{"id":"https://openalex.org/W2002991449","doi":"https://doi.org/10.1002/aja.1002030408","title":"Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential","display_name":"Uncoupling histogenesis from morphogenesis in the vertebrate embryo by collapse of the transneural tube potential","publication_year":1995,"publication_date":"1995-08-01","ids":{"openalex":"https://openalex.org/W2002991449","doi":"https://doi.org/10.1002/aja.1002030408","mag":"2002991449","pmid":"https://pubmed.ncbi.nlm.nih.gov/7496037"},"language":"en","primary_location":{"id":"doi:10.1002/aja.1002030408","doi":"https://doi.org/10.1002/aja.1002030408","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aja.1002030408","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aja.1002030408","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aja.1002030408","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045100984","display_name":"Richard B. Borgens","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Richard B. Borgens","raw_affiliation_strings":["Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1244, USA","Center for Paralysis Research, Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907\u20131244"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907-1244, USA","institution_ids":["https://openalex.org/I219193219"]},{"raw_affiliation_string":"Center for Paralysis Research, Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907\u20131244","institution_ids":["https://openalex.org/I219193219"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058022813","display_name":"Riyi Shi","orcid":"https://orcid.org/0000-0002-7297-9428","observed_orcids":["https://orcid.org/0000-0002-7297-9428"]},"institutions":[{"id":"https://openalex.org/I219193219","display_name":"Purdue University West Lafayette","ror":"https://ror.org/02dqehb95","country_code":"US","type":"education","lineage":["https://openalex.org/I219193219"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Riyi Shi","raw_affiliation_strings":["Center for Paralysis Research, Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907\u20131244"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Paralysis Research, Department of Anatomy, School of Veterinary Medicine, Purdue University, West Lafayette, IN 47907\u20131244","institution_ids":["https://openalex.org/I219193219"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045100984"],"corresponding_institution_ids":["https://openalex.org/I219193219"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.5188,"has_fulltext":true,"cited_by_count":72,"citation_normalized_percentile":{"value":0.57832574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"203","issue":"4","first_page":"456","last_page":"467"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10724","display_name":"Ion Transport and Channel Regulation","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neural-tube","display_name":"neural tube","score":0.7860000133514404},{"id":"https://openalex.org/keywords/histogenesis","display_name":"histogenesis","score":0.7279999852180481},{"id":"https://openalex.org/keywords/morphogenesis","display_name":"morphogenesis","score":0.9940000176429749},{"id":"https://openalex.org/keywords/amiloride","display_name":"amiloride","score":0.9980000257492065},{"id":"https://openalex.org/keywords/benzamil","display_name":"benzamil","score":0.9990000128746033},{"id":"https://openalex.org/keywords/transepithelial-potential","display_name":"transepithelial potential","score":0.8320000171661377},{"id":"https://openalex.org/keywords/neuroepithelium","display_name":"neuroepithelium","score":0.7210000157356262},{"id":"https://openalex.org/keywords/neural-fold-fusion","display_name":"neural fold fusion","score":0.4880000054836273},{"id":"https://openalex.org/keywords/ion-gradients","display_name":"ion gradients","score":0.5009999871253967},{"id":"https://openalex.org/keywords/ion-pumps","display_name":"ion pumps","score":0.3319999873638153}],"concepts":[{"id":"https://openalex.org/C2780594696","wikidata":"https://www.wikidata.org/wiki/Q1127402","display_name":"Neural tube","level":3,"score":0.8167657852172852},{"id":"https://openalex.org/C191548132","wikidata":"https://www.wikidata.org/wiki/Q2355306","display_name":"Histogenesis","level":3,"score":0.766189455986023},{"id":"https://openalex.org/C2779329299","wikidata":"https://www.wikidata.org/wiki/Q272474","display_name":"Ectoderm","level":4,"score":0.7384434938430786},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.71644127368927},{"id":"https://openalex.org/C2779608910","wikidata":"https://www.wikidata.org/wiki/Q419995","display_name":"Amiloride","level":3,"score":0.7118185758590698},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.6374040246009827},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.57575923204422},{"id":"https://openalex.org/C2778166480","wikidata":"https://www.wikidata.org/wiki/Q6453151","display_name":"Toad","level":2,"score":0.5565838813781738},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5514014959335327},{"id":"https://openalex.org/C197849852","wikidata":"https://www.wikidata.org/wiki/Q2314823","display_name":"Neural plate","level":4,"score":0.5397201180458069},{"id":"https://openalex.org/C103607123","wikidata":"https://www.wikidata.org/wiki/Q7002059","display_name":"Neural fold","level":5,"score":0.4195302128791809},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.3943560719490051},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.38673901557922363},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2933821678161621},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1895495057106018},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0800764262676239},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C537181965","wikidata":"https://www.wikidata.org/wiki/Q658","display_name":"Sodium","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000557","descriptor_name":"Ambystoma","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D004625","descriptor_name":"Embryo, Nonmammalian","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D004848","descriptor_name":"Epithelium","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D005333","descriptor_name":"Fetus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009024","descriptor_name":"Morphogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/aja.1002030408","doi":"https://doi.org/10.1002/aja.1002030408","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aja.1002030408","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aja.1002030408","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},{"id":"pmid:7496037","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7496037","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental