wikidata.org/wiki/Q3285695","display_name":"Mutant","level":3,"score":0.43564993143081665},{"id":"https://openalex.org/C2781228645","wikidata":"https://www.wikidata.org/wiki/Q4941575","display_name":"Bone morphogenetic protein receptor","level":4,"score":0.43321019411087036},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.4141077697277069},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.39809972047805786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.272906094789505},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.21112856268882751},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09327414631843567},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.07645204663276672},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1086/674312","doi":"https://doi.org/10.1086/674312","is_oa":true,"landing_page_url":"https://doi.org/10.1086/674312","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/674312","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3059230","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070799","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4070799","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4070799","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulm Circ","raw_type":"Text"},{"id":"pmid:24618541","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24618541","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary circulation","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1086/674312","doi":"https://doi.org/10.1086/674312","is_oa":true,"landing_page_url":"https://doi.org/10.1086/674312","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1086/674312","source":{"id":"https://openalex.org/S2764573606","display_name":"Pulmonary Circulation","issn_l":"2045-8932","issn":["2045-8932","2045-8940"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pulmonary Circulation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3803024886","display_name":"Hormonal, Metabolic and Signaling Interactions in PAH","funder_award_id":"P01HL108800","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6916765345","display_name":"Interventions Against the Molecular Etiology of BMPR2-induced PAH","funder_award_id":"R01HL095797","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003155673.pdf","grobid_xml":"https://content.openalex.org/works/W2003155673.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W1537871945","https://openalex.org/W1606441445","https://openalex.org/W1902229708","https://openalex.org/W1963911542","https://openalex.org/W1970846664","https://openalex.org/W1976100166","https://openalex.org/W1980548655","https://openalex.org/W1987540231","https://openalex.org/W1996248643","https://openalex.org/W2020617101","https://openalex.org/W2025947830","https://openalex.org/W2028325343","https://openalex.org/W2029509991","https://openalex.org/W2033870835","https://openalex.org/W2035005764","https://openalex.org/W2036510075","https://openalex.org/W2037568417","https://openalex.org/W2042333083","https://openalex.org/W2046448515","https://openalex.org/W2050400259","https://openalex.org/W2055401216","https://openalex.org/W2062986243","https://openalex.org/W2067603961","https://openalex.org/W2070004323","https://openalex.org/W2072612511","https://openalex.org/W2075349277","https://openalex.org/W2084729840","https://openalex.org/W2102181984","https://openalex.org/W2110241360","https://openalex.org/W2112488807","https://openalex.org/W2115479497","https://openalex.org/W2115896439","https://openalex.org/W2133917486","https://openalex.org/W2141262339","https://openalex.org/W2144327307","https://openalex.org/W2147478280","https://openalex.org/W2154332638","https://openalex.org/W2161520297","https://openalex.org/W2168349771","https://openalex.org/W2168595762","https://openalex.org/W2209500513","https://openalex.org/W3140907331","https://openalex.org/W4236353214"],"related_works":["https://openalex.org/W7165596628","https://openalex.org/W2200344714","https://openalex.org/W7099934214","https://openalex.org/W2063608650","https://openalex.org/W2161520297","https://openalex.org/W2168595762","https://openalex.org/W2144534157","https://openalex.org/W2421478670","https://openalex.org/W1897452238","https://openalex.org/W68878742"],"abstract_inverted_index":{"Abstract":[0],"The":[1,76],"majority":[2],"of":[3,30,56,65,74,78,91,165,187,203,211,246,255],"heritable":[4],"pulmonary":[5,170],"arterial":[6],"hypertension":[7],"(HPAH)":[8],"cases":[9],"are":[10],"associated":[11,70,126,182,200],"with":[12,53,71,127,144,183,201,207,239],"mutations":[13],"in":[14,40,93,110,142,151,215,249],"bone":[15,157],"morphogenetic":[16,158],"protein":[17,159],"receptor":[18,189,251],"type":[19],"2":[20],"(BMPR2).":[21],"BMPR2":[22],"mutation":[23],"carries":[24],"about":[25],"a":[26,46,135,229],"20%":[27],"lifetime":[28],"risk":[29,73],"PAH":[31,237],"development,":[32],"but":[33,149,206],"penetrance":[34,90],"is":[35],"approximately":[36],"three":[37],"times":[38],"higher":[39],"females.":[41],"Previous":[42],"studies":[43],"have":[44,134],"shown":[45],"correlation":[47],"between":[48,232],"estrogen":[49,58,177,188,250],"metabolism":[50],"and":[51,62,87,194,224,235,253,258],"penetrance,":[52,125,238],"increased":[54,72,86,208,233,236],"levels":[55,64],"the":[57,66,240],"metabolite":[59,67],"16\u03b1-hydroxyestrone":[60],"(16\u03b1OHE)":[61],"reduced":[63,128],"2-methoxyestrogen":[68],"(2ME)":[69],"disease.":[75],"goal":[77],"this":[79],"study":[80],"was":[81,108,199],"to":[82,176,218],"determine":[83],"whether":[84],"16\u03b1OHE":[85,121,155,198,234],"2ME":[88,131],"decreased":[89],"disease":[92,124],"Bmpr2":[94,115,152,166,168,195],"mutant":[95,116,153,169,196],"mice":[96,118,148],"and,":[97],"if":[98],"so,":[99],"by":[100],"what":[101],"mechanism.":[102],"We":[103],"found":[104],"that":[105],"16\u03b1OHE\u22362ME":[106],"ratio":[107],"high":[109],"male":[111,117],"human":[112],"HPAH":[113],"patients.":[114],"receiving":[119],"chronic":[120],"had":[122],"doubled":[123],"cardiac":[129],"output.":[130],"did":[132],"not":[133,150],"significant":[136],"protective":[137],"effect,":[138],"either":[139],"alone":[140],"or":[141],"combination":[143],"16\u03b1OHE.":[145],"In":[146,191],"control":[147,193],"mice,":[154,197],"suppressed":[156],"signaling,":[160],"probably":[161],"directly":[162],"through":[163,179],"suppression":[164,202,245],"protein.":[167],"microvascular":[171],"endothelial":[172],"cells":[173],"were":[174],"insensitive":[175],"signaling":[178],"canonical":[180],"pathways,":[181],"aberrant":[184],"intracellular":[185],"localization":[186],"\u03b1.":[190],"both":[192],"cytokine":[204],"expression":[205],"alternate":[209],"markers":[210],"injury,":[212],"including":[213,244],"alterations":[214,248],"genes":[216],"related":[217],"thrombotic":[219],"function,":[220],"angiogenesis,":[221],"planar":[222],"polarity,":[223],"metabolism.":[225],"These":[226],"data":[227],"support":[228],"causal":[230],"relationship":[231],"likely":[241],"molecular":[242],"mechanisms":[243],"BMPR2,":[247],"translocation,":[252],"induction":[254],"vascular":[256],"injury":[257],"insulin":[259],"resistance-related":[260],"pathways.":[261]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}