{"id":"https://openalex.org/W2003000604","doi":"https://doi.org/10.1016/j.carbpol.2013.09.013","title":"Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier","display_name":"Synthesis and characterization of biotin modified cholesteryl pullulan as a novel anticancer drug carrier","publication_year":2013,"publication_date":"2013-09-10","ids":{"openalex":"https://openalex.org/W2003000604","doi":"https://doi.org/10.1016/j.carbpol.2013.09.013","mag":"2003000604","pmid":"https://pubmed.ncbi.nlm.nih.gov/24274563"},"language":"en","primary_location":{"id":"doi:10.1016/j.carbpol.2013.09.013","doi":"https://doi.org/10.1016/j.carbpol.2013.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2013.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5053701797","display_name":"Wenzhi Yang","orcid":"https://orcid.org/0000-0002-5080-335X","observed_orcids":["https://orcid.org/0000-0002-5080-335X"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenzhi Yang","raw_affiliation_strings":["College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China. Electronic address: wenzhi_yang@sina.com","College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China. Electronic address: wenzhi_yang@sina.com","institution_ids":["https://openalex.org/I43337087"]},{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100343771","display_name":"Miaomiao Wang","orcid":"https://orcid.org/0000-0002-8957-4443","observed_orcids":["https://orcid.org/0000-0002-8957-4443","https://orcid.org/0009-0008-9119-0896"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Miaomiao Wang","raw_affiliation_strings":["College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036061132","display_name":"Lilan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lilan Ma","raw_affiliation_strings":["College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5085239097","display_name":"Haiying Li","orcid":"https://orcid.org/0000-0001-8240-564X","observed_orcids":["https://orcid.org/0000-0001-8240-564X"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haiying Li","raw_affiliation_strings":["College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5109288865","display_name":"Le Huang","orcid":"https://orcid.org/0000-0001-5227-2575","observed_orcids":["https://orcid.org/0000-0001-5227-2575"]},"institutions":[{"id":"https://openalex.org/I43337087","display_name":"Hebei University","ror":"https://ror.org/01p884a79","country_code":"CN","type":"education","lineage":["https://openalex.org/I43337087"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Le Huang","raw_affiliation_strings":["College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Pharmacy & Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding 071002, China","institution_ids":["https://openalex.org/I43337087"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5053701797"],"corresponding_institution_ids":["https://openalex.org/I43337087"],"apc_list":{"value":5340,"currency":"USD","value_usd":5340},"apc_paid":null,"fwci":2.0222,"has_fulltext":false,"cited_by_count":85,"citation_normalized_percentile":{"value":0.84318913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"99","issue":null,"first_page":"720","last_page":"727"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10063","display_name":"Nanoparticle-Based Drug Delivery","score":0.8651999831199646,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10920","display_name":"Advanced Drug Delivery Systems","score":0.11569999903440475,"subfield":{"id":"https://openalex.org/subfields/3003","display_name":"Pharmaceutical Science"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11686","display_name":"Dendrimers and Hyperbranched Polymers","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2507","display_name":"Polymers and Plastics"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/degree-of-substitution","display_name":"degree of substitution","score":0.7160000205039978},{"id":"https://openalex.org/keywords/amphiphilic-conjugates","display_name":"amphiphilic conjugates","score":0.7649999856948853},{"id":"https://openalex.org/keywords/self-aggregation","display_name":"self-aggregation","score":0.8939999938011169},{"id":"https://openalex.org/keywords/nanoparticles","display_name":"nanoparticles","score":0.8109999895095825},{"id":"https://openalex.org/keywords/anticancer-drug-carriers","display_name":"anticancer drug carriers","score":0.75},{"id":"https://openalex.org/keywords/mitoxantrone","display_name":"mitoxantrone","score":0.9710000157356262},{"id":"https://openalex.org/keywords/toxicity","display_name":"toxicity","score":0.5389999747276306},{"id":"https://openalex.org/keywords/intravenous-administration","display_name":"intravenous administration","score":0.4569999873638153},{"id":"https://openalex.org/keywords/drug-delivery","display_name":"drug delivery","score":0.39500001072883606}],"concepts":[{"id":"https://openalex.org/C2779257994","wikidata":"https://www.wikidata.org/wiki/Q419779","display_name":"Pullulan","level":3,"score":0.8077781796455383},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.710422158241272},{"id":"https://openalex.org/C86181022","wikidata":"https://www.wikidata.org/wiki/Q196823","display_name":"Zeta potential","level":3,"score":0.6858103275299072},{"id":"https://openalex.org/C103319777","wikidata":"https://www.wikidata.org/wiki/Q1979695","display_name":"Proton NMR","level":2,"score":0.4958725869655609},{"id":"https://openalex.org/C197336794","wikidata":"https://www.wikidata.org/wiki/Q5161150","display_name":"Conjugate","level":2,"score":0.47205644845962524},{"id":"https://openalex.org/C13965031","wikidata":"https://www.wikidata.org/wiki/Q243545","display_name":"Nuclear chemistry","level":1,"score":0.46376606822013855},{"id":"https://openalex.org/C67407626","wikidata":"https://www.wikidata.org/wiki/Q5723218","display_name":"Amphiphile","level":4,"score":0.46094971895217896},{"id":"https://openalex.org/C2780749602","wikidata":"https://www.wikidata.org/wiki/Q425680","display_name":"Deoxycholic acid","level":3,"score":0.45928502082824707},{"id":"https://openalex.org/C14631669","wikidata":"https://www.wikidata.org/wiki/Q896108","display_name":"Dynamic light