{"id":"https://openalex.org/W2002959623","doi":"https://doi.org/10.1186/1742-2094-8-170","title":"CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivoaxial diffusivity","display_name":"CXCR7 antagonism prevents axonal injury during experimental autoimmune encephalomyelitis as revealed by in vivoaxial diffusivity","publication_year":2011,"publication_date":"2011-12-01","ids":{"openalex":"https://openalex.org/W2002959623","doi":"https://doi.org/10.1186/1742-2094-8-170","mag":"2002959623","pmid":"https://pubmed.ncbi.nlm.nih.gov/22145790","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305694"},"language":"en","primary_location":{"id":"doi:10.1186/1742-2094-8-170","doi":"https://doi.org/10.1186/1742-2094-8-170","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-170","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-170","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-170","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5086056532","display_name":"Lillian Cruz\u2010Orengo","orcid":"https://orcid.org/0000-0002-6050-8231","observed_orcids":["https://orcid.org/0000-0002-6050-8231"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lillian Cruz-Orengo","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, 660 S, Euclid Ave, St. Louis, MO 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, 660 S, Euclid Ave, St. Louis, MO 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007065902","display_name":"Ying\u2010Jr Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ying-Jr Chen","raw_affiliation_strings":["Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001004689","display_name":"Joong Hee Kim","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joong Hee Kim","raw_affiliation_strings":["Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054435285","display_name":"Denise A. Dorsey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Denise Dorsey","raw_affiliation_strings":["Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029351001","display_name":"Sheng\u2010Kwei Song","orcid":"https://orcid.org/0000-0003-1050-7449","observed_orcids":["https://orcid.org/0000-0003-1050-7449"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sheng-Kwei Song","raw_affiliation_strings":["Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5046722897","display_name":"Robyn S. Klein","orcid":"https://orcid.org/0000-0003-0281-1352","observed_orcids":["https://orcid.org/0000-0003-0281-1352"]},"institutions":[{"id":"https://openalex.org/I204465549","display_name":"Washington University in St. Louis","ror":"https://ror.org/01yc7t268","country_code":"US","type":"education","lineage":["https://openalex.org/I204465549"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Robyn S Klein","raw_affiliation_strings":["Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Internal Medicine, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]},{"raw_affiliation_string":"Department of Pathology and Immunology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, MO, 63110, USA","institution_ids":["https://openalex.org/I204465549"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046722897"],"corresponding_institution_ids":["https://openalex.org/I204465549"],"apc_list":{"value":4090,"currency":"USD","value_usd":4090},"apc_paid":{"value":4090,"currency":"USD","value_usd":4090},"fwci":2.5438,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88382913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"8","issue":"1","first_page":"170","last_page":"170"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10137","display_name":"Multiple Sclerosis Research Studies","score":0.9707000255584717,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.018799999728798866,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11266","display_name":"Neuroinflammation and Neurodegeneration Mechanisms","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/experimental-autoimmune-encephalomyelitis","display_name":"experimental autoimmune encephalomyelitis","score":0.9670000076293945},{"id":"https://openalex.org/keywords/multiple-sclerosis","display_name":"multiple sclerosis","score":0.9409999847412109},{"id":"https://openalex.org/keywords/axonal-injury","display_name":"axonal injury","score":0.9940000176429749},{"id":"https://openalex.org/keywords/leukocyte-migration","display_name":"leukocyte migration","score":0.7459999918937683},{"id":"https://openalex.org/keywords/cxcl12","display_name":"CXCL12","score":0.9350000023841858},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":0.9490000009536743},{"id":"https://openalex.org/keywords/axial-diffusivity","display_name":"axial diffusivity","score":0.6959999799728394},{"id":"https://openalex.org/keywords/diffusion-tensor-imaging","display_name":"diffusion