{"id":"https://openalex.org/W2003125553","doi":"https://doi.org/10.1016/j.neuroscience.2010.11.012","title":"Effect of chronic pain on morphine-induced respiratory depression in mice","display_name":"Effect of chronic pain on morphine-induced respiratory depression in mice","publication_year":2010,"publication_date":"2010-11-15","ids":{"openalex":"https://openalex.org/W2003125553","doi":"https://doi.org/10.1016/j.neuroscience.2010.11.012","mag":"2003125553","pmid":"https://pubmed.ncbi.nlm.nih.gov/21081158"},"language":"en","primary_location":{"id":"doi:10.1016/j.neuroscience.2010.11.012","doi":"https://doi.org/10.1016/j.neuroscience.2010.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2010.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://teikyo-u.repo.nii.ac.jp/records/2019265","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5110072645","display_name":"Junzo Kamei","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"J. Kamei","raw_affiliation_strings":["Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-Chome, Shinagawa-Ku, Tokyo 142-8501, Japan. kamei@hoshi.ac.jp","Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-Chome, Shinagawa-Ku, Tokyo 142-8501, Japan. kamei@hoshi.ac.jp","institution_ids":["https://openalex.org/I36296616"]},{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071224187","display_name":"Masahiro Ohsawa","orcid":"https://orcid.org/0000-0003-4108-2500","observed_orcids":["https://orcid.org/0000-0003-4108-2500"]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"M. Ohsawa","raw_affiliation_strings":["Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113560546","display_name":"Shun-suke Hayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"S.-S. Hayashi","raw_affiliation_strings":["Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]},{"author_position":"last","author":{"id":null,"display_name":"Y. Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36296616","display_name":"Hoshi University","ror":"https://ror.org/01mrvbd33","country_code":"JP","type":"education","lineage":["https://openalex.org/I36296616"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Y. Nakanishi","raw_affiliation_strings":["Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathophysiology and Therapeutics, School of Pharmacy and Pharmaceutical Sciences, Hoshi University, 4-41, Ebara 2-chome, Shinagawa-ku, Tokyo 142-8501, Japan","institution_ids":["https://openalex.org/I36296616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I36296616"],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":0.891,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.6853339,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"174","issue":null,"first_page":"224","last_page":"233"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11456","display_name":"Neuroscience of respiration and sleep","score":0.573199987411499,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.2386000007390976,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.11309999972581863,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.8360000252723694},{"id":"https://openalex.org/keywords/morphine","display_name":"morphine","score":0.9459999799728394},{"id":"https://openalex.org/keywords/respiratory-depression","display_name":"respiratory depression","score":0.7910000085830688},{"id":"https://openalex.org/keywords/opioid-side-effects","display_name":"opioid side effects","score":0.8799999952316284},{"id":"https://openalex.org/keywords/5-ht4-receptor","display_name":"5-HT4 receptor","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mosapride","display_name":"mosapride","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tidal-volume","display_name":"tidal volume","score":0.8199999928474426},{"id":"https://openalex.org/keywords/minute-ventilation","display_name":"minute ventilation","score":0.8759999871253967},{"id":"https://openalex.org/keywords/respiratory-rate","display_name":"respiratory rate","score":0.9660000205039978},{"id":"https://openalex.org/keywords/nerve-ligation","display_name":"nerve ligation","score":0.8429999947547913},{"id":"https://openalex.org/keywords/brainstem","display_name":"brainstem","score":0.8069999814033508},{"id":"https://openalex.org/keywords/plethysmography","display_name":"plethysmography","score":0.7850000262260437}],"concepts":[{"id":"https://openalex.org/C2777389121","wikidata":"https://www.wikidata.org/wiki/Q81225","display_name":"Morphine","level":2,"score":0.7656518220901489},{"id":"https://openalex.org/C534529494","wikidata":"https://www.wikidata.org/wiki/Q7891","display_name":"Respiratory system","level":2,"score":0.6860560178756714},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6220852136611938},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5858343839645386},{"id":"https://openalex.org/C2781063702","wikidata":"https://www.wikidata.org/wiki/Q427523","display_name":"Opioid","level":3,"score":0.521870493888855},{"id":"https://openalex.org/C2778938600","wikidata":"https://www.wikidata.org/wiki/Q389934","display_name":"Agonist","level":3,"score":0.47786539793014526},{"id":"https://openalex.org/C551621295","wikidata":"https://www.wikidata.org/wiki/Q182228","display_name":"Brainstem","level":2,"score":0.4446415305137634},{"id":"https://openalex.org/C2777257755","wikidata":"https://www.wikidata.org/wiki/Q3493813","display_name":"Tidal volume","level":3,"score":0.44452381134033203},{"id":"https://openalex.org/C14397066","wikidata":"https://www.wikidata.org/wiki/Q14911924","display_name":"\u03bc-opioid receptor","level":4,"score":0.42014622688293457},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.394523948431015},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.38205140829086304},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3684123754501343},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3516273498535156}],"mesh":[{"descriptor_ui":"D000701","descriptor_name":"Analgesics, Opioid","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001549","descriptor_name":"Benzamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001933","descriptor_name":"Brain