{"id":"https://openalex.org/W2003117865","doi":"https://doi.org/10.1016/s0960-894x(03)00347-0","title":"d-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety","display_name":"d-Phe-Pro-Arg type thrombin inhibitors: unexpected selectivity by modification of the P1 moiety","publication_year":2003,"publication_date":"2003-05-12","ids":{"openalex":"https://openalex.org/W2003117865","doi":"https://doi.org/10.1016/s0960-894x(03)00347-0","mag":"2003117865","pmid":"https://pubmed.ncbi.nlm.nih.gov/12781189"},"language":"en","primary_location":{"id":"doi:10.1016/s0960-894x(03)00347-0","doi":"https://doi.org/10.1016/s0960-894x(03)00347-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(03)00347-0","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002395814","display_name":"Udo E. W. Lange","orcid":"https://orcid.org/0000-0003-1609-4120","observed_orcids":["https://orcid.org/0000-0003-1609-4120"]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Udo E.W Lange","raw_affiliation_strings":["BASF AG, D-67056, Ludwigshafen, Germany. wolfgang.hoeffken@basf-ag.de","BASF AG, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF AG, D-67056, Ludwigshafen, Germany. wolfgang.hoeffken@basf-ag.de","institution_ids":["https://openalex.org/I4210107087"]},{"raw_affiliation_string":"BASF AG, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054329693","display_name":"Dorit Baucke","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Dorit Baucke","raw_affiliation_strings":["BASF AG, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF AG, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088204264","display_name":"Wilfried Hornberger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126753","display_name":"Abbott (Germany)","ror":"https://ror.org/02x2gk324","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088555","https://openalex.org/I4210126753"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wilfried Hornberger","raw_affiliation_strings":["Abbott GmbH & Co. KG, D-67061 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott GmbH & Co. KG, D-67061 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210126753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109425927","display_name":"Helmut Mack","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126753","display_name":"Abbott (Germany)","ror":"https://ror.org/02x2gk324","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210088555","https://openalex.org/I4210126753"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Helmut Mack","raw_affiliation_strings":["Abbott GmbH & Co. KG, D-67061 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Abbott GmbH & Co. KG, D-67061 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210126753"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032740362","display_name":"Werner Seitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Werner Seitz","raw_affiliation_strings":["BASF AG, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF AG, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5062955299","display_name":"Hans Wolfgang H\u00f6ffken","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210107087","display_name":"BASF (Germany)","ror":"https://ror.org/01q8f6705","country_code":"DE","type":"company","lineage":["https://openalex.org/I4210107087"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"H.Wolfgang H\u00f6ffken","raw_affiliation_strings":["BASF AG, D-67056 Ludwigshafen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"BASF AG, D-67056 Ludwigshafen, Germany","institution_ids":["https://openalex.org/I4210107087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5002395814"],"corresponding_institution_ids":["https://openalex.org/I4210107087"],"apc_list":{"value":3880,"currency":"USD","value_usd":3880},"apc_paid":null,"fwci":0.8529,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.72588664,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":93},"biblio":{"volume":"13","issue":"12","first_page":"2029","last_page":"2033"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10881","display_name":"Blood Coagulation and Thrombosis Mechanisms","score":0.9560999870300293,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.03180000185966492,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10274","display_name":"Heterocyclic Compound Synthesis and Bioactivity","score":0.0034000000450760126,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thrombin-inhibitors","display_name":"thrombin inhibitors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/protein-ligand-binding-mode","display_name":"protein-ligand binding mode","score":0.6480000019073486},{"id":"https://openalex.org/keywords/peptide-synthesis","display_name":"peptide synthesis","score":0.37400001287460327}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.934775710105896},{"id":"https://openalex.org/C2776568683","wikidata":"https://www.wikidata.org/wiki/Q23005640","display_name":"Moiety","level":2,"score":0.8951324820518494},{"id":"https://openalex.org/C2777292125","wikidata":"https://www.wikidata.org/wiki/Q409166","display_name":"Thrombin","level":3,"score":0.8895710110664368},{"id":"https://openalex.org/C118792377","wikidata":"https://www.wikidata.org/wiki/Q108584245","display_name":"Selectivity","level":3,"score":0.8571930527687073},{"id":"https://openalex.org/C57002609","wikidata":"https://www.wikidata.org/wiki/Q5281999","display_name":"Discovery and development of direct thrombin inhibitors","level":4,"score":0.7519305944442749},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5605345964431763},{"id":"https://openalex.org/C2776980637","wikidata":"https://www.wikidata.org/wiki/Q427492","display_name":"Enzyme inhibitor","level":3,"score":0.4510969817638397},{"id":"https://openalex.org/C2780340462","wikidata":"https://www.wikidata.org/wiki/Q127450","display_name":"Trypsin","level":3,"score":0.4400288462638855},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3478282392024994},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.33583781123161316},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.28250652551651},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.07008516788482666},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.05372580885887146},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D009842","descriptor_name":"Oligopeptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013379","descriptor_name":"Substrate Specificity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D013917","descriptor_name":"Thrombin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014361","descriptor_name":"Trypsin Inhibitors","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015195","descriptor_name":"Drug Design","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018360","descriptor_name":"Crystallography, X-Ray","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1016/s0960-894x(03)00347-0","doi":"https://doi.org/10.1016/s0960-894x(03)00347-0","is_oa":false,"landing_page_url":"https://doi.org/10.1016/s0960-894x(03)00347-0","pdf_url":null,"source":{"id":"https://openalex.org/S30970080","display_name":"Bioorganic & Medicinal Chemistry Letters","issn_l":"0960-894X","issn":["0960-894X","1464-3405"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic &amp; Medicinal Chemistry Letters","raw_type":"journal-article"},{"id":"pmid:12781189","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12781189","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioorganic & medicinal chemistry letters","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W1518197977","https://openalex.org/W1775065314","https://openalex.org/W1985469117","https://openalex.org/W1986430846","https://openalex.org/W1993336603","https://openalex.org/W2009943025","https://openalex.org/W2028015715","https://openalex.org/W2052881139","https://openalex.org/W2069377150","https://openalex.org/W2118918180","https://openalex.org/W2122520819","https://openalex.org/W2140748973","https://openalex.org/W2142820798","https://openalex.org/W2950897182","https://openalex.org/W2952583697"],"related_works":["https://openalex.org/W2022149323","https://openalex.org/W2018907977","https://openalex.org/W2174441395","https://openalex.org/W2033496659","https://openalex.org/W2073915431","https://openalex.org/W2000208080","https://openalex.org/W1973737489","https://openalex.org/W2917028849","https://openalex.org/W2240180620","https://openalex.org/W2040957525"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