tensor imaging","score":0.8230000138282776},{"id":"https://openalex.org/keywords/neurofilament-h","display_name":"neurofilament H","score":0.8090000152587891},{"id":"https://openalex.org/keywords/myelin","display_name":"myelin","score":0.4790000021457672},{"id":"https://openalex.org/keywords/oligodendrocytes","display_name":"oligodendrocytes","score":0.9900000095367432},{"id":"https://openalex.org/keywords/spinal-cord-white-matter","display_name":"spinal cord white matter","score":0.7070000171661377},{"id":"https://openalex.org/keywords/neuroinflammation","display_name":"neuroinflammation","score":0.7239999771118164},{"id":"https://openalex.org/keywords/functional-recovery","display_name":"functional recovery","score":0.7639999985694885},{"id":"https://openalex.org/keywords/chemokine-receptor-antagonism","display_name":"chemokine receptor antagonism","score":0.5049999952316284}],"concepts":[{"id":"https://openalex.org/C2778486448","wikidata":"https://www.wikidata.org/wiki/Q494066","display_name":"Experimental autoimmune encephalomyelitis","level":3,"score":0.7408208847045898},{"id":"https://openalex.org/C90224389","wikidata":"https://www.wikidata.org/wiki/Q6706410","display_name":"Luxol fast blue stain","level":4,"score":0.6506990194320679},{"id":"https://openalex.org/C2780876595","wikidata":"https://www.wikidata.org/wiki/Q410974","display_name":"Myelin basic protein","level":4,"score":0.6120760440826416},{"id":"https://openalex.org/C2780640218","wikidata":"https://www.wikidata.org/wiki/Q8277","display_name":"Multiple sclerosis","level":2,"score":0.5391119122505188},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5126551985740662},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5037373900413513},{"id":"https://openalex.org/C2778609137","wikidata":"https://www.wikidata.org/wiki/Q105790271","display_name":"Myelin","level":3,"score":0.45391327142715454},{"id":"https://openalex.org/C2777899865","wikidata":"https://www.wikidata.org/wiki/Q1634879","display_name":"Encephalomyelitis","level":3,"score":0.4429134428501129},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.4262591004371643},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.4162839651107788},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.2964732348918915},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.2921450734138489},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25996631383895874},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.254920095205307},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22200626134872437}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001369","descriptor_name":"Axons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002634","descriptor_name":"Chemotaxis, Leukocyte","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004681","descriptor_name":"Encephalomyelitis, Autoimmune, Experimental","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D005455","descriptor_name":"Fluorescent Antibody Technique","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013116","descriptor_name":"Spinal Cord","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D018696","descriptor_name":"Neuroprotective Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D020127","descriptor_name":"Recovery of Function","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054387","descriptor_name":"Receptors, CXCR","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D056324","descriptor_name":"Diffusion Tensor Imaging","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1186/1742-2094-8-170","doi":"https://doi.org/10.1186/1742-2094-8-170","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-170","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-170","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3305694","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3305694","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Neuroinflammation","raw_type":"Text"},{"id":"pmid:22145790","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22145790","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroinflammation","raw_type":"Journal Article"},{"id":"pmh:oai:digitalcommons.wustl.edu:open_access_pubs-1853","doi":null,"is_oa":true,"landing_page_url":"https://digitalcommons.wustl.edu/open_access_pubs/855","pdf_url":"https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=1853&context=open_access_pubs","source":{"id":"https://openalex.org/S4306400764","display_name":"Digital Commons@Becker (Washington University School of Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I204465549","host_organization_name":"Washington University in