{"id":"https://openalex.org/W2003154618","doi":"https://doi.org/10.1074/jbc.m607003200","title":"FRAT1, a Substrate-specific Regulator of Glycogen Synthase Kinase-3 Activity, Is a Cellular Substrate of Protein Kinase A","display_name":"FRAT1, a Substrate-specific Regulator of Glycogen Synthase Kinase-3 Activity, Is a Cellular Substrate of Protein Kinase A","publication_year":2006,"publication_date":"2006-09-19","ids":{"openalex":"https://openalex.org/W2003154618","doi":"https://doi.org/10.1074/jbc.m607003200","mag":"2003154618","pmid":"https://pubmed.ncbi.nlm.nih.gov/16982607"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m607003200","doi":"https://doi.org/10.1074/jbc.m607003200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m607003200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m607003200","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5079388173","display_name":"Thilo Hagen","orcid":"https://orcid.org/0000-0001-7834-0601","observed_orcids":["https://orcid.org/0000-0001-7834-0601"]},"institutions":[{"id":"https://openalex.org/I142263535","display_name":"University of Nottingham","ror":"https://ror.org/01ee9ar58","country_code":"GB","type":"education","lineage":["https://openalex.org/I142263535"]},{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]},{"id":"https://openalex.org/I4405268060","display_name":"GlaxoSmithKline Research & Development Limited (United Kingdom)","ror":"https://ror.org/05mayyh83","country_code":"GB","type":"company","lineage":["https://openalex.org/I4405268060"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Thilo Hagen","raw_affiliation_strings":["Discovery Research Biology, Neurology Centre of Excellence in Drug Discovery, Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom. Thilo.Hagen@nottingham.ac.uk","Discovery Research Biology, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2UH, United Kindom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Biology, Neurology Centre of Excellence in Drug Discovery, Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom. Thilo.Hagen@nottingham.ac.uk","institution_ids":["https://openalex.org/I188950975","https://openalex.org/I4405268060"]},{"raw_affiliation_string":"Discovery Research Biology, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","institution_ids":["https://openalex.org/I188950975"]},{"raw_affiliation_string":"Wolfson Digestive Diseases Centre, University of Nottingham, Nottingham NG7 2UH, United Kindom","institution_ids":["https://openalex.org/I142263535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026352956","display_name":"Darren A.E. Cross","orcid":"https://orcid.org/0000-0002-5227-2871","observed_orcids":["https://orcid.org/0000-0002-5227-2871"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Darren A.E. Cross","raw_affiliation_strings":["Discovery Research Biology, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Discovery Research Biology, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008924160","display_name":"Ainsley A. Culbert","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Ainsley A. Culbert","raw_affiliation_strings":["Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Andrew West","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Andrew West","raw_affiliation_strings":["Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Computational, Analytical, and Structural Sciences, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109334062","display_name":"Sheelagh Frame","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Sheelagh Frame","raw_affiliation_strings":["Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028009861","display_name":"Nick A. MORRICE","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I177639307","display_name":"University of Dundee","ror":"https://ror.org/03h2bxq36","country_code":"GB","type":"education","lineage":["https://openalex.org/I177639307"]},{"id":"https://openalex.org/I4210110201","display_name":"MRC Protein Phosphorylation and Ubiquitylation Unit","ror":"https://ror.org/01zg1tt02","country_code":"GB","type":"facility","lineage":["https://openalex.org/I177639307","https://openalex.org/I4210087105","https://openalex.org/I4210110201","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Nick Morrice","raw_affiliation_strings":["Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Research