{"id":"https://openalex.org/W2003116247","doi":"https://doi.org/10.1179/174327807x238909","title":"Biodegradation mechanisms of polyurethane elastomers","display_name":"Biodegradation mechanisms of polyurethane elastomers","publication_year":2007,"publication_date":"2007-12-01","ids":{"openalex":"https://openalex.org/W2003116247","doi":"https://doi.org/10.1179/174327807x238909","mag":"2003116247"},"language":"en","primary_location":{"id":"doi:10.1179/174327807x238909","doi":"https://doi.org/10.1179/174327807x238909","is_oa":false,"landing_page_url":"https://doi.org/10.1179/174327807x238909","pdf_url":null,"source":{"id":"https://openalex.org/S38341973","display_name":"Corrosion Engineering Science and Technology The International Journal of Corrosion Processes and Corrosion Control","issn_l":"1478-422X","issn":["1478-422X","1743-2782"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Corrosion Engineering, Science and Technology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5047588685","display_name":"Elizabeth M. Christenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I74775410","display_name":"Rice University","ror":"https://ror.org/008zs3103","country_code":"US","type":"education","lineage":["https://openalex.org/I74775410"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. M. Christenson","raw_affiliation_strings":["**Rice University;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"**Rice University;","institution_ids":["https://openalex.org/I74775410"]}]},{"author_position":"middle","author":{"id":null,"display_name":"J. M. Anderson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4390039247","display_name":"Case Comprehensive Cancer Center","ror":"https://ror.org/00fpjq451","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4390039247","https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"J. M. Anderson","raw_affiliation_strings":["Case Comprehensive Cancer Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Comprehensive Cancer Center","institution_ids":["https://openalex.org/I4390039247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110162087","display_name":"Ann Hiltner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A. Hiltner","raw_affiliation_strings":["Case Western Reserve University ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Case Western Reserve University ,","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.5979,"has_fulltext":false,"cited_by_count":154,"citation_normalized_percentile":{"value":0.78818081,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"42","issue":"4","first_page":"312","last_page":"323"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10661","display_name":"biodegradable polymer synthesis and properties","score":0.9818999767303467,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10859","display_name":"Polymer Surface Interaction Studies","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2508","display_name":"Surfaces, Coatings and Films"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10343","display_name":"Hydrogels: synthesis, properties, applications","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/polyurethane-biodegradation","display_name":"polyurethane biodegradation","score":0.9620000123977661},{"id":"https://openalex.org/keywords/polyurethane-elastomers","display_name":"polyurethane elastomers","score":0.8529999852180481},{"id":"https://openalex.org/keywords/biostability","display_name":"biostability","score":0.6869999766349792},{"id":"https://openalex.org/keywords/polycarbonate-urethane","display_name":"polycarbonate urethane","score":0.8500000238418579},{"id":"https://openalex.org/keywords/poly-ether-urethane","display_name":"polyether polyurethane","score":0.8550000190734863},{"id":"https://openalex.org/keywords/oxidative-degradation","display_name":"oxidative degradation","score":0.7730000019073486},{"id":"https://openalex.org/keywords/hydrolytic-degradation","display_name":"hydrolytic degradation","score":0.8880000114440918},{"id":"https://openalex.org/keywords/cholesterol-esterase","display_name":"cholesterol