{"id":"https://openalex.org/W2003087616","doi":"https://doi.org/10.1074/jbc.m111.225805","title":"Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms","display_name":"Caloric Restriction Mimetic 2-Deoxyglucose Antagonizes Doxorubicin-induced Cardiomyocyte Death by Multiple Mechanisms","publication_year":2011,"publication_date":"2011-04-27","ids":{"openalex":"https://openalex.org/W2003087616","doi":"https://doi.org/10.1074/jbc.m111.225805","mag":"2003087616","pmid":"https://pubmed.ncbi.nlm.nih.gov/21521688","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121344"},"language":"en","primary_location":{"id":"doi:10.1074/jbc.m111.225805","doi":"https://doi.org/10.1074/jbc.m111.225805","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.225805","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1074/jbc.m111.225805","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Kai Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kai Chen","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104, USA","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100963231","display_name":"Xianmin Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xianmin Xu","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Satoru Kobayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satoru Kobayashi","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113752709","display_name":"Derek J. Timm","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Derek Timm","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027873043","display_name":"Tyler N. Jepperson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tyler Jepperson","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065390666","display_name":"Qiangrong Liang","orcid":"https://orcid.org/0000-0002-6123-5685","observed_orcids":["https://orcid.org/0000-0002-6123-5685"]},"institutions":[{"id":"https://openalex.org/I189957204","display_name":"University of South Dakota","ror":"https://ror.org/0043h8f16","country_code":"US","type":"education","lineage":["https://openalex.org/I189957204"]},{"id":"https://openalex.org/I4210095855","display_name":"Sanford Research","ror":"https://ror.org/00sfn8y78","country_code":"US","type":"facility","lineage":["https://openalex.org/I1305840828","https://openalex.org/I4210095855"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Qiangrong Liang","raw_affiliation_strings":["Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cardiovascular Health Research Center, Sanford Research/University of South Dakota, Sioux Falls, South Dakota 57104","institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065390666"],"corresponding_institution_ids":["https://openalex.org/I189957204","https://openalex.org/I4210095855"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":3.5114,"has_fulltext":false,"cited_by_count":66,"citation_normalized_percentile":{"value":0.93142361,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"286","issue":"25","first_page":"21993","last_page":"22006"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11535","display_name":"Chemotherapy-induced cardiotoxicity and mitigation","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11057","display_name":"Cardiac Ischemia and Reperfusion","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/2-deoxy-d-glucose","display_name":"2-deoxyglucose","score":0.8939999938011169},{"id":"https://openalex.org/keywords/caloric-restriction-mimetics","display_name":"caloric restriction mimetics","score":0.9490000009536743},{"id":"https://openalex.org/keywords/doxorubicin-induced-cardiotoxicity","display_name":"doxorubicin cardiotoxicity","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cardiomyocyte-death","display_name":"cardiomyocyte death","score":0.9779999852180481},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6389999985694885},{"id":"https://openalex.org/keywords/ampk","display_name":"AMPK","score":0.8709999918937683},{"id":"https://openalex.org/keywords/autophagy","display_name":"autophagy","score":0.9120000004768372},{"id":"https://openalex.org/keywords/intracellular-atp-depletion","display_name":"intracellular ATP depletion","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cardioprotection","display_name":"cardioprotection","score":0.8510000109672546},{"id":"https://openalex.org/keywords/drug-induced-heart-failure","display_name":"drug-induced heart failure","score":0.6150000095367432}],"concepts":[{"id":"https://openalex.org/C2780124434","wikidata":"https://www.wikidata.org/wiki/Q12357464","display_name":"AMPK","level":4,"score":0.8105361461639404},{"id":"https://openalex.org/C203522944","wikidata":"https://www.wikidata.org/wiki/Q288322","display_name":"Autophagy","level":3,"score":0.7945875525474548},{"id":"https://openalex.org/C2781303535","wikidata":"https://www.wikidata.org/wiki/Q18936","display_name":"Doxorubicin","level":3,"score":0.5106540322303772},{"id":"https://openalex.org/C2775934118","wikidata":"https://www.wikidata.org/wiki/Q424169","display_name":"Propidium