{"id":"https://openalex.org/W2003148399","doi":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","title":"Imatinib Mesylate in the Treatment of Refractory Idiopathic Pulmonary Arterial Hypertension","display_name":"Imatinib Mesylate in the Treatment of Refractory Idiopathic Pulmonary Arterial Hypertension","publication_year":2006,"publication_date":"2006-07-18","ids":{"openalex":"https://openalex.org/W2003148399","doi":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","mag":"2003148399","pmid":"https://pubmed.ncbi.nlm.nih.gov/16847299"},"language":"en","primary_location":{"id":"doi:10.7326/0003-4819-145-2-200607180-00020","doi":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044203041","display_name":"Karen C. Patterson","orcid":"https://orcid.org/0000-0002-5596-6801","observed_orcids":["https://orcid.org/0000-0002-5596-6801"]},"institutions":[{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karen C. Patterson","raw_affiliation_strings":["From Boston Medical Center, Boston, MA 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Boston Medical Center, Boston, MA 02118","institution_ids":["https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065261698","display_name":"Ariel Weissmann","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ariel Weissmann","raw_affiliation_strings":["From Boston Medical Center, Boston, MA 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Boston Medical Center, Boston, MA 02118","institution_ids":["https://openalex.org/I1286490081"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077388722","display_name":"Tahamtan Ahmadi","orcid":"https://orcid.org/0009-0007-5031-3792","observed_orcids":["https://orcid.org/0009-0007-5031-3792"]},"institutions":[{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tahamtan Ahmadi","raw_affiliation_strings":["From Boston Medical Center, Boston, MA 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Boston Medical Center, Boston, MA 02118","institution_ids":["https://openalex.org/I1286490081"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032869220","display_name":"Harrison W. Farber","orcid":"https://orcid.org/0000-0002-0297-7902","observed_orcids":["https://orcid.org/0000-0002-0297-7902"]},"institutions":[{"id":"https://openalex.org/I1286490081","display_name":"Boston Medical Center","ror":"https://ror.org/010b9wj87","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1286490081"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harrison W. Farber","raw_affiliation_strings":["From Boston Medical Center, Boston, MA 02118"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"From Boston Medical Center, Boston, MA 02118","institution_ids":["https://openalex.org/I1286490081"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1286490081"],"apc_list":null,"apc_paid":null,"fwci":14.8666,"has_fulltext":false,"cited_by_count":148,"citation_normalized_percentile":{"value":0.991764,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"145","issue":"2","first_page":"152","last_page":"153"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/idiopathic-pulmonary-arterial-hypertension","display_name":"idiopathic pulmonary arterial hypertension","score":0.9879999756813049},{"id":"https://openalex.org/keywords/tyrosine-kinase-inhibitors","display_name":"tyrosine kinase