{"id":"https://openalex.org/W2003023940","doi":"https://doi.org/10.1159/000097632","title":"Distinct Effects of Z-335, a New Thromboxane A2 Receptor Antagonist, on Rabbit Platelets and Aortic Smooth Muscle","display_name":"Distinct Effects of Z-335, a New Thromboxane A2 Receptor Antagonist, on Rabbit Platelets and Aortic Smooth Muscle","publication_year":2006,"publication_date":"2006-11-30","ids":{"openalex":"https://openalex.org/W2003023940","doi":"https://doi.org/10.1159/000097632","mag":"2003023940","pmid":"https://pubmed.ncbi.nlm.nih.gov/17139194"},"language":"en","primary_location":{"id":"doi:10.1159/000097632","doi":"https://doi.org/10.1159/000097632","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000097632","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Makoto Yoshida","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I201537933","display_name":"Tohoku University","ror":"https://ror.org/01dq60k83","country_code":"JP","type":"education","lineage":["https://openalex.org/I201537933"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Makoto Yoshida","raw_affiliation_strings":["Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. yoshida@takasaki-u.ac.jp","Department of Cellular Signaling,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan. yoshida@takasaki-u.ac.jp","institution_ids":["https://openalex.org/I201537933"]},{"raw_affiliation_string":"Department of Cellular Signaling,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068376175","display_name":"Yukari Sato","orcid":"https://orcid.org/0000-0002-9314-1974","observed_orcids":["https://orcid.org/0000-0002-9314-1974"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yukari Sato","raw_affiliation_strings":["Department of Cellular Signaling,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053522096","display_name":"Tokuro Shimura","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tokuro Shimura","raw_affiliation_strings":["Department of Cellular Signaling,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109135089","display_name":"Satoko Ohkubo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Satoko Ohkubo","raw_affiliation_strings":["Department of Cellular Signaling,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111677553","display_name":"Shigeyoshi Honma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25859482","display_name":"Takasaki University of Health and Welfare","ror":"https://ror.org/00n3e1d98","country_code":"JP","type":"education","lineage":["https://openalex.org/I25859482"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeyoshi Honma","raw_affiliation_strings":["Department of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Faculty of Pharmacy, Takasaki University of Health and Welfare, Takasaki,","institution_ids":["https://openalex.org/I25859482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007633679","display_name":"Takao Tanaka","orcid":"https://orcid.org/0000-0001-9311-256X","observed_orcids":["https://orcid.org/0000-0001-9311-256X"]},"institutions":[{"id":"https://openalex.org/I4210126322","display_name":"Zeria Pharmaceutical (Japan)","ror":"https://ror.org/02j4jqr44","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210126322"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takao Tanaka","raw_affiliation_strings":["Central Research Laboratories, ZERIA Pharmaceutical Co., Ltd., Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, ZERIA Pharmaceutical Co., Ltd., Saitama, Japan","institution_ids":["https://openalex.org/I4210126322"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109920066","display_name":"Tadashi Kurimoto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210126322","display_name":"Zeria Pharmaceutical (Japan)","ror":"https://ror.org/02j4jqr44","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210126322"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tadashi Kurimoto","raw_affiliation_strings":["Central Research Laboratories, ZERIA Pharmaceutical Co., Ltd., Saitama, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Central Research Laboratories, ZERIA Pharmaceutical Co., Ltd., Saitama, Japan","institution_ids":["https://openalex.org/I4210126322"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109294034","display_name":"Norimichi Nakahata","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Norimichi Nakahata","raw_affiliation_strings":["Department of Cellular Signaling,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cellular Signaling,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.1362,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.38974943,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"79","issue":"1","first_page":"50","last_page":"56"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12910","display_name":"Eicosanoids and Hypertension Pharmacology","score":0.5932999849319458,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10746","display_name":"Platelet Disorders and Treatments","score":0.219200000166893,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10678","display_name":"Inflammatory mediators and NSAID effects","score":0.07810000330209732,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thromboxane-receptor-antagonist","display_name":"thromboxane A2 receptor antagonist","score":0.9779999852180481},{"id":"https://openalex.org/keywords/platelet-shape-change","display_name":"platelet shape change","score":0.7879999876022339},{"id":"https://openalex.org/keywords/platelet-aggregation","display_name":"platelet aggregation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/aortic-vasoconstriction","display_name":"aortic vasoconstriction","score":0.9100000262260437},{"id":"https://openalex.org/keywords/aortic-smooth-muscle","display_name":"aortic smooth muscle","score":0.8730000257492065},{"id":"https://openalex.org/keywords/u46619","display_name":"U46619","score":0.9710000157356262},{"id":"https://openalex.org/keywords/sq29548","display_name":"SQ29548","score":0.9940000176429749},{"id":"https://openalex.org/keywords/receptor-binding-affinity","display_name":"receptor binding affinity","score":0.6380000114440918},{"id":"https://openalex.org/keywords/non-competitive-inhibition","display_name":"non-competitive inhibition","score":0.6510000228881836},{"id":"https://openalex.org/keywords/competitive-inhibition","display_name":"competitive inhibition","score":0.6790000200271606},{"id":"https://openalex.org/keywords/rabbits","display_name":"rabbits","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C2781024287","wikidata":"https://www.wikidata.org/wiki/Q774909","display_name":"Thromboxane