iodide","level":4,"score":0.5002529621124268},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.5000002384185791},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4917176067829132},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.48771747946739197},{"id":"https://openalex.org/C2780967304","wikidata":"https://www.wikidata.org/wiki/Q246156","display_name":"Cytoprotection","level":3,"score":0.48698410391807556},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48420217633247375},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.4824543595314026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4771251678466797},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4318754971027374},{"id":"https://openalex.org/C22615655","wikidata":"https://www.wikidata.org/wiki/Q203221","display_name":"Small interfering RNA","level":4,"score":0.42443132400512695},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.3491087555885315},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3115929365158081},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.2448001503944397},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.24008700251579285},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22341826558113098},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.212682843208313},{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.13096216320991516},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.06995633244514465},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003847","descriptor_name":"Deoxyglucose","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019610","descriptor_name":"Cytoprotection","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D031204","descriptor_name":"Caloric Restriction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1074/jbc.m111.225805","doi":"https://doi.org/10.1074/jbc.m111.225805","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.225805","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2385462","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121344","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3121344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3121344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Biol Chem","raw_type":"Text"},{"id":"pmid:21521688","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21521688","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of biological chemistry","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1074/jbc.m111.225805","doi":"https://doi.org/10.1074/jbc.m111.225805","is_oa":true,"landing_page_url":"https://doi.org/10.1074/jbc.m111.225805","pdf_url":null,"source":{"id":"https://openalex.org/S140251998","display_name":"Journal of Biological Chemistry","issn_l":"0021-9258","issn":["0021-9258","1067-8816","1083-351X"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Biological Chemistry","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G134977647","display_name":null,"funder_award_id":"P20-RR-017662","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G1506177965","display_name":null,"funder_award_id":"2P20-RR-017662-06A1","funder_id":"https://openalex.org/F4320337375","funder_display_name":"National Center for Research Resources"},{"id":"https://openalex.org/G617233157","display_name":"Mechanisms of cardiovascular remodeling","funder_award_id":"7p20rr017662-07","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":87,"referenced_works":["https://openalex.org/W139642302","https://openalex.org/W1492360552","https://openalex.org/W1699564438","https://openalex.org/W1915979543","https://openalex.org/W1947805383","https://openalex.org/W1963521777","https://openalex.org/W1966132436","https://openalex.org/W1968162183","https://openalex.org/W1971228310","https://openalex.org/W1972545707","https://openalex.org/W1973472942","https://openalex.org/W1974369116","https://openalex.org/W1977767269","https://openalex.org/W1980212785","https://openalex.org/W1982181214","https://openalex.org/W1982647833","https://openalex.org/W1984098639","https://openalex.org/W1987417961","https://openalex.org/W1987593270","https://openalex.org/W1987826934","https://openalex.org/W1990138203","https://openalex.org/W1991096049","https://openalex.org/W1992659717","https://openalex.org/W1998877815","https://openalex.org/W2000776278","https://openalex.org/W2005915142","https://openalex.org/W2006287843","https://openalex.org/W2006992985","https://openalex.org/W2010933392","https://openalex.org/W2019576484","https://openalex.org/W2019974695","https://openalex.org/W2021117623","https://openalex.org/W2024630544","https://openalex.org/W2025223586","https://openalex.org/W2025665129","https://openalex.org/W2027722653","https://openalex.org/W2030926513","https://openalex.org/W2040605398","https://openalex.org/W2046984143","https://openalex