{"id":"https://openalex.org/W2003013587","doi":"https://doi.org/10.1194/jlr.r800056-jlr200","title":"Emerging role of Toll-like receptors in atherosclerosis","display_name":"Emerging role of Toll-like receptors in atherosclerosis","publication_year":2008,"publication_date":"2008-11-02","ids":{"openalex":"https://openalex.org/W2003013587","doi":"https://doi.org/10.1194/jlr.r800056-jlr200","mag":"2003013587","pmid":"https://pubmed.ncbi.nlm.nih.gov/18980945","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2674724"},"language":"en","primary_location":{"id":"doi:10.1194/jlr.r800056-jlr200","doi":"https://doi.org/10.1194/jlr.r800056-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.r800056-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.1194/jlr.r800056-jlr200","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112868349","display_name":"Linda K. Curtiss","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Linda K. Curtiss","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. lcurtiss@scripps.edu","Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA. lcurtiss@scripps.edu","institution_ids":["https://openalex.org/I123431417"]},{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA","institution_ids":["https://openalex.org/I123431417"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109914190","display_name":"Peter S. Tobias","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I123431417","display_name":"Scripps Research Institute","ror":"https://ror.org/02dxx6824","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I123431417"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter S. Tobias","raw_affiliation_strings":["Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Immunology and Microbial Science, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037","institution_ids":["https://openalex.org/I123431417"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I123431417"],"apc_list":{"value":3430,"currency":"USD","value_usd":3430},"apc_paid":{"value":3430,"currency":"USD","value_usd":3430},"fwci":1.0235,"has_fulltext":false,"cited_by_count":226,"citation_normalized_percentile":{"value":0.72860636,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"50","issue":null,"first_page":"S340","last_page":"S345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.0027000000700354576,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11618","display_name":"Cholesterol and Lipid Metabolism","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toll-like-receptors","display_name":"Toll-like receptors","score":0.996999979019165},{"id":"https://openalex.org/keywords/atherosclerosis","display_name":"atherosclerosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/endothelial-inflammation","display_name":"endothelial inflammation","score":0.7990000247955322},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.777999997138977},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":1.0},{"id":"https://openalex.org/keywords/blood-flow","display_name":"blood flow","score":0.6549999713897705},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.746999979019165},{"id":"https://openalex.org/keywords/lipid-accumulation","display_name":"lipid accumulation","score":0.734000027179718},{"id":"https://openalex.org/keywords/leukocyte-accumulation","display_name":"leukocyte accumulation","score":0.9350000023841858},{"id":"https://openalex.org/keywords/arterial-lesions","display_name":"arterial lesions","score":0.3889999985694885},{"id":"https://openalex.org/keywords/vascular-inflammation","display_name":"vascular inflammation","score":0.5509999990463257}],"concepts":[{"id":"https://openalex.org/C2778025104","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll","level":2,"score":0.7316327095031738},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.649547815322876},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.34423181414604187},{"id":"https://openalex.org/C144133560","wikidata":"https://www.wikidata.org/wiki/Q4830453","display_name":"Business","level":0,"score":0.3233081102371216},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30241847038269043},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.29736870527267456},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2859734892845154},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.1764514148235321}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050197","descriptor_name":"Atherosclerosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051193","descriptor_name":"Toll-Like Receptors","qualifier_ui":"Q000819","qualifier_name":"agonists","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1194/jlr.r800056-jlr200","doi":"https://doi.org/10.1194/jlr.r800056-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.r800056-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2674724","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2674724","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Lipid Res","raw_type":"Text"},{"id":"pmid:18980945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18980945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of lipid