{"id":"https://openalex.org/W2003003147","doi":"https://doi.org/10.1371/journal.pone.0072843","title":"Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients","display_name":"Cancer Stem Cell Gene Profile as Predictor of Relapse in High Risk Stage II and Stage III, Radically Resected Colon Cancer Patients","publication_year":2013,"publication_date":"2013-09-04","ids":{"openalex":"https://openalex.org/W2003003147","doi":"https://doi.org/10.1371/journal.pone.0072843","mag":"2003003147","pmid":"https://pubmed.ncbi.nlm.nih.gov/24023782"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0072843","doi":"https://doi.org/10.1371/journal.pone.0072843","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072843","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072843&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072843&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015406288","display_name":"Riccardo Giampieri","orcid":"https://orcid.org/0000-0001-7344-0590","observed_orcids":["https://orcid.org/0000-0001-7344-0590"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Riccardo Giampieri","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034035272","display_name":"Mario Scartozzi","orcid":"https://orcid.org/0000-0001-5977-5546","observed_orcids":["https://orcid.org/0000-0001-5977-5546"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Mario Scartozzi","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087468685","display_name":"Cristian Loretelli","orcid":"https://orcid.org/0000-0002-7583-8540","observed_orcids":["https://orcid.org/0000-0002-7583-8540"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cristian Loretelli","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054063272","display_name":"Francesco Piva","orcid":"https://orcid.org/0000-0003-1850-2482","observed_orcids":["https://orcid.org/0000-0003-1850-2482"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Francesco Piva","raw_affiliation_strings":["UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"UNIVPM, Ancona, Italy","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077825350","display_name":"Alessandra Mandolesi","orcid":"https://orcid.org/0000-0002-5297-3061","observed_orcids":["https://orcid.org/0000-0002-5297-3061"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandra Mandolesi","raw_affiliation_strings":["Institute of Pathology, AO ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, AO ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012129483","display_name":"Giovanni Lezoche","orcid":"https://orcid.org/0000-0002-4210-6386","observed_orcids":["https://orcid.org/0000-0002-4210-6386"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giovanni Lezoche","raw_affiliation_strings":["Institute of Surgery, AO ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgery, AO ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102814419","display_name":"Michela Del Prete","orcid":"https://orcid.org/0000-0003-3702-8931","observed_orcids":["https://orcid.org/0000-0003-3702-8931"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michela Del Prete","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036243769","display_name":"Alessandro Bittoni","orcid":"https://orcid.org/0000-0002-4056-0067","observed_orcids":["https://orcid.org/0000-0002-4056-0067"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Bittoni","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006012062","display_name":"Luca Faloppi","orcid":"https://orcid.org/0000-0003-3689-3085","observed_orcids":["https://orcid.org/0000-0003-3689-3085"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Faloppi","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066886113","display_name":"Maristella Bianconi","orcid":"https://orcid.org/0000-0003-3475-2529","observed_orcids":["https://orcid.org/0000-0003-3475-2529"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maristella Bianconi","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033672350","display_name":"Luca Cecchini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luca Cecchini","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064483974","display_name":"Mario Guerrieri","orcid":"https://orcid.org/0000-0001-8210-0379","observed_orcids":["https://orcid.org/0000-0001-8210-0379"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Mario Guerrieri","raw_affiliation_strings":["Institute of Surgery, AO ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Surgery, AO ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086745354","display_name":"Italo Bearzi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Italo Bearzi","raw_affiliation_strings":["Institute of Pathology, AO ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, AO ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042028913","display_name":"Stefano Cascinu","orcid":"https://orcid.org/0000-0003-2215-0731","observed_orcids":["https://orcid.org/0000-0003-2215-0731"]},"institutions":[{"id":"https://openalex.org/I4210108813","display_name":"Azienda Ospedaliero-Universitaria delle Marche","ror":"https://ror.org/0213f0637","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210108813"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Cascinu","raw_affiliation_strings":["Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medical Oncology, AO Ospedali Riuniti-UNIVPM, Ancona, Italy","institution_ids":["https://openalex.org/I4210108813"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5034035272"],"corresponding_institution_ids":["https://openalex.org/I4210108813"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.3769,"has_fulltext":true,"cited_by_count":40,"citation_normalized_percentile":{"value":0.8867721,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"8","issue":"9","first_page":"e72843","last_page":"e72843"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10336","display_name":"Cancer Cells and Metastasis","score":0.9945999979972839,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11067","display_name":"Colorectal