St. Louis","host_organization_lineage":["https://openalex.org/I204465549"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Open Access Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:a51a7678ebb244999b13b7e643fec60a","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/a51a7678ebb244999b13b7e643fec60a","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, Vol 8, Iss 1, p 170 (2011)","raw_type":"article"},{"id":"pmh:oai:escholarship.org/ark:/13030/qt75x3b90d","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/75x3b90d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of neuroinflammation, vol 8, iss 1","raw_type":"article"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt75x3b90d","doi":null,"is_oa":true,"landing_page_url":"https://escholarship.org/uc/item/75x3b90d","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal of Neuroinflammation, vol 8, iss 1","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1186/1742-2094-8-170","doi":"https://doi.org/10.1186/1742-2094-8-170","is_oa":true,"landing_page_url":"https://doi.org/10.1186/1742-2094-8-170","pdf_url":"https://jneuroinflammation.biomedcentral.com/counter/pdf/10.1186/1742-2094-8-170","source":{"id":"https://openalex.org/S199572710","display_name":"Journal of Neuroinflammation","issn_l":"1742-2094","issn":["1742-2094"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-2","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroinflammation","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5080950515","display_name":null,"funder_award_id":"NS059560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G5130636508","display_name":"Biomarkers and Pathogenesis of MS: From Mouse to Human","funder_award_id":"P01NS059560","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8048267219","display_name":null,"funder_award_id":"NS054194","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"},{"id":"https://openalex.org/G8197993180","display_name":"Noninvasive Quantification of Axon Damage in EAE and MS","funder_award_id":"R01NS054194","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306161","display_name":"National Multiple Sclerosis Society","ror":"https://ror.org/03019wv17"},{"id":"https://openalex.org/F4320320084","display_name":"Multiple Sclerosis Society","ror":"https://ror.org/043fwdk81"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2002959623.pdf","grobid_xml":"https://content.openalex.org/works/W2002959623.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W35975993","https://openalex.org/W1582875450","https://openalex.org/W1601155059","https://openalex.org/W1791569952","https://openalex.org/W1944845116","https://openalex.org/W1964565539","https://openalex.org/W1965891711","https://openalex.org/W1969118134","https://openalex.org/W1971088892","https://openalex.org/W1973468054","https://openalex.org/W1974131316","https://openalex.org/W1977091420","https://openalex.org/W1981453697","https://openalex.org/W1982198467","https://openalex.org/W2000389453","https://openalex.org/W2002433576","https://openalex.org/W2007412750","https://openalex.org/W2007983808","https://openalex.org/W2013061553","https://openalex.org/W2013220371","https://openalex.org/W2013846797","https://openalex.org/W2014996595","https://openalex.org/W2018859301","https://openalex.org/W2020392927","https://openalex.org/W2026171674","https://openalex.org/W2028031986","https://openalex.org/W2030409379","https://openalex.org/W2032955707","https://openalex.org/W2037588444","https://openalex.org/W2038651295","https://openalex.org/W2039223093","https://openalex.org/W2041264117","https://openalex.org/W2047410266","https://openalex.org/W2051391308","https://openalex.org/W2055599834","https://openalex.org/W2058116209","https://openalex.org/W2060473020","https://openalex.org/W2063754878","https://openalex.org/W2082820637","https://openalex.org/W2084761689","https://openalex.org/W2085879860","https://openalex.org/W2090476586","https://openalex.org/W2099534838","https://openalex.org/W2101043097","https://openalex.org/W2108282360","https://openalex.org/W2108971625","https://openalex.org/W2117823483","https://openalex.org/W2120259577","https://openalex.org/W2122347714","https://openalex.org/W2122665472","https://openalex.org/W2128898409","https://openalex.org/W2130750706","https://openalex.org/W2138825607","https://openalex.org/W2142767602","https://openalex.org/W2142947426","https://openalex.org/W2147149841","https://openalex.org/W2153790845","https://openalex.org/W2155510294","https://openalex.org/W2158064024","https://openalex.org/W2158156478","https://openalex.org/W2161766823","https://openalex.org/W2161775276","https://openalex.org/W2166858899","https://openalex.org/W2169982975","https://openalex.org/W2171581347