{"id":"https://openalex.org/W2003031817","doi":"https://doi.org/10.1002/ibd.23007","title":"Phenotype\u2013Genotype Profiles in Crohn\u02bcs Disease Predicted by Genetic Markers in Autophagy-Related Genes (GOIA Study II)","display_name":"Phenotype\u2013Genotype Profiles in Crohn\u02bcs Disease Predicted by Genetic Markers in Autophagy-Related Genes (GOIA Study II)","publication_year":2012,"publication_date":"2012-05-09","ids":{"openalex":"https://openalex.org/W2003031817","doi":"https://doi.org/10.1002/ibd.23007","mag":"2003031817","pmid":"https://pubmed.ncbi.nlm.nih.gov/22573572"},"language":"en","primary_location":{"id":"doi:10.1002/ibd.23007","doi":"https://doi.org/10.1002/ibd.23007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ibd.23007","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039583866","display_name":"Cec\u00edlia Dur\u00e3es","orcid":"https://orcid.org/0000-0001-9282-0708","observed_orcids":["https://orcid.org/0000-0001-9282-0708"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cec\u00edlia Dur\u00e3es","raw_affiliation_strings":["Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018172201","display_name":"Jos\u00e9 Carlos Machado","orcid":"https://orcid.org/0000-0003-4741-8415","observed_orcids":["https://orcid.org/0000-0003-4741-8415"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jos\u00e9 C. Machado","raw_affiliation_strings":["Faculty of Medicine of the University of Porto, Porto, Portugal","Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060736099","display_name":"Francisco Portela","orcid":"https://orcid.org/0000-0002-7593-6124","observed_orcids":["https://orcid.org/0000-0002-7593-6124"]},"institutions":[{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Francisco Portela","raw_affiliation_strings":["Hospital of the University of Coimbra, Coimbra, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of the University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007560083","display_name":"Susana Gomes Rodrigues","orcid":"https://orcid.org/0000-0002-3261-2795","observed_orcids":["https://orcid.org/0000-0002-3261-2795"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Susana Rodrigues","raw_affiliation_strings":["Hospital of S\u00e3o Jo\u00e3o, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Jo\u00e3o, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108279291","display_name":"Paula M. Lago","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127365","display_name":"Hospital de Santo Ant\u00f3nio","ror":"https://ror.org/02m9pj861","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210127365"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Lago","raw_affiliation_strings":["Hospital of Santo Ant\u00f3nio, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Santo Ant\u00f3nio, Porto, Portugal","institution_ids":["https://openalex.org/I4210127365"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065822684","display_name":"Marilia L. Cravo","orcid":"https://orcid.org/0000-0001-8309-4599","observed_orcids":["https://orcid.org/0000-0001-8309-4599"]},"institutions":[{"id":"https://openalex.org/I4210103180","display_name":"Instituto Portugu\u00eas de Oncologia Francisco Gentil","ror":"https://ror.org/00r7b5b77","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210103180"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Mar\u00edlia Cravo","raw_affiliation_strings":["Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Portuguese Institute of Oncology of Lisbon, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210103180"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056740989","display_name":"Paula Ministro","orcid":"https://orcid.org/0000-0003-2439-9522","observed_orcids":["https://orcid.org/0000-0003-2439-9522"]},"institutions":[{"id":"https://openalex.org/I4210128062","display_name":"Hospital S\u00e3o Teot\u00f3nio","ror":"https://ror.org/02dc47z81","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210128062"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paula Ministro","raw_affiliation_strings":["Hospital of S\u00e3o Teot\u00f3nio, Viseu, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Teot\u00f3nio, Viseu, Portugal","institution_ids":["https://openalex.org/I4210128062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040350966","display_name":"Margarida Marques","orcid":"https://orcid.org/0000-0002-9636-0443","observed_orcids":["https://orcid.org/0000-0002-9636-0443"]},"institutions":[{"id":"https://openalex.org/I3018176973","display_name":"Hospital