{"id":"https://openalex.org/W2003142837","doi":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","title":"Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome","display_name":"Laboratory diagnosis of the antiphospholipid syndrome: a plethora of obstacles to overcome","publication_year":2009,"publication_date":"2009-02-17","ids":{"openalex":"https://openalex.org/W2003142837","doi":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","mag":"2003142837","pmid":"https://pubmed.ncbi.nlm.nih.gov/19226362"},"language":"en","primary_location":{"id":"doi:10.1111/j.1600-0609.2009.01243.x","doi":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0609.2009.01243.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0609.2009.01243.x","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5071705224","display_name":"Katrien M.J. Devreese","orcid":"https://orcid.org/0000-0002-7559-2579","observed_orcids":["https://orcid.org/0000-0002-7559-2579"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Katrien Devreese","raw_affiliation_strings":["Department of Clinical Chemistry, Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium. katrien.devreese@uzgent.be","Coagulation Laboratory, Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Chemistry, Coagulation Laboratory, Ghent University Hospital, Ghent, Belgium. katrien.devreese@uzgent.be","institution_ids":["https://openalex.org/I2801227569"]},{"raw_affiliation_string":"Coagulation Laboratory, Department of Clinical Chemistry, Microbiology, and Immunology, Ghent University Hospital, Ghent","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5006329944","display_name":"Marc Hoylaerts","orcid":"https://orcid.org/0000-0002-6474-3933","observed_orcids":["https://orcid.org/0000-0002-6474-3933"]},"institutions":[{"id":"https://openalex.org/I99464096","display_name":"KU Leuven","ror":"https://ror.org/05f950310","country_code":"BE","type":"education","lineage":["https://openalex.org/I99464096"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Marc F. Hoylaerts","raw_affiliation_strings":["Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium","institution_ids":["https://openalex.org/I99464096"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5071705224"],"corresponding_institution_ids":["https://openalex.org/I2801227569"],"apc_list":{"value":4650,"currency":"USD","value_usd":4650},"apc_paid":null,"fwci":5.8365,"has_fulltext":true,"cited_by_count":79,"citation_normalized_percentile":{"value":0.96261187,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"83","issue":"1","first_page":"1","last_page":"16"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10697","display_name":"Vasculitis and related conditions","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiphospholipid-syndrome","display_name":"antiphospholipid syndrome","score":0.9950000047683716},{"id":"https://openalex.org/keywords/antiphospholipid-antibodies","display_name":"antiphospholipid antibodies","score":0.902999997138977},{"id":"https://openalex.org/keywords/lupus-anticoagulant","display_name":"lupus anticoagulant","score":0.972000002861023},{"id":"https://openalex.org/keywords/laboratory-diagnosis","display_name":"laboratory diagnosis","score":0.9330000281333923},{"id":"https://openalex.org/keywords/sapporo-criteria","display_name":"Sapporo criteria","score":0.9639999866485596},{"id":"https://openalex.org/keywords/venous-thrombosis","display_name":"venous thrombosis","score":0.7710000276565552},{"id":"https://openalex.org/keywords/pregnancy-morbidity","display_name":"pregnancy morbidity","score":0.9279999732971191},{"id":"https://openalex.org/keywords/diagnostic-criteria","display_name":"diagnostic criteria","score":0.421999990940094},{"id":"https://openalex.org/keywords/laboratory-guidelines","display_name":"laboratory guidelines","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2776874634","wikidata":"https://www.wikidata.org/wiki/Q582207","display_name":"Antiphospholipid syndrome","level":3,"score":0.8716241121292114},{"id":"https://openalex.org/C2780022809","wikidata":"https://www.wikidata.org/wiki/Q5786759","display_name":"Lupus anticoagulant","level":3,"score":0.7769957780838013},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7580916881561279},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5923997163772583},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3770493268966675},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.32821184396743774},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3067959249019623}],"mesh":[{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001780","descriptor_name":"Blood