{"id":"https://openalex.org/W2003137448","doi":"https://doi.org/10.1248/cpb.55.372","title":"Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines","display_name":"Synthesis and Evaluation of Adenosine Antagonist Activity of a Series of [1,2,4]Triazolo[1,5-c]quinazolines","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2003137448","doi":"https://doi.org/10.1248/cpb.55.372","mag":"2003137448","pmid":"https://pubmed.ncbi.nlm.nih.gov/17329874"},"language":"en","primary_location":{"id":"doi:10.1248/cpb.55.372","doi":"https://doi.org/10.1248/cpb.55.372","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.55.372","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/55/3/55_3_372/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2003137448"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.jstage.jst.go.jp/article/cpb/55/3/55_3_372/_pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011176168","display_name":"Carmen Balo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen Balo","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100719792","display_name":"Carmen L\u00f3pez","orcid":"https://orcid.org/0000-0003-1417-3087","observed_orcids":["https://orcid.org/0000-0003-1417-3087"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carmen L\u00f3pez","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058712463","display_name":"Jose Manuel Brea","orcid":"https://orcid.org/0000-0002-5523-1979","observed_orcids":["https://orcid.org/0000-0002-5523-1979"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Manuel Brea","raw_affiliation_strings":["Departamento de Farmacolog\u00eda, Facultade de Farmacia, Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Farmacolog\u00eda, Facultade de Farmacia, Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5097144103","display_name":"Franco Fern\u00e1nde","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Franco Fern\u00e1nde","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5056553288","display_name":"Olga Caama\u00f1o","orcid":"https://orcid.org/0000-0001-9213-4636","observed_orcids":["https://orcid.org/0000-0001-9213-4636"]},"institutions":[{"id":"https://openalex.org/I200284239","display_name":"Universidade de Santiago de Compostela","ror":"https://ror.org/030eybx10","country_code":"ES","type":"education","lineage":["https://openalex.org/I200284239"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Olga Caama\u00f1o","raw_affiliation_strings":["Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departamento de Qu\u00edmica Org\u00e1nica, Facultade de Farmacia, Universidade de Santiago de Compostela","institution_ids":["https://openalex.org/I200284239"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I200284239"],"apc_list":null,"apc_paid":null,"fwci":0.9569,"has_fulltext":true,"cited_by_count":28,"citation_normalized_percentile":{"value":0.65335052,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"55","issue":"3","first_page":"372","last_page":"375"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11193","display_name":"Adenosine and Purinergic Signaling","score":0.8984000086784363,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14099","display_name":"Synthesis and Characterization of Heterocyclic Compounds","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12318","display_name":"Quinazolinone synthesis and applications","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/adenosine-receptor-antagonists","display_name":"adenosine receptor antagonists","score":0.8740000128746033},{"id":"https://openalex.org/keywords/adenosine-a2a-receptor","display_name":"adenosine A2A receptor","score":0.9670000076293945},{"id":"https://openalex.org/keywords/adenosine-a2b-receptor","display_name":"adenosine A2B receptor","score":1.0},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.8960000276565552},{"id":"https://openalex.org/keywords/heterocycle-synthesis","display_name":"heterocyclic synthesis","score":0.8659999966621399}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.9619731307029724},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.6663718819618225},{"id":"https://openalex.org/C67907053","wikidata":"https://www.wikidata.org/wiki/Q356147","display_name":"Adenosine receptor","level":4,"score":0.6587502956390381},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.6403993368148804},{"id":"https://openalex.org/C2780283098","wikidata":"https://www.wikidata.org/wiki/Q4688960","display_name":"Affinities","level":2,"score":0.6115999221801758},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5936194062232971},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5501042008399963},{"id":"https://openalex.org/C2776991684","wikidata":"https://www.wikidata.org/wiki/Q190012","display_name":"Adenosine","level":2,"score":0.5136870741844177},{"id":"https://openalex.org/C2778491162","wikidata":"https://www.wikidata.org/wiki/Q3063865","display_name":"Adenosine A2A receptor","level":5,"score":0.4747388958930969},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3214718699455261},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2497280240058899},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.05516350269317627},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011799","descriptor_name":"Quinazolines","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D043704","descriptor_name":"Receptor, Adenosine A2B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043704","descriptor_name":"Receptor, Adenosine A2B","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D043705","descriptor_name":"Receptor, Adenosine A2A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D043705","descriptor_name":"Receptor, Adenosine A2A","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058917","descriptor_name":"Adenosine A2 Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1248/cpb.55.372","doi":"https://doi.org/10.1248/cpb.55.372","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.55.372","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/55/3/55_3_372/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},{"id":"pmid:17329874","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17329874","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical & pharmaceutical bulletin","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1248/cpb.55.372","doi":"https://doi.org/10.1248/cpb.55.372","is_oa":true,"landing_page_url":"https://doi.org/10.1248/cpb.55.372","pdf_url":"https://www.jstage.jst.go.jp/article/cpb/55/3/55_3_372/_pdf","source":{"id":"https://openalex.org/S3861430","display_name":"Chemical and Pharmaceutical Bulletin","issn_l":"0009-2363","issn":["0009-2363","1347-5223"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310313382","host_organization_name":"Pharmaceutical Society of Japan","host_organization_lineage":["https://openalex.org/P4310313382"],"host_organization_lineage_names":["Pharmaceutical Society of Japan"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical and Pharmaceutical Bulletin","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5683000087738037,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003137448.pdf","grobid_xml":"https://content.openalex.org/works/W2003137448.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1490279270","https://openalex.org/W1965631010","https://openalex.org/W1969266962","https://openalex.org/W1993879912","https://openalex.org/W2027274772","https://openalex.org/W2038863059","https://openalex.org/W2046467234","https://openalex.org/W2050237873","https://openalex.org/W2093356686","https://openalex.org/W2106861254","https://openalex.org/W2116418941","https://openalex.org/W2123829225","https://openalex.org/W2159187513","https://openalex.org/W2173637498","https://openalex.org/W2415704481","https://openalex.org/W4233297510"],"related_works":["https://openalex.org/W1979896546","https://openalex.org/W2514194550","https://openalex.org/W2912879925","https://openalex.org/W1979587158","https://openalex.org/W1998521433","https://openalex.org/W2034658253","https://openalex.org/W2005762428","https://openalex.org/W2101540378","https://openalex.org/W1975237626","https://openalex.org/W4235215414"],"abstract_inverted_index":{"A":[0],"series":[1],"of":[2,11,14,19,38,62,69],"[1,2,4]triazolo[1,5-c]quinazolines":[3],"were":[4,35],"prepared":[5],"in":[6],"satisfactory":[7],"yields":[8],"by":[9],"reaction":[10],"some":[12],"derivatives":[13],"2-aminobenzohydrazide":[15],"with":[16],"several":[17],"hydrochlorides":[18],"aromatic":[20],"amidines,":[21],"and":[22,32],"their":[23],"binding":[24],"affinities":[25],"for":[26,45,53,67],"the":[27,39,54,70],"recombinant":[28],"human":[29],"adenosine":[30],"A2A":[31,55],"A2B":[33],"receptors":[34],"determined.":[36],"None":[37],"new":[40],"compounds":[41],"showed":[42],"noteworthy":[43],"affinity":[44,52],"these":[46],"receptors,":[47],"though":[48],"a":[49,59],"very":[50],"high":[51,60],"receptor":[56],"and,":[57],"consequently,":[58],"level":[61],"A2A/A2B":[63],"selectivity":[64],"was":[65],"revealed":[66],"one":[68],"synthesized":[71],"compounds.":[72]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}