dynamics : an official publication of the American Association of Anatomists","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/aja.1002030408","doi":"https://doi.org/10.1002/aja.1002030408","is_oa":true,"landing_page_url":"https://doi.org/10.1002/aja.1002030408","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/aja.1002030408","source":{"id":"https://openalex.org/S104993753","display_name":"Developmental Dynamics","issn_l":"1058-8388","issn":["1058-8388","1097-0177"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Dynamics","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002991449.pdf","grobid_xml":"https://content.openalex.org/works/W2002991449.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1010912423","https://openalex.org/W1966163405","https://openalex.org/W1974813506","https://openalex.org/W1976094538","https://openalex.org/W1979787537","https://openalex.org/W1981907433","https://openalex.org/W1982256640","https://openalex.org/W1985200095","https://openalex.org/W1993324438","https://openalex.org/W1997087466","https://openalex.org/W1999609256","https://openalex.org/W2003867001","https://openalex.org/W2011061147","https://openalex.org/W2014634302","https://openalex.org/W2019452888","https://openalex.org/W2022902413","https://openalex.org/W2029844383","https://openalex.org/W2033073850","https://openalex.org/W2037567691","https://openalex.org/W2047922146","https://openalex.org/W2049744505","https://openalex.org/W2051216399","https://openalex.org/W2054566195","https://openalex.org/W2058200250","https://openalex.org/W2059314814","https://openalex.org/W2071033492","https://openalex.org/W2072475080","https://openalex.org/W2074200449","https://openalex.org/W2074358917","https://openalex.org/W2088067134","https://openalex.org/W2088690314","https://openalex.org/W2092586757","https://openalex.org/W2098159540","https://openalex.org/W2158352565","https://openalex.org/W2323743459","https://openalex.org/W2338111940","https://openalex.org/W2419114085","https://openalex.org/W2428965217","https://openalex.org/W4214864747","https://openalex.org/W4255699209","https://openalex.org/W4388316487"],"related_works":["https://openalex.org/W2088067134","https://openalex.org/W7037782529","https://openalex.org/W2037567691","https://openalex.org/W3110433702","https://openalex.org/W2049764955","https://openalex.org/W2029281335","https://openalex.org/W1985200095","https://openalex.org/W1999609256","https://openalex.org/W3109014244","https://openalex.org/W2051216399"],"abstract_inverted_index":{"We":[0,222],"have":[1],"shown":[2],"that":[3,45,180],"unidirectional":[4],"pumping":[5],"of":[6,9,81,101,174,200,205,211,218,249],"Na+":[7,40,83],"out":[8],"the":[10,28,39,61,67,82,90,99,161,175,178,198,215,224,246,250],"neural":[11,62,68,114],"tube's":[12],"luminal":[13],"fluids":[14],"in":[15,54,146,159,197,214,226],"amphibian":[16],"embryos":[17,108,138,145,158,207],"produces":[18],"a":[19,110,172,195,228,254],"large":[20,229],"potential":[21,34,43,237],"difference":[22,238],"(40-90":[23],"mV,":[24],"lumen":[25,91],"negative":[26],"to":[27,38,65,127,136,144,184],"abluminal":[29],"surface).":[30],"This":[31,50],"transneural":[32],"tube":[33,115],"(TNTP)":[35],"is":[36,52,58],"analogous":[37],"dependent":[41],"transepithelial":[42],"(TEP)":[44],"exists":[46],"across":[47],"surface":[48,155],"ectoderm.":[49,156],"TEP":[51],"retained":[53],"ectoderm":[55],"after":[56],"it":[57],"internalized":[59],"when":[60],"folds":[63],"fuse":[64],"form":[66,185,213],"tube.":[69],"The":[70],"TNTP":[71,102,162],"can":[72],"be":[73,242],"markedly":[74],"reduced":[75,164],"for":[76,130,245,256],"several":[77],"hours":[78],"by":[79,92,171],"injection":[80],"channel":[84],"blockers":[85],"amiloride":[86,122,148],"or":[87,123,143,149],"benzamil":[88,124,150],"into":[89],"iontophoresis":[93],"through":[94],"microelectrodes.":[95],"Here":[96],"we":[97],"describe":[98],"effect":[100],"modification":[103],"on":[104],"developmental":[105],"anatomy.":[106],"Axolotl":[107],"possessing":[109],"fused":[111],"and":[112,125,253],"closed":[113],"(stage":[116],"21-23)":[117],"were":[118,134,165,169],"injected":[119,139],"with":[120,140,234],"either":[121],"allowed":[126],"continue":[128],"development":[129,199,210],"36-52":[131],"hr.":[132],"These":[133,168],"compared":[135],"control":[137],"vehicle":[141],"alone,":[142],"which":[147,160,227],"was":[151,163],"iontophoresed":[152],"just":[153],"beneath":[154],"All":[157],"grossly":[166],"defective.":[167],"characterized":[170],"disaggregation":[173],"cells":[176],"comprising":[177],"structures":[179],"had":[181],"already":[182],"begun":[183],"(otic":[186],"primordia,":[187],"brain,":[188],"spinal":[189],"cord,":[190],"notochord)":[191],"as":[192,194],"well":[193],"failure":[196],"new":[201],"structures.":[202],"Remarkably,":[203],"some":[204],"these":[206],"displayed":[208],"continuing":[209],"external":[212],"complete":[216],"absence":[217],"concomitant":[219],"internal":[220],"histogenesis.":[221],"discuss":[223],"ways":[225],"endogenous":[230],"voltage":[231],"gradient":[232],"associated":[233],"an":[235],"epithelial":[236],"(the":[239],"TNTP)":[240],"may":[241],"required":[243],"both":[244],"structural":[247],"integrity":[248],"early":[251],"neuroepithelium,":[252],"prerequisite":[255],"normal":[257],"morphogenesis.":[258]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":5},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
