{"id":"https://openalex.org/W2003028136","doi":"https://doi.org/10.1073/pnas.1423536112","title":"RETRACTED: Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases","display_name":"RETRACTED: Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W2003028136","doi":"https://doi.org/10.1073/pnas.1423536112","mag":"2003028136","pmid":"https://pubmed.ncbi.nlm.nih.gov/25848049","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413331"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.1423536112","doi":"https://doi.org/10.1073/pnas.1423536112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1423536112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","datacite","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413331","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080636450","display_name":"Elsa Germain","orcid":"https://orcid.org/0000-0002-9697-8454","observed_orcids":["https://orcid.org/0000-0002-9697-8454"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Elsa Germain","raw_affiliation_strings":["Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002016887","display_name":"Mohammad Roghanian","orcid":"https://orcid.org/0000-0003-3116-3817","observed_orcids":["https://orcid.org/0000-0003-3116-3817"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Mohammad Roghanian","raw_affiliation_strings":["Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I84884186"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070618817","display_name":"Kenn Gerdes","orcid":"https://orcid.org/0000-0002-7462-4612","observed_orcids":["https://orcid.org/0000-0002-7462-4612"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Kenn Gerdes","raw_affiliation_strings":["Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I124055696","https://openalex.org/I84884186"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047204599","display_name":"Etienne Maisonneuve","orcid":"https://orcid.org/0000-0003-3451-1223","observed_orcids":["https://orcid.org/0000-0003-3451-1223"]},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I84884186","display_name":"Newcastle University","ror":"https://ror.org/01kj2bm70","country_code":"GB","type":"education","lineage":["https://openalex.org/I84884186"]}],"countries":["DK","GB"],"is_corresponding":false,"raw_author_name":"Etienne Maisonneuve","raw_affiliation_strings":["Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centre for Bacterial Cell Biology, Institute for Cell and Molecular Biosciences, Newcastle University, NE2 4AX, Newcastle upon Tyne, United Kingdom","institution_ids":["https://openalex.org/I84884186"]},{"raw_affiliation_string":"Department of Biology, University of Copenhagen, DK-2200 Copenhagen, Denmark; and","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":14.3101,"has_fulltext":false,"cited_by_count":162,"citation_normalized_percentile":{"value":0.99480896,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":100},"biblio":{"volume":"112","issue":"16","first_page":"5171","last_page":"5176"},"is_retracted":true,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10195","display_name":"Antimicrobial Resistance in Staphylococcus","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10593","display_name":"Bacterial biofilms and quorum sensing","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterial-persistence","display_name":"bacterial persistence","score":0.9129999876022339},{"id":"https://openalex.org/keywords/persister-cells","display_name":"persister cells","score":0.9300000071525574},{"id":"https://openalex.org/keywords/type-ii-toxin-antitoxin-systems","display_name":"type II toxin-antitoxin systems","score":0.9039999842643738},{"id":"https://openalex.org/keywords/p-ppgpp","display_name":"(p)ppGpp","score":0.8790000081062317},{"id":"https://openalex.org/keywords/stringent-response","display_name":"stringent response","score":0.996999979019165},{"id":"https://openalex.org/keywords/lon-protease","display_name":"Lon protease","score":0.8899999856948853},{"id":"https://openalex.org/keywords/polyphosphate","display_name":"polyphosphate","score":0.9909999966621399},{"id":"https://openalex.org/keywords/multidrug-tolerance","display_name":"multidrug tolerance","score":0.9179999828338623},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.906000018119812}],"concepts":[{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.5846500992774963},{"id":"https://openalex.org/C136622501","wikidata":"https://www.wikidata.org/wiki/Q6934671","display_name":"Multidrug