esterase","score":0.8920000195503235},{"id":"https://openalex.org/keywords/chain-scission","display_name":"chain scission","score":0.8790000081062317},{"id":"https://openalex.org/keywords/cross-linking","display_name":"crosslinking","score":0.9480000138282776},{"id":"https://openalex.org/keywords/accelerated-degradation","display_name":"accelerated degradation","score":0.4449999928474426},{"id":"https://openalex.org/keywords/explanted-implants","display_name":"explanted implants","score":0.4819999933242798},{"id":"https://openalex.org/keywords/pacemaker-leads","display_name":"pacemaker leads","score":0.8740000128746033},{"id":"https://openalex.org/keywords/biocompatibility","display_name":"biocompatibility","score":0.5659999847412109}],"concepts":[{"id":"https://openalex.org/C157021035","wikidata":"https://www.wikidata.org/wiki/Q696715","display_name":"Biodegradation","level":2,"score":0.8904754519462585},{"id":"https://openalex.org/C2779578285","wikidata":"https://www.wikidata.org/wiki/Q146322","display_name":"Polyurethane","level":2,"score":0.8847073316574097},{"id":"https://openalex.org/C2777230088","wikidata":"https://www.wikidata.org/wiki/Q864426","display_name":"Biocompatibility","level":2,"score":0.8527584671974182},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.6509016752243042},{"id":"https://openalex.org/C38052585","wikidata":"https://www.wikidata.org/wiki/Q252266","display_name":"Elastomer","level":2,"score":0.6504024267196655},{"id":"https://openalex.org/C2779769944","wikidata":"https://www.wikidata.org/wiki/Q146439","display_name":"Silicone","level":2,"score":0.44922131299972534},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.444527804851532},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2462574541568756},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.24445390701293945},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.22782853245735168},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.2189566195011139},{"id":"https://openalex.org/C191897082","wikidata":"https://www.wikidata.org/wiki/Q11467","display_name":"Metallurgy","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1179/174327807x238909","doi":"https://doi.org/10.1179/174327807x238909","is_oa":false,"landing_page_url":"https://doi.org/10.1179/174327807x238909","pdf_url":null,"source":{"id":"https://openalex.org/S38341973","display_name":"Corrosion Engineering Science and Technology The International Journal of Corrosion Processes and Corrosion Control","issn_l":"1478-422X","issn":["1478-422X","1743-2782"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","jufo-1","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Corrosion Engineering, Science and Technology","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4000000059604645,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":37,"referenced_works":["https://openalex.org/W592618414","https://openalex.org/W613194791","https://openalex.org/W1524961740","https://openalex.org/W1570133114","https://openalex.org/W1598825449","https://openalex.org/W1966632417","https://openalex.org/W1968218735","https://openalex.org/W1974705988","https://openalex.org/W1975563012","https://openalex.org/W1976692738","https://openalex.org/W1977657698","https://openalex.org/W1983094801","https://openalex.org/W1985048604","https://openalex.org/W1994890268","https://openalex.org/W1999969083","https://openalex.org/W2022901882","https://openalex.org/W2031722693","https://openalex.org/W2032258644","https://openalex.org/W2032478134","https://openalex.org/W2038684562","https://openalex.org/W2042995201","https://openalex.org/W2049929455","https://openalex.org/W2050379989","https://openalex.org/W2051959713","https://openalex.org/W2054934288","https://openalex.org/W2059910850","https://openalex.org/W2077012531","https://openalex.org/W2093430959","https://openalex.org/W2095317259","https://openalex.org/W2103722820","https://openalex.org/W2111625223","https://openalex.org/W2117626381","https://openalex.org/W2118876290","https://openalex.org/W2138194857","https://openalex.org/W2147286676","https://openalex.org/W2150134551","https://openalex.org/W2171868192"],"related_works":["https://openalex.org