inhibitors","score":0.7170000076293945},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.9010000228881836},{"id":"https://openalex.org/keywords/right-heart-failure","display_name":"right heart failure","score":0.703000009059906},{"id":"https://openalex.org/keywords/hemodynamic-response","display_name":"hemodynamic response","score":0.6380000114440918}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9271770715713501},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5570759773254395},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5567495822906494},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.5087695717811584},{"id":"https://openalex.org/C3019892230","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib mesylate","level":4,"score":0.4986763000488281},{"id":"https://openalex.org/C142424586","wikidata":"https://www.wikidata.org/wiki/Q7307572","display_name":"Refractory (planetary science)","level":2,"score":0.46800270676612854},{"id":"https://openalex.org/C2777583451","wikidata":"https://www.wikidata.org/wiki/Q177094","display_name":"Imatinib","level":3,"score":0.1655227541923523},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C87355193","wikidata":"https://www.wikidata.org/wiki/Q411","display_name":"Astrobiology","level":1,"score":0.0},{"id":"https://openalex.org/C2778729363","wikidata":"https://www.wikidata.org/wiki/Q11688946","display_name":"Myeloid leukemia","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000068877","descriptor_name":"Imatinib Mesylate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010879","descriptor_name":"Piperazines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D011743","descriptor_name":"Pyrimidines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.7326/0003-4819-145-2-200607180-00020","doi":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","is_oa":false,"landing_page_url":"https://doi.org/10.7326/0003-4819-145-2-200607180-00020","pdf_url":null,"source":{"id":"https://openalex.org/S119722071","display_name":"Annals of Internal Medicine","issn_l":"0003-4819","issn":["0003-4819","1539-3704"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310316812","host_organization_name":"American College of Physicians","host_organization_lineage":["https://openalex.org/P4310316812"],"host_organization_lineage_names":["American College of Physicians"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Internal Medicine","raw_type":"journal-article"},{"id":"pmid:16847299","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16847299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of internal medicine","raw_type":"Case Reports"},{"id":"pmh:oai:bibmed.ucla.edu.ve:T070000063264/14","doi":null,"is_oa":false,"landing_page_url":"http://bibmed.ucla.edu.ve/cgi-win/be_alex.exe?Acceso=T070000063264/14&Nombrebd=bmucla","pdf_url":null,"source":{"id":"https://openalex.org/S7407064131","display_name":"UCLA - Biblioteca de Ciencias de la Salud","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I19325673","host_organization_name":"Universidad Centroccidental Lisandro