.org/W2049128885","https://openalex.org/W2056006220","https://openalex.org/W2056673369","https://openalex.org/W2058642498","https://openalex.org/W2058959188","https://openalex.org/W2062340497","https://openalex.org/W2068091527","https://openalex.org/W2070703520","https://openalex.org/W2073966701","https://openalex.org/W2074740541","https://openalex.org/W2075088486","https://openalex.org/W2078903854","https://openalex.org/W2078911476","https://openalex.org/W2081479137","https://openalex.org/W2086469250","https://openalex.org/W2088425779","https://openalex.org/W2088586959","https://openalex.org/W2092218251","https://openalex.org/W2092752244","https://openalex.org/W2094395583","https://openalex.org/W2095240020","https://openalex.org/W2097668381","https://openalex.org/W2100110742","https://openalex.org/W2104083311","https://openalex.org/W2105665055","https://openalex.org/W2106465332","https://openalex.org/W2106926141","https://openalex.org/W2107497146","https://openalex.org/W2110323753","https://openalex.org/W2110960199","https://openalex.org/W2112357840","https://openalex.org/W2125747634","https://openalex.org/W2130354109","https://openalex.org/W2130693972","https://openalex.org/W2134775482","https://openalex.org/W2150540788","https://openalex.org/W2155408559","https://openalex.org/W2156029342","https://openalex.org/W2159600136","https://openalex.org/W2160845673","https://openalex.org/W2162514244","https://openalex.org/W2163849426","https://openalex.org/W2167273541","https://openalex.org/W2168277151","https://openalex.org/W2168807041","https://openalex.org/W2168919362","https://openalex.org/W2226497574","https://openalex.org/W2914002569"],"related_works":["https://openalex.org/W2620496115","https://openalex.org/W1987826934","https://openalex.org/W2920989382","https://openalex.org/W2017193021","https://openalex.org/W1971710954","https://openalex.org/W2625460370","https://openalex.org/W4365506158","https://openalex.org/W3047237011","https://openalex.org/W7163007295","https://openalex.org/W2968079023"],"abstract_inverted_index":{"Caloric":[0],"restriction":[1],"(CR)":[2],"is":[3,27,213],"a":[4,75,170],"dietary":[5],"intervention":[6],"known":[7],"to":[8,29,41,108,190],"enhance":[9],"cardiovascular":[10],"health.":[11],"The":[12],"glucose":[13],"analog":[14],"2-deoxy-D-glucose":[15],"(2-DG)":[16],"mimics":[17],"CR":[18,204],"effects":[19,140,159],"in":[20],"several":[21],"animal":[22],"models.":[23],"However,":[24],"whether":[25],"2-DG":[26,40,67,90,112,167,193,206],"beneficial":[28],"the":[30,37,114,133,138,184,203,219,224,229],"heart":[31,57],"remains":[32],"obscure.":[33],"Here,":[34],"we":[35],"tested":[36],"ability":[38,189],"of":[39,60,78,103,116,132,141,221,226,231],"reduce":[42],"cardiomyocyte":[43,210],"death":[44],"triggered":[45],"by":[46,74,95,146],"doxorubicin":[47],"(DOX,":[48],"1":[49],"\u03bcm),":[50],"an":[51],"antitumor":[52],"drug":[53],"that":[54,80,202],"can":[55,207],"cause":[56],"failure.":[58],"Treatment":[59],"neonatal":[61],"rat":[62],"cardiomyocytes":[63],"with":[64,124,163],"0.5":[65],"mm":[66],"dramatically":[68],"suppressed":[69],"DOX":[70,152],"cytotoxicity":[71],"as":[72],"indicated":[73],"decreased":[76,91],"number":[77],"cells":[79],"stained":[81],"positive":[82],"for":[83],"propidium":[84],"iodide":[85],"and":[86,228],"reduced":[87,151],"apoptotic":[88],"markers.":[89],"intracellular":[92],"ATP":[93,222],"levels":[94],"17.9%,":[96],"but":[97,154],"it":[98],"prevented":[99,194],"DOX-induced":[100,195,209],"severe":[101],"depletion":[102],"ATP,":[104],"which":[105,212],"may":[106],"contribute":[107],"2-DG-mediated":[109],"cytoprotection.":[110],"Also,":[111],"increased":[113],"activity":[115],"AMP-activated":[117],"protein":[118],"kinase":[119],"(AMPK).":[120],"Blocking":[121],"AMPK":[122,144],"signaling":[123],"compound":[125],"C":[126],"or":[127,148,180],"small":[128],"interfering":[129],"RNA-mediated":[130],"knockdown":[131],"catalytic":[134],"subunit":[135],"markedly":[136],"attenuated":[137],"protective":[139,179],"2-DG.":[142,164],"Conversely,":[143],"activation":[145,175,225],"pharmacological":[147],"genetic":[149],"approach":[150],"cardiotoxicity":[153],"did":[155],"not":[156],"produce":[157],"additive":[158],"when":[160],"used":[161],"together":[162],"In":[165],"addition,":[166],"induced":[168],"autophagy,":[169,192],"cellular":[171],"degradation":[172],"pathway":[173],"whose":[174],"could":[176],"be":[177],"either":[178],"detrimental":[181,196],"depending":[182],"on":[183],"context.":[185],"Paradoxically,":[186],"despite":[187],"its":[188],"activate":[191],"autophagy.":[197,232],"Together,":[198],"these":[199],"results":[200],"suggest":[201],"mimetic":[205],"antagonize":[208],"death,":[211],"mediated":[214],"through":[215],"multiple":[216],"mechanisms,":[217],"including":[218],"preservation":[220],"content,":[223],"AMPK,":[227],"inhibition":[230]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
