{"id":"https://openalex.org/W2003010451","doi":"https://doi.org/10.1152/ajpcell.00499.2003","title":"Urea transport in MDCK cells that are stably transfected with UT-A1","display_name":"Urea transport in MDCK cells that are stably transfected with UT-A1","publication_year":2004,"publication_date":"2004-02-10","ids":{"openalex":"https://openalex.org/W2003010451","doi":"https://doi.org/10.1152/ajpcell.00499.2003","mag":"2003010451","pmid":"https://pubmed.ncbi.nlm.nih.gov/14749217"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00499.2003","doi":"https://doi.org/10.1152/ajpcell.00499.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00499.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061722289","display_name":"Otto Fr\u00f6hlich","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Otto Fr\u00f6hlich","raw_affiliation_strings":["Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA","Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Emory University School of Medicine, Atlanta, GA 30322, USA","institution_ids":["https://openalex.org/I150468666"]},{"raw_affiliation_string":"Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066353889","display_name":"Janet D. Klein","orcid":"https://orcid.org/0000-0001-6663-1129","observed_orcids":["https://orcid.org/0000-0001-6663-1129"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Janet D. Klein","raw_affiliation_strings":["","Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Pauline M. Smith","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Pauline M. Smith","raw_affiliation_strings":["","Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014014770","display_name":"Jeff M. Sands","orcid":"https://orcid.org/0000-0001-9822-0607","observed_orcids":["https://orcid.org/0000-0001-9822-0607"]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeff M. Sands","raw_affiliation_strings":["","Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5110291102","display_name":"Robert Burns Gunn","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I150468666","display_name":"Emory University","ror":"https://ror.org/03czfpz43","country_code":"US","type":"education","lineage":["https://openalex.org/I150468666"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert B. Gunn","raw_affiliation_strings":["","Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]},{"raw_affiliation_string":"Department of Physiology and Renal Division, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia 30322","institution_ids":["https://openalex.org/I150468666"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I150468666"],"apc_list":null,"apc_paid":null,"fwci":1.8931,"has_fulltext":false,"cited_by_count":65,"citation_normalized_percentile":{"value":0.84026517,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"286","issue":"6","first_page":"C1264","last_page":"C1270"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12770","display_name":"Amino Acid Enzymes and Metabolism","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/urea-transport","display_name":"urea transport","score":0.843999981880188},{"id":"https://openalex.org/keywords/ut-a1","display_name":"UT-A1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/urea-transporter","display_name":"urea transporter","score":0.8289999961853027},{"id":"https://openalex.org/keywords/mdck-cells","display_name":"MDCK cells","score":0.9449999928474426},{"id":"https://openalex.org/keywords/kidney-collecting-duct","display_name":"renal collecting duct","score":0.5839999914169312},{"id":"https://openalex.org/keywords/forskolin","display_name":"forskolin","score":0.6349999904632568},{"id":"https://openalex.org/keywords/vasopressin","display_name":"vasopressin","score":0.9990000128746033},{"id":"https://openalex.org/keywords/protein-phosphorylation","display_name":"protein phosphorylation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/dimethylurea","display_name":"dimethylurea","score":0.8700000047683716},{"id":"https://openalex.org/keywords/phloretin","display_name":"phloretin","score":0.9860000014305115},{"id":"https://openalex.org/keywords/cell-culture-model","display_name":"cell culture model","score":0.4180000126361847}],"concepts":[{"id":"https://openalex.org/C54009773","wikidata":"https://www.wikidata.org/wiki/Q1429031","display_name":"Transfection","level":3,"score":0.8441226482391357},{"id":"https://openalex.org/C2779276759","wikidata":"https://www.wikidata.org/wiki/Q412747","display_name":"Forskolin","level":3,"score":0.7468001246452332},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5521103143692017},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.5505164861679077},{"id":"https://openalex.org/C2777468819","wikidata":"https://www.wikidata.org/wiki/Q173670","display_name":"Arginine","level":3,"score":0.4889868497848511},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.4889727830886841},{"id":"https://openalex.org/C2776370428","wikidata":"https://www.wikidata.org/wiki/Q21124841","display_name":"Vasopressin","level":2,"score":0.46032634377479553},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4426094591617584},{"id":"https://openalex.org/C2776415932","wikidata":"https://www.wikidata.org/wiki/Q48743","display_name":"Western blot","level":3,"score":0.42051127552986145},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.410497784614563},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.37054699659347534},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2424633800983429},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.16252952814102173},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.07768195867538452},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0662432610988617},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001127","descriptor_name":"Arginine Vasopressin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001692","descriptor_name":"Biological Transport","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002463","descriptor_name":"Cell