Alvarado","host_organization_lineage":["https://openalex.org/I19325673"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":10,"referenced_works":["https://openalex.org/W1983657617","https://openalex.org/W1987031019","https://openalex.org/W2020924652","https://openalex.org/W2036199559","https://openalex.org/W2065613113","https://openalex.org/W2072860615","https://openalex.org/W2112604150","https://openalex.org/W2121376498","https://openalex.org/W2147944062","https://openalex.org/W2166028076"],"related_works":["https://openalex.org/W2036199559","https://openalex.org/W2322900403","https://openalex.org/W2096128609","https://openalex.org/W2031414702","https://openalex.org/W2016332264","https://openalex.org/W1899260817","https://openalex.org/W2128796651","https://openalex.org/W1979770196","https://openalex.org/W2169963968","https://openalex.org/W2023462472"],"abstract_inverted_index":{"Letters18":[0],"July":[1,1349,1363,1368],"2006Imatinib":[2],"Mesylate":[3,637,648,989,1035],"in":[4,102,287,434,449,490,519,534,579,607,625,638,661,684,692,734,740,746,767,799,845,850,857,880,892,896,913,967,981,986,1006,1015,1050,1076,1090,1111,1125,1137,1161,1202,1208,1217,1249,1256,1274,1295,1321,1328],"the":[5,254,385,467,563,593,603,608,670,755,828,842,922,1016,1042,1051,1064,1091,1152,1239,1275,1333,1336],"Treatment":[6,455,526,594,609,726,982,1052,1065],"of":[7,91,197,256,292,322,375,387,393,432,445,456,470,517,524,538,543,549,557,565,595,610,620,633,658,666,679,688,710,713,727,731,742,750,757,779,801,808,821,830,909,918,924,950,962,983,1002,1012,1018,1033,1045,1053,1066,1084,1093,1103,1118,1154,1184,1225,1229,1238,1244,1253,1261,1279,1325,1335,1378],"Refractory":[8],"Idiopathic":[9,82,1218],"Pulmonary":[10,394,450,457,528,535,544,554,567,576,580,586,596,600,640,653,685,714,728,748,751,797,814,823,893,897,933,969,973,1009,1059,1067,1140,1158,1186,1219,1227,1257,1281,1287,1296,1322,1346],"Arterial":[11,395,458,536,545,555,568,577,581,587,597,654,686,729,824,868,894,898,974,1010,1068,1220,1258,1288,1297],"HypertensionKaren":[12],"C.":[13,29,343],"Patterson,":[14,30,344],"MD,":[15,18,22,40,50,348,352],"Ariel":[16,38,346],"Weissmann,":[17,39,347],"MPH,":[19],"Tahamtan":[20,48,350],"Ahmadi,":[21,49,351],"PhD,":[23],"and":[24,58,70,101,111,118,124,147,176,195,295,339,390,404,424,466,515,531,547,571,599,697,722,789,816,848,864,873,907,958,971,977,1058,1086,1099,1109,1176,1188,1193,1198,1215,1232,1277,1291],"Harrison":[25,59,354],"W.":[26,60,355],"Farber,":[27,61,356],"MDKaren":[28],"MDFrom":[31,62],"Boston":[32,42,52,63,359],"Medical":[33,43,53,64,360],"Center,":[34,44,54,65,361],"Boston,":[35,45,55,66,362],"MA":[36,46,56,67,363],"02118.,":[37,47,57],"MPHFrom":[41],"PhDFrom":[51],"02118.Author,":[68],"Article,":[69,338],"Disclosure":[71,340],"Informationhttps://doi.org/10.7326/0003-4819-145-2-200607180-00020":[72],"SectionsAboutFull":[73],"TextPDF":[74],"ToolsAdd":[75],"to":[76,108,140,150,499,871,904,946,993,1074,1151,1268,1285],"favoritesDownload":[77],"CitationsTrack":[78],"CitationsPermissions":[79],"ShareFacebookTwitterLinkedInRedditEmail":[80],"Background:":[81],"pulmonary":[83,201,234,257,289,324,380,409,414,485,491,501,511,520,622,644,718,737,758,769,782,784,802,831,851,858,938,1019,1023,1071,1094,1127,1147,1155,1162,1203,1209,1254,1326,1340],"arterial":[84,202,235,258,381,410,415,460,486,492,512,521,623,719,738,759,785,803,833,859,939,1020,1024,1095,1128,1148,1156,1163,1171,1204,1210,1311,1341],"hypertension":[85,325,461,624,739,804,834,1025,1072],"(PAH)":[86],"is":[87],"a":[88,129,204,429,435,479,1077,1134,1245,1250,1265],"pathologic":[89],"process":[90],"inappropriate":[92],"vasoconstriction,":[93],"vascular":[94,157,677,770,1262],"remodeling":[95,856],"with":[96,131,163,615,627,675,805,836,841,885,901,1027,1079,1114],"smooth":[97