Coagulation Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D004797","descriptor_name":"Enzyme-Linked Immunosorbent Assay","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011247","descriptor_name":"Pregnancy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012698","descriptor_name":"Serologic Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D012698","descriptor_name":"Serologic Tests","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D016682","descriptor_name":"Lupus Coagulation Inhibitor","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D016736","descriptor_name":"Antiphospholipid Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017152","descriptor_name":"Antibodies, Antiphospholipid","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1600-0609.2009.01243.x","doi":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0609.2009.01243.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},{"id":"pmid:19226362","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19226362","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European journal of haematology","raw_type":"Comparative Study"},{"id":"pmh:oai:archive.ugent.be:877284","doi":null,"is_oa":false,"landing_page_url":"https://biblio.ugent.be/publication/877284","pdf_url":null,"source":{"id":"https://openalex.org/S4306400478","display_name":"Ghent University Academic Bibliography (Ghent University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I32597200","host_organization_name":"Ghent University","host_organization_lineage":["https://openalex.org/I32597200"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN: 0902-4441","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1111/j.1600-0609.2009.01243.x","doi":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","is_oa":true,"landing_page_url":"https://doi.org/10.1111/j.1600-0609.2009.01243.x","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/j.1600-0609.2009.01243.x","source":{"id":"https://openalex.org/S159715054","display_name":"European Journal Of Haematology","issn_l":"0902-4441","issn":["0902-4441","1600-0609"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Journal of Haematology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320890","display_name":"Fondation Leducq","ror":"https://ror.org/01czwga19"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003142837.pdf","grobid_xml":"https://content.openalex.org/works/W2003142837.grobid-xml"},"referenced_works_count":118,"referenced_works":["https://openalex.org/W6119856","https://openalex.org/W100923001","https://openalex.org/W120343659","https://openalex.org/W203063431","https://openalex.org/W1488742384","https://openalex.org/W1506022441","https://openalex.org/W1507631870","https://openalex.org/W1510973863","https://openalex.org/W1573826699","https://openalex.org/W1604069935","https://openalex.org/W1753709933","https://openalex.org/W1836279654","https://openalex.org/W1837307598","https://openalex.org/W1837874984","https://openalex.org/W1856856308","https://openalex.org/W1922522961","https://openalex.org/W1926091065","https://openalex.org/W1927965016","https://openalex.org/W1953041691","https://openalex.org/W1963752281","https://openalex.org/W1965771173","https://openalex.org/W1966816249","https://openalex.org/W1969799426","https://openalex.org/W1971498975","https://openalex.org/W1975691738","https://openalex.org/W1976378461","https://openalex.org/W1977161453","https://openalex.org/W1980096532","https://openalex.org/W1981539235","https://openalex.org/W1988239216","https://openalex.org/W1988521312","https://openalex.org/W1991721757","https://openalex.org/W1992650827","https://openalex.org/W1996195830","https://openalex.org/W2001576342","https://openalex.org/W2001864923","https://openalex.org/W2002029553","https://openalex.org/W2011800549","https://openalex.org/W2012170918","https://openalex.org/W2015068969","https://openalex.org/W2015162021","https://openalex.org/W2019788447","https://openalex.org/W2020466018","https://openalex.org/W2022339909","https://openalex.org/W2023377316","https://openalex.org/W2029246409","https://openalex.org/W2029444930","https://openalex.org/W2030638382","https://openalex.org/W2035425054","https://openalex.org/W2035922913","https://openalex.org/W2038609233","https://openalex.org/W2038610371","https://openalex.org/W2041919675","https://openalex.org/W2043079180","https://openalex.org/W2043451614","https://openalex.org/W2044043417","https://openalex.org/W2046220427","https://openalex.org/W2046433232","https://openalex.org/W2048370365","https://openalex.org/W2049179400","https://openalex.org/W2049561149","https://openalex.org/W2049562629","https://openalex.org/W2049637515","https://openalex.org/W2050253806","https://openalex.org/W2054330426","https://openalex.org/W2055791340","https://openalex.org/W2056248535","https://openalex.org/W2056708575","https://openalex.org/W2059163354","https://openalex.org/W2060235689","https://openalex.org/W2062466582","https://openalex.org/W2064072392","https://openalex.org/W2068646829","https://openalex.org/W2070685533","https://openalex.org/W2072635751","https://openalex.org/W2074683983","https://openalex.org/W2074735065","https://openalex.org/W2077094496","https://openalex.org/W2077800201","https://openalex.org/W2079155196","https://openalex.org/W2080268645","https://openalex.org/W2084234423","https://openalex.org/W2087646765","https://openalex.org/W2094859214","https://openalex.org/W2095982855","https://openalex.org/W2097202341","https://openalex.org/W2097487666","https://openalex.org/W2099286273","https://openalex.org/W2100680349","https://openalex.org/W2105534574","https://openalex.org/W2110803155","https://openalex.org/W2110832637","https://openalex.org/W2111238248","https://openalex.org/W2113097329","https://openalex.org/W2119768870","https://openalex.org/W2123780397","https://openalex.org/W2125864147","https://openalex.org/W2130794902","https://openalex.org/W2132421890","https://openalex.org/W2134355273","https://openalex.org/W2134407598","https://openalex.org/W2134906267","https://openalex.org/W2136734845","https://openalex.org/W2137951823","https://openalex.org/W2143086319","https://openalex.org/W2146146405","https://openalex.org/W2146466204","https://openalex.org/W2148265494","https://openalex.org/W2151857581","https://openalex.org/W2152169495","https://openalex.org/W2161048162","https://openalex.org/W2172282476","https://openalex.org/W2179951463","https://openalex.org/W2411625707","https://openalex.org/W2415213344","https://openalex.org/W4296981399","https://openalex.org/W4323283585","https://openalex.org/W4324264884"],"related_works":["https://openalex.org/W2144827646","https://openalex.org/W2468680936","https://openalex.org/W4223978464","https://openalex.org/W2977867744","https://openalex.org/W2161234546","https://openalex.org/W1993871310","https://openalex.org/W2791992225","https://openalex.org/W3045625076","https://openalex.org/W4412693574","https://openalex.org/W3035635782"],"abstract_inverted_index":{"The":[0,53,95,125],"antiphospholipid":[1,18],"antibody":[2],"syndrome":[3],"(APS)":[4],"is":[5],"defined":[6,60],"by":[7],"two":[8],"major":[9],"elements:":[10],"the":[11,21,39,43,48,69,88,104,109,112,121,130,141],"presence":[12],"in":[13,66,68,81,97,140],"plasma":[14],"of":[15,23,41,51,76,85,91,108,111,123,129,143],"auto-antibodies,":[16],"i.e.":[17],"antibodies":[19],"and":[20,56,106,127],"occurrence":[22],"clinical":[24,55],"features,":[25],"categorised":[26],"as":[27,115],"vascular":[28],"thrombosis":[29],"or":[30],"pregnancy":[31],"morbidity.":[32],"In":[33],"contrast":[34],"to":[35],"recent":[36],"reviews":[37],"on":[38,47,87,103],"physiopathology":[40,142],"APS,":[42],"present":[44],"review":[45,99],"focuses":[46],"laboratory":[49,57,89,118,132],"diagnosis":[50,90,122],"APS.":[52,124,144],"original":[54],"criteria":[58,78],"that":[59],"patients":[61],"with":[62],"APS":[63,92],"were":[64],"set":[65],"1998":[67],"so-called":[70],"Sapporo":[71],"criteria.":[72],"Although":[73],"a":[74,83],"revision":[75],"these":[77],"was":[79],"published":[80],"2006,":[82],"number":[84],"questions":[86],"remain":[93],"unresolved.":[94],"highlight":[96],"this":[98],"will":[100],"therefore":[101],"be":[102],"potential":[105],"limitations":[107],"detection":[110],"lupus":[113],"anticoagulant,":[114],"an":[116],"established":[117],"criterion":[119],"for":[120],"strengths":[126],"weaknesses":[128],"current":[131,138],"guidelines":[133],"are":[134],"discussed":[135],"against":[136],"our":[137],"insight":[139]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":10}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}