research","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:eb344e77c4884c6e87f86343c6a35e00","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eb344e77c4884c6e87f86343c6a35e00","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Lipid Research, Vol 50, Iss , Pp S340-S345 (2009)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1194/jlr.r800056-jlr200","doi":"https://doi.org/10.1194/jlr.r800056-jlr200","is_oa":true,"landing_page_url":"https://doi.org/10.1194/jlr.r800056-jlr200","pdf_url":null,"source":{"id":"https://openalex.org/S11400418","display_name":"Journal of Lipid Research","issn_l":"0022-2275","issn":["0022-2275","1539-7262"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-140","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Lipid Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W183599942","https://openalex.org/W274441265","https://openalex.org/W1488196937","https://openalex.org/W1591714343","https://openalex.org/W1830583197","https://openalex.org/W1932677272","https://openalex.org/W1969457486","https://openalex.org/W1970456030","https://openalex.org/W1976901255","https://openalex.org/W1978369960","https://openalex.org/W1985477675","https://openalex.org/W1988516892","https://openalex.org/W1988649393","https://openalex.org/W1991731944","https://openalex.org/W1993223367","https://openalex.org/W2001056724","https://openalex.org/W2006336809","https://openalex.org/W2008961036","https://openalex.org/W2010866783","https://openalex.org/W2016259117","https://openalex.org/W2018475901","https://openalex.org/W2018653121","https://openalex.org/W2018788678","https://openalex.org/W2018950002","https://openalex.org/W2025447518","https://openalex.org/W2027550447","https://openalex.org/W2030237203","https://openalex.org/W2050288401","https://openalex.org/W2056612274","https://openalex.org/W2056879548","https://openalex.org/W2060916776","https://openalex.org/W2061626698","https://openalex.org/W2063477340","https://openalex.org/W2067982460","https://openalex.org/W2079745624","https://openalex.org/W2086131760","https://openalex.org/W2090579059","https://openalex.org/W2097097751","https://openalex.org/W2103504373","https://openalex.org/W2106267762","https://openalex.org/W2113769407","https://openalex.org/W2114426105","https://openalex.org/W2114918865","https://openalex.org/W2119218397","https://openalex.org/W2120653802","https://openalex.org/W2125175295","https://openalex.org/W2126510623","https://openalex.org/W2126616483","https://openalex.org/W2126659405","https://openalex.org/W2126725396","https://openalex.org/W2133924221","https://openalex.org/W2137485611","https://openalex.org/W2141584522","https://openalex.org/W2142737852","https://openalex.org/W2146234609","https://openalex.org/W2147508491","https://openalex.org/W2148178789","https://openalex.org/W2150782716","https://openalex.org/W2152415811","https://openalex.org/W2153328681","https://openalex.org/W2153539209","https://openalex.org/W2153540038","https://openalex.org/W2154067087","https://openalex.org/W2156280702","https://openalex.org/W2157108473","https://openalex.org/W2157122108","https://openalex.org/W2158431134","https://openalex.org/W2160369507","https://openalex.org/W2160591905","https://openalex.org/W2172180334","https://openalex.org/W2324841714","https://openalex.org/W6675857232"],"related_works":["https://openalex.org/W2152415811","https://openalex.org/W2045121602","https://openalex.org/W1978636999","https://openalex.org/W65926371","https://openalex.org/W2103348550","https://openalex.org/W2044277177","https://openalex.org/W1995671732","https://openalex.org/W7097695965","https://openalex.org/W2052962282","https://openalex.org/W2129221953"],"abstract_inverted_index":{"Atherosclerosis":[0],"is":[1],"inflammation":[2,12],"of":[3,7,29,42,61,73,80,98],"the":[4,8,26,30,59,71,99],"vessel":[5],"wall":[6],"arterial":[9],"tree.":[10],"This":[11,55],"arises":[13],"at":[14],"specific":[15],"areas":[16],"that":[17],"experience":[18],"disturbed":[19],"blood":[20,68],"flow":[21,69],"such":[22],"as":[23],"bifurcations":[24],"and":[25,83,86,104],"lesser":[27],"curvature":[28],"aortic":[31],"arch.":[32],"Although":[33],"all":[34],"endothelial":[35,47],"cells":[36,48],"are":[37,78],"exposed":[38],"to":[39],"comparable":[40],"levels":[41],"circulating":[43],"plasma":[44],"cholesterol,":[45],"only":[46],"overlaying":[49],"lesions":[50],"display":[51],"an":[52,89],"inflamed":[53],"phenotype.":[54],"occurs":[56],"even":[57],"in":[58,93],"absence":[60],"any":[62],"additional":[63],"exacerbating":[64],"disease":[65],"factors":[66],"because":[67],"controls":[70],"expression":[72],"Toll-like":[74],"receptors":[75],"(TLR),":[76],"which":[77],"initiators":[79],"cellular":[81],"activation":[82,97],"inflammation.":[84],"TLR2-":[85],"4-expression":[87],"exert":[88],"overall":[90],"proatherogenic":[91],"effect":[92],"hyperlipidemic":[94],"mice.":[95],"TLR":[96],"endothelium":[100],"promotes":[101],"lipid":[102],"accumulation":[103,106],"leukocyte":[105],"within":[107],"lesions.":[108]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":14},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":21},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":25},{"year":2015,"cited_by_count":16},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":18}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}