,503,853,1106,1199],"muscle":[98,504,854,1107,1200,1359],"cell":[99,505,1191],"hypertrophy,":[100],"situ":[103],"thrombosis,":[104],"which":[105,154],"eventually":[106],"leads":[107],"right-heart":[109,177],"failure":[110],"death.":[112],"Current":[113,721],"treatments":[114,642,788,985,1338],"primarily":[115],"attenuate":[116],"vasoconstriction":[117],"do":[119],"not":[120,138],"substantially":[121],"reduce":[122],"morbidity":[123],"mortality":[125],"rates.Objective:":[126],"To":[127],"describe":[128],"patient":[130,1078],"severe,":[132],"refractory":[133],"idiopathic":[134,166],"PAH":[135,167],"that":[136],"did":[137,144],"respond":[139],"conventional":[141],"treatment":[142,255,373,756,829,866,1017],"but":[143],"show":[145],"clinical":[146],"hemodynamic":[148],"response":[149],"imatinib":[151,412,433,518,1013,1123],"mesylate":[152,753,1014,1124],"therapy,":[153],"may":[155],"affect":[156],"remodeling.Case":[158],"Report:":[159],"A":[160,417,664,1142,1271],"52-year-old":[161],"man":[162],"rapidly":[164],"progressive":[165,171],"was":[168],"evaluated":[169],"for":[170,200,233,253,408,413,454,482,509,527,553,575,585,592,635,643,652,754,827,937,1022,1063,1145,1339],"dyspnea":[172],"on":[173,401,669,810,921,932,943,1036,1236],"exertion.":[174],"Echocardiography":[175],"catheterization":[178],"...References1.":[179],"Tapson":[180],"VF,":[181],"Gomberg-Maitland":[182],"M,":[183,270,274,318],"McLaughlin":[184],"VV,":[185],"Benza":[186],"RL,":[187],"Widlitz":[188],"AC,":[189],"Krichman":[190],"A,":[191,221,276],"et":[192,228,281,319,929,1300],"al.":[193,229,282,320],"Safety":[194,548],"efficacy":[196,516],"IV":[198],"treprostinil":[199],"hypertension:":[203,290,382,416,645,720,786,860,940,1096,1312],"prospective,":[205],"multicenter,":[206],"open-label,":[207],"12-week":[208],"trial.":[209],"Chest.":[210],"2006;129:683-8.":[211],"[PMID:":[212,242,265,303,333],"16537868]":[213],"CrossrefMedlineGoogle":[214,244,267,335],"Scholar2.":[215],"Galie":[216],"N,":[217],"Ghofrani":[218,246,311],"HA,":[219,247,312],"Torbicki":[220],"Barst":[222],"RJ,":[223],"Rubin":[224],"LJ,":[225],"Badesch":[226],"D,":[227],"Sildenafil":[230],"citrate":[231],"therapy":[232],"hypertension.":[236,259],"N":[237,260],"Engl":[238,261],"J":[239,262,329],"Med.":[240,263],"2005;353:2148-57.":[241],"16291984]":[243],"Scholar3.":[245],"Seeger":[248],"W,":[249],"Grimminger":[250],"F.":[251],"Imatinib":[252,551,636,1034,1284],"2005;353:1412-3.":[264],"16192491]":[266],"Scholar4.":[268],"Humbert":[269],"Monti":[271],"G,":[272],"Fartoukh":[273],"Magnan":[275],"Brenot":[277],"F,":[278],"Rain":[279],"B,":[280],"Platelet-derived":[283],"growth":[284,764,1130],"factor":[285,765,1131],"expression":[286,496],"primary":[288],"comparison":[291],"HIV":[293,296],"seropositive":[294],"seronegative":[297],"patients.":[298],"Eur":[299],"Respir":[300],"J.":[301],"1998;11:554-9.":[302],"9596101]":[304],"MedlineGoogle":[305],"Scholar5.":[306],"Schermuly":[307],"RT,":[308],"Dony":[309],"E,":[310],"Pullamsetti":[313],"S,":[314],"Savai":[315],"R,":[316],"Roth":[317],"Reversal":[321],"experimental":[323],"by":[326,397,997,1122,1180,1375],"PDGF":[327,604,732],"inhibition.":[328],"Clin":[330],"Invest.":[331],"2005;115:2811-21.":[332],"16200212]":[334],"Scholar":[336],"Author,":[337],"InformationAuthors:":[341],"Karen":[342],"MD;":[345],"MPH;":[349],"PhD;":[353],"MDAffiliations:":[357],"From":[358],"02