{"id":"https://openalex.org/W2002979656","doi":"https://doi.org/10.1002/ijc.1492","title":"Augmentation of death ligand\u2010induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines","display_name":"Augmentation of death ligand\u2010induced apoptosis by aminopeptidase inhibitors in human solid tumor cell lines","publication_year":2001,"publication_date":"2001-11-15","ids":{"openalex":"https://openalex.org/W2002979656","doi":"https://doi.org/10.1002/ijc.1492","mag":"2002979656","pmid":"https://pubmed.ncbi.nlm.nih.gov/11745433"},"language":"en","primary_location":{"id":"doi:10.1002/ijc.1492","doi":"https://doi.org/10.1002/ijc.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1492","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1492","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111527730","display_name":"Keiko Sekine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150228","display_name":"Nippon Kayaku (Japan)","ror":"https://ror.org/05cbf4214","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210150228"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Keiko Sekine","raw_affiliation_strings":["Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan. yosi@nipponkayaku.gr.jp","Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan. yosi@nipponkayaku.gr.jp","institution_ids":["https://openalex.org/I4210150228"]},{"raw_affiliation_string":"Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan","institution_ids":["https://openalex.org/I4210150228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100827907","display_name":"Hideji Fujii","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150228","display_name":"Nippon Kayaku (Japan)","ror":"https://ror.org/05cbf4214","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210150228"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hideji Fujii","raw_affiliation_strings":["Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan","institution_ids":["https://openalex.org/I4210150228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108196353","display_name":"Fuminori Abe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210150228","display_name":"Nippon Kayaku (Japan)","ror":"https://ror.org/05cbf4214","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210150228"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Fuminori Abe","raw_affiliation_strings":["Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan","institution_ids":["https://openalex.org/I4210150228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023090524","display_name":"Kiyohiro Nishikawa","orcid":"https://orcid.org/0000-0003-2350-6189","observed_orcids":["https://orcid.org/0000-0003-2350-6189"]},"institutions":[{"id":"https://openalex.org/I4210150228","display_name":"Nippon Kayaku (Japan)","ror":"https://ror.org/05cbf4214","country_code":"JP","type":"company","lineage":["https://openalex.org/I4210150228"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kiyohiro Nishikawa","raw_affiliation_strings":["Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Evaluation Group, Drug Research Department, R. & D. Division, Pharmaceuticals Group, Nippon Kayaku Company, Tokyo, Japan","institution_ids":["https://openalex.org/I4210150228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5111527730"],"corresponding_institution_ids":["https://openalex.org/I4210150228"],"apc_list":{"value":5030,"currency":"USD","value_usd":5030},"apc_paid":null,"fwci":0.8656,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.68110863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"94","issue":"4","first_page":"485","last_page":"491"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12505","display_name":"Peptidase Inhibition and Analysis","score":0.008700000122189522,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ubenimex","display_name":"bestatin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/aminopeptidase-inhibitors","display_name":"aminopeptidase inhibitors","score":0.9679999947547913},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6309999823570251},{"id":"https://openalex.org/keywords/fas-ligand","display_name":"Fas ligand","score":0.7670000195503235},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8700000047683716},{"id":"https://openalex.org/keywords/death-ligands","display_name":"death ligands","score":0.6819999814033508},{"id":"https://openalex.org/keywords/caspase-3-activation","display_name":"caspase-3 