de S\u00e3o Jo\u00e3o","ror":"https://ror.org/04qsnc772","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I3018176973"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Margarida Marques","raw_affiliation_strings":["Hospital of S\u00e3o Jo\u00e3o, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Jo\u00e3o, Porto, Portugal","institution_ids":["https://openalex.org/I3018176973"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076445998","display_name":"Isabelle Cremers","orcid":"https://orcid.org/0000-0002-2377-0097","observed_orcids":["https://orcid.org/0000-0002-2377-0097"]},"institutions":[{"id":"https://openalex.org/I4210132506","display_name":"Hospital de S\u00e3o Bernardo","ror":"https://ror.org/02y9x6z24","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210132506"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Isabelle Cremers","raw_affiliation_strings":["Hospital of S\u00e3o Bernardo, Set\u00fabal, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Bernardo, Set\u00fabal, Portugal","institution_ids":["https://openalex.org/I4210132506"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077174807","display_name":"Jo\u00e3o Freitas","orcid":"https://orcid.org/0009-0008-9057-5890","observed_orcids":["https://orcid.org/0009-0008-9057-5890"]},"institutions":[{"id":"https://openalex.org/I4210146790","display_name":"Hospital Garcia de Orta","ror":"https://ror.org/04jq4p608","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210146790"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Freitas","raw_affiliation_strings":["Hospital of Garcia de Orta, Almada, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Garcia de Orta, Almada, Portugal","institution_ids":["https://openalex.org/I4210146790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053850016","display_name":"Jos\u00e9 B. Cotter","orcid":"https://orcid.org/0000-0002-2921-0648","observed_orcids":["https://orcid.org/0000-0002-2921-0648"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jos\u00e9 Cotter","raw_affiliation_strings":["Hospital Centre of Alto Ave, Guimar\u00e3es, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Centre of Alto Ave, Guimar\u00e3es, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007998077","display_name":"Lurdes Tavares","orcid":"https://orcid.org/0000-0001-8209-8942","observed_orcids":["https://orcid.org/0000-0001-8209-8942"]},"institutions":[{"id":"https://openalex.org/I4210149283","display_name":"Hospital de Santa Maria","ror":"https://ror.org/05bz1tw26","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210149283"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lurdes Tavares","raw_affiliation_strings":["Hospital of Santa Maria, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Santa Maria, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210149283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107145257","display_name":"Leopoldo Matos","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210106487","display_name":"Hospital de Egas Moniz","ror":"https://ror.org/012habm93","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210106487"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Leopoldo Matos","raw_affiliation_strings":["Hospital of Egas Moniz, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Egas Moniz, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210106487"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109998461","display_name":"Isabelly B. B. G. de Medeiros","orcid":"https://orcid.org/0009-0003-2947-1498","observed_orcids":["https://orcid.org/0009-0003-2947-1498"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabel Medeiros","raw_affiliation_strings":["Hospital of \u00c9vora, \u00c9vora, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of \u00c9vora, \u00c9vora, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Rui Sousa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rui Sousa","raw_affiliation_strings":["Hospital of Amato Lusitano, Castelo Branco, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Amato Lusitano, Castelo Branco, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103231347","display_name":"Jaime Ramos","orcid":"https://orcid.org/0000-0001-6223-3844","observed_orcids":["https://orcid.org/0000-0001-6223-3844"]},"institutions":[{"id":"https://openalex.org/I4210143200","display_name":"Hospital Santo Ant\u00f3nio dos