118.Disclosures:":[364],"None":[365],"disclosed.":[366],"PreviousarticleNextarticle":[367],"Advertisement":[368],"FiguresReferencesRelatedDetails":[369],"Metrics":[370],"Cited":[371],"byThe":[372],"strategy":[374],"connective":[376],"tissue":[377],"disease":[378],"associated":[379,835,1026],"Evolving":[383],"into":[384,476,560],"futureIdentification":[386],"Signal":[388],"Pathways":[389],"Hub":[391],"Genes":[392],"Hypertension":[396,598,613,869,899,934,1187,1259,1347],"Bioinformatic":[398],"AnalysisComprehensive":[399],"review":[400],"novel":[402,777,1266],"targets":[403,1160],"emerging":[405],"therapeutic":[406,480,1135,1314],"modalities":[407],"HypertensionPositioning":[411],"phase":[418],"I/II":[419],"design":[420],"comprising":[421],"dose":[422],"finding":[423],"single\u2010arm":[425],"efficacyIntracerebral":[426],"hemorrhage":[427],"as":[428,478,649,776,1133,1264],"rare":[430],"complication":[431],"Philadelphia":[436],"chromosome":[437],"positive":[438],"acute":[439],"lymphoblastic":[440],"leukemia":[441],"pediatric":[442],"patientTherapeutic":[443],"Potential":[444,992],"Regorafenib\u2014A":[446],"Multikinase":[447],"Inhibitor":[448],"HypertensionNovel":[451],"Experimental":[452,639,747,968,1185,1222],"Therapies":[453,530],"HypertensionPulmonary":[459],"specific":[462],"therapy:":[463],"The":[464,991,999],"old":[465],"newMuscle":[468],"Toxicity":[469],"Drugs:":[471],"When":[472],"Drugs":[473,570,691],"Turn":[474],"Physiology":[475],"PathophysiologyKIT":[477],"target":[481,1136],"non-oncological":[483],"diseasesDasatinib-induced":[484],"hypertensionIdentifying":[487],"\"super":[488],"responders\"":[489],"hypertensionPDGF":[493],"induces":[494],"SphK1":[495],"via":[497],"Egr-1":[498],"promote":[500],"artery":[502,852],"proliferationNovel":[506],"investigational":[507],"therapies":[508,936],"treating":[510,1269],"hypertensionLong-term":[513],"safety":[514],"hypertensionNovel":[522,1149],"Targets":[523],"Drug":[525],"HypertensionEmerging":[529],"Future":[532],"Directions":[533],"HypertensionTreatment":[537,749],"Chronic":[539,1046],"Right":[540,589],"Heart":[541],"FailurePathogenesis":[542],"HypertensionEfficacy":[546],"Long-Term":[550],"Therapy":[552,651,911],"HypertensionDelivery":[556],"Imatinib-Incorporated":[558],"Nanoparticles":[559],"Lungs":[561],"Suppresses":[562],"Development":[564],"Monocrotaline-Induced":[566],"HypertensionExisting":[569],"Agents":[572],"Under":[573],"Investigation":[574],"HypertensionImatinib":[578,752,895],"Hypertension:":[582,1141],"C\u2010Kit":[583],"InhibitionTreatment":[584],"Hypertension\u2013Associated":[588],"Ventricular":[590],"DysfunctionImatinib":[591],"Capillary":[601,1323],"HemangiomatosisTargeting":[602],"Signaling":[605,683],"Pathway":[606],"Non-Malignant":[611],"DiseasesPulmonary":[612,876],"Associated":[614,1345],"Connective":[616],"Tissue":[617,1343],"DiseaseThe":[618],"challenge":[619],"managing":[621],"adults":[626],"congenital":[628],"heart":[629],"diseaseA":[630],"Lymphocyte-Dependent":[631],"Mode":[632],"Action":[634],"HypertensionPharmacologic":[641],"exploring":[646],"pharmacogenomicsImatinib":[647],"Add-on":[650],"HypertensionImpression,":[655],"SunsetTherapeutic":[656],"Inhibition":[657,966,1179],"Tyrosine":[659,744,1175],"Kinases":[660,745],"Systemic":[662,914,1054],"Sclerosis:":[663],"Review":[665,709],"Published":[667],"Experience":[668],"First":[671],"108":[672],"Patients":