activation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/caspase-8","display_name":"caspase-8","score":0.906000018119812},{"id":"https://openalex.org/keywords/solid-tumor-cell-lines","display_name":"solid tumor cell lines","score":0.6869999766349792},{"id":"https://openalex.org/keywords/actinonin","display_name":"actinonin","score":0.7979999780654907},{"id":"https://openalex.org/keywords/puromycin","display_name":"puromycin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/ebc-1-cells","display_name":"EBC-1 cells","score":0.7490000128746033},{"id":"https://openalex.org/keywords/hela-s3-cells","display_name":"HeLa S3 cells","score":0.9160000085830688}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.6824321746826172},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5937795042991638},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.585322916507721},{"id":"https://openalex.org/C2779707156","wikidata":"https://www.wikidata.org/wiki/Q5611758","display_name":"Growth inhibition","level":3,"score":0.5389178395271301},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.5355695486068726},{"id":"https://openalex.org/C2780985610","wikidata":"https://www.wikidata.org/wiki/Q419527","display_name":"Aminopeptidase","level":4,"score":0.5068345665931702},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.48935264348983765},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.48051342368125916},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4438056945800781},{"id":"https://openalex.org/C12519072","wikidata":"https://www.wikidata.org/wiki/Q14914370","display_name":"Caspase 3","level":4,"score":0.4309979975223541},{"id":"https://openalex.org/C48297814","wikidata":"https://www.wikidata.org/wiki/Q14911965","display_name":"Caspase 8","level":5,"score":0.4236519932746887},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4006659984588623},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3722143769264221},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.3363008499145508},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.09791296720504761},{"id":"https://openalex.org/C2776580952","wikidata":"https://www.wikidata.org/wiki/Q483745","display_name":"Leucine","level":3,"score":0.04480871558189392},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000255","descriptor_name":"Adenosine Triphosphate","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D000626","descriptor_name":"Aminopeptidases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000903","descriptor_name":"Antibiotics, Antineoplastic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002474","descriptor_name":"Cell-Free System","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004591","descriptor_name":"Electrophoresis, Polyacrylamide Gel","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006877","descriptor_name":"Hydroxamic Acids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D007930","descriptor_name":"Leucine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011691","descriptor_name":"Puromycin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014409","descriptor_name":"Tumor Necrosis Factor-alpha","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015153","descriptor_name":"Blotting, Western","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016923","descriptor_name":"Cell Death","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019014","descriptor_name":"fas Receptor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D053148","descriptor_name":"Caspase 3","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053181","descriptor_name":"Caspase 8","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053453","descriptor_name":"Caspase 9","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053938","descriptor_name":"DNA Fragmentation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1002/ijc.1492","doi":"https://doi.org/10.1002/ijc.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1492","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},{"id":"pmid:11745433","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11745433","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of cancer","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1002/ijc.1492","doi":"https://doi.org/10.1002/ijc.1492","is_oa":true,"landing_page_url":"https://doi.org/10.1002/ijc.1492","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/ijc.1492","source":{"id":"https://openalex.org/S5382288","display_name":"International Journal of Cancer","issn_l":"0020-7136","issn":["0020-7136","1097-0215"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Cancer","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002979656.pdf","grobid_xml":"https://content.openalex.org/works/W2002979656.