Cancer Treatments and Studies","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11369","display_name":"Genetic factors in colorectal cancer","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/colorectal-cancer","display_name":"colorectal cancer","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cancer-stem-cells","display_name":"cancer stem cells","score":0.8980000019073486},{"id":"https://openalex.org/keywords/stem-cell-markers","display_name":"stem cell markers","score":0.8169999718666077},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"gene expression profiling","score":0.7549999952316284},{"id":"https://openalex.org/keywords/recurrence-prediction","display_name":"recurrence prediction","score":0.8299999833106995},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8550000190734863},{"id":"https://openalex.org/keywords/radical-resection","display_name":"radical resection","score":0.6959999799728394},{"id":"https://openalex.org/keywords/stage-ii-colon-cancer","display_name":"stage II colon cancer","score":0.8479999899864197},{"id":"https://openalex.org/keywords/stage-iii-colon-cancer","display_name":"stage III colon cancer","score":0.9980000257492065},{"id":"https://openalex.org/keywords/cd44","display_name":"CD44","score":0.8529999852180481},{"id":"https://openalex.org/keywords/abcg2","display_name":"ABCG2","score":0.8550000190734863},{"id":"https://openalex.org/keywords/activated-leukocyte-cell-adhesion-molecule","display_name":"ALCAM","score":0.734000027179718},{"id":"https://openalex.org/keywords/pdx1","display_name":"PDX1","score":0.7590000033378601},{"id":"https://openalex.org/keywords/col1a1","display_name":"COL1A1","score":0.7760000228881836},{"id":"https://openalex.org/keywords/hspa9","display_name":"HSPA9","score":0.9399999976158142},{"id":"https://openalex.org/keywords/cyclin-a2","display_name":"cyclin A2","score":0.8130000233650208},{"id":"https://openalex.org/keywords/relapse-free-survival","display_name":"relapse-free survival","score":0.8889999985694885}],"concepts":[{"id":"https://openalex.org/C526805850","wikidata":"https://www.wikidata.org/wiki/Q188874","display_name":"Colorectal cancer","level":3,"score":0.766247034072876},{"id":"https://openalex.org/C2780456743","wikidata":"https://www.wikidata.org/wiki/Q17816630","display_name":"ALCAM","level":3,"score":0.7324913144111633},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6733632683753967},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6328611373901367},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5868907570838928},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.5864777565002441},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5673137903213501},{"id":"https://openalex.org/C2780932548","wikidata":"https://www.wikidata.org/wiki/Q1056532","display_name":"CD44","level":3,"score":0.49324315786361694},{"id":"https://openalex.org/C2779492189","wikidata":"https://www.wikidata.org/wiki/Q1190762","display_name":"CD24","level":4,"score":0.4801289737224579},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.4552858769893646},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.4229530990123749},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.41994109749794006},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.3851894736289978},{"id":"https://openalex.org/C90924648","wikidata":"https://www.wikidata.org/wiki/Q120569","display_name":"Gastroenterology","level":1,"score":0.36181893944740295},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.21275675296783447},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15619409084320068},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.14203190803527832},{"id":"https://openalex.org/C16224149","wikidata":"https://www.wikidata.org/wiki/Q187637","display_name":"Cell adhesion molecule","level":2,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009364","descriptor_name":"Neoplasm Recurrence, Local","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009367","descriptor_name":"Neoplasm Staging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014408","descriptor_name":"Biomarkers, Tumor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014411","descriptor_name":"Neoplastic Stem Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":11,"locations":[{"id":"doi:10.1371/journal.pone.0072843","doi":"https://doi.org/10.1371/journal.pone.0072843","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072843","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072843&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:24023782","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24023782","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unica.it:11584/56009","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11584/56009","pdf_url":"http://hdl.handle.net/11584/56009","source":{"id":"https://openalex.org/S4377196293","display_name":"UNICA IRIS Institutional Research Information System (University of Cagliari)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I172446870","host_organization_name":"University of Cagliari","host_organization_lineage":["https://openalex.org/I172446870"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unimore.it:11380/1079323","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11380/1079323","pdf_url":"https://iris.unimore.it/bitstream/11380/1079323/2/journal.pone.0072843.PDF","source":{"id":"https://openalex.org/S4306400718","display_name":"IRIS UNIMORE (University of Modena and Reggio Emilia)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122346577","host_organization_name":"University of Modena and Reggio