Capuchos","ror":"https://ror.org/04abkkn33","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210095157","https://openalex.org/I4210143200"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jaime Ramos","raw_affiliation_strings":["Hospital of Santo Ant\u00f3nio dos Capuchos, Lisbon, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Santo Ant\u00f3nio dos Capuchos, Lisbon, Portugal","institution_ids":["https://openalex.org/I4210143200"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039460383","display_name":"Jo\u00e3o de Deus","orcid":"https://orcid.org/0009-0008-3483-6646","observed_orcids":["https://orcid.org/0009-0008-3483-6646"]},"institutions":[{"id":"https://openalex.org/I4210099144","display_name":"Hospital Prof. Dr. Fernando Fonseca","ror":"https://ror.org/010bsbc18","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210099144"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Jo\u00e3o Deus","raw_affiliation_strings":["Hospital of Prof. Dr Fernando Fonseca, Amadora, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Prof. Dr Fernando Fonseca, Amadora, Portugal","institution_ids":["https://openalex.org/I4210099144"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108867171","display_name":"Paulo M. Caldeira","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105457","display_name":"Hospital de Faro EPE","ror":"https://ror.org/00z769k62","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210105457"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Paulo Caldeira","raw_affiliation_strings":["Hospital of Faro, Faro, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Faro, Faro, Portugal","institution_ids":["https://openalex.org/I4210105457"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110662960","display_name":"Cristina Chagas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122709","display_name":"Hospital de Santa Cruz","ror":"https://ror.org/02r581p42","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210122709"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Cristina Chagas","raw_affiliation_strings":["Hospital of Santa Cruz, Oeiras, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Santa Cruz, Oeiras, Portugal","institution_ids":["https://openalex.org/I4210122709"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112796292","display_name":"Maria Ant\u00f3nia Duarte","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117409","display_name":"Hospital do Divino Esp\u00edrito Santo","ror":"https://ror.org/02ehsvt70","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210117409"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Maria A. Duarte","raw_affiliation_strings":["Hospital of Divino Esp\u00edrito Santo, Ponta Delgada, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Divino Esp\u00edrito Santo, Ponta Delgada, Portugal","institution_ids":["https://openalex.org/I4210117409"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101666913","display_name":"Raquel Gon\u00e7alves","orcid":"https://orcid.org/0000-0002-5930-8611","observed_orcids":["https://orcid.org/0000-0002-5930-8611","https://orcid.org/0009-0003-5819-2447"]},"institutions":[{"id":"https://openalex.org/I4210125208","display_name":"Hospital de S\u00e3o Marcos","ror":"https://ror.org/040bb8882","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210125208"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Raquel Gon\u00e7alves","raw_affiliation_strings":["Hospital of S\u00e3o Marcos, Braga, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Marcos, Braga, Portugal","institution_ids":["https://openalex.org/I4210125208"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028161393","display_name":"Rui Loureiro","orcid":"https://orcid.org/0000-0002-5152-2453","observed_orcids":["https://orcid.org/0000-0002-5152-2453"]},"institutions":[{"id":"https://openalex.org/I4210146790","display_name":"Hospital Garcia de Orta","ror":"https://ror.org/04jq4p608","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210146790"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Rui Loureiro","raw_affiliation_strings":["Hospital of Garcia de Orta, Almada, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Garcia de Orta, Almada, Portugal","institution_ids":["https://openalex.org/I4210146790"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020584664","display_name":"Lu\u00edsa Leite Barros","orcid":"https://orcid.org/0000-0002-7782-2825","observed_orcids":["https://orcid.org/0000-0002-7782-2825"]},"institutions":[{"id":"https://openalex.org/I4210088610","display_name":"Hospital Padre