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1478056656","https://openalex.org/W1529548523","https://openalex.org/W1542886054","https://openalex.org/W1885844537","https://openalex.org/W1917998910","https://openalex.org/W1968009051","https://openalex.org/W1968858321","https://openalex.org/W1996068332","https://openalex.org/W2003257617","https://openalex.org/W2008598927","https://openalex.org/W2010608533","https://openalex.org/W2012173926","https://openalex.org/W2015432131","https://openalex.org/W2030892254","https://openalex.org/W2032666280","https://openalex.org/W2035574998","https://openalex.org/W2049694879","https://openalex.org/W2068001899","https://openalex.org/W2081322385","https://openalex.org/W2103995594","https://openalex.org/W2105695475","https://openalex.org/W2111246679","https://openalex.org/W2136279000","https://openalex.org/W2149967205","https://openalex.org/W2156496263","https://openalex.org/W2164220376","https://openalex.org/W2262204207","https://openalex.org/W2313663700","https://openalex.org/W2321550773","https://openalex.org/W2329315557","https://openalex.org/W2410984240","https://openalex.org/W2498871995","https://openalex.org/W4313341495"],"related_works":["https://openalex.org/W2321550773","https://openalex.org/W2066693911","https://openalex.org/W1992862305","https://openalex.org/W2048802496","https://openalex.org/W1614798604","https://openalex.org/W2079861151","https://openalex.org/W958438850","https://openalex.org/W2004766935","https://openalex.org/W2066665513","https://openalex.org/W2035329189"],"abstract_inverted_index":{"We":[0],"previously":[1],"reported":[2],"that":[3,248],"the":[4,46,55,95,169,189,200,242],"aminopeptidase":[5,143,163,212,251],"inhibitor":[6],"bestatin":[7,24,70,121,161,180],"induced":[8],"apoptosis":[9,28,44,61,243],"in":[10,29,45,83,216,223,241,257],"several":[11],"human":[12],"leukemia":[13],"cell":[14,32,48,87,98,131,152,263],"lines.":[15,33],"The":[16,67,174],"present":[17],"study":[18],"was":[19,71,213],"performed":[20],"to":[21,90,103,126,188],"examine":[22],"whether":[23],"can":[25],"also":[26,72,150],"induce":[27],"solid":[30,261],"tumor":[31,47,79,262],"Bestatin":[34,113,227],"alone":[35],"exhibited":[36],"neither":[37],"direct":[38],"growth":[39,107,132,153],"inhibition":[40,108,133],"nor":[41],"induction":[42,59],"of":[43,60,120,134,160,172,176,179,185,195,211,231,237],"lines":[49],"examined.":[50],"However,":[51,94],"it":[52],"significantly":[53,228],"augmented":[54,151,229],"growth-inhibitory":[56,170],"effect":[57],"and":[58,148,193,204,218],"by":[62,69,110,155],"agonistic":[63],"anti-Fas":[64],"antibody":[65],"(CH11).":[66],"augmentation":[68],"observed":[73],"with":[74,122,181],"other":[75],"death":[76,92],"ligands":[77],"including":[78],"necrosis":[80],"factor-alpha":[81],"(TNF-alpha)":[82],"EBC-1":[84],"cells,":[85],"a":[86,116,224],"line":[88],"sensitive":[89],"these":[91],"ligands.":[93],"HeLa":[96],"S3":[97],"line,":[99],"which":[100,234],"is":[101,235],"insensitive":[102],"TNF-alpha,":[104],"showed":[105],"no":[106],"even":[109],"combination":[111,175],"treatment.":[112],"methyl":[114],"ester,":[115],"more":[117,136,202,205],"cell-permeable":[118],"derivative":[119],"similar":[123],"inhibitory":[124,164],"activity":[125],"cytosolic":[127,141],"neutral":[128,142,250],"aminopeptidase,":[129],"potentiated":[130],"CH11":[135,182,208],"efficiently":[137],"than":[138,207],"bestatin.":[139],"Other":[140],"inhibitors":[144],"such":[145],"as":[146],"actinonin":[147],"puromycin":[149],"suppression":[154],"CH11,":[156],"while":[157],"an":[158,254],"enantiomer":[159],"lacking":[162],"action":[165],"did":[166],"not":[167,214],"increase":[168],"effects":[171],"CH11.":[173],"10":[177],"microg/ml":[178],"promoted":[183],"processing":[184],"caspase":[186,221,232],"3":[187],"active":[190],"form":[191],"p17":[192],"efflux":[194,240],"mitochondrial":[196],"cytochrome":[197,219,238],"c":[198,239],"into":[199],"cytosol":[201],"quickly":[203],"intensely":[206],"alone.":[209],"Inhibition":[210],"involved":[215],"dATP-":[217],"c-dependent":[220],"3-activation":[222],"cell-free":[225],"system.":[226],"activation":[230],"8,":[233],"upstream":[236],"cascade.":[244],"These":[245],"results":[246],"suggested":[247],"intracellular":[249],"might":[252],"play":[253],"important":[255],"role":[256],"Fas-":[258],"or":[259],"TNF-alpha-induced":[260],"apoptosis.":[264]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}