Emilia","host_organization_lineage":["https://openalex.org/I122346577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:europepmc.org:2759984","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3762853","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3762853","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3762853","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.793.4569","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.793.4569","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/7b/f8/pone.0072843.PMC3762853.pdf","raw_type":"text"},{"id":"pmh:oai:air.unimi.it:2434/570221","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2434/570221","pdf_url":null,"source":{"id":"https://openalex.org/S4306400516","display_name":"Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I189158943","host_organization_name":"University of Milan","host_organization_lineage":["https://openalex.org/I189158943"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:d77f787decfb4d558ac2bee5360ddb17","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/d77f787decfb4d558ac2bee5360ddb17","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 8, Iss 9, p e72843 (2013)","raw_type":"article"},{"id":"pmh:oai:iris.unisr.it:20.500.11768/113001","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/20.500.11768/113001","pdf_url":null,"source":{"id":"https://openalex.org/S7407055348","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 Vita-Salute San Raffaele","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.univpm.it:11566/157105","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11566/157105","pdf_url":null,"source":{"id":"https://openalex.org/S4306402571","display_name":"Universit\u00e0 Politecnica delle Marche (Universit\u00e0 Politecnica delle Marche)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I122534668","host_organization_name":"Marche Polytechnic University","host_organization_lineage":["https://openalex.org/I122534668"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0072843","doi":"https://doi.org/10.1371/journal.pone.0072843","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0072843","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0072843&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9922999739646912,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.8299999833106995,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2003003147.pdf","grobid_xml":"https://content.openalex.org/works/W2003003147.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W1925901205","https://openalex.org/W1972932862","https://openalex.org/W1975231055","https://openalex.org/W1990680946","https://openalex.org/W1996757731","https://openalex.org/W2000245494","https://openalex.org/W2025177279","https://openalex.org/W2025994860","https://openalex.org/W2037632318","https://openalex.org/W2070436817","https://openalex.org/W2070907700","https://openalex.org/W2080148300","https://openalex.org/W2085362515","https://openalex.org/W2090487408","https://openalex.org/W2099188406","https://openalex.org/W2103762083","https://openalex.org/W2108224617","https://openalex.org/W2110310689","https://openalex.org/W2115582986","https://openalex.org/W2136754094","https://openalex.org/W2138842322","https://openalex.org/W2138985803","https://openalex.org/W2155521795","https://openalex.org/W2156365913","https://openalex.org/W2167831294","https://openalex.org/W2171232394","https://openalex.org/W2905498282"],"related_works":["https://openalex.org/W4387523696","https://openalex.org/W2357791003","https://openalex.org/W2388542696","https://openalex.org/W2105916911","https://openalex.org/W2253401643","https://openalex.org/W1994718022","https://openalex.org/W2543270089","https://openalex.org/W4379285651","https://openalex.org/W1854105605","https://openalex.org/W4253059881"],"abstract_inverted_index":{"Clinical":[0],"data":[1],"indicate":[2],"that":[3,25],"prognostic":[4],"stratification":[5],"of":[6,34,41,50,69,72,107,154,193,207],"radically":[7],"resected":[8,59,210],"colorectal":[9,35,211],"cancer":[10,26,36,65,195,212],"based":[11],"on":[12],"disease":[13],"stage":[14,60],"only":[15],"may":[16,29,199],"not":[17],"be":[18,20,200],"always":[19],"adequate.":[21],"Preclinical":[22],"findings":[23],"suggest":[24],"stem":[27,196],"cells":[28],"influence":[30],"the":[31,42,116,145,160,181],"biological":[32,187],"behaviour":[33],"independently":[37],"from":[38],"stage:":[39],"objective":[40],"study":[43],"was":[44,142],"to":[45,98],"assess":[46],"whether":[47],"a":[48,92,102],"panel":[49,68],"stemness":[51,73],"markers":[52,71],"were":[53,74,79,110,128,167],"correlated":[54],"with":[55,87,95,159],"clinical":[56],"outcome":[57],"in":[58,91,163,202,209],"II":[61],"and":[62,76,85,124,133,176],"III":[63],"colon":[64,194],"patients.":[66,213],"A":[67,105,132,136],"66":[70],"analysed":[75],"thus":[77],"patients":[78,89,109,127],"divided":[80],"into":[81,130],"two":[82],"groups":[83,147],"(A":[84],"B)":[86],"most":[88],"clustering":[90],"manner":[93],"consistent":[94],"different":[96,138,165],"time":[97],"relapse":[99,208],"by":[100],"using":[101],"statistical":[103],"algorithm.":[104],"total":[106],"62":[108],"analysed.":[111],"Thirty-six":[112],"(58%)":[113],"relapsed":[114],"during":[115],"follow-up":[117],"period":[118],"(range":[119],"1.63-86.5":[120],"months).":[121],"Twelve":[122],"(19%)":[123],"50":[125],"(81%)":[126],"allocated":[129],"group":[131],"B,":[134],"respectively.":[135],"significantly":[137],"median":[139],"relapse-free":[140],"survival":[141],"observed":[143],"between":[144],"2":[146],"(22.18":[148],"vs":[149],"42.85":[150],"months,":[151],"p=0.0296).":[152],"Among":[153],"all":[155],"genes":[156],"tested,":[157],"those":[158],"higher":[161],"\"weight\"":[162],"determining":[164,203],"prognosis":[166],"CD44,":[168],"ALCAM,":[169],"DTX2,":[170],"HSPA9,":[171],"CCNA2,":[172],"PDX1,":[173],"MYST1,":[174],"COL1A1":[175],"ABCG2.":[177],"This":[178],"analysis":[179],"supports":[180],"idea":[182],"that,":[183],"other":[184],"than":[185],"stage,":[186],"variables,":[188],"such":[189],"as":[190],"expression":[191],"levels":[192],"cell":[197],"genes,":[198],"relevant":[201],"an":[204],"increased":[205],"risk":[206]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":8},{"year":2013,"cited_by_count":1}],"updated_date":"2026-10-03T13:16:28.481748","created_date":"2025-10-10T00:00:00"}