{"id":"https://openalex.org/W2003117759","doi":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","title":"Twenty-one hormones fail to inhibit the brain to blood transport system for Tyr-MIF-1 and the enkephalins in mice","display_name":"Twenty-one hormones fail to inhibit the brain to blood transport system for Tyr-MIF-1 and the enkephalins in mice","publication_year":1988,"publication_date":"1988-04-01","ids":{"openalex":"https://openalex.org/W2003117759","doi":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","mag":"2003117759","pmid":"https://pubmed.ncbi.nlm.nih.gov/2900314"},"language":"en","primary_location":{"id":"doi:10.1111/j.2042-7158.1988.tb05248.x","doi":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054959155","display_name":"William A. Banks","orcid":"https://orcid.org/0000-0002-0496-3619","observed_orcids":["https://orcid.org/0000-0002-0496-3619"]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"William A Banks","raw_affiliation_strings":["Veterans Administration Medical Center (151) and Tulane University School of Medicine , 1601 Perdido St., New Orleans, LA 70146,","Veterans Administration Medical Center (151) and Tulane University School of Medicine, 1601 Perdido St., New Orleans, LA 70146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration Medical Center (151) and Tulane University School of Medicine , 1601 Perdido St., New Orleans, LA 70146,","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Veterans Administration Medical Center (151) and Tulane University School of Medicine, 1601 Perdido St., New Orleans, LA 70146, USA","institution_ids":["https://openalex.org/I114832834"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032152107","display_name":"Abba J. Kastin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I114832834","display_name":"Tulane University","ror":"https://ror.org/04vmvtb21","country_code":"US","type":"education","lineage":["https://openalex.org/I114832834"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Abba J Kastin","raw_affiliation_strings":["Veterans Administration Medical Center (151) and Tulane University School of Medicine , 1601 Perdido St., New Orleans, LA 70146,","Veterans Administration Medical Center (151) and Tulane University School of Medicine, 1601 Perdido St., New Orleans, LA 70146, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Veterans Administration Medical Center (151) and Tulane University School of Medicine , 1601 Perdido St., New Orleans, LA 70146,","institution_ids":["https://openalex.org/I114832834"]},{"raw_affiliation_string":"Veterans Administration Medical Center (151) and Tulane University School of Medicine, 1601 Perdido St., New Orleans, LA 70146, USA","institution_ids":["https://openalex.org/I114832834"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5054959155"],"corresponding_institution_ids":["https://openalex.org/I114832834"],"apc_list":{"value":2911,"currency":"GBP","value_usd":3839},"apc_paid":null,"fwci":1.5673,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.81360805,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"40","issue":"4","first_page":"289","last_page":"291"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11872","display_name":"Barrier Structure and Function Studies","score":0.8711000084877014,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10814","display_name":"Neuropeptides and Animal Physiology","score":0.04769999906420708,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tyr-mif-1","display_name":"Tyr-MIF-1","score":0.972000002861023},{"id":"https://openalex.org/keywords/met-enkephalin","display_name":"met-enkephalin","score":0.9670000076293945},{"id":"https://openalex.org/keywords/blood-brain-barrier","display_name":"blood-brain barrier","score":0.7099999785423279},{"id":"https://openalex.org/keywords/peptide-transport","display_name":"peptide transport","score":0.6370000243186951},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.4950000047683716},{"id":"https://openalex.org/keywords/enkephalin","display_name":"enkephalin","score":0.6620000004768372}],"concepts":[{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.7163681983947754},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.5807129144668579},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43086445331573486},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.40313974022865295},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3433957099914551},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2936730682849884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2586709260940552},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.24250683188438416}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001812","descriptor_name":"Blood-Brain Barrier","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004745","descriptor_name":"Enkephalins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D006728","descriptor_name":"Hormones","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009075","descriptor_name":"MSH Release-Inhibiting Hormone","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D009075","descriptor_name":"MSH Release-Inhibiting Hormone","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.2042-7158.1988.tb05248.x","doi":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.2042-7158.1988.tb05248.x","pdf_url":null,"source":{"id":"https://openalex.org/S118304455","display_name":"Journal of Pharmacy and Pharmacology","issn_l":"0022-3573","issn":["0022-3573","2042-7158"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Pharmacy and Pharmacology","raw_type":"journal-article"},{"id":"pmid:2900314","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/2900314","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pharmacy and pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8960000276565552}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W109177298","https://openalex.org/W1539556724","https://openalex.org/W1799890456","https://openalex.org/W1972671726","https://openalex.org/W1975774424","https://openalex.org/W1978134963","https://openalex.org/W1978469480","https://openalex.org/W1984959935","https://openalex.org/W1998411920","https://openalex.org/W2001694851","https://openalex.org/W2009658745","https://openalex.org/W2011761626","https://openalex.org/W2014724311","https://openalex.org/W2026545417","https://openalex.org/W2032377813","https://openalex.org/W2033278281","https://openalex.org/W2033912043","https://openalex.org/W2052184389","https://openalex.org/W2057526688","https://openalex.org/W2254240946","https://openalex.org/W2315066199"],"related_works":["https://openalex.org/W2060060795","https://openalex.org/W2051333269","https://openalex.org/W1996836354","https://openalex.org/W2013739117","https://openalex.org/W2073877913","https://openalex.org/W1126274060","https://openalex.org/W1886831098","https://openalex.org/W2016606361","https://openalex.org/W1986431519","https://openalex.org/W2081983412"],"abstract_inverted_index":{"Tyr-MIF-1":[0,49],"(Tyr-Pro-Leu-Gly-amide)":[1],"and":[2,30,37,50,70],"methionine":[3],"enkephalin":[4],"are":[5],"transported":[6],"intact":[7],"across":[8],"the":[9,42,51,88,105,108,134],"blood-brain":[10],"barrier":[11],"by":[12,25,31,82],"a":[13,26],"saturable,":[14],"stereospecific":[15],"system.":[16,137],"This":[17],"system":[18],"has":[19],"been":[20],"found":[21],"to":[22,48,79,117,122,131],"be":[23,55,100],"modulated":[24],"few":[27],"non-peptide":[28],"substances":[29,106,114],"certain":[32],"conditions":[33],"such":[34],"as":[35,119],"ageing":[36],"some":[38],"stresses.":[39],"We":[40],"investigated":[41],"possibility":[43],"that":[44],"hormones":[45,62],"structurally":[46],"unrelated":[47],"enkephalins":[52],"might":[53],"also":[54],"capable":[56],"of":[57,104,112],"modulating":[58],"this":[59],"transport.":[60],"Twenty-one":[61],"were":[63],"tested":[64],"including":[65],"steroids,":[66],"proteins,":[67],"glycoproteins,":[68],"peptides,":[69],"thyroid":[71],"hormones,":[72],"in":[73],"doses":[74,109],"ranging":[75],"from":[76],"0.01":[77],"pmol":[78],"1":[80],"nmol/mouse":[81],"injecting":[83],"each":[84],"hormone":[85],"directly":[86],"into":[87],"lateral":[89],"ventricle":[90],"simultaneously":[91],"with":[92,128],"[125I]Tyr-MIF-1.":[93],"No":[94],"clear":[95],"effect":[96],"on":[97],"transport":[98,126,136],"could":[99],"established":[101],"for":[102],"any":[103],"at":[107],"tested.":[110],"None":[111],"these":[113],"seemed":[115],"able":[116],"act":[118],"competitive":[120],"inhibitors,":[121],"share":[123],"their":[124],"respective":[125],"systems":[127],"Tyr-MIF-1,":[129],"or":[130],"modulate":[132],"immediately":[133],"saturable":[135]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}