Council Protein Phosphorylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, United Kingdom","institution_ids":["https://openalex.org/I177639307","https://openalex.org/I4210110201"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076324765","display_name":"Alastair D. Reith","orcid":"https://orcid.org/0000-0001-5092-0604","observed_orcids":["https://orcid.org/0000-0001-5092-0604"]},"institutions":[{"id":"https://openalex.org/I188950975","display_name":"GlaxoSmithKline (United Kingdom)","ror":"https://ror.org/01xsqw823","country_code":"GB","type":"company","lineage":["https://openalex.org/I188950975"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Alastair D. Reith","raw_affiliation_strings":["Medicines Research Centre, Stevenage, Herts SG1 2NY, United Kingdom","Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medicines Research Centre, Stevenage, Herts SG1 2NY, United Kingdom","institution_ids":[]},{"raw_affiliation_string":"Neurology Centre of Excellence in Drug Discovery, GlaxoSmithKline Pharmaceuticals, Harlow, Essex CM19 5AD, United Kingdom","institution_ids":["https://openalex.org/I188950975"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5079388173"],"corresponding_institution_ids":["https://openalex.org/I142263535","https://openalex.org/I188950975","https://openalex.org/I4405268060"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":0.3368,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.50113187,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"281","issue":"46","first_page":"35021","last_page":"35029"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glycogen-synthase-kinase-3","display_name":"glycogen synthase kinase-3","score":0.9700000286102295},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.9129999876022339},{"id":"https://openalex.org/keywords/beta-catenin","display_name":"\u03b2-catenin","score":0.8370000123977661},{"id":"https://openalex.org/keywords/camp-signaling","display_name":"cAMP signaling","score":0.6129999756813049},{"id":"https://openalex.org/keywords/beta-adrenergic-receptors","display_name":"beta-adrenergic receptors","score":0.9290000200271606},{"id":"https://openalex.org/keywords/norepinephrine","display_name":"norepinephrine","score":0.9610000252723694},{"id":"https://openalex.org/keywords/kinase-regulation","display_name":"kinase regulation","score":0.6159999966621399}],"concepts":[{"id":"https://openalex.org/C182996813","wikidata":"https://www.wikidata.org/wiki/Q910847","display_name":"GSK-3","level":3,"score":0.8784361481666565},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.7066589593887329},{"id":"https://openalex.org/C192118531","wikidata":"https://www.wikidata.org/wiki/Q86360001","display_name":"Glycogen synthase","level":3,"score":0.5480731129646301},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5307963490486145},{"id":"https://openalex.org/C104629339","wikidata":"https://www.wikidata.org/wiki/Q18258585","display_name":"GSK3B","level":4,"score":0.5036501288414001},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4760708212852478},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.475463330745697},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4673348665237427},{"id":"https://openalex.org/C90934575","wikidata":"https://www.wikidata.org/wiki/Q6593810","display_name":"Mitogen-activated protein kinase kinase","level":4,"score":0.4565746784210205},{"id":"https://openalex.org/C159479382","wikidata":"https://www.wikidata.org/wiki/Q18030801","display_name":"MAP2K7","level":5,"score":0.43031707406044006},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3966965675354004},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.35569295287132263},{"id":"https://openalex.org/C82495950","wikidata":"https://www.wikidata.org/wiki/Q14911732","display_name":"Cyclin-dependent kinase 2","level":4,"score":0.3414572775363922},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33683234453201294}],"mesh":[{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D038362","descriptor_name":"Glycogen Synthase Kinase 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D047908","descriptor_name":"Intracellular Signaling Peptides and Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051176","descriptor_name":"beta