","https://openalex.org/W2186130713","https://openalex.org/W2593654596","https://openalex.org/W2904473752"],"related_works":["https://openalex.org/W7095798823","https://openalex.org/W2275391726","https://openalex.org/W2176768804","https://openalex.org/W2010508497","https://openalex.org/W2161766823","https://openalex.org/W4389460236","https://openalex.org/W2077943662","https://openalex.org/W3131131338","https://openalex.org/W2592841162","https://openalex.org/W2035363365"],"abstract_inverted_index":{"BACKGROUND:":[0],"Multiple":[1],"Sclerosis":[2],"(MS)":[3],"is":[4],"characterized":[5],"by":[6,83,139,201,204,282],"the":[7,13,19,33,45,297],"pathological":[8],"trafficking":[9],"of":[10,32,41,48,58,62,74,119,153,176,224,233,257,272,289,299,342],"leukocytes":[11,59],"into":[12],"central":[14],"nervous":[15],"system":[16],"(CNS).":[17],"Using":[18],"murine":[20],"MS":[21],"model,":[22],"experimental":[23],"autoimmune":[24],"encephalomyelitis":[25],"(EAE),":[26],"we":[27,93],"previously":[28],"demonstrated":[29],"that":[30,70,309],"antagonism":[31,52,311],"chemokine":[34],"receptor":[35],"CXCR7":[36,51,75,104,129,236,300,310,324],"blocks":[37],"endothelial":[38],"cell":[39],"sequestration":[40],"CXCL12,":[42],"thereby":[43],"enhancing":[44],"abluminal":[46],"localization":[47],"CXCR4-expressing":[49],"leukocytes.":[50],"led":[53],"to":[54,78,99,141,184],"decreased":[55,245],"parenchymal":[56],"entry":[57],"and":[60,123,136,155,164,171,195,235,270,329],"amelioration":[61],"ongoing":[63],"disease":[64,327],"during":[65,331],"EAE.":[66,112],"Of":[67],"note,":[68],"animals":[69,243],"received":[71],"high":[72],"doses":[73],"antagonist":[76,130],"recovered":[77],"baseline":[79],"function,":[80],"as":[81,253,280],"assessed":[82,254],"standard":[84],"clinical":[85],"scoring.":[86],"Because":[87],"functional":[88],"recovery":[89,110,330],"reflects":[90],"axonal":[91,101,144,320],"integrity,":[92],"utilized":[94],"diffusion":[95],"tensor":[96],"imaging":[97],"(DTI)":[98],"evaluate":[100],"injury":[102],"in":[103,250,276,339],"antagonist-":[105],"versus":[106,303],"vehicle-treated":[107,242],"mice":[108,115,238,302],"after":[109],"from":[111],"METHODS:":[113],"C57BL6/J":[114],"underwent":[116,150],"adoptive":[117],"transfer":[118],"MOG-reactive":[120],"Th1":[121],"cells":[122],"were":[124,199,239,260,274],"treated":[125],"daily":[126],"with":[127,159,262],"either":[128],"or":[131],"vehicle":[132],"for":[133,143,166,190,336],"28":[134],"days;":[135],"then":[137],"evaluated":[138],"DTI":[140,193,222],"assess":[142],"injury.":[145],"After":[146],"imaging,":[147],"spinal":[148,225],"cords":[149],"histological":[151],"analysis":[152,189,211],"myelin":[154,167,268],"oligodendrocytes":[156,273],"via":[157,255],"staining":[158],"luxol":[160],"fast":[161],"blue":[162],"(LFB),":[163],"immunofluorescence":[165,198],"basic":[168],"protein":[169],"(MBP)":[170],"glutathione":[172],"S-transferase-\u03c0":[173],"(GST-\u03c0).":[174],"Detection":[175],"non-phosphorylated":[177,196,258],"neurofilament":[178],"H":[179],"(NH-F)":[180],"was":[181,216],"also":[182,318],"performed":[183],"detect":[185],"injured":[186,251],"axons.":[187],"Statistical":[188],"EAE":[191],"scores,":[192],"parameters":[194],"NH-F":[197],"done":[200],"ANOVA":[202],"followed":[203],"Bonferroni":[205],"post-hoc":[206],"test.":[207],"For":[208],"all":[209,277],"statistical":[210],"a":[212,334],"p":[213],"<":[214],"0.05":[215],"considered":[217],"significant.":[218],"RESULTS:":[219],"In":[220],"vivo":[221],"maps":[223],"cord":[226],"ventrolateral":[227],"white":[228],"matter":[229],"(VLWM)":[230],"axial":[231,246,263],"diffusivities":[232],"na\u00efve":[234],"antagonist-treated":[237,301],"indistinguishable,":[240],"while":[241],"exhibited":[244],"diffusivities.":[247],"Quantitative":[248,287],"differences":[249],"axons,":[252],"detection":[256],"NH-F,":[259],"consistent":[261],"diffusivity":[264,285],"measurements.":[265],"Overall,":[266],"qualitative":[267],"content":[269],"presence":[271],"similar":[275],"treatment":[278],"groups,":[279],"expected":[281],"their":[283],"radial":[284],"values.":[286],"assessment":[288],"persistent":[290,315],"inflammatory":[291],"infiltrates":[292],"revealed":[293],"significant":[294],"decreases":[295],"within":[296],"parenchyma":[298],"controls.":[304],"CONCLUSIONS:":[305],"These":[306],"data":[307],"suggest":[308],"not":[312],"only":[313],"prevents":[314],"inflammation":[316],"but":[317],"preserves":[319],"integrity.":[321],"Thus,":[322],"targeting":[323],"modifies":[325],"both":[326,340],"severity":[328],"EAE,":[332],"suggesting":[333],"role":[335],"this":[337],"molecule":[338],"phases":[341],"disease.":[343]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}