[673,693,900,1007],"Treated":[674],"ImatinibPulmonary":[676],"pathologyTargeting":[678],"Platelet-Derived":[680,1003],"Growth":[681,964,1004,1056,1212,1317],"Factor":[682,965,1005,1213,1318],"HypertensionMonitoring":[687],"Nonsteroidal":[689],"Immunosuppressive":[690,910],"With":[694,1008,1283],"Lung":[695,698],"Disease":[696,1344],"Transplant":[699],"RecipientsApplications":[700],"th\u00e9rapeutiques":[701],"non":[702],"oncologiques":[703],"des":[704],"th\u00e9rapies":[705],"mol\u00e9culaires":[706,1301],"cibl\u00e9esA":[707],"Process\u2010Based":[708],"Mouse":[711],"Models":[712],"HypertensionWHO":[715],"Group":[716],"1":[717],"investigative":[723],"therapiesThe":[724],"Pharmacological":[725],"HypertensionImplication":[730],"signaling":[733,847],"cigarette":[735],"smoke-induced":[736],"ratRole":[741],"Src":[743],"hypertensionHypoxia-inducible":[760],"factor-1":[761],"\u03b1/platelet":[762],"derived":[763],"axis":[766],"HIV-associated":[768],"remodelingMulti":[771],"tyrosine":[772,886],"kinase":[773,887],"inhibitor":[774],"dasatinib":[775,1075],"cause":[778],"severe":[780,1070],"pre-capillary":[781],"hypertension?Treating":[783],"current":[787,944,1097,1313],"future":[790,1100],"prospectsTyrosine":[791],"Kinase":[792,1178],"Inhibitors":[793],"Are":[794],"Potent":[795],"Acute":[796,822],"Vasodilators":[798],"RatsTreatment":[800],"targeted":[806],"therapiesEffect":[807],"Cocaine":[809],"Human":[811],"Immunodeficiency":[812],"Virus\u2013Mediated":[813],"Endothelial":[815],"Smooth":[817],"Muscle":[818],"DysfunctionThe":[819],"Management":[820,1278],"HypertensionNew":[825],"perspectives":[826],"hypertensionPulmonary":[832],"systemic":[837,881,925,987,1028,1138,1329],"sclerosisSerotonin":[838],"transporter":[839],"interacts":[840],"PDGF\u03b2":[843],"receptor":[844,960,1088],"PDGF-BB-induced":[846],"mitogenesis":[849],"cellsVascular":[855],"Multiple":[861],"cancer-like":[862],"pathways":[863],"possible":[865],"modalitiesPulmonary":[867],"Related":[870],"Scleroderma":[872],"Collagen":[874],"Vascular":[875,1060],"Veno-occlusive":[877],"DiseaseLung":[878],"involvement":[879],"sclerosisTargeting":[882],"non-malignant":[883],"disorders":[884],"inhibitorsReversible":[888],"or":[889],"Irreversible":[890],"Remodeling":[891],"Inadequate":[902],"Response":[903],"Established":[905],"TherapyToxicity":[906],"Monitoring":[908],"Used":[912],"Autoimmune":[915],"DiseasesThe":[916],"impact":[917],"Fli1":[919],"deficiency":[920],"pathogenesis":[923],"sclerosisHypertension":[926],"art\u00e9rielle":[927,1304,1309],"pulmonaire":[928],"h\u00e9mopathies":[930],"malignesUpdate":[931],"2009New":[935],"an":[941],"update":[942],"bench":[945],"bedside":[947],"translationThe":[948],"role":[949],"calcium":[951],"channel":[952],"blockers,":[953],"steroids,":[954],"anticoagulation,":[955],"antiplatelet":[956],"drugs,":[957],"endothelin":[959,1087],"antagonistsRole":[961],"Epidermal":[963],"HypertensionIdiopathic":[970],"Familial":[972],"HypertensionPDGF":[975],"Receptor":[976],"its":[978],"Antagonists:":[979],"Role":[980],"PAHFuture":[984],"sclerosisImatinib":[988],"Has":[990],"Exert":[994],"Its":[995],"Efficacy":[996],"Down-Regulating":[998],"Plasma":[1000],"Concentration":[1001],"HypertensionEvaluation":[1011],"hypertensionTherapy":[1021],"sclerosisTherapie":[1029],"der":[1030],"pulmonalarteriellen":[1031],"HypertonieEffects":[1032],"Renin\u2013Angiotensin":[1037],"System