Catenin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1074/jbc.m607003200","doi":"https://doi.org/10.1074/jbc.m607003200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m607003200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmid:16982607","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16982607","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m607003200","doi":"https://doi.org/10.1074/jbc.m607003200","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m607003200","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W1554815317","https://openalex.org/W1850214287","https://openalex.org/W1905797098","https://openalex.org/W1964631519","https://openalex.org/W1974076636","https://openalex.org/W1975912195","https://openalex.org/W1982958012","https://openalex.org/W1997345969","https://openalex.org/W2002404925","https://openalex.org/W2005063238","https://openalex.org/W2012868552","https://openalex.org/W2019041110","https://openalex.org/W2019867611","https://openalex.org/W2022309233","https://openalex.org/W2024206002","https://openalex.org/W2027286743","https://openalex.org/W2054720359","https://openalex.org/W2058138221","https://openalex.org/W2061170173","https://openalex.org/W2066497759","https://openalex.org/W2069704514","https://openalex.org/W2074883812","https://openalex.org/W2075319861","https://openalex.org/W2075834144","https://openalex.org/W2080661409","https://openalex.org/W2082889823","https://openalex.org/W2109069210","https://openalex.org/W2118945982","https://openalex.org/W2119284420","https://openalex.org/W2120657906","https://openalex.org/W2121685290","https://openalex.org/W2121745326","https://openalex.org/W2122807946","https://openalex.org/W2123027097","https://openalex.org/W2142493853","https://openalex.org/W2148893919","https://openalex.org/W2149166183","https://openalex.org/W2151558240","https://openalex.org/W2170296743"],"related_works":["https://openalex.org/W2118729125","https://openalex.org/W2066497759","https://openalex.org/W2074883812","https://openalex.org/W4248376947","https://openalex.org/W1974981299","https://openalex.org/W2024206002","https://openalex.org/W7111955221","https://openalex.org/W1997345969","https://openalex.org/W1908612571","https://openalex.org/W2025308343"],"abstract_inverted_index":{"FRAT1,":[0],"like":[1],"its":[2],"Xenopus":[3],"homolog":[4],"glycogen":[5],"synthase":[6],"kinase-3":[7],"(GSK-3)-binding":[8],"protein,":[9],"is":[10,19,28,150],"known":[11],"to":[12,35,76,87,118,141,168],"inhibit":[13],"GSK-3-mediated":[14],"phosphorylation":[15,69,75,109,144],"of":[16,63,73,100,110,159,166,195],"beta-catenin.":[17],"It":[18],"currently":[20],"unknown":[21],"how":[22],"FRAT-GSK-3-binding":[23],"protein":[24],"activity":[25,194],"toward":[26,197],"GSK-3":[27,114,137,149],"regulated.":[29],"FRAT1":[30,77,111,120,143,154,167,176,196],"has":[31],"recently":[32],"been":[33,47],"shown":[34],"be":[36],"a":[37,56,152,188],"phosphoprotein":[38],"in":[39,59,90,95,126,131,145,156,177,182,190],"vivo;":[40],"however,":[41],"the":[42,64,71,108,164,192],"responsible":[43],"kinase(s)":[44],"have":[45],"not":[46,139,151],"determined.":[48],"In":[49,134,172],"this":[50,74],"study,":[51],"we":[52],"identified":[53],"Ser188":[54,68,89,122,160],"as":[55,92,94,179,181],"phosphorylated":[57],"residue":[58],"FRAT1.":[60],"The":[61],"identity":[62],"kinase":[65,82,155],"that":[66,148],"catalyzes":[67],"and":[70,123,185],"significance":[72],"function":[78],"were":[79],"investigated.":[80],"Protein":[81],"A":[83],"(PKA)":[84],"was":[85,115],"found":[86],"phosphorylate":[88,119],"vitro":[91,127,178],"well":[93,180],"intact":[96,132,183],"cells.":[97,133],"Importantly,":[98],"activation":[99],"endogenous":[101,136],"cAMP-coupled":[102],"beta-adrenergic":[103],"receptors":[104],"with":[105],"norepinephrine":[106],"stimulated":[107],"at":[112,121],"Ser188.":[113],"also":[116],"able":[117],"other":[124],"residues":[125],"or":[128],"when":[129],"overexpressed":[130],"contrast,":[135],"did":[138],"lead":[140],"significant":[142],"cells,":[146],"suggesting":[147],"major":[153],"vivo.":[157],"Phosphorylation":[158],"by":[161],"PKA":[162,174],"inhibited":[163],"ability":[165],"activate":[169],"beta-catenin-dependent":[170],"transcription.":[171],"conclusion,":[173],"phosphorylates":[175],"cells":[184],"may":[186],"play":[187],"role":[189],"regulating":[191],"inhibitory":[193],"GSK-3.":[198]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}