{"id":"https://openalex.org/W2003083293","doi":"https://doi.org/10.1073/pnas.74.7.2746","title":"Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides","display_name":"Mutagenicity and cytotoxicity of benz[ a ]anthracene diol epoxides and tetrahydro-epoxides: Exceptional activity of the bay region 1,2-epoxides","publication_year":1977,"publication_date":"1977-07-01","ids":{"openalex":"https://openalex.org/W2003083293","doi":"https://doi.org/10.1073/pnas.74.7.2746","mag":"2003083293","pmid":"https://pubmed.ncbi.nlm.nih.gov/331315","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/431274"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.74.7.2746","doi":"https://doi.org/10.1073/pnas.74.7.2746","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.74.7.2746","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/431274","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111444600","display_name":"Alexander W. Wood","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Alexander W. Wood","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111929355","display_name":"Richard L. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Richard L. Chang","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045174225","display_name":"Wayne Levin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Wayne Levin","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110","institution_ids":["https://openalex.org/I118019719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069252081","display_name":"Roland E. Lehr","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roland E. Lehr","raw_affiliation_strings":["Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053114935","display_name":"Maria Schaefer-Ridder","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Maria Schaefer-Ridder","raw_affiliation_strings":["Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072054342","display_name":"Jean M. Karle","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jean M. Karle","raw_affiliation_strings":["Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111387113","display_name":"Donald M. Jerina","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Donald M. Jerina","raw_affiliation_strings":["Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]},{"raw_affiliation_string":"tSection on Oxidation Mechanisms, Laboratory of Chemistry, National Institute of Arthritis, Metabolism, and Digestive Diseases, National Institutes of Health, Bethesda, Maryland 20014","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010768963","display_name":"Allan H. Conney","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I118019719","display_name":"F. Hoffmann-La Roche AG","ror":"https://ror.org/00by1q217","country_code":"CH","type":"company","lineage":["https://openalex.org/I118019719"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Allan H. Conney","raw_affiliation_strings":["Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, New Jersey 07110","institution_ids":["https://openalex.org/I118019719"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":9.5041,"has_fulltext":false,"cited_by_count":92,"citation_normalized_percentile":{"value":0.98933902,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":98},"biblio":{"volume":"74","issue":"7","first_page":"2746","last_page":"2750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12356","display_name":"Bioactive Compounds and Antitumor Agents","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/benzo-a-anthracene","display_name":"benz[a]anthracene","score":0.9470000267028809},{"id":"https://openalex.org/keywords/diol-epoxides","display_name":"diol epoxides","score":0.9750000238418579},{"id":"https://openalex.org/keywords/1-2-epoxides","display_name":"1,2-epoxides","score":0.8899999856948853},{"id":"https://openalex.org/keywords/mutagenicity","display_name":"mutagenicity","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.996999979019165},{"id":"https://openalex.org/keywords/polycyclic-aromatic-hydrocarbons","display_name":"polycyclic aromatic hydrocarbons","score":0.8840000033378601},{"id":"https://openalex.org/keywords/ultimate-carcinogens","display_name":"ultimate carcinogens","score":0.6869999766349792},{"id":"https://openalex.org/keywords/epoxide-hydrolase","display_name":"epoxide hydrolase","score":0.6930000185966492},{"id":"https://openalex.org/keywords/diastereomers","display_name":"diastereomers","score":0.6840000152587891},{"id":"https://openalex.org/keywords/benzo-a-pyrene-diol-epoxide","display_name":"benzo[a]pyrene diol epoxide","score":0.8399999737739563},{"id":"https://openalex.org/keywords/salmonella-typhimurium-ta100","display_name":"Salmonella typhimurium TA100","score":0.847000002861023},{"id":"https://openalex.org/keywords/chinese-hamster-lung-cells","display_name":"Chinese hamster lung cells","score":0.8370000123977661}],"concepts":[{"id":"https://openalex.org/C2779563022","wikidata":"https://www.wikidata.org/wiki/Q422152","display_name":"Anthracene","level":2,"score":0.952567994594574},{"id":"https://openalex.org/C138716334","wikidata":"https://www.wikidata.org/wiki/Q268477","display_name":"Diastereomer","level":2,"score":0.7498899698257446},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7452777624130249},{"id":"https://openalex.org/C2776920199","wikidata":"https://www.wikidata.org/wiki/Q408028","display_name":"Epoxide","level":3,"score":0.6716718673706055},{"id":"https://openalex.org/C2778951431","wikidata":"https://www.wikidata.org/wiki/Q415723","display_name":"Pyrene","level":2,"score":0.6244069337844849},{"id":"https://openalex.org/C2779515768","wikidata":"https://www.wikidata.org/wiki/Q421916","display_name":"Diol","level":2,"score":0.5421581864356995},{"id":"https://openalex.org/C2779033964","wikidata":"https://www.wikidata.org/wiki/Q407212","display_name":"Polycyclic