{"id":"https://openalex.org/W2003137409","doi":"https://doi.org/10.1139/y94-011","title":"Effect of extracellular Ca2+ on indomethacin-induced injury to rabbit dispersed gastric mucosal cells","display_name":"Effect of extracellular Ca2+ on indomethacin-induced injury to rabbit dispersed gastric mucosal cells","publication_year":1994,"publication_date":"1994-01-01","ids":{"openalex":"https://openalex.org/W2003137409","doi":"https://doi.org/10.1139/y94-011","mag":"2003137409","pmid":"https://pubmed.ncbi.nlm.nih.gov/8012901"},"language":"en","primary_location":{"id":"doi:10.1139/y94-011","doi":"https://doi.org/10.1139/y94-011","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y94-011","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112349319","display_name":"Barry L. Tepperman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I125749732","display_name":"Western University","ror":"https://ror.org/02grkyz14","country_code":"CA","type":"education","lineage":["https://openalex.org/I125749732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"B. L. Tepperman","raw_affiliation_strings":["Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada","institution_ids":["https://openalex.org/I125749732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108288677","display_name":"B. D. Soper","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"B. D. Soper","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.1918,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.77882163,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"72","issue":"1","first_page":"63","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.98580002784729,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10276","display_name":"Helicobacter pylori-related gastroenterology studies","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/indomethacin","display_name":"indomethacin","score":0.9919999837875366},{"id":"https://openalex.org/keywords/gastric-mucosal-injury","display_name":"gastric mucosal injury","score":0.7710000276565552},{"id":"https://openalex.org/keywords/extracellular-calcium","display_name":"extracellular calcium","score":0.9440000057220459},{"id":"https://openalex.org/keywords/a23187","display_name":"A23187","score":0.9190000295639038},{"id":"https://openalex.org/keywords/verapamil","display_name":"verapamil","score":0.9190000295639038},{"id":"https://openalex.org/keywords/calcium-channel-blockade","display_name":"calcium channel blockade","score":0.6060000061988831},{"id":"https://openalex.org/keywords/intracellular-calcium","display_name":"intracellular calcium","score":0.9079999923706055},{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":0.8679999709129333},{"id":"https://openalex.org/keywords/lysosomal-enzyme-release","display_name":"lysosomal enzyme release","score":0.824999988079071},{"id":"https://openalex.org/keywords/acid-phosphatase","display_name":"acid phosphatase","score":0.9589999914169312},{"id":"https://openalex.org/keywords/drug-induced-gastric-injury","display_name":"drug-induced gastric injury","score":0.5329999923706055}],"concepts":[{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.8313196301460266},{"id":"https://openalex.org/C2780070996","wikidata":"https://www.wikidata.org/wiki/Q61482373","display_name":"Trypan blue","level":3,"score":0.8060932159423828},{"id":"https://openalex.org/C2777022698","wikidata":"https://www.wikidata.org/wiki/Q410291","display_name":"Verapamil","level":3,"score":0.7619175314903259},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5249617099761963},{"id":"https://openalex.org/C25642318","wikidata":"https://www.wikidata.org/wiki/Q1992532","display_name":"Incubation","level":2,"score":0.5152409672737122},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.41604018211364746},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3865056335926056},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.38432595133781433},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3695099353790283},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.36414003372192383},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.2653220295906067},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23831936717033386},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.13058418035507202},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000001","descriptor_name":"Calcimycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000135","descriptor_name":"Acid Phosphatase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005753","descriptor_name":"Gastric Mucosa","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007213","descriptor_name":"Indomethacin","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D010741","descriptor_name":"Phospholipases A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011453","descriptor_name":"Prostaglandins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014343","descriptor_name":"Trypan Blue","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014700","descriptor_name":"Verapamil","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015064","descriptor_name":"16,16-Dimethylprostaglandin E2","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016718","descriptor_name":"Arachidonic Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1139/y94-011","doi":"https://doi.org/10.1139/y94-011","is_oa":false,"landing_page_url":"https://doi.org/10.1139/y94-011","pdf_url":null,"source":{"id":"https://openalex.org/S82722058","display_name":"Canadian Journal of Physiology and Pharmacology","issn_l":"0008-4212","issn":["0008-4212","1205-7541"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310312929","host_organization_name":"Canadian Science Publishing","host_organization_lineage":["https://openalex.org/P4310312929"],"host_organization_lineage_names":["Canadian Science Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian Journal of Physiology and Pharmacology","raw_type":"journal-article"},{"id":"pmid:8012901","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/8012901","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Canadian journal of physiology and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8999999761581421}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320324195","display_name":"Medical Research Council Canada","ror":"https://ror.org/01gavpb45"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2226506925","https://openalex.org/W2416671681","https://openalex.org/W2021508856","https://openalex.org/W2010321222","https://openalex.org/W149330456","https://openalex.org/W2070913905","https://openalex.org/W1966622947","https://openalex.org/W2080586480","https://openalex.org/W4234224686","https://openalex.org/W1972317944"],"abstract_inverted_index":{"The":[0,77,106],"effects":[1],"of":[2,32,45,85,89,108,115,152,178],"extracellular":[3,188],"Ca2+":[4,47,116,125,148,192],"on":[5],"indomethacin-induced":[6,134,176,197],"disruption":[7,26,80,177],"to":[8,58,83,184,196,199],"rabbit":[9],"dispersed":[10],"gastric":[11,179,200],"mucosal":[12,18,180,201],"cells":[13,19,86,153,181],"have":[14],"been":[15],"examined.":[16],"Fundic":[17],"were":[20,27,103],"isolated,":[21],"and":[22,25,38,51,54,69,91,133,141,167],"cellular":[23,79,165],"viability":[24],"assessed":[28],"by":[29,39,113],"the":[30,33,46,59,75,101,118,124,168],"release":[31,68],"lysosomal":[34],"enzyme":[35,66],"acid":[36],"phosphatase":[37],"trypan":[40,70],"blue":[41,71],"dye":[42,72],"exclusion.":[43],"Addition":[44],"ionophore":[48],"A23187":[49,92,138],"(12.5":[50],"25":[52],"microM)":[53,57,130,140,144,158,163],"indomethacin":[55,90,142,161],"(0.1-10":[56,157],"incubation":[60,84,119],"medium":[61],"induced":[62,164],"concentration-dependent":[63],"increases":[64],"in":[65,74,81,170],"marker":[67],"uptake":[73],"cells.":[76,202],"resultant":[78],"response":[82],"with":[87,123,154],"combinations":[88],"was":[93,111],"not":[94],"significantly":[95],"different":[96],"from":[97,117],"that":[98,175],"observed":[99],"when":[100],"agents":[102],"administered":[104],"separately.":[105],"degree":[107],"cell":[109,135],"injury":[110],"reduced":[112,131,159],"removal":[114],"medium.":[120],"Similarly":[121],"preincubation":[122],"channel":[126],"antagonist":[127],"verapamil":[128],"(1":[129],"A23187-":[132],"injury.":[136],"Both":[137],"(25":[139],"(10":[143,162],"treatments":[145],"increased":[146],"cytosolic":[147],"concentration":[149],"([Ca2+]i).":[150],"Pretreatment":[151],"16,16-dimethylprostaglandin":[155],"E2":[156],"both":[160],"damage":[166,198],"elevation":[169],"[Ca2+]i.":[171],"These":[172],"data":[173],"suggest":[174],"is":[182],"dependent":[183],"some":[185],"extent":[186],"upon":[187],"Ca2+.":[189],"An":[190],"inappropriate":[191],"flux":[193],"may":[194],"contribute":[195]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}