":[1038],"(RAS)":[1039],"Activity":[1040],"during":[1041],"Clinical":[1043,1293],"Course":[1044],"Myeloid":[1047],"LeukaemiaRecent":[1048],"Advances":[1049],"SclerosisInflammation,":[1055],"Factors,":[1057],"RemodelingFuture":[1061],"Perspectives":[1062],"HypertensionReversible":[1069],"secondary":[1073],"chronic":[1080],"myeloid":[1081],"leukemiaThe":[1082],"science":[1083],"endothelin-1":[1085],"antagonists":[1089],"management":[1092],"understanding":[1098],"studiesProliferative":[1101],"capacity":[1102],"vein":[1104],"graft":[1105,1115],"cells":[1108,1201],"fibroblasts":[1110],"vitro":[1112],"correlates":[1113],"stenosisSignificant":[1116],"improvement":[1117],"right":[1119],"ventricular":[1120],"function":[1121],"scleroderma-associated":[1126],"hypertensionTransforming":[1129],"\u03b2":[1132],"sclerosisPediatric":[1139],"Pharmacotherapeutic":[1143],"ReviewTherapies":[1144],"scleroderma-related":[1146],"approaches":[1150],"pharmacotherapy":[1153],"hypertensionChronic":[1157],"HypertensionTherapeutic":[1159],"hypertensionExperiencia":[1164],"en":[1165],"el":[1166],"tratamiento":[1167],"de":[1168,1302,1307],"la":[1169],"hipertensi\u00f3n":[1170],"pulmonar":[1172],"con":[1173],"imatinibCombined":[1174],"Serine/Threonine":[1177],"Sorafenib":[1181],"Prevents":[1182],"Progression":[1183],"Myocardial":[1189],"RemodelingEndothelial":[1190],"dysfunction":[1192],"cross":[1194],"talk":[1195],"between":[1196],"endothelium":[1197],"hypertensionReview:":[1205],"Therapeutic":[1206],"advances":[1207],"hypertensionPlatelet-derived":[1211],"Expression":[1214],"Function":[1216],"HypertensionAn":[1221],"Animal":[1223],"Model":[1224],"Postobstructive":[1226],"HypertensionEffects":[1228],"external":[1230],"wrapping":[1231],"increased":[1233],"blood":[1234],"flow":[1235],"atrophy":[1237,1263],"baboon":[1240],"iliac":[1241],"arteryGenomic":[1242],"assessment":[1243],"multikinase":[1246],"inhibitor,":[1247],"sorafenib,":[1248],"rodent":[1251],"model":[1252],"hypertensionUpdate":[1255],"2007Induction":[1260],"approach":[1267],"restenosis.":[1270],"reviewNew":[1272],"Developments":[1273],"Pathogenesis":[1276],"Neonatal":[1280],"HypertensionExperience":[1282],"Treat":[1286],"HypertensionPhase":[1289],"2":[1290],"3":[1292],"Trials":[1294],"HypertensionBases":[1298],"cellulaires":[1299],"l'hypertension":[1303,1308],"pulmonaireTraitement":[1305],"m\u00e9dical":[1306],"pulmonairePulmonary":[1310],"strategiesAtrial":[1315],"SeptostomyPlatelet-Derived":[1316],"Is":[1319],"Increased":[1320],"HemangiomatosisTreatment":[1324],"fibrosis":[1327],"sclerosis:":[1330],"Light":[1331],"at":[1332],"end":[1334],"tunnel?Emerging":[1337],"hypertensionConnective":[1342],"18":[1348,1362,1367],"2006Volume":[1350],"145,":[1351],"Issue":[1352,1365],"2Page:":[1353],"152-153KeywordsDeath":[1354],"ratesGlobal":[1355],"healthMorbidityOxygenPulmonary":[1356],"arteriesPulmonary":[1357],"hypertensionSmooth":[1358],"cellsThrombosisVasoconstrictionVasodilators":[1360],"ePublished:":[1361],"2006":[1364,1369,1374],"Published:":[1366],"Copyright":[1370],"&":[1371],"PermissionsCopyright":[1372],"\u00a9":[1373],"American":[1376],"College":[1377],"Physicians.":[1379],"All":[1380],"Rights":[1381],"Reserved.PDF":[1382],"downloadLoading":[1383],"...":[1384]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":11},{"year":2012,"cited_by_count":14}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}