Am\u00e9rico","ror":"https://ror.org/003zfh275","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210088610","https://openalex.org/I4210123791"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Lu\u00edsa Barros","raw_affiliation_strings":["Hospital of Padre Am\u00e9rico, Penafiel, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Padre Am\u00e9rico, Penafiel, Portugal","institution_ids":["https://openalex.org/I4210088610"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103514281","display_name":"Isabel Bastos","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabel Bastos","raw_affiliation_strings":["Hospital of Infante D. Pedro, Aveiro, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Infante D. Pedro, Aveiro, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054027304","display_name":"Eug\u00e9nia Maria Cancela","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210128062","display_name":"Hospital S\u00e3o Teot\u00f3nio","ror":"https://ror.org/02dc47z81","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210128062"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Eug\u00e9nia Cancela","raw_affiliation_strings":["Hospital of S\u00e3o Teot\u00f3nio, Viseu, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of S\u00e3o Teot\u00f3nio, Viseu, Portugal","institution_ids":["https://openalex.org/I4210128062"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111624371","display_name":"M\u00e1rio C. Moraes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405259234","display_name":"Unidade Hospitalar de Portim\u00e3o","ror":"https://ror.org/01yv6t270","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4405259234"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"M\u00e1rio C. Moraes","raw_affiliation_strings":["Hospital of Portim\u00e3o, Portim\u00e3o, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Portim\u00e3o, Portim\u00e3o, Portugal","institution_ids":["https://openalex.org/I4405259234"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043456532","display_name":"Maria Jo\u00e3o Moreira","orcid":"https://orcid.org/0000-0002-3442-3939","observed_orcids":["https://orcid.org/0000-0002-3442-3939"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maria J. Moreira","raw_affiliation_strings":["Hospital Centre of Alto Ave, Guimar\u00e3es, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital Centre of Alto Ave, Guimar\u00e3es, Portugal","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113850856","display_name":"Ana Vieira","orcid":"https://orcid.org/0009-0002-6990-3083","observed_orcids":["https://orcid.org/0009-0002-6990-3083"]},"institutions":[{"id":"https://openalex.org/I4210146790","display_name":"Hospital Garcia de Orta","ror":"https://ror.org/04jq4p608","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I4210146790"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Ana I. Vieira","raw_affiliation_strings":["Hospital of Garcia de Orta, Almada, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Hospital of Garcia de Orta, Almada, Portugal","institution_ids":["https://openalex.org/I4210146790"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052535018","display_name":"Fernando Magro","orcid":"https://orcid.org/0000-0003-2634-9668","observed_orcids":["https://orcid.org/0000-0003-2634-9668"]},"institutions":[{"id":"https://openalex.org/I182534213","display_name":"Universidade do Porto","ror":"https://ror.org/043pwc612","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213"]},{"id":"https://openalex.org/I2802025818","display_name":"Unidade Local de Sa\u00fade de Coimbra","ror":"https://ror.org/04032fz76","country_code":"PT","type":"healthcare","lineage":["https://openalex.org/I2802025818"]},{"id":"https://openalex.org/I4387153674","display_name":"Instituto de Biologia Molecular e Celular","ror":"https://ror.org/005dkht93","country_code":"PT","type":"education","lineage":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}],"countries":["PT"],"is_corresponding":false,"raw_author_name":"Fernando Magro","raw_affiliation_strings":["Faculty of Medicine of the University of Porto, Porto, Portugal","Hospital of the University of Coimbra, Coimbra, Portugal","Institute for Molecular and Cell Biology of the Universiy of Porto, Porto, Portugal"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Faculty of Medicine of the University of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213"]},{"raw_affiliation_string":"Hospital of the University of