scattering","level":3,"score":0.43312498927116394},{"id":"https://openalex.org/C155672457","wikidata":"https://www.wikidata.org/wiki/Q61231","display_name":"Nanoparticle","level":2,"score":0.4051515460014343},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.3625904619693756},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.28174054622650146},{"id":"https://openalex.org/C100817775","wikidata":"https://www.wikidata.org/wiki/Q134219","display_name":"Polysaccharide","level":2,"score":0.2502290606498718},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.16252481937408447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.14923226833343506},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.14882060885429382},{"id":"https://openalex.org/C15920480","wikidata":"https://www.wikidata.org/wiki/Q421281","display_name":"Copolymer","level":3,"score":0.1275106966495514},{"id":"https://openalex.org/C2779399885","wikidata":"https://www.wikidata.org/wiki/Q413288","display_name":"Bile acid","level":2,"score":0.06843119859695435},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.06315666437149048},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000970","descriptor_name":"Antineoplastic Agents","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001710","descriptor_name":"Biotin","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D004337","descriptor_name":"Drug Carriers","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004339","descriptor_name":"Drug Compounding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005936","descriptor_name":"Glucans","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006001","descriptor_name":"Glycoconjugates","qualifier_ui":"Q000138","qualifier_name":"chemical synthesis","is_major_topic":true},{"descriptor_ui":"D006001","descriptor_name":"Glycoconjugates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008813","descriptor_name":"Mice, Inbred ICR","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008942","descriptor_name":"Mitoxantrone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009682","descriptor_name":"Magnetic Resonance Spectroscopy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010316","descriptor_name":"Particle Size","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014961","descriptor_name":"X-Ray Diffraction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017550","descriptor_name":"Spectroscopy, Fourier Transform Infrared","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053758","descriptor_name":"Nanoparticles","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1016/j.carbpol.2013.09.013","doi":"https://doi.org/10.1016/j.carbpol.2013.09.013","is_oa":false,"landing_page_url":"https://doi.org/10.1016/j.carbpol.2013.09.013","pdf_url":null,"source":{"id":"https://openalex.org/S64311837","display_name":"Carbohydrate Polymers","issn_l":"0144-8617","issn":["0144-8617","1879-1344"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-2","ki-jl-2","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate Polymers","raw_type":"journal-article"},{"id":"pmid:24274563","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24274563","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Carbohydrate polymers","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1985121344","display_name":null,"funder_award_id":"H2012201069","funder_id":"https://openalex.org/F4320322163","funder_display_name":"Natural Science Foundation of Hebei Province"}],"funders":[{"id":"https://openalex.org/F4320322163","display_name":"Natural Science Foundation of Hebei Province","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320324851","display_name":"Hebei University","ror":"https://ror.org/01p884a79"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":58,"referenced_works":["https://openalex.org/W326271711","https://openalex.org/W1973751970","https://openalex.org/W1978500958","https://openalex.org/W1981865234","https://openalex.org/W1983503441","https://openalex.org/W1990636775","https://openalex.org/W1993249612","https://openalex.org/W1997356899","https://openalex.org/W2000181977","https://openalex.org/W2002975415","https://openalex.org/W2004842967","https://openalex.org/W2007648314","https://openalex.org/W2008989467","https://openalex.org/W2012176374","https://openalex.org/W2013440753","https://openalex.org/W2015150662","https://openalex.org/W2020781559","https://openalex.org/W2022511160","https://openalex.org/W2023376720","https://openalex.org/W2024211405","https://openalex.org/W2025069216","https://openalex.org/W2029313327","https://openalex.org/W2030069334","https://openalex.org/W2030592137","https://openalex.org/W2032029233","https://openalex.org/W2032734476","https://openalex.org/W2034383957","https://openalex.org/W2034576335","https://openalex.org/W2034691053","https://openalex.org/W2037600243","https://openalex.org/W2038535235","https://openalex.org/W2039418035","https://openalex.org/W2042244102","https://openalex.org/W2053339951","https://openalex.org/W2056151272","https://openalex.org/W2058561609","https://openalex.org/W2064103744","https://openalex.org/W2066613071","https://openalex.org/W2074732835","https://openalex.org/W2078822954","https://openalex.org/W2079745748","https://openalex.org/W2083765388","https://openalex.org/W2084268767","https://openalex.org/W2088382534","https://openalex.org/W2088614027","https://openalex.org/W2090813373","https://openalex.org/W2092319622","https://openalex.org/W2093622084","https://openalex.org/W2105972520","https://openalex.org/W2110233014","https://openalex.org/W2112326782","https://openalex.org/W2124935141","https://openalex.org/W2125505454","https://openalex.org/W2132198153","https://openalex.org/W2134203244","https://openalex.org/W2145402774","https://openalex.org/W2146894143","https://openalex.org/W2170331034"],"related_works":["https://openalex.org/W2381776513","https://openalex.org/W1997356899","https://openalex.org/W2775827901","https://openalex.org/W2316034914","https://openalex.org/W2513458874","https://openalex.org/W2178152861","https://openalex.org/W2460671862","https://openalex.org/W83886135","https://openalex.org/W2389693803","https://openalex.org/W2895895769"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":14},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":7},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}