Stem","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002908","descriptor_name":"Chronic Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007211","descriptor_name":"Indoles","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008026","descriptor_name":"Ligation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009020","descriptor_name":"Morphine","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D009025","descriptor_name":"Morpholines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010146","descriptor_name":"Pain","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D010523","descriptor_name":"Peripheral Nervous System Diseases","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D012119","descriptor_name":"Respiration","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D012131","descriptor_name":"Respiratory Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012584","descriptor_name":"Sciatic Nerve","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":false},{"descriptor_ui":"D013449","descriptor_name":"Sulfonamides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044422","descriptor_name":"Receptors, Serotonin, 5-HT4","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058828","descriptor_name":"Serotonin 5-HT4 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D058832","descriptor_name":"Serotonin 5-HT4 Receptor Antagonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1016/j.neuroscience.2010.11.012","doi":"https://doi.org/10.1016/j.neuroscience.2010.11.012","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.neuroscience.2010.11.012","pdf_url":null,"source":{"id":"https://openalex.org/S30122339","display_name":"Neuroscience","issn_l":"0306-4522","issn":["0306-4522","1873-7544"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"journal-article"},{"id":"pmid:21081158","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21081158","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Neuroscience","raw_type":"Journal Article"},{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006734357","doi":null,"is_oa":true,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2019265","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal article"}],"best_oa_location":{"id":"pmh:oai:irdb.nii.ac.jp:00953:0006734357","doi":null,"is_oa":true,"landing_page_url":"https://teikyo-u.repo.nii.ac.jp/records/2019265","pdf_url":null,"source":{"id":"https://openalex.org/S7407056385","display_name":"Institutional Repositories DataBase (IRDB)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I184597095","host_organization_name":"National Institute of Informatics","host_organization_lineage":["https://openalex.org/I184597095"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Neuroscience","raw_type":"journal article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":67,"referenced_works":["https://openalex.org/W1486894689","https://openalex.org/W1560498709","https://openalex.org/W1635543723","https://openalex.org/W1643041936","https://openalex.org/W1828538530","https://openalex.org/W1920209237","https://openalex.org/W1965063801","https://openalex.org/W1965070710","https://openalex.org/W1965169739","https://openalex.org/W1965201205","https://openalex.org/W1967546795","https://openalex.org/W1968967467","https://openalex.org/W1972504341","https://openalex.org/W1972576960","https://openalex.org/W1974669292","https://openalex.org/W1979639875","https://openalex.org/W1985522462","https://openalex.org/W1987052599","https://openalex.org/W1988034711","https://openalex.org/W1993893814","https://openalex.org/W1997670741","https://openalex.org/W1999140395","https://openalex.org/W2000744528","https://openalex.org/W2006410388","https://openalex.org/W2014007136","https://openalex.org/W2020460680","https://openalex.org/W2022131604","https://openalex.org/W2023867415","https://openalex.org/W2025276797","https://openalex.org/W2029909904","https://openalex.org/W2030195620","https://openalex.org/W2030759164","https://openalex.org/W2031811175","https://openalex.org/W2033603525","https://openalex.org/W2040540166","https://openalex.org/W2044364976","https://openalex.org/W2052881256","https://openalex.org/W2062426538","https://openalex.org/W2064153996","https://openalex.org/W2067924690","https://openalex.org/W2069344808","https://openalex.org/W2072827946","https://openalex.org/W2075936963","https://openalex.org/W2077185029","https://openalex.org/W2078169449","https://openalex.org/W2079279101","https://openalex.org/W2083207935","https://openalex.org/W2086255598","https://openalex.org/W2091199925","https://openalex.org/W2092984973","https://openalex.org/W2094215072","https://openalex.org/W2101199014","https://openalex.org/W2120457258","https://openalex.org/W2123491442","https://openalex.org/W2127687530","https://openalex.org/W2128168215","https://openalex.org/W2139453672","https://openalex.org/W2143325670","https://openalex.org/W2146631034","https://openalex.org/W2151527826","https://openalex.org/W2159395955","https://openalex.org/W2161934021","https://openalex.org/W2163547524","https://openalex.org/W2171037951","https://openalex.org/W2260556967","https://openalex.org/W2413369383","https://openalex.org/W2419338750"],"related_works":["https://openalex.org/W2073376991","https://openalex.org/W2326268982","https://openalex.org/W1974669292","https://openalex.org/W1972576960","https://openalex.org/W2040627091","https://openalex.org/W3176216012","https://openalex.org/W2223342695","https://openalex.org/W2151727962","https://openalex.org/W7160859006","https://openalex.org/W2022131604"],"abstract_inverted_index":null,"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}