Coimbra, Coimbra, Portugal","institution_ids":["https://openalex.org/I2802025818"]},{"raw_affiliation_string":"Institute for Molecular and Cell Biology of the Universiy of Porto, Porto, Portugal","institution_ids":["https://openalex.org/I182534213","https://openalex.org/I4387153674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":19,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3862,"currency":"USD","value_usd":3862},"apc_paid":null,"fwci":6.3145,"has_fulltext":false,"cited_by_count":39,"citation_normalized_percentile":{"value":0.96591677,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"19","issue":"2","first_page":"230","last_page":"239"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0020000000949949026,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crohn-s-disease","display_name":"Crohn's disease","score":0.9990000128746033},{"id":"https://openalex.org/keywords/autophagy-related-genes","display_name":"autophagy-related genes","score":0.7860000133514404}],"concepts":[{"id":"https://openalex.org/C187092789","wikidata":"https://www.wikidata.org/wiki/Q4654662","display_name":"ATG16L1","level":4,"score":0.9377801418304443},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.7346357703208923},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.733062744140625},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.6927450895309448},{"id":"https://openalex.org/C2779280984","wikidata":"https://www.wikidata.org/wiki/Q1472","display_name":"Crohn's disease","level":3,"score":0.6020343899726868},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.5899397134780884},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5457479357719421},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4329746663570404},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.3729901909828186},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3661958873271942},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.34539976716041565},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2807731032371521},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.27698343992233276},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2018955945968628}],"mesh":[{"descriptor_ui":"D000071183","descriptor_name":"Autophagy-Related Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000293","descriptor_name":"Adolescent","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D001343","descriptor_name":"Autophagy","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D002648","descriptor_name":"Child","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003424","descriptor_name":"Crohn Disease","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011174","descriptor_name":"Portugal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016015","descriptor_name":"Logistic Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016022","descriptor_name":"Case-Control Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D037102","descriptor_name":"Lectins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D055815","descriptor_name":"Young Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058851","descriptor_name":"GPI-Linked Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/ibd.23007","doi":"https://doi.org/10.1002/ibd.23007","is_oa":false,"landing_page_url":"https://doi.org/10.1002/ibd.23007","pdf_url":null,"source":{"id":"https://openalex.org/S45123234","display_name":"Inflammatory Bowel Diseases","issn_l":"1078-0998","issn":["1078-0998","1536-4844"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory Bowel Diseases","raw_type":"journal-article"},{"id":"pmid:22573572","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22573572","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inflammatory bowel diseases","raw_type":"Journal Article"},{"id":"pmh:oai:repositorio.hff.min-saude.pt:10400.10/1090","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10400.10/1090","pdf_url":null,"source":{"id":"https://openalex.org/S4306402433","display_name":"Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"journal