tolerance","level":4,"score":0.5509256720542908},{"id":"https://openalex.org/C26628138","wikidata":"https://www.wikidata.org/wiki/Q22272147","display_name":"Stringent response","level":4,"score":0.46158531308174133},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46158367395401},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.41158682107925415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3091420531272888},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19540148973464966},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.19399669766426086},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.16181939840316772},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.15064582228660583},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.09902432560920715},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.038209348917007446}],"mesh":[{"descriptor_ui":"D000483","descriptor_name":"Alleles","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000992","descriptor_name":"Antitoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001427","descriptor_name":"Bacterial Toxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004720","descriptor_name":"Endonucleases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006158","descriptor_name":"Guanosine Pentaphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006159","descriptor_name":"Guanosine Tetraphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D059008","descriptor_name":"Time-Lapse Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1073/pnas.1423536112","doi":"https://doi.org/10.1073/pnas.1423536112","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.1423536112","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3583441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25848049","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25848049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4413331","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4413331/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/08feea7f-34da-4ff0-bc98-befeac241907","doi":null,"is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/08feea7f-34da-4ff0-bc98-befeac241907","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Germain-Maisonneuve, E, Roghanian, M, Gerdes, K & Maisonneuve, E 2015, 'Stochastic induction of persister cells by HipA through (p)ppGpp-mediated activation of mRNA endonucleases', Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 16, pp. 5171-5176. https://doi.org/10.1073/pnas.1423536112","raw_type":"info:eu-repo/semantics/article"},{"id":"doi:10.25405/ncl.34270794.v1","doi":"https://doi.org/10.25405/ncl.34270794.v1","is_oa":true,"landing_page_url":"https://doi.org/10.25405/ncl.34270794.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306402485","display_name":"Newcastle University ePrints (Newcastle Univesity)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I84884186","host_organization_name":"Newcastle University","host_organization_lineage":["https://openalex.org/I84884186"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3583441","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4413331","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2877363052","display_name":null,"funder_award_id":"294517 \u00ef\u00bf1/2??PERSIST\u00ef\u00bf1/2??","funder_id":"https://openalex.org/F4320334678","funder_display_name":"European Research Council"},{"id":"https://openalex.org/G7734840155","display_name":null,"funder_award_id":"NNF12OC0000638","funder_id":"https://openalex.org/F4320325957","funder_display_name":"Novo Nordisk Fonden"}],"funders":[{"id":"https://openalex.org/F4320321091","display_name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","ror":"https://ror.org/00x0ma614"},{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320334678","display_name":"European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":48,"referenced_works":["https://openalex.org/W1527303322","https://openalex.org/W1528273806","https://openalex.org/W1594475813","https://openalex.org/W1666867306","https://openalex.org/W1969244937","https://openalex.org/W1985002373","https://openalex.org/W1992572387","https://openalex.org/W1993476922","https://openalex.org/W1996890828","https://openalex.org/W1998314143","https://openalex.org/W2007296377","https://openalex.org/W2012375289","https://