/W2031722693","https://openalex.org/W2118876290","https://openalex.org/W2024915137","https://openalex.org/W2353511366","https://openalex.org/W2032236882","https://openalex.org/W1990920389","https://openalex.org/W1978953095","https://openalex.org/W1598825449","https://openalex.org/W2093430959","https://openalex.org/W1543971078"],"abstract_inverted_index":{"After":[0],"over":[1],"40":[2],"years":[3],"of":[4,12,28,46,77,87,103,114,131,135,151,156,163,208,225,227,245,260,268,307],"use":[5],"in":[6,37,161,213,249,294],"biomedical":[7,52,79],"applications,":[8],"polyurethanes":[9,80,136],"remain":[10],"one":[11],"the":[13,38,42,58,84,91,101,104,111,132,164,172,200,206,222,243,298,305,308,315],"most":[14],"popular":[15],"biomaterials":[16],"due":[17],"to":[18,60,109,179,205,238,286,291,303],"their":[19],"exceptional":[20],"biocompatibility,":[21],"mechanical":[22,73],"properties":[23],"and":[24,33,68,72,90,107,117,126,159,190,215,229,271,310],"versatility.":[25],"However,":[26],"failure":[27],"polyurethane":[29,63,88,115,165,198,210],"based":[30,122,264],"pacemaker":[31],"leads":[32],"breast":[34],"implant":[35],"coatings":[36],"late":[39],"1980s":[40],"brought":[41],"long":[43,246],"term":[44,247],"stability":[45],"these":[47,96,209,261],"implants":[48],"under":[49],"scrutiny.":[50],"The":[51,75,212,231,257,279],"device":[53],"industry":[54],"was":[55,169,202,284,301],"faced":[56],"with":[57,252],"need":[59],"find":[61],"replacement":[62,78],"compositions":[64],"that":[65,94,171],"were":[66,177,186],"biostable":[67,281],"maintained":[69],"excellent":[70,236],"biocompatibility":[71],"properties.":[74,318],"design":[76],"is":[81,274],"dependent":[82],"on":[83,123,265],"mechanistic":[85],"understanding":[86],"biodegradation":[89,116,184,226,241],"biological":[92,112],"processes":[93],"govern":[95],"mechanisms.":[97],"This":[98],"review":[99],"summarises":[100],"efforts":[102],"authors'":[105],"lab":[106],"others":[108],"elucidate":[110],"mechanisms":[113,185],"evaluate":[118],"promising":[119],"new":[120,133],"elastomers":[121,312],"poly(carbonate":[124],"urethane)":[125],"silicone":[127,299],"copolymer":[128],"chemistries.":[129],"Several":[130],"classes":[134],"reviewed":[137],"here":[138],"show":[139],"great":[140],"promise;":[141],"however,":[142],"attenuated":[143],"total":[144],"reflectance":[145],"Fourier":[146],"transform":[147],"infrared":[148],"spectroscopy":[149],"analysis":[150],"explanted":[152],"samples":[153],"provided":[154],"evidence":[155],"chain":[157,269],"scission":[158,270],"cross-linking":[160],"all":[162],"specimens.":[166],"Therefore,":[167],"it":[168],"concluded":[170,285],"chosen":[173],"soft":[174],"segment":[175],"modifications":[176],"insufficient":[178],"fully":[180],"inhibit":[181],"biodegradation.":[182],"Potential":[183],"explored":[187],"using":[188],"oxidative":[189,240],"hydrolytic":[191],"enzyme":[192],"systems.":[193],"Although":[194],"cholesterol":[195],"esterase":[196],"initiated":[197],"degradation,":[199],"effect":[201],"minimal":[203],"compared":[204],"oxidation":[207,220],"elastomers.":[211],"vivo":[214],"accelerated":[216],"degradation":[217],"studies":[218],"supported":[219],"as":[221,275],"dominant":[223],"mechanism":[224],"PEU":[228,293,309],"PCU.":[230],"H2O2/CoCl2":[232],"system":[233],"remains":[234],"an":[235],"choice":[237,290],"accelerate":[239],"for":[242],"prediction":[244],"biostability":[248,258,306],"quantitative":[250],"comparison":[251],"current":[253],"clinical":[254],"poly(ether":[255],"urethanes).":[256],"ranking":[259],"four":[262],"materials":[263],"statistical":[266],"comparisons":[267],"surface":[272],"pitting":[273],"follows:":[276],"PEU<PEU-S\u2264(":[277],"PCU<PCU-S.":[278],"more":[280],"PCU":[282,311],"elastomer":[283],"be":[287],"a":[288],"suitable":[289],"replace":[292],"medical":[295],"applications.":[296],"Furthermore,":[297],"modification":[300],"shown":[302],"increase":[304],"while":[313],"maintaining":[314],"thermoplastic":[316],"elastomeric":[317]},"counts_by_year":[{"year":2026,"cited_by_count":7},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":15},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}