aromatic hydrocarbon","level":2,"score":0.4838053584098816},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.483675092458725},{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.42626866698265076},{"id":"https://openalex.org/C155647269","wikidata":"https://www.wikidata.org/wiki/Q243455","display_name":"Medicinal chemistry","level":1,"score":0.36097419261932373},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.3016852140426636},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.0638720691204071}],"mesh":[{"descriptor_ui":"D001551","descriptor_name":"Benz(a)Anthracenes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001551","descriptor_name":"Benz(a)Anthracenes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004851","descriptor_name":"Epoxide Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004988","descriptor_name":"Ethers, Cyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009153","descriptor_name":"Mutagens","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012486","descriptor_name":"Salmonella typhimurium","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.74.7.2746","doi":"https://doi.org/10.1073/pnas.74.7.2746","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.74.7.2746","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:431274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/431274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmid:331315","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/331315","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:431274","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/431274","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"score":0.428600013256073,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W1519899868","https://openalex.org/W1602211564","https://openalex.org/W1941873609","https://openalex.org/W1974074449","https://openalex.org/W1974648730","https://openalex.org/W2008393535","https://openalex.org/W2010272845","https://openalex.org/W2017682851","https://openalex.org/W2022806505","https://openalex.org/W2023796599","https://openalex.org/W2035585231","https://openalex.org/W2046490713","https://openalex.org/W2048307591","https://openalex.org/W2049714709","https://openalex.org/W2052189615","https://openalex.org/W2054188135","https://openalex.org/W2061001369","https://openalex.org/W2062093570","https://openalex.org/W2066257734","https://openalex.org/W2068270570","https://openalex.org/W2072389657","https://openalex.org/W2078363670","https://openalex.org/W2089719345","https://openalex.org/W2093684972","https://openalex.org/W2156389002","https://openalex.org/W2778118850"],"related_works":["https://openalex.org/W1693521579","https://openalex.org/W2142207491","https://openalex.org/W2161259148","https://openalex.org/W1941873609","https://openalex.org/W2127068732","https://openalex.org/W2006901186","https://openalex.org/W1526327087","https://openalex.org/W2115368145","https://openalex.org/W2061001369","https://openalex.org/W1527786650"],"abstract_inverted_index":{"Three":[0],"diastereomeric":[1,41,72],"pairs":[2,73],"of":[3,12,27,34,43,46,74,85,117,120,122,131,170,177,181,188,199],"diol":[4,158,163],"epoxides,":[5,159,164],"two":[6,40],"tetrahydro-epoxides,":[7],"and":[8,30,58,83,89,92,101,186],"the":[9,13,44,56,66,71,80,86,118,123,132,141,147,161,168,178,189],"K-region":[10],"oxide":[11],"polycyclic":[14,201],"aromatic":[15,202],"hydrocarbon":[16],"benz[a]anthracene":[17,47,109,157,182],"were":[18],"evaluated":[19],"for":[20,140],"mutagenic":[21,54,64,82,96,144,149,175],"activity":[22,119,145,176],"in":[23,31,99,134,143],"strain":[24],"TA":[25],"100":[26],"Salmonella":[28],"typhimurium":[29],"line":[32],"V79-6":[33],"Chinese":[35],"hamster":[36],"lung":[37],"cells.":[38],"The":[39,128,156,173],"1,2-epoxides":[42,124],"trans-3,4-dihydrodiol":[45],"are":[48,70,165,204],"15":[49],"to":[50,55,60,65,152,167],"35":[51],"times":[52,62,94],"more":[53,63,95,148],"bacteria":[57],"65":[59],"125":[61],"mammalian":[67,102],"cells":[68],"than":[69,97,115],"benz[a]anthracene-8,9-diol-10,11-epoxides":[75],"or":[76],"benz[a]anthracene-10,11-diol-8,9-epoxides.":[77],"1,2-Epoxy-1,2,3,4-tetrahydrobenz[a]anthracene":[78],"is":[79,90,183],"most":[81],"cytotoxic":[84],"nine":[87],"derivatives":[88,133,150,180],"5":[91],"25":[93],"3,4-epoxy-1,2,3,4-tetrahydrobenz[a]anthracene":[98],"bacterial":[100],"cells,":[103],"respectively.":[104],"In":[105],"either":[106],"test":[107],"system,":[108],"5,6-oxide":[110],"(K-region":[111],"oxide)":[112],"has":[113],"less":[114,154],"10%":[116],"any":[121],"derived":[125],"from":[126],"benz[a]anthracene.":[127],"relative":[129],"stabilities":[130],"aqueous":[135],"solution":[136],"do":[137],"not":[138],"account":[139],"differences":[142],"because":[146],"tend":[151],"be":[153],"stable.":[155],"like":[160],"benzo[a]pyrene":[162],"refractory":[166],"action":[169],"epoxide":[171],"hydrase.":[172],"exceptional":[174],"1,2-epoxide":[179],"consistent":[184],"with":[185],"supportive":[187],"hypothesis":[190],"that":[191],"bay":[192],"region":[193],"epoxides":[194],"on":[195],"saturated,":[196],"angular":[197],"benzo-rings":[198],"unsubstituted":[200],"hydrocarbons":[203],"ultimate":[205],"carcinogens.":[206]},"counts_by_year":[{"year":2023,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