Membrane Permeability","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002999","descriptor_name":"Clone Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005576","descriptor_name":"Colforsin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007685","descriptor_name":"Kidney Tubules, Collecting","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D009536","descriptor_name":"Niacinamide","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010693","descriptor_name":"Phloretin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014162","descriptor_name":"Transfection","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014508","descriptor_name":"Urea","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014882","descriptor_name":"Water-Electrolyte Balance","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D018929","descriptor_name":"Cell Culture Techniques","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D026901","descriptor_name":"Membrane Transport Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1152/ajpcell.00499.2003","doi":"https://doi.org/10.1152/ajpcell.00499.2003","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00499.2003","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:14749217","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/14749217","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G2861663120","display_name":"Regulation of Urea Transport by Adrenal Steroids","funder_award_id":"R01DK063657","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G3547890629","display_name":null,"funder_award_id":"R01-DK41707","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G818867089","display_name":null,"funder_award_id":"R01 DK 63657","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G8985077591","display_name":"Regulation of Renal Inner Medullary Function","funder_award_id":"R01DK041707","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W583722635","https://openalex.org/W1800388541","https://openalex.org/W1882549210","https://openalex.org/W1975794640","https://openalex.org/W1976107813","https://openalex.org/W2020233709","https://openalex.org/W2027936732","https://openalex.org/W2041613806","https://openalex.org/W2053407380","https://openalex.org/W2059803506","https://openalex.org/W2074936851","https://openalex.org/W2087906737","https://openalex.org/W2114078055","https://openalex.org/W2115432376","https://openalex.org/W2120464865","https://openalex.org/W2132452783","https://openalex.org/W2134075371","https://openalex.org/W2151980005","https://openalex.org/W2154517332","https://openalex.org/W2163038289","https://openalex.org/W2168390987","https://openalex.org/W2183806402","https://openalex.org/W2193285404","https://openalex.org/W2205814209","https://openalex.org/W2223937487","https://openalex.org/W2250701677","https://openalex.org/W2302385627","https://openalex.org/W2315892236","https://openalex.org/W2317342302","https://openalex.org/W2398107752","https://openalex.org/W2409647080","https://openalex.org/W2415680613","https://openalex.org/W2464471942"],"related_works":["https://openalex.org/W2051692813","https://openalex.org/W2061346668","https://openalex.org/W2106666583","https://openalex.org/W188032655","https://openalex.org/W2163038289","https://openalex.org/W2135374199","https://openalex.org/W1953206860","https://openalex.org/W7113790113","https://openalex.org/W1964027633","https://openalex.org/W129396044"],"abstract_inverted_index":{"Progress":[0],"in":[1,100,129,171,181,205],"understanding":[2],"the":[3,14,38,41,86,130,158,167,172,201],"cell":[4,19,33,192],"biology":[5],"of":[6,16,24,40,160,200],"urea":[7,44,144],"transporter":[8,45],"proteins":[9],"has":[10],"been":[11],"hampered":[12],"by":[13,139,147],"lack":[15],"an":[17,66],"appropriate":[18],"culture":[20],"system.":[21],"The":[22,49,72,110],"goal":[23],"this":[25],"study":[26],"was":[27,53,88,133],"to":[28,80],"create":[29],"a":[30,75,101],"polarized":[31,190],"epithelial":[32,191],"line":[34,193],"that":[35],"stably":[36,194],"expresses":[37,195],"largest":[39],"rat":[42,182,206],"renal":[43],"UT-A":[46],"isoforms,":[47],"UT-A1.":[48,161],"gene":[50],"for":[51],"UT-A1":[52,134,196],"cloned":[54],"into":[55,59],"pcDNA5/FRT":[56],"and":[57,121,143,153,164,197],"transfected":[58],"Madin-Darby":[60],"canine":[61],"kidney":[62],"(MDCK)":[63],"cells":[64,73,120,132],"with":[65,106],"integrated":[67],"Flp":[68],"recombination":[69],"target":[70],"site.":[71],"from":[74],"single":[76],"clone":[77],"were":[78,94,113],"grown":[79],"confluence":[81],"on":[82],"collagen-coated":[83],"membranes":[84],"until":[85],"resistance":[87],">1,500":[89],"Omega.cm(2).":[90],"Transepithelial":[91],"[(14)C]urea":[92,169],"fluxes":[93,112,170],"measured":[95,138],"at":[96],"37":[97],"degrees":[98],"C":[99],"HCO(3)(-)/CO(2)":[102],"buffer,":[103],"pH":[104],"7.4,":[105],"5":[107],"mM":[108],"urea.":[109],"baseline":[111],"not":[114],"different":[115],"between":[116],"unstimulated":[117],"UT-A1-transfected":[118,131,173],"MDCK":[119,125,174],"nontransfected":[122],"or":[123,149],"sham-transfected":[124],"cells.":[126,175],"However,":[127],"only":[128],"protein":[135],"expressed":[136],"(as":[137],"Western":[140],"blot":[141],"analysis)":[142],"transport":[145],"stimulated":[146],"forskolin":[148],"arginine":[150,154],"vasopressin.":[151],"Forskolin":[152],"vasopressin":[155],"also":[156],"increased":[157],"phosphorylation":[159],"Thionicotinamide,":[162],"dimethylurea,":[163],"phloretin":[165],"inhibited":[166],"forskolin-stimulated":[168],"These":[176],"characteristics":[177],"mimic":[178],"those":[179],"seen":[180],"terminal":[183,207],"inner":[184,208],"medullary":[185,209],"collecting":[186,210],"ducts.":[187,211],"This":[188],"new":[189],"reproduces":[198],"several":[199],"physiological":[202],"responses":[203],"observed":[204]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":5}],"updated_date":"2026-10-16T09:59:22.235173","created_date":"2016-06-24T00:00:00"}