{"id":"https://openalex.org/W2003025878","doi":"https://doi.org/10.1371/journal.pone.0007815","title":"Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies","display_name":"Genotyping of Genetically Monomorphic Bacteria: DNA Sequencing in Mycobacterium tuberculosis Highlights the Limitations of Current Methodologies","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W2003025878","doi":"https://doi.org/10.1371/journal.pone.0007815","mag":"2003025878","pmid":"https://pubmed.ncbi.nlm.nih.gov/19915672","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772813"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0007815","doi":"https://doi.org/10.1371/journal.pone.0007815","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007815","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007815&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007815&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072542589","display_name":"I\u00f1aki Comas","orcid":"https://orcid.org/0000-0001-5504-9408","observed_orcids":["https://orcid.org/0000-0001-5504-9408"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"I\u00f1aki Comas","raw_affiliation_strings":["Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK","Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, UK","institution_ids":["https://openalex.org/I90344618"]},{"raw_affiliation_string":"Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, United Kingdom","institution_ids":["https://openalex.org/I4405285715","https://openalex.org/I90344618"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040606159","display_name":"Susanne Homolka","orcid":"https://orcid.org/0000-0003-4972-5638","observed_orcids":["https://orcid.org/0000-0003-4972-5638"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Susanne Homolka","raw_affiliation_strings":["Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063438724","display_name":"Stefan Niemann","orcid":"https://orcid.org/0000-0002-6604-0684","observed_orcids":["https://orcid.org/0000-0002-6604-0684"]},"institutions":[{"id":"https://openalex.org/I4210128097","display_name":"Research Center Borstel - Leibniz Lung Center","ror":"https://ror.org/036ragn25","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210128097"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Stefan Niemann","raw_affiliation_strings":["Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Mycobacteriology, Research Center Borstel, Borstel, Germany","institution_ids":["https://openalex.org/I4210128097"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081756586","display_name":"S\u00e9bastien Gagneux","orcid":"https://orcid.org/0000-0001-7783-9048","observed_orcids":["https://orcid.org/0000-0001-7783-9048","https://orcid.org/0000-0001-5360-2193"]},"institutions":[{"id":"https://openalex.org/I4405285715","display_name":"National Institute for Medical Research","ror":"https://ror.org/00146rb91","country_code":"GB","type":"facility","lineage":["https://openalex.org/I2801081054","https://openalex.org/I4210087105","https://openalex.org/I4405285715","https://openalex.org/I90344618"]},{"id":"https://openalex.org/I90344618","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517","country_code":"GB","type":"government","lineage":["https://openalex.org/I4210087105","https://openalex.org/I90344618"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Sebastien Gagneux","raw_affiliation_strings":["Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, United Kingdom"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Mycobacterial Research, Medical Research Council, National Institute for Medical Research, London, United Kingdom","institution_ids":["https://openalex.org/I4405285715","https://openalex.org/I90344618"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5081756586"],"corresponding_institution_ids":["https://openalex.org/I4405285715","https://openalex.org/I90344618"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":24.0695,"has_fulltext":true,"cited_by_count":402,"citation_normalized_percentile":{"value":0.99814598,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"4","issue":"11","first_page":"e7815","last_page":"e7815"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10038","display_name":"Tuberculosis Research and Epidemiology","score":0.9746000170707703,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11316","display_name":"Mycobacterium research and diagnosis","score":0.004600000102072954,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis-complex","display_name":"Mycobacterium tuberculosis complex","score":0.9800000190734863},{"id":"https://openalex.org/keywords/spoligotyping","display_name":"spoligotyping","score":0.7620000243186951},{"id":"https://openalex.org/keywords/miru-vntr-typing","display_name":"MIRU-VNTR typing","score":0.9179999828338623},{"id":"https://openalex.org/keywords/crispr-typing","display_name":"CRISPR typing","score":0.7540000081062317},{"id":"https://openalex.org/keywords/phylogenetic-accuracy","display_name":"phylogenetic accuracy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/homoplasy","display_name":"homoplasy","score":0.7009999752044678},{"id":"https://openalex.org/keywords/convergent-evolution","display_name":"convergent evolution","score":0.9620000123977661},{"id":"https://openalex.org/keywords/bacterial-typing","display_name":"strain typing","score":0.503000020980835},{"id":"https://openalex.org/keywords/discriminatory-power","display_name":"discriminatory power","score":0.593999981880188},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphisms","display_name":"single nucleotide polymorphisms","score":0.8190000057220459},{"id":"https://openalex.org/keywords/strain-lineages","display_name":"strain lineages","score":0.5070000290870667},{"id":"https://openalex.org/keywords/tuberculosis-epidemiology","display_name":"tuberculosis epidemiology","score":0.6100000143051147}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8010366559028625},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.7305805683135986},{"id":"https://openalex.org/C31467283","wikidata":"https://www.wikidata.org/wiki/Q912147","display_name":"Genotyping","level":4,"score":0.7082980871200562},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6573700308799744},{"id":"https://openalex.org/C77434933","wikidata":"https://www.wikidata.org/wiki/Q4043440","display_name":"Multilocus sequence typing","level":4,"score":0.5673425793647766},{"id":"https://openalex.org/C189036908","wikidata":"https://www.wikidata.org/wiki/Q2587423","display_name":"Variable number tandem repeat","level":4,"score":0.4574602544307709},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.44448283314704895},{"id":"https://openalex.org/C27149982","wikidata":"https://www.wikidata.org/wiki/Q3456514","display_name":"Tandem repeat","level":4,"score":0.44158151745796204},{"id":"https://openalex.org/C2776817793","wikidata":"https://www.wikidata.org/wiki/Q6553369","display_name":"Lineage (genetic)","level":3,"score":0.4171687662601471},{"id":"https://openalex.org/C51679486","wikidata":"https://www.wikidata.org/wiki/Q380546","display_name":"DNA sequencing","level":3,"score":0.4160211980342865},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.32943636178970337},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.1751594841480255},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1680968999862671},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.13420170545578003},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D004251","descriptor_name":"DNA Transposable Elements","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005819","descriptor_name":"Genetic Markers","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005838","descriptor_name":"Genotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009169","descriptor_name":"Mycobacterium tuberculosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015373","descriptor_name":"Bacterial Typing Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016172","descriptor_name":"DNA Fingerprinting","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019070","descriptor_name":"Cell Lineage","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pone.0007815","doi":"https://doi.org/10.1371/journal.pone.0007815","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007815","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007815&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2772813","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2772813","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmid:19915672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19915672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.802.379","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.802.379","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/97/53/pone.0007815.PMC2772813.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:d1b0a8af280f48a88039ec785305b637","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d1b0a8af280f48a88039ec785305b637","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 4, Iss 11, p e7815 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145737","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/Genotyping_of_Genetically_Monomorphic_Bacteria_DNA_Sequencing_in_Mycobacterium_tuberculosis_Highlights_the_Limitations_of_Current_Methodologies/145737","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0007815","doi":"https://doi.org/10.1371/journal.pone.0007815","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0007815","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0007815&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1724443539","display_name":null,"funder_award_id":"HHSN 266200700022C","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G6579469485","display_name":null,"funder_award_id":"HHSN266200700022C","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8650939292","display_name":"Population Based Molecular epidemiology of Tuberculosis","funder_award_id":"R01AI034238","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003025878.pdf","grobid_xml":"https://content.openalex.org/works/W2003025878.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W1922405592","https://openalex.org/W1964501807","https://openalex.org/W1969464199","https://openalex.org/W1972786625","https://openalex.org/W1977633672","https://openalex.org/W1980066896","https://openalex.org/W1985986410","https://openalex.org/W1997027430","https://openalex.org/W1999045045","https://openalex.org/W1999809115","https://openalex.org/W2003960936","https://openalex.org/W2005212780","https://openalex.org/W2014141216","https://openalex.org/W2025153546","https://openalex.org/W2033415336","https://openalex.org/W2034166604","https://openalex.org/W2052550780","https://openalex.org/W2055200195","https://openalex.org/W2057212110","https://openalex.org/W2057528483","https://openalex.org/W2061555533","https://openalex.org/W2072187332","https://openalex.org/W2082928585","https://openalex.org/W2085436536","https://openalex.org/W2087793347","https://openalex.org/W2088101132","https://openalex.org/W2089966564","https://openalex.org/W2092343047","https://openalex.org/W2096162460","https://openalex.org/W2098618245","https://openalex.org/W2102246203","https://openalex.org/W2103546861","https://openalex.org/W2104332925","https://openalex.org/W2106813347","https://openalex.org/W2106839160","https://openalex.org/W2110397906","https://openalex.org/W2110949356","https://openalex.org/W2111205680","https://openalex.org/W2112956791","https://openalex.org/W2115317782","https://openalex.org/W2117580564","https://openalex.org/W2123694222","https://openalex.org/W2125121305","https://openalex.org/W2126568957","https://openalex.org/W2134558351","https://openalex.org/W2135959003","https://openalex.org/W2142392294","https://openalex.org/W2142503351","https://openalex.org/W2142635246","https://openalex.org/W2145004751","https://openalex.org/W2145282362","https://openalex.org/W2146058063","https://openalex.org/W2146344742","https://openalex.org/W2147141708","https://openalex.org/W2147571700","https://openalex.org/W2147883537","https://openalex.org/W2148015529","https://openalex.org/W2148496884","https://openalex.org/W2149688703","https://openalex.org/W2152363872","https://openalex.org/W2152895327","https://openalex.org/W2153927725","https://openalex.org/W2154091239","https://openalex.org/W2157413902","https://openalex.org/W2159138215","https://openalex.org/W2159367931","https://openalex.org/W2159854313","https://openalex.org/W2165822919","https://openalex.org/W2170996473","https://openalex.org/W2259225862","https://openalex.org/W4242673342"],"related_works":["https://openalex.org/W2072187332","https://openalex.org/W1985287479","https://openalex.org/W2131753257","https://openalex.org/W6921248743","https://openalex.org/W2090776398","https://openalex.org/W2766364966","https://openalex.org/W2116821066","https://openalex.org/W7098724426","https://openalex.org/W2272525996","https://openalex.org/W2049937571"],"abstract_inverted_index":{"Because":[0],"genetically":[1,275],"monomorphic":[2,276],"bacterial":[3],"pathogens":[4],"harbour":[5],"little":[6],"DNA":[7,104,170],"sequence":[8,125,171,250],"diversity,":[9],"most":[10],"current":[11],"genotyping":[12],"techniques":[13],"used":[14,33,97,261],"to":[15,57,152,164],"study":[16],"the":[17,64,74,102,135,153,178,196,213,217],"epidemiology":[18],"of":[19,77,106,134,192,216],"these":[20,35,123,206],"organisms":[21],"are":[22,52,85],"based":[23,238],"on":[24,239],"mobile":[25],"or":[26,146,248],"repetitive":[27],"genetic":[28,61],"elements.":[29],"Molecular":[30],"markers":[31,242],"commonly":[32],"in":[34,83,233,262,273],"bacteria":[36],"include":[37],"Clustered":[38],"Regulatory":[39],"Short":[40],"Palindromic":[41],"Repeats":[42,48],"(CRISPR)":[43],"and":[44,59,79,89,130,184,195,252],"Variable":[45],"Number":[46],"Tandem":[47],"(VNTR).":[49],"These":[50],"methods":[51,137],"also":[53,210],"increasingly":[54],"being":[55],"applied":[56],"phylogenetic":[58,75,119,136,202],"population":[60],"studies.":[62],"Using":[63],"Mycobacterium":[65],"tuberculosis":[66],"complex":[67],"(MTBC)":[68],"as":[69,87,98,244],"a":[70,99,111,263],"model,":[71],"we":[72],"evaluated":[73],"accuracy":[76],"CRISPR-":[78],"VNTR-based":[80],"genotyping,":[81],"which":[82,186],"MTBC":[84,234],"known":[86],"spoligotyping":[88,145,183],"Mycobacterial":[90],"Interspersed":[91],"Repetitive":[92],"Units":[93],"(MIRU)-VNTR-typing,":[94],"respectively.":[95],"We":[96],"gold":[100],"standard":[101,218],"complete":[103],"sequences":[105],"89":[107],"coding":[108],"genes":[109],"from":[110,122,144],"global":[112],"strain":[113,167,224,231,271],"collection.":[114],"Our":[115,208,266],"results":[116,209],"showed":[117,173],"that":[118,212,253],"trees":[120],"derived":[121],"multilocus":[124],"data":[126,172],"were":[127,148],"highly":[128],"congruent":[129],"statistically":[131],"robust,":[132],"irrespective":[133],"used.":[138],"By":[139],"contrast,":[140],"corresponding":[141],"phylogenies":[142],"inferred":[143],"15-loci-MIRU-VNTR":[147],"incongruent":[149],"with":[150,189],"respect":[151],"sequence-based":[154],"trees.":[155],"Although":[156],"24-loci-MIRU-VNTR":[157],"performed":[158],"better,":[159],"it":[160],"was":[161,180,187],"still":[162],"unable":[163],"detect":[165],"all":[166],"lineages.":[168],"The":[169],"virtually":[174],"no":[175],"homoplasy,":[176],"but":[177],"opposite":[179],"true":[181],"for":[182,201,254,270],"MIRU-VNTR,":[185],"consistent":[188],"high":[190],"rates":[191],"convergent":[193],"evolution":[194],"low":[197],"statistical":[198],"support":[199],"obtained":[200],"groupings":[203],"defined":[204,237],"by":[205,223],"markers.":[207],"revealed":[211],"discriminatory":[214],"power":[215],"24":[219],"MIRU-VNTR":[220,257],"loci":[221,258],"varied":[222],"lineage.":[225],"Taken":[226],"together,":[227],"our":[228],"findings":[229,267],"suggest":[230],"lineages":[232],"should":[235,259],"be":[236,260],"phylogenetically":[240],"robust":[241],"such":[243],"single":[245],"nucleotide":[246],"polymorphisms":[247],"large":[249],"polymorphisms,":[251],"epidemiological":[255],"purposes,":[256],"lineage-dependent":[264],"manner.":[265],"have":[268],"implications":[269],"typing":[272],"other":[274],"bacteria.":[277]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":16},{"year":2021,"cited_by_count":13},{"year":2020,"cited_by_count":24},{"year":2019,"cited_by_count":19},{"year":2018,"cited_by_count":36},{"year":2017,"cited_by_count":29},{"year":2016,"cited_by_count":28},{"year":2015,"cited_by_count":33},{"year":2014,"cited_by_count":37},{"year":2013,"cited_by_count":32},{"year":2012,"cited_by_count":37}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