A2","level":3,"score":0.7344717383384705},{"id":"https://openalex.org/C2776885963","wikidata":"https://www.wikidata.org/wiki/Q245204","display_name":"Antagonist","level":3,"score":0.7129204869270325},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.6910415887832642},{"id":"https://openalex.org/C89560881","wikidata":"https://www.wikidata.org/wiki/Q101026","display_name":"Platelet","level":2,"score":0.6411479115486145},{"id":"https://openalex.org/C2779980429","wikidata":"https://www.wikidata.org/wiki/Q101004","display_name":"Aorta","level":2,"score":0.6124045252799988},{"id":"https://openalex.org/C2776785769","wikidata":"https://www.wikidata.org/wiki/Q412212","display_name":"Thromboxane","level":3,"score":0.5992316007614136},{"id":"https://openalex.org/C2778122271","wikidata":"https://www.wikidata.org/wiki/Q410943","display_name":"Receptor antagonist","level":4,"score":0.5500411987304688},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5354291200637817},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.47615528106689453},{"id":"https://openalex.org/C51603380","wikidata":"https://www.wikidata.org/wiki/Q411978","display_name":"Thromboxane receptor","level":4,"score":0.4739021360874176},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4464947283267975},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.42098894715309143},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4113170802593231},{"id":"https://openalex.org/C2992686903","wikidata":"https://www.wikidata.org/wiki/Q208453","display_name":"Smooth muscle","level":2,"score":0.33460962772369385},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3241259455680847},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.2671358585357666}],"mesh":[{"descriptor_ui":"D000804","descriptor_name":"Angiotensin II","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001013","descriptor_name":"Aorta, Thoracic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D001792","descriptor_name":"Blood Platelets","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005231","descriptor_name":"Fatty Acids, Unsaturated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006834","descriptor_name":"Hydrazines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007189","descriptor_name":"Indans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D007295","descriptor_name":"Inositol Phosphates","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009131","descriptor_name":"Muscle, Smooth, Vascular","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009638","descriptor_name":"Norepinephrine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010974","descriptor_name":"Platelet Aggregation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011869","descriptor_name":"Radioligand Assay","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014316","descriptor_name":"Tritium","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014661","descriptor_name":"Vasoconstriction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014662","descriptor_name":"Vasoconstrictor Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016232","descriptor_name":"Endothelins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D019086","descriptor_name":"Bridged Bicyclo Compounds, Heterocyclic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019796","descriptor_name":"15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D044244","descriptor_name":"Receptors, Thromboxane A2, Prostaglandin H2","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D048430","descriptor_name":"Cell Shape","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1159/000097632","doi":"https://doi.org/10.1159/000097632","is_oa":false,"landing_page_url":"https://doi.org/10.1159/000097632","pdf_url":null,"source":{"id":"https://openalex.org/S106137443","display_name":"Pharmacology","issn_l":"0031-7012","issn":["0031-7012","1423-0313"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","ki-jl-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4310317820","host_organization_name":"Karger Publishers","host_organization_lineage":["https://openalex.org/P4310317820"],"host_organization_lineage_names":["Karger Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"journal-article"},{"id":"pmid:17139194","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17139194","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8371999859809875}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":21,"referenced_works":["https://openalex.org/W1578779257","https://openalex.org/W1640144340","https://openalex.org/W1802267091","https://openalex.org/W1867621675","https://openalex.org/W1962449024","https://openalex.org/W1967764176","https://openalex.org/W1979961507","https://openalex.org/W1996228057","https://openalex.org/W2014046848","https://openalex.org/W2036456076","https://openalex.org/W2048009051","https://openalex.org/W2052817546","https://openalex.org/W2057963472","https://openalex.org/W2074864786","https://openalex.org/W2092219033","https://openalex.org/W2100658366","https://openalex.org/W2130963215","https://openalex.org/W2135805417","https://openalex.org/W2143442358","https://openalex.org/W2146416151","https://openalex.org/W2158979977"],"related_works":["https://openalex.org/W2074864786","https://openalex.org/W2019585417","https://openalex.org/W1990653891","https://openalex.org/W2050941950","https://openalex.org/W3101065198","https://openalex.org/W1979961507","https://openalex.org/W2016051580","https://openalex.org/W2418073068","https://openalex.org/W3098242616","https://openalex.org/W2260198274"],"abstract_inverted_index":{"The":[0,42,73,89],"effect":[1],"of":[2,65,76,98,120],"a":[3,38,51],"novel":[4],"thromboxane":[5],"A2":[6],"receptor":[7],"(TP)":[8],"antagonist,":[9],"(+/-)-sodium[2-(4-chlorophenylsulfonylaminomethyl)-":[10],"indan-5-yl]acetate":[11],"monohydrate":[12],"(Z-335),":[13],"on":[14],"the":[15,94],"U46619-induced":[16,43,63],"responses":[17],"was":[18,46,56,81],"compared":[19],"between":[20],"rabbit":[21,66,104],"platelets":[22],"and":[23],"aorta.":[24],"Z-335":[25,49,61,77,99,116],"inhibited":[26,47,58,62],"platelet":[27,44,86],"shape":[28,87],"change":[29],"induced":[30],"by":[31,48,59],"U46619":[32],"with":[33,68],"higher":[34,69,83,95],"efficacy":[35,70],"than":[36,71,84,109],"SQ29548,":[37],"common":[39],"TP":[40,121],"antagonist.":[41],"aggregation":[45],"in":[50,78,85,103,110],"noncompetitive":[52],"manner,":[53],"while":[54],"it":[55],"competitively":[57],"SQ29548.":[60,72],"vasoconstriction":[64,80],"aorta":[67],"pA2":[74],"value":[75,97],"aortic":[79,105],"significantly":[82],"change.":[88],"competitive":[90],"binding":[91,102],"study":[92],"showed":[93],"pKi":[96],"against":[100],"[3H]-SQ29548":[101],"smooth":[106],"muscle":[107],"cells":[108],"platelets.":[111],"These":[112],"data":[113],"suggest":[114],"that":[115],"has":[117],"useful":[118],"characteristics":[119],"antagonism.":[122]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}