{"id":"https://openalex.org/W2003148658","doi":"https://doi.org/10.1126/science.3144042","title":"Accuracy of in Vivo Aminoacylation Requires Proper Balance of tRNA and Aminoacyl-tRNA Synthetase","display_name":"Accuracy of in Vivo Aminoacylation Requires Proper Balance of tRNA and Aminoacyl-tRNA Synthetase","publication_year":1988,"publication_date":"1988-12-16","ids":{"openalex":"https://openalex.org/W2003148658","doi":"https://doi.org/10.1126/science.3144042","mag":"2003148658","pmid":"https://pubmed.ncbi.nlm.nih.gov/3144042"},"language":"en","primary_location":{"id":"doi:10.1126/science.3144042","doi":"https://doi.org/10.1126/science.3144042","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3144042","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Robert Swanson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert Swanson","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020678852","display_name":"Patricia J. Hoben","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia Hoben","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002109293","display_name":"Martin Sumner-Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Martin Sumner-Smith","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018192888","display_name":"Haruki Uemura","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Haruki Uemura","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031577358","display_name":"Lynley A. Watson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynley Watson","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063450287","display_name":"Dieter G. S\u00f6ll","orcid":"https://orcid.org/0000-0002-3077-8986","observed_orcids":["https://orcid.org/0000-0002-3077-8986"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dieter S\u00f6ll","raw_affiliation_strings":["Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Biophysics and Biochemistry, Yale University, New Haven, CT 06511","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":2.8987,"has_fulltext":false,"cited_by_count":135,"citation_normalized_percentile":{"value":0.92335494,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"242","issue":"4885","first_page":"1548","last_page":"1551"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11482","display_name":"RNA modifications and cancer","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11445","display_name":"Origins and Evolution of Life","score":0.0,"subfield":{"id":"https://openalex.org/subfields/3103","display_name":"Astronomy and Astrophysics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoacylation","display_name":"aminoacylation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/aminoacyl-trna-synthetase","display_name":"aminoacyl-tRNA synthetase","score":0.906000018119812},{"id":"https://openalex.org/keywords/trna","display_name":"tRNA","score":0.9240000247955322},{"id":"https://openalex.org/keywords/translation-fidelity","display_name":"translation fidelity","score":0.7009999752044678},{"id":"https://openalex.org/keywords/protein-synthesis","display_name":"protein synthesis","score":0.640999972820282},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.8209999799728394},{"id":"https://openalex.org/keywords/trna-misacylation","display_name":"tRNA misacylation","score":0.8299999833106995}],"concepts":[{"id":"https://openalex.org/C151238385","wikidata":"https://www.wikidata.org/wiki/Q4746444","display_name":"Aminoacylation","level":5,"score":0.9353703260421753},{"id":"https://openalex.org/C2779315393","wikidata":"https://www.wikidata.org/wiki/Q415968","display_name":"Aminoacyl tRNA synthetase","level":5,"score":0.8247523903846741},{"id":"https://openalex.org/C153957851","wikidata":"https://www.wikidata.org/wiki/Q201448","display_name":"Transfer RNA","level":4,"score":0.7361976504325867},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.4515489935874939},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.415443480014801},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34624916315078735},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.34516197443008423},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2086852788925171},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.18246567249298096},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05059728026390076}],"mesh":[{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000604","descriptor_name":"Amino Acyl-tRNA Synthetases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001616","descriptor_name":"beta-Galactosidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012345","descriptor_name":"RNA, Transfer, Amino Acid-Specific","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012351","descriptor_name":"RNA, Transfer, Gln","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.3144042","doi":"https://doi.org/10.1126/science.3144042","is_oa":false,"landing_page_url":"https://doi.org/10.1126/science.3144042","pdf_url":null,"source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:3144042","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3144042","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W1513669884","https://openalex.org/W1517327749","https://openalex.org/W1546783991","https://openalex.org/W1658189890","https://openalex.org/W1835328317","https://openalex.org/W1923250545","https://openalex.org/W1992443142","https://openalex.org/W1992746198","https://openalex.org/W1996107324","https://openalex.org/W1996631481","https://openalex.org/W1999136148","https://openalex.org/W2004073738","https://openalex.org/W2006074942","https://openalex.org/W2038174665","https://openalex.org/W2039907902","https://openalex.org/W2044114110","https://openalex.org/W2054887464","https://openalex.org/W2073998024","https://openalex.org/W2078709591","https://openalex.org/W2084377313","https://openalex.org/W2141653906","https://openalex.org/W2174000974","https://openalex.org/W2396555106","https://openalex.org/W2468682524"],"related_works":["https://openalex.org/W4313635084","https://openalex.org/W2013734587","https://openalex.org/W1012338537","https://openalex.org/W2032185255","https://openalex.org/W2462302923","https://openalex.org/W1973694785","https://openalex.org/W1975604623","https://openalex.org/W2324597487","https://openalex.org/W2468682524","https://openalex.org/W2743012463"],"abstract_inverted_index":{"The":[0,16],"fidelity":[1,125],"of":[2,12,14,19,29,42,58,88,101,116,126,136],"protein":[3,127],"biosynthesis":[4],"in":[5,68,108,122],"any":[6],"cell":[7],"rests":[8],"on":[9,25,132],"the":[10,26,39,73,85,89,99,105,113,117,124,133],"accuracy":[11],"aminoacylation":[13],"tRNA.":[15],"exquisite":[17],"specificity":[18],"this":[20],"reaction":[21],"is":[22,35,66,82,92,120],"critically":[23],"dependent":[24],"correct":[27],"recognition":[28],"tRNA":[30,44],"by":[31],"aminoacyl-tRNA":[32,48,102,139],"synthetases.":[33],"It":[34],"shown":[36],"here":[37],"that":[38,98],"relative":[40,134],"concentrations":[41],"a":[43,142],"and":[45,54,104,138],"its":[46],"cognate":[47,90,106],"synthetase":[49,65,103],"are":[50],"normally":[51],"well":[52],"balanced":[53],"crucial":[55],"for":[56],"maintenance":[57],"accurate":[59],"aminoacylation.":[60],"When":[61],"Escherichia":[62],"coli":[63],"Gln-tRNA":[64],"overproduced":[67],"vivo,":[69],"it":[70],"incorrectly":[71],"acylates":[72],"supF":[74],"amber":[75],"suppressor":[76],"tRNA(Tyr)":[77],"with":[78],"Gln.":[79],"This":[80],"effect":[81],"abolished":[83],"when":[84],"intracellular":[86],"concentration":[87],"tRNA(Gln2)":[91],"also":[93],"elevate.":[94],"These":[95],"data":[96],"indicate":[97],"presence":[100],"tRNAs":[107,137],"complexed":[109],"form,":[110],"which":[111],"requires":[112],"proper":[114],"balance":[115],"two":[118],"macromolecules,":[119],"critical":[121],"maintaining":[123],"biosynthesis.":[128],"Thus,":[129],"limits":[130],"exist":[131],"levels":[135],"synthetases":[140],"within":[141],"cell.":[143]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