article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9940000176429749}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W130578996","https://openalex.org/W1642457845","https://openalex.org/W1670573097","https://openalex.org/W1732275446","https://openalex.org/W1974340541","https://openalex.org/W1978890834","https://openalex.org/W1981411352","https://openalex.org/W1982342187","https://openalex.org/W1983251816","https://openalex.org/W1991263018","https://openalex.org/W1996838604","https://openalex.org/W2002758290","https://openalex.org/W2009258758","https://openalex.org/W2011197968","https://openalex.org/W2013407385","https://openalex.org/W2016138147","https://openalex.org/W2025184453","https://openalex.org/W2028404155","https://openalex.org/W2056295525","https://openalex.org/W2061321571","https://openalex.org/W2061783703","https://openalex.org/W2063062108","https://openalex.org/W2064027072","https://openalex.org/W2071103029","https://openalex.org/W2081521541","https://openalex.org/W2083945275","https://openalex.org/W2084708009","https://openalex.org/W2087587407","https://openalex.org/W2091990218","https://openalex.org/W2093356677","https://openalex.org/W2097087846","https://openalex.org/W2100443415","https://openalex.org/W2100649505","https://openalex.org/W2102013054","https://openalex.org/W2104857999","https://openalex.org/W2106048192","https://openalex.org/W2110946019","https://openalex.org/W2119809052","https://openalex.org/W2122031852","https://openalex.org/W2133411196","https://openalex.org/W2134783591","https://openalex.org/W2134898472","https://openalex.org/W2143778690","https://openalex.org/W2158944369","https://openalex.org/W2165872127","https://openalex.org/W2171643823","https://openalex.org/W2342579157","https://openalex.org/W2357371632"],"related_works":["https://openalex.org/W7073779454","https://openalex.org/W2327188688","https://openalex.org/W2981559061","https://openalex.org/W1934000495","https://openalex.org/W2028787189","https://openalex.org/W2140541163","https://openalex.org/W2322319275","https://openalex.org/W2027560883","https://openalex.org/W2021935808","https://openalex.org/W2811156921"],"abstract_inverted_index":{"BACKGROUND:":[0],"About":[1],"70":[2],"loci":[3],"are":[4,24,122,190],"associated":[5,123,164,192],"with":[6,62,74,124,165,193,211],"susceptibility":[7,28],"to":[8,169,174,179,197,231],"Crohn's":[9],"disease":[10],"(CD),":[11],"particularly":[12],"in":[13,49,80,161,186],"pathways":[14],"of":[15,72,143,214],"innate":[16],"immunity,":[17],"autophagy,":[18],"and":[19,44,58,107,131,139,141,152,155,178,188,205,224,249],"pathogen":[20],"recognition.":[21],"Phenotype-genotype":[22],"associations":[23,248],"inconsistent.":[25],"METHODS:":[26],"CD":[27,54,63,73,246],"polymorphisms":[29,78],"ATG16L1":[30,81,151,162],"rs2241880,":[31],"ICAM1":[32],"rs5498,":[33],"IL4":[34],"rs2070874,":[35],"IL17F":[36],"rs763780,":[37],"IRGM":[38,95,189],"rs13361189,":[39],"ITLN1":[40,108,187],"rs2274910,":[41],"LRRK2":[42],"rs11175593,":[43],"TLR4":[45],"rs4986790":[46],"were":[47],"genotyped":[48],"a":[50,69,194],"Portuguese":[51],"population":[52],"(511":[53],"patients,":[55],"626":[56],"controls)":[57],"assessed":[59],"for":[60,92,104,117,150,202,218,228,252],"association":[61,71],"clinical":[64],"characteristics.":[65],"RESULTS:":[66],"There":[67],"is":[68,163,234],"significant":[70],"the":[75,144,212,226],"single":[76],"nucleotide":[77],"(SNPs)":[79],"(odds":[82],"ratio":[83],"[OR]":[84],"1.36":[85],"[1.15-1.60],":[86],"P":[87,99,112],"=":[88,100,113],"2.7":[89],"\u00d7":[90,102,115],"10(-6)":[91],"allele":[93,105,118],"G),":[94],"(OR":[96,109,171,176,182,217],"1.56":[97],"[1.21-1.93],":[98],"3.9":[101],"10(-4)":[103,116],"C),":[106],"1.55":[110],"[1.28-1.88],":[111],"4.9":[114],"C).":[119],"These":[120],"SNPs":[121,185],"ileal":[125],"location":[126,134],"(OR,":[127,135,148],"respectively,":[128,136,221],"1.49,":[129],"1.52,":[130],"1.70),":[132],"ileocolonic":[133],"1.31,":[137],"1.57,":[138],"1.68),":[140],"involvement":[142],"upper":[145,206],"digestive":[146,207],"tract":[147,208],"respectively":[149],"IRGM,":[153],"1.96":[154],"1.95).":[156],"The":[157,184,200],"risk":[158,201,215],"genotype":[159],"GG":[160],"patients":[166],"who":[167],"respond":[168,173],"steroids":[170],"1.89),":[172],"immunosuppressants":[175],"1.77),":[177],"biologic":[180,198,232],"therapy":[181,233],"1.89).":[183],"both":[191],"positive":[195,229],"response":[196,230],"therapy.":[199],"ileal,":[203],"ileocolonic,":[204],"locations":[209],"increases":[210],"number":[213],"alleles":[216],"three":[219],"alleles,":[220],"7.10,":[222],"3.54,":[223],"12.07);":[225],"OR":[227],"3.66.":[235],"CONCLUSIONS:":[236],"A":[237],"multilocus":[238],"approach":[239],"using":[240],"autophagy-related":[241],"genes":[242],"provides":[243],"insight":[244],"into":[245],"phenotype-genotype":[247],"genetic":[250],"markers":[251],"predicting":[253],"therapeutic":[254],"responses.":[255]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}