openalex.org/W2016691753","https://openalex.org/W2017165733","https://openalex.org/W2041367172","https://openalex.org/W2043487490","https://openalex.org/W2045825103","https://openalex.org/W2051780892","https://openalex.org/W2069250280","https://openalex.org/W2076073652","https://openalex.org/W2076809355","https://openalex.org/W2083873972","https://openalex.org/W2087345689","https://openalex.org/W2090280039","https://openalex.org/W2093855789","https://openalex.org/W2096792353","https://openalex.org/W2102114757","https://openalex.org/W2103650497","https://openalex.org/W2105786825","https://openalex.org/W2107600014","https://openalex.org/W2109335024","https://openalex.org/W2112864683","https://openalex.org/W2115712103","https://openalex.org/W2120095832","https://openalex.org/W2121315499","https://openalex.org/W2124562476","https://openalex.org/W2124980889","https://openalex.org/W2127967394","https://openalex.org/W2132980978","https://openalex.org/W2135133274","https://openalex.org/W2141365940","https://openalex.org/W2146120613","https://openalex.org/W2147638815","https://openalex.org/W2148323109","https://openalex.org/W2153148799","https://openalex.org/W2159620582","https://openalex.org/W2171451207","https://openalex.org/W4213353716"],"related_works":["https://openalex.org/W7221099775","https://openalex.org/W3013560289","https://openalex.org/W2016691753","https://openalex.org/W2955364297","https://openalex.org/W2415055120","https://openalex.org/W2586386056","https://openalex.org/W2051780892","https://openalex.org/W7128579982","https://openalex.org/W7096068269","https://openalex.org/W3087913825"],"abstract_inverted_index":{"The":[0],"model":[1,76,144],"organism":[2],"Escherichia":[3],"coli":[4],"codes":[5],"for":[6,74],"at":[7],"least":[8],"11":[9],"type":[10,114],"II":[11,115],"toxin-antitoxin":[12],"(TA)":[13],"modules,":[14,179],"all":[15,112],"implicated":[16],"in":[17,93,156,206,221],"bacterial":[18,234],"persistence":[19,126,166,205,220],"(multidrug":[20],"tolerance).":[21],"Ten":[22],"of":[23,35,58,87,91,117,138,158,195,200,209,224,233],"these":[24,228],"encode":[25],"messenger":[26],"RNA":[27],"endonucleases":[28],"(mRNases)":[29],"inhibiting":[30],"translation":[31,61],"by":[32,198],"catalytic":[33],"degradation":[34],"mRNA,":[36],"and":[37,62,67,81,104,127,159,182],"the":[38,64,84,122,175,192,207,222],"11th":[39],"module,":[40],"hipBA,":[41],"encodes":[42],"HipA":[43,139,201],"(high":[44],"persister":[45],"protein":[46],"A)":[47],"kinase,":[48],"which":[49],"inhibits":[50,60],"glutamyl":[51],"tRNA":[52],"synthetase":[53],"(GltX).":[54],"In":[55,120],"turn,":[56,121],"inhibition":[57],"GltX":[59],"induces":[63],"stringent":[65],"response":[66],"persistence.":[68,88,151,235],"Previously,":[69],"we":[70,153],"presented":[71],"strong":[72],"support":[73,157],"a":[75,100],"proposing":[77],"(p)ppGpp":[78,141,171,196],"(guanosine":[79],"tetra":[80],"penta-phosphate)":[82],"as":[83,230],"master":[85],"regulator":[86],"Stochastic":[89],"variation":[90],"[(p)ppGpp]":[92],"single":[94,187],"cells":[95,188],"induced":[96,125,150],"TA-encoded":[97,210,225],"mRNases":[98,124],"via":[99],"pathway":[101],"involving":[102],"polyphosphate":[103],"Lon":[105,109,180],"protease.":[106],"Polyphosphate":[107],"activated":[108,123],"to":[110],"degrade":[111],"known":[113,135],"antitoxins":[116],"E.":[118],"coli.":[119],"multidrug":[128],"tolerance.":[129],"However,":[130],"even":[131],"though":[132],"it":[133],"was":[134],"that":[136,191],"activation":[137,199],"stimulated":[140],"synthesis,":[142],"our":[143,162],"did":[145],"not":[146,168,203,218],"explain":[147],"how":[148],"hipBA":[149],"Here":[152],"show":[154,190],"that,":[155],"consistent":[160],"with":[161,186],"initial":[163],"model,":[164],"HipA-induced":[165],"depends":[167],"only":[169],"on":[170,174],"but":[172],"also":[173],"10":[176],"mRNase-encoding":[177],"TA":[178],"protease,":[181],"polyphosphate.":[183],"Importantly,":[184],"observations":[185],"convincingly":[189],"high":[193],"level":[194],"caused":[197],"does":[202,217],"induce":[204,219],"absence":[208,223],"mRNases.":[211],"Thus,":[212],"slow":[213],"growth":[214],"per":[215],"se":[216],"toxins,":[226],"placing":[227],"genes":[229],"central":[231],"effectors":[232]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":18},{"year":2018,"